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Found 24 hits Enz. Inhib. hit(s) with Target = 'Arachidonate 12-lipoxygenase' AND taxid = 9823   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054838
PNG
(3-(4-Tridec-2-ynyloxymethyl-phenyl)-propionic acid...)
Show SMILES CCCCCCCCCCC#CCOCc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C23H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-19-26-20-22-15-13-21(14-16-22)17-18-23(24)25/h13-16H,2-10,17-20H2,1H3,(H,24,25)
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n/an/a 35n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054833
PNG
(3-{4-[((E)-Tridec-2-enyl)oxymethyl]-phenyl}-propio...)
Show SMILES CCCCCCCCCC\C=C\COCc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C23H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-19-26-20-22-15-13-21(14-16-22)17-18-23(24)25/h11-16H,2-10,17-20H2,1H3,(H,24,25)/b12-11+
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n/an/a 40n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054836
PNG
((4-Tridec-2-ynyloxymethyl-phenyl)-acetic acid | CH...)
Show SMILES CCCCCCCCCCC#CCOCc1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C22H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-17-25-19-21-15-13-20(14-16-21)18-22(23)24/h13-16H,2-10,17-19H2,1H3,(H,23,24)
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n/an/a 50n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054851
PNG
(4-Tridec-2-ynyloxymethyl-benzoic acid | CHEMBL1422...)
Show SMILES CCCCCCCCCCC#CCOCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-17-24-18-19-13-15-20(16-14-19)21(22)23/h13-16H,2-10,17-18H2,1H3,(H,22,23)
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n/an/a 60n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50109702
PNG
(CHEMBL3604174)
Show SMILES Clc1ccc(NC(=O)c2cn[nH]n2)c(Cl)c1
Show InChI InChI=1S/C9H6Cl2N4O/c10-5-1-2-7(6(11)3-5)13-9(16)8-4-12-15-14-8/h1-4H,(H,13,16)(H,12,14,15)
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n/an/a 78n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Inhibition of pig 15-LOX-1 expressed in Sf9 cells assessed as reduction in conversion of arachidonic acid to 15-HETE pre-incubated 5 min before arach...


Bioorg Med Chem Lett 25: 3024-9 (2015)

More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054840
PNG
(3-(4-Undec-2-ynyloxymethyl-phenyl)-propionic acid ...)
Show SMILES CCCCCCCCC#CCOCc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C21H30O3/c1-2-3-4-5-6-7-8-9-10-17-24-18-20-13-11-19(12-14-20)15-16-21(22)23/h11-14H,2-8,15-18H2,1H3,(H,22,23)
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n/an/a 100n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054844
PNG
(3-(4-Tetradeca-2,3-dienyloxymethyl-phenyl)-propion...)
Show SMILES CCCCCCCCCCC=C=CCOCc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C24H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-20-27-21-23-16-14-22(15-17-23)18-19-24(25)26/h11,13-17H,2-10,18-21H2,1H3,(H,25,26)
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n/an/a 280n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054832
PNG
(3-(3-Tridec-2-ynyloxymethyl-phenyl)-propionic acid...)
Show SMILES CCCCCCCCCCC#CCOCc1cccc(CCC(O)=O)c1
Show InChI InChI=1S/C23H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-18-26-20-22-15-13-14-21(19-22)16-17-23(24)25/h13-15,19H,2-10,16-18,20H2,1H3,(H,24,25)
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n/an/a 320n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054846
PNG
(3-(4-Pentadec-2-ynyloxymethyl-phenyl)-propionic ac...)
Show SMILES CCCCCCCCCCCCC#CCOCc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C25H38O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-21-28-22-24-17-15-23(16-18-24)19-20-25(26)27/h15-18H,2-12,19-22H2,1H3,(H,26,27)
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n/an/a 320n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054849
PNG
(3-(4-Non-2-ynyloxymethyl-phenyl)-propionic acid | ...)
Show SMILES CCCCCCC#CCOCc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C19H26O3/c1-2-3-4-5-6-7-8-15-22-16-18-11-9-17(10-12-18)13-14-19(20)21/h9-12H,2-6,13-16H2,1H3,(H,20,21)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054850
PNG
(3-{4-[((Z)-Tridec-2-enyl)oxymethyl]-phenyl}-propio...)
Show SMILES CCCCCCCCCC\C=C/COCc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C23H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-19-26-20-22-15-13-21(14-16-22)17-18-23(24)25/h11-16H,2-10,17-20H2,1H3,(H,24,25)/b12-11-
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n/an/a 2.50E+3n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50041161
PNG
(1-(4-Chloro-benzyl)-2-[2,2-dimethyl-3-(1H-tetrazol...)
Show SMILES CC1Cc2c(OCc3ccc(cn3)-c3ccccc3)ccc3n(Cc4ccc(Cl)cc4)c(CC(C)(C)Cc4nnn[nH]4)c(S1)c23
Show InChI InChI=1S/C36H35ClN6OS/c1-23-17-29-32(44-22-28-14-11-26(20-38-28)25-7-5-4-6-8-25)16-15-30-34(29)35(45-23)31(18-36(2,3)19-33-39-41-42-40-33)43(30)21-24-9-12-27(37)13-10-24/h4-16,20,23H,17-19,21-22H2,1-3H3,(H,39,40,41,42)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Tested for inhibition against porcine 12-LO


J Med Chem 36: 2771-87 (1993)

More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50407987
PNG
(CHEMBL2112001)
Show SMILES OC(=O)CCc1cccc(COCC#CCCCCCc2ccccc2)c1
Show InChI InChI=1S/C24H28O3/c25-24(26)17-16-22-14-10-15-23(19-22)20-27-18-9-4-2-1-3-6-11-21-12-7-5-8-13-21/h5,7-8,10,12-15,19H,1-3,6,11,16-18,20H2,(H,25,26)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054841
PNG
(3-[4-(7-Phenyl-hept-2-ynyloxymethyl)-phenyl]-propi...)
Show SMILES OC(=O)CCc1ccc(COCC#CCCCCc2ccccc2)cc1
Show InChI InChI=1S/C23H26O3/c24-23(25)17-16-21-12-14-22(15-13-21)19-26-18-8-3-1-2-5-9-20-10-6-4-7-11-20/h4,6-7,10-15H,1-2,5,9,16-19H2,(H,24,25)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054835
PNG
(4-Dec-2-ynyloxymethyl-benzoic acid | CHEMBL359394)
Show SMILES CCCCCCCC#CCOCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C18H24O3/c1-2-3-4-5-6-7-8-9-14-21-15-16-10-12-17(13-11-16)18(19)20/h10-13H,2-7,14-15H2,1H3,(H,19,20)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054848
PNG
(3-(3-Non-3-ynyloxymethyl-phenyl)-propionic acid | ...)
Show SMILES CCCCCC#CCCOCc1cccc(CCC(O)=O)c1
Show InChI InChI=1S/C19H26O3/c1-2-3-4-5-6-7-8-14-22-16-18-11-9-10-17(15-18)12-13-19(20)21/h9-11,15H,2-5,8,12-14,16H2,1H3,(H,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054839
PNG
(3-(4-Heptadec-2-ynyloxymethyl-phenyl)-propionic ac...)
Show SMILES CCCCCCCCCCCCCCC#CCOCc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C27H42O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-23-30-24-26-19-17-25(18-20-26)21-22-27(28)29/h17-20H,2-14,21-24H2,1H3,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054837
PNG
(3-(3-Undec-2-ynyloxymethyl-phenyl)-propionic acid ...)
Show SMILES CCCCCCCCC#CCOCc1cccc(CCC(O)=O)c1
Show InChI InChI=1S/C21H30O3/c1-2-3-4-5-6-7-8-9-10-16-24-18-20-13-11-12-19(17-20)14-15-21(22)23/h11-13,17H,2-8,14-16,18H2,1H3,(H,22,23)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054843
PNG
(3-(3-Undec-2-ynylsulfanylmethyl-phenyl)-propionic ...)
Show SMILES CCCCCCCCC#CCSCc1cccc(CCC(O)=O)c1
Show InChI InChI=1S/C21H30O2S/c1-2-3-4-5-6-7-8-9-10-16-24-18-20-13-11-12-19(17-20)14-15-21(22)23/h11-13,17H,2-8,14-16,18H2,1H3,(H,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054845
PNG
(4-(4-Tridec-2-ynyloxymethyl-phenyl)-butyric acid |...)
Show SMILES CCCCCCCCCCC#CCOCc1ccc(CCCC(O)=O)cc1
Show InChI InChI=1S/C24H36O3/c1-2-3-4-5-6-7-8-9-10-11-12-20-27-21-23-18-16-22(17-19-23)14-13-15-24(25)26/h16-19H,2-10,13-15,20-21H2,1H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054847
PNG
(4-Heptadec-2-ynyloxymethyl-benzoic acid | CHEMBL14...)
Show SMILES CCCCCCCCCCCCCCC#CCOCc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H38O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-21-28-22-23-17-19-24(20-18-23)25(26)27/h17-20H,2-14,21-22H2,1H3,(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054834
PNG
(3-(4-Tridecyloxymethyl-phenyl)-propionic acid | CH...)
Show SMILES CCCCCCCCCCCCCOCc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C23H38O3/c1-2-3-4-5-6-7-8-9-10-11-12-19-26-20-22-15-13-21(14-16-22)17-18-23(24)25/h13-16H,2-12,17-20H2,1H3,(H,24,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50054842
PNG
(3-(3-Non-2-ynyloxymethyl-phenyl)-propionic acid | ...)
Show SMILES CCCCCCC#CCOCc1cccc(CCC(O)=O)c1
Show InChI InChI=1S/C19H26O3/c1-2-3-4-5-6-7-8-14-22-16-18-11-9-10-17(15-18)12-13-19(20)21/h9-11,15H,2-6,12-14,16H2,1H3,(H,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibitory activity against conversion of [1-14C]-arachidonic acid to 12-HPETE and its reduction product 12-HETE by porcine leukocyte type 12-lipoxyg...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 12-lipoxygenase


(Sus scrofa)
BDBM50016986
PNG
(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Show SMILES CCCc1cc(Cl)c2oc(Cc3ccc(OC)cc3)c(C)c2c1O
Show InChI InChI=1S/C20H21ClO3/c1-4-5-14-11-16(21)20-18(19(14)22)12(2)17(24-20)10-13-6-8-15(23-3)9-7-13/h6-9,11,22H,4-5,10H2,1-3H3
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n/an/a 4.00E+4n/an/an/an/an/an/a



Merck Frosst Canada Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound towards porcine 12-lipoxygenase


J Med Chem 32: 1190-7 (1989)

More data for this
Ligand-Target Pair