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Found 18 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator BAX' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078022
PNG
(CHEMBL3417402)
Show SMILES CCOc1ccccc1N\N=C1\C(C)=NN(C1=O)c1cc(O)cc(c1)-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C26H27N5O3/c1-5-34-24-9-7-6-8-23(24)27-28-25-17(2)29-31(26(25)33)21-14-19(15-22(32)16-21)18-10-12-20(13-11-18)30(3)4/h6-16,27,32H,5H2,1-4H3/b28-25-
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800n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078029
PNG
(CHEMBL3417409)
Show SMILES CN(C)c1ccc(cc1)-c1cc(O)cc(c1)N1N=C(C)\C(=N\Nc2ccc3ccccc3c2)C1=O
Show InChI InChI=1S/C28H25N5O2/c1-18-27(30-29-23-11-8-19-6-4-5-7-21(19)14-23)28(35)33(31-18)25-15-22(16-26(34)17-25)20-9-12-24(13-10-20)32(2)3/h4-17,29,34H,1-3H3/b30-27-
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1.00E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078015
PNG
(CHEMBL3417395)
Show SMILES CCOc1ccccc1N\N=C1/C(C)=NN(C1=O)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+
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1.10E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078027
PNG
(CHEMBL3417407)
Show SMILES CCOc1ccccc1N\N=C1\C(C)=NN(C1=O)c1cc(O)cc(c1)-c1ccc(cc1)C(C)C
Show InChI InChI=1S/C27H28N4O3/c1-5-34-25-9-7-6-8-24(25)28-29-26-18(4)30-31(27(26)33)22-14-21(15-23(32)16-22)20-12-10-19(11-13-20)17(2)3/h6-17,28,32H,5H2,1-4H3/b29-26-
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1.20E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078028
PNG
(CHEMBL3417408)
Show SMILES CCOc1ccccc1N\N=C1\C(C)=NN(C1=O)c1cccc(c1)-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C26H27N5O2/c1-5-33-24-12-7-6-11-23(24)27-28-25-18(2)29-31(26(25)32)22-10-8-9-20(17-22)19-13-15-21(16-14-19)30(3)4/h6-17,27H,5H2,1-4H3/b28-25-
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1.30E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078026
PNG
(CHEMBL3417406)
Show SMILES CCOc1ccccc1N\N=C1\C(C)=NN(C1=O)c1cc(O)cc(c1)-c1cccc(N)c1
Show InChI InChI=1S/C24H23N5O3/c1-3-32-22-10-5-4-9-21(22)26-27-23-15(2)28-29(24(23)31)19-12-17(13-20(30)14-19)16-7-6-8-18(25)11-16/h4-14,26,30H,3,25H2,1-2H3/b27-23-
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1.30E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078024
PNG
(CHEMBL3417404)
Show SMILES CCOc1ccccc1N\N=C1\C(C)=NN(C1=O)c1cc(O)cc(c1)-c1ccncc1
Show InChI InChI=1S/C23H21N5O3/c1-3-31-21-7-5-4-6-20(21)25-26-22-15(2)27-28(23(22)30)18-12-17(13-19(29)14-18)16-8-10-24-11-9-16/h4-14,25,29H,3H2,1-2H3/b26-22-
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1.70E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078030
PNG
(CHEMBL3417410)
Show SMILES CC1=NN(C(=O)\C1=C\c1ccccc1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C20H15N3OS/c1-14-17(12-15-8-4-2-5-9-15)19(24)23(22-14)20-21-18(13-25-20)16-10-6-3-7-11-16/h2-13H,1H3/b17-12+
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2.50E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078023
PNG
(CHEMBL3417403)
Show SMILES CCOc1ccccc1N\N=C1\C(C)=NN(C1=O)c1cc(O)cc(c1)-c1ccccc1
Show InChI InChI=1S/C24H22N4O3/c1-3-31-22-12-8-7-11-21(22)25-26-23-16(2)27-28(24(23)30)19-13-18(14-20(29)15-19)17-9-5-4-6-10-17/h4-15,25,29H,3H2,1-2H3/b26-23-
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9.10E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078018
PNG
(CHEMBL3417398)
Show SMILES CC1=NN(C(=O)\C1=C\c1ccc2ccccc2c1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C24H17N3OS/c1-16-21(14-17-11-12-18-7-5-6-10-20(18)13-17)23(28)27(26-16)24-25-22(15-29-24)19-8-3-2-4-9-19/h2-15H,1H3/b21-14+
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1.26E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078017
PNG
(CHEMBL3417397)
Show SMILES CC1=NN(C(=O)\C1=C\c1ccc(cc1)-c1ccccc1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C26H19N3OS/c1-18-23(16-19-12-14-21(15-13-19)20-8-4-2-5-9-20)25(30)29(28-18)26-27-24(17-31-26)22-10-6-3-7-11-22/h2-17H,1H3/b23-16+
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1.29E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078016
PNG
(CHEMBL3417396)
Show SMILES CC1=NN(C(=O)\C1=C\C(c1ccccc1)c1ccccc1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C27H21N3OS/c1-19-23(17-24(20-11-5-2-6-12-20)21-13-7-3-8-14-21)26(31)30(29-19)27-28-25(18-32-27)22-15-9-4-10-16-22/h2-18,24H,1H3/b23-17+
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1.35E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078019
PNG
(CHEMBL3417399)
Show SMILES CC1=NN(C(=O)\C1=C\c1ncc[nH]1)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C17H13N5OS/c1-11-13(9-15-18-7-8-19-15)16(23)22(21-11)17-20-14(10-24-17)12-5-3-2-4-6-12/h2-10H,1H3,(H,18,19)/b13-9+
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1.58E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078025
PNG
(CHEMBL3417405)
Show SMILES CCOc1ccccc1N\N=C1\C(C)=NN(C1=O)c1cc(O)cc(c1)-c1cccs1
Show InChI InChI=1S/C22H20N4O3S/c1-3-29-19-8-5-4-7-18(19)23-24-21-14(2)25-26(22(21)28)16-11-15(12-17(27)13-16)20-9-6-10-30-20/h4-13,23,27H,3H2,1-2H3/b24-21-
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3.09E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078020
PNG
(CHEMBL3417400)
Show SMILES CCOc1ccccc1CC(=O)C1C(C)=NN(C1=O)c1nc(cs1)-c1ccccc1
Show InChI InChI=1/C23H21N3O3S/c1-3-29-20-12-8-7-11-17(20)13-19(27)21-15(2)25-26(22(21)28)23-24-18(14-30-23)16-9-5-4-6-10-16/h4-12,14,21H,3,13H2,1-2H3
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6.31E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078021
PNG
(CHEMBL3417401)
Show SMILES CCOc1ccccc1C(=O)C(=O)C1C(C)=NN(C1=O)c1nc(cs1)-c1ccccc1
Show InChI InChI=1/C23H19N3O4S/c1-3-30-18-12-8-7-11-16(18)20(27)21(28)19-14(2)25-26(22(19)29)23-24-17(13-31-23)15-9-5-4-6-10-15/h4-13,19H,3H2,1-2H3
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8.51E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Displacement of FITC-BIM from recombinant N-terminal GST-tagged human BAX expressed in Escherichia coli after 30 mins by fluorescence polarization as...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078022
PNG
(CHEMBL3417402)
Show SMILES CCOc1ccccc1N\N=C1\C(C)=NN(C1=O)c1cc(O)cc(c1)-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C26H27N5O3/c1-5-34-24-9-7-6-8-23(24)27-28-25-17(2)29-31(26(25)33)21-14-19(15-22(32)16-21)18-10-12-20(13-11-18)30(3)4/h6-16,27,32H,5H2,1-4H3/b28-25-
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n/an/an/an/a 700n/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Activation of Bax in human HuH7 cells assessed as inhibition of mitochondrial accumulation of fluorescent probe Mitotracker Red after 12 to 72 hrs by...


Citation and Details
More data for this
Ligand-Target Pair
Apoptosis regulator BAX


(Homo sapiens)
BDBM50078015
PNG
(CHEMBL3417395)
Show SMILES CCOc1ccccc1N\N=C1/C(C)=NN(C1=O)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+
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n/an/an/an/a 8.20E+3n/an/an/an/a



Universit£ di Napoli"Federico II"

Curated by ChEMBL


Assay Description
Activation of Bax in human HuH7 cells assessed as inhibition of mitochondrial accumulation of fluorescent probe Mitotracker Red after 12 to 72 hrs by...


Citation and Details
More data for this
Ligand-Target Pair