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Found 65 hits Enz. Inhib. hit(s) with Target = 'Arachidonate 5-lipoxygenase' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50043670
PNG
(2-{(S)-1-[3-Fluoro-5-(naphthalen-2-ylmethoxy)-phen...)
Show SMILES CC[C@@](OC)(c1nccs1)c1cc(F)cc(OCc2ccc3ccccc3c2)c1
Show InChI InChI=1S/C24H22FNO2S/c1-3-24(27-2,23-26-10-11-29-23)20-13-21(25)15-22(14-20)28-16-17-8-9-18-6-4-5-7-19(18)12-17/h4-15H,3,16H2,1-2H3/t24-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from mouse macrophage


J Med Chem 37: 113-24 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50043682
PNG
((R)-2-[3-Fluoro-5-(naphthalen-2-ylmethoxy)-phenyl]...)
Show SMILES CC[C@](OC)(C(=O)OC)c1cc(F)cc(OCc2ccc3ccccc3c2)c1
Show InChI InChI=1S/C23H23FO4/c1-4-23(27-3,22(25)26-2)19-12-20(24)14-21(13-19)28-15-16-9-10-17-7-5-6-8-18(17)11-16/h5-14H,4,15H2,1-3H3/t23-/m1/s1
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n/an/a 1.30n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from mouse macrophage


J Med Chem 37: 113-24 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50043669
PNG
(6-[3-Fluoro-5-((S)-1-methoxy-1-thiazol-2-yl-propyl...)
Show SMILES CC[C@@](OC)(c1nccs1)c1cc(F)cc(OCc2ccc3n(C)c(=O)ccc3c2)c1
Show InChI InChI=1S/C24H23FN2O3S/c1-4-24(29-3,23-26-9-10-31-23)18-12-19(25)14-20(13-18)30-15-16-5-7-21-17(11-16)6-8-22(28)27(21)2/h5-14H,4,15H2,1-3H3/t24-/m0/s1
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n/an/a 1.60n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from mouse macrophage


J Med Chem 37: 113-24 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50000832
PNG
(2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...)
Show SMILES COC(C)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1
Show InChI InChI=1S/C23H21NO2S/c1-23(25-2,22-24-12-13-27-22)20-8-5-9-21(15-20)26-16-17-10-11-18-6-3-4-7-19(18)14-17/h3-15H,16H2,1-2H3
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n/an/a 5n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in mouse macrophages.


J Med Chem 34: 2176-86 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50043677
PNG
((S)-2-[3-Fluoro-5-(naphthalen-2-ylmethoxy)-phenyl]...)
Show SMILES CC[C@@](OC)(C(=O)OC)c1cc(F)cc(OCc2ccc3ccccc3c2)c1
Show InChI InChI=1S/C23H23FO4/c1-4-23(27-3,22(25)26-2)19-12-20(24)14-21(13-19)28-15-16-9-10-17-7-5-6-8-18(17)11-16/h5-14H,4,15H2,1-3H3/t23-/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from mouse macrophage


J Med Chem 37: 113-24 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50007052
PNG
(1-[3-(3-Phenyl-allyloxy)-phenyl]-1-thiazol-2-yl-pr...)
Show SMILES CCC(O)(c1nccs1)c1cccc(OC\C=C\c2ccccc2)c1
Show InChI InChI=1S/C21H21NO2S/c1-2-21(23,20-22-13-15-25-20)18-11-6-12-19(16-18)24-14-7-10-17-8-4-3-5-9-17/h3-13,15-16,23H,2,14H2,1H3/b10-7+
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ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in mouse macrophages.


J Med Chem 34: 2176-86 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50000857
PNG
(2-(1-methoxy-1-(3-(naphthalen-2-ylmethoxy)phenyl)p...)
Show SMILES CCC(OC)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1
Show InChI InChI=1S/C24H23NO2S/c1-3-24(26-2,23-25-13-14-28-23)21-9-6-10-22(16-21)27-17-18-11-12-19-7-4-5-8-20(19)15-18/h4-16H,3,17H2,1-2H3
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n/an/a 8n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in mouse macrophages.


J Med Chem 34: 2176-86 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50043666
PNG
((R)-2-[3-Fluoro-5-(1-methyl-2-oxo-1,2-dihydro-quin...)
Show SMILES CC[C@](OC)(C(=O)OC)c1cc(F)cc(OCc2ccc3n(C)c(=O)ccc3c2)c1
Show InChI InChI=1S/C23H24FNO5/c1-5-23(29-4,22(27)28-3)17-11-18(24)13-19(12-17)30-14-15-6-8-20-16(10-15)7-9-21(26)25(20)2/h6-13H,5,14H2,1-4H3/t23-/m1/s1
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n/an/a 9.60n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from mouse macrophage


J Med Chem 37: 113-24 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50043678
PNG
((S)-2-[3-Fluoro-5-(1-methyl-2-oxo-1,2-dihydro-quin...)
Show SMILES CC[C@@](OC)(C(=O)OC)c1cc(F)cc(OCc2ccc3n(C)c(=O)ccc3c2)c1
Show InChI InChI=1S/C23H24FNO5/c1-5-23(29-4,22(27)28-3)17-11-18(24)13-19(12-17)30-14-15-6-8-20-16(10-15)7-9-21(26)25(20)2/h6-13H,5,14H2,1-4H3/t23-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from mouse macrophage


J Med Chem 37: 113-24 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50007040
PNG
(2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...)
Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1
Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3
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n/an/a 14n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in mouse macrophages.


J Med Chem 34: 2176-86 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50007057
PNG
(1-[3-(3-Phenyl-prop-2-ynyloxy)-phenyl]-1-thiazol-2...)
Show SMILES CCC(O)(c1nccs1)c1cccc(OCC#Cc2ccccc2)c1
Show InChI InChI=1S/C21H19NO2S/c1-2-21(23,20-22-13-15-25-20)18-11-6-12-19(16-18)24-14-7-10-17-8-4-3-5-9-17/h3-6,8-9,11-13,15-16,23H,2,14H2,1H3
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n/an/a 30n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in mouse macrophages.


J Med Chem 34: 2176-86 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50000832
PNG
(2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...)
Show SMILES COC(C)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1
Show InChI InChI=1S/C23H21NO2S/c1-23(25-2,22-24-12-13-27-22)20-8-5-9-21(15-20)26-16-17-10-11-18-6-3-4-7-19(18)14-17/h3-15H,16H2,1-2H3
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ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in mouse macrophages.


J Med Chem 34: 2176-86 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50006811
PNG
(2-(12-Hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-p...)
Show SMILES Cc1c(C)c(O)c(C=CCCC#CCCCC#CCO)c(C)c1O
Show InChI InChI=1S/C21H26O3/c1-16-17(2)21(24)19(18(3)20(16)23)14-12-10-8-6-4-5-7-9-11-13-15-22/h12,14,22-24H,5,7-10,15H2,1-3H3
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n/an/a 32n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibitory activity against murine lipoxygenase-2.


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50043676
PNG
(6-[3-Fluoro-5-((S)-1-methoxy-1-methoxymethyl-propy...)
Show SMILES CC[C@](COC)(OC)c1cc(F)cc(OCc2ccc3n(C)c(=O)ccc3c2)c1
Show InChI InChI=1S/C23H26FNO4/c1-5-23(28-4,15-27-3)18-11-19(24)13-20(12-18)29-14-16-6-8-21-17(10-16)7-9-22(26)25(21)2/h6-13H,5,14-15H2,1-4H3/t23-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from mouse macrophage


J Med Chem 37: 113-24 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50043671
PNG
(6-[3-Fluoro-5-((R)-1-methoxy-1-methoxymethyl-propy...)
Show SMILES CC[C@@](COC)(OC)c1cc(F)cc(OCc2ccc3n(C)c(=O)ccc3c2)c1
Show InChI InChI=1S/C23H26FNO4/c1-5-23(28-4,15-27-3)18-11-19(24)13-20(12-18)29-14-16-6-8-21-17(10-16)7-9-22(26)25(21)2/h6-13H,5,14-15H2,1-4H3/t23-/m0/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from mouse macrophage


J Med Chem 37: 113-24 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50007051
PNG
(1-[3-(Naphthalen-2-ylmethoxy)-phenyl]-1-thiazol-2-...)
Show SMILES CCCC(O)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1
Show InChI InChI=1S/C24H23NO2S/c1-2-12-24(26,23-25-13-14-28-23)21-8-5-9-22(16-21)27-17-18-10-11-19-6-3-4-7-20(19)15-18/h3-11,13-16,26H,2,12,17H2,1H3
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ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in mouse macrophages.


J Med Chem 34: 2176-86 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50329397
PNG
(CHEMBL1269648 | N-(4-Ethylphenyl)-5-methylbenzo[d]...)
Show SMILES CCc1ccc(Nc2nc3cc(C)ccc3o2)cc1
Show InChI InChI=1S/C16H16N2O/c1-3-12-5-7-13(8-6-12)17-16-18-14-10-11(2)4-9-15(14)19-16/h4-10H,3H2,1-2H3,(H,17,18)
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Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassay


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50000541
PNG
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Show SMILES CC(N(O)C(N)=O)c1cc2ccccc2s1
Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
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n/an/a 190n/an/an/an/an/an/a



Sookmyung Women's University

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassay


Bioorg Med Chem 23: 7069-78 (2015)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50006795
PNG
(2-(Naphthalen-1-yloxymethyl)-quinoline | CHEMBL847...)
Show SMILES C(Oc1cccc2ccccc12)c1ccc2ccccc2n1
Show InChI InChI=1S/C20H15NO/c1-3-9-18-15(6-1)8-5-11-20(18)22-14-17-13-12-16-7-2-4-10-19(16)21-17/h1-13H,14H2
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory activity against 5-lipoxygenase in mouse macrophages


J Med Chem 35: 2501-24 (1992)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50043672
PNG
(6-[3-Fluoro-5-((R)-1-methoxy-1-thiazol-2-yl-propyl...)
Show SMILES CC[C@](OC)(c1nccs1)c1cc(F)cc(OCc2ccc3n(C)c(=O)ccc3c2)c1
Show InChI InChI=1S/C24H23FN2O3S/c1-4-24(29-3,23-26-9-10-31-23)18-12-19(25)14-20(13-18)30-15-16-5-7-21-17(11-16)6-8-22(28)27(21)2/h5-14H,4,15H2,1-3H3/t24-/m1/s1
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Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from mouse macrophage


J Med Chem 37: 113-24 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50007042
PNG
(2-{Methoxy-[3-(naphthalen-2-ylmethoxy)-phenyl]-met...)
Show SMILES COC(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1
Show InChI InChI=1S/C22H19NO2S/c1-24-21(22-23-11-12-26-22)19-7-4-8-20(14-19)25-15-16-9-10-17-5-2-3-6-18(17)13-16/h2-14,21H,15H2,1H3
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ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in mouse macrophages.


J Med Chem 34: 2176-86 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50145514
PNG
((E)-1-Furan-2-yl-3-pyridin-2-yl-propenone | CHEMBL...)
Show SMILES O=C(\C=C\c1ccccn1)c1ccco1
Show InChI InChI=1S/C12H9NO2/c14-11(12-5-3-9-15-12)7-6-10-4-1-2-8-13-10/h1-9H/b7-6+
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Yeungnam University

Curated by ChEMBL


Assay Description
Inhibitory activity against murine lipoxygenase-2.


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM22372
PNG
(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Show SMILES C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+
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n/an/a 400n/an/an/an/an/an/a



Universiti Putra Malaysia

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in calcium ionophore A23187-stimulated NMRI mouse macrophage assessed as inhibition of LTC4 production preincubated for 60 mins b...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50043673
PNG
(2-{(R)-1-[3-Fluoro-5-(naphthalen-2-ylmethoxy)-phen...)
Show SMILES CC[C@](OC)(c1nccs1)c1cc(F)cc(OCc2ccc3ccccc3c2)c1
Show InChI InChI=1S/C24H22FNO2S/c1-3-24(27-2,23-26-10-11-29-23)20-13-21(25)15-22(14-20)28-16-17-8-9-18-6-4-5-7-19(18)12-17/h4-15H,3,16H2,1-2H3/t24-/m1/s1
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n/an/a 513n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from mouse macrophage


J Med Chem 37: 113-24 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50007047
PNG
(1-[3-(3,4-Difluoro-benzyloxy)-phenyl]-1-thiazol-2-...)
Show SMILES CCC(O)(c1nccs1)c1cccc(OCc2ccc(F)c(F)c2)c1
Show InChI InChI=1S/C19H17F2NO2S/c1-2-19(23,18-22-8-9-25-18)14-4-3-5-15(11-14)24-12-13-6-7-16(20)17(21)10-13/h3-11,23H,2,12H2,1H3
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n/an/a 800n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in mouse macrophages.


J Med Chem 34: 2176-86 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50007060
PNG
(1-(4-Methyl-thiazol-2-yl)-1-[3-(naphthalen-2-ylmet...)
Show SMILES CCC(O)(c1nc(C)cs1)c1cccc(OCc2ccc3ccccc3c2)c1
Show InChI InChI=1S/C24H23NO2S/c1-3-24(26,23-25-17(2)16-28-23)21-9-6-10-22(14-21)27-15-18-11-12-19-7-4-5-8-20(19)13-18/h4-14,16,26H,3,15H2,1-2H3
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n/an/a 820n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in mouse macrophages.


J Med Chem 34: 2176-86 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50329394
PNG
(5-Chloro-N-(4-ethylphenyl)benzo[d]oxazol-2-amine |...)
Show SMILES CCc1ccc(Nc2nc3cc(Cl)ccc3o2)cc1
Show InChI InChI=1S/C15H13ClN2O/c1-2-10-3-6-12(7-4-10)17-15-18-13-9-11(16)5-8-14(13)19-15/h3-9H,2H2,1H3,(H,17,18)
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n/an/a 950n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassay


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50007048
PNG
(2-Methyl-1-[3-(naphthalen-2-ylmethoxy)-phenyl]-1-t...)
Show SMILES CC(C)C(O)(c1nccs1)c1cccc(OCc2ccc3ccccc3c2)c1
Show InChI InChI=1S/C24H23NO2S/c1-17(2)24(26,23-25-12-13-28-23)21-8-5-9-22(15-21)27-16-18-10-11-19-6-3-4-7-20(19)14-18/h3-15,17,26H,16H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



ICI Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in mouse macrophages.


J Med Chem 34: 2176-86 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50329392
PNG
(CHEMBL1269619 | N-(4-Ethylphenyl)benzo[d]oxazol-2-...)
Show SMILES CCc1ccc(Nc2nc3ccccc3o2)cc1
Show InChI InChI=1S/C15H14N2O/c1-2-11-7-9-12(10-8-11)16-15-17-13-5-3-4-6-14(13)18-15/h3-10H,2H2,1H3,(H,16,17)
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n/an/a 1.21E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassay


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50007040
PNG
(2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...)
Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1nccs1
Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-25-12-13-28-23)11-10-19-8-9-21(15-22(19)24)27-16-17-6-7-18-4-2-3-5-20(18)14-17/h2-9,12-15H,10-11,16H2,1H3
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n/an/a 1.25E+3n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound against 5-lipoxygenase from mouse macrophage


J Med Chem 37: 113-24 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50043675
PNG
(5-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...)
Show SMILES COC1(CCc2ccc(OCc3ccc4ccccc4c3)cc12)c1cncs1
Show InChI InChI=1S/C24H21NO2S/c1-26-24(23-14-25-16-28-23)11-10-19-8-9-21(13-22(19)24)27-15-17-6-7-18-4-2-3-5-20(18)12-17/h2-9,12-14,16H,10-11,15H2,1H3
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n/an/a 1.25E+3n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from mouse macrophage


J Med Chem 37: 113-24 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Mus musculus)
BDBM50078146
PNG
(CHEMBL3417531)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1nc(no1)[C@](C)(C1CC1)c1ccc(cc1)-c1cnc(N)nc1
Show InChI InChI=1/C24H27N7O2/c1-23(2,32)14-31-13-17(12-28-31)20-29-21(30-33-20)24(3,19-8-9-19)18-6-4-15(5-7-18)16-10-26-22(25)27-11-16/h4-7,10-13,19,32H,8-9,14H2,1-3H3,(H2,25,26,27)/t24-/s2
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n/an/a 1.50E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of FLAP in calcimycin-stimulated mouse whole blood assessed as inhibition of LTB4 synthesis preincubated for 15 mins followed by calcimyci...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50128342
PNG
(CHEMBL3629175)
Show SMILES CCc1ccc(Nc2nc3cc(NC(=O)CCCCOc4ccc(cc4)C(\N)=N\O)ccc3o2)cc1
Show InChI InChI=1S/C27H29N5O4/c1-2-18-6-10-20(11-7-18)30-27-31-23-17-21(12-15-24(23)36-27)29-25(33)5-3-4-16-35-22-13-8-19(9-14-22)26(28)32-34/h6-15,17,34H,2-5,16H2,1H3,(H2,28,32)(H,29,33)(H,30,31)
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n/an/a 1.72E+3n/an/an/an/an/an/a



Sookmyung Women's University

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassay


Bioorg Med Chem 23: 7069-78 (2015)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50357364
PNG
(CHEMBL1242095)
Show SMILES CC(C)=CCC\C(C)=C\Cc1c(O)cc(O)c(C(C)=O)c1O
Show InChI InChI=1S/C18H24O4/c1-11(2)6-5-7-12(3)8-9-14-15(20)10-16(21)17(13(4)19)18(14)22/h6,8,10,20-22H,5,7,9H2,1-4H3/b12-8+
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n/an/a 1.80E+3n/an/an/an/an/an/a



Universiti Putra Malaysia

Curated by ChEMBL


Assay Description
Inhibition of 5-LOX in calcium ionophore A23187-stimulated NMRI mouse macrophage assessed as inhibition of LTC4 production preincubated for 60 mins b...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50329404
PNG
(CHEMBL1269727 | N-(3-Bromophenyl)-5-methoxybenzo[d...)
Show SMILES COc1ccc2oc(Nc3cccc(Br)c3)nc2c1
Show InChI InChI=1S/C14H11BrN2O2/c1-18-11-5-6-13-12(8-11)17-14(19-13)16-10-4-2-3-9(15)7-10/h2-8H,1H3,(H,16,17)
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n/an/a 2.03E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassay


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50329402
PNG
(CHEMBL1269907 | N-(4-Isopropylphenyl)-5-methoxyben...)
Show SMILES COc1ccc2oc(Nc3ccc(cc3)C(C)C)nc2c1
Show InChI InChI=1S/C17H18N2O2/c1-11(2)12-4-6-13(7-5-12)18-17-19-15-10-14(20-3)8-9-16(15)21-17/h4-11H,1-3H3,(H,18,19)
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n/an/a 2.64E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassay


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50329403
PNG
(5-Methoxy-N-(4-(methylthio)phenyl)benzo[d]oxazol-2...)
Show SMILES COc1ccc2oc(Nc3ccc(SC)cc3)nc2c1
Show InChI InChI=1S/C15H14N2O2S/c1-18-11-5-8-14-13(9-11)17-15(19-14)16-10-3-6-12(20-2)7-4-10/h3-9H,1-2H3,(H,16,17)
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n/an/a 2.77E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassay


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50128343
PNG
(CHEMBL3629176)
Show SMILES N\C(=N/O)c1ccc(OCCCCC(=O)Nc2ccc3oc(Nc4ccccc4)nc3c2)cc1
Show InChI InChI=1S/C25H25N5O4/c26-24(30-32)17-9-12-20(13-10-17)33-15-5-4-8-23(31)27-19-11-14-22-21(16-19)29-25(34-22)28-18-6-2-1-3-7-18/h1-3,6-7,9-14,16,32H,4-5,8,15H2,(H2,26,30)(H,27,31)(H,28,29)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Sookmyung Women's University

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassay


Bioorg Med Chem 23: 7069-78 (2015)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50329393
PNG
(5-Chloro-N-phenylbenzo[d]oxazol-2-amine | CHEMBL12...)
Show SMILES Clc1ccc2oc(Nc3ccccc3)nc2c1
Show InChI InChI=1S/C13H9ClN2O/c14-9-6-7-12-11(8-9)16-13(17-12)15-10-4-2-1-3-5-10/h1-8H,(H,15,16)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassay


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50329396
PNG
(5-Methyl-N-phenylbenzo[d]oxazol-2-amine | CHEMBL12...)
Show SMILES Cc1ccc2oc(Nc3ccccc3)nc2c1
Show InChI InChI=1S/C14H12N2O/c1-10-7-8-13-12(9-10)16-14(17-13)15-11-5-3-2-4-6-11/h2-9H,1H3,(H,15,16)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassay


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein


(Mus musculus)
BDBM50078119
PNG
(CHEMBL3417525)
Show SMILES CN(C)C(=O)Cn1cc(cn1)-c1nc(no1)[C@](C)(C1CC1)c1ccc(cc1)-c1cnc(N)nc1
Show InChI InChI=1/C24H26N8O2/c1-24(19-8-9-19,18-6-4-15(5-7-18)16-10-26-23(25)27-11-16)22-29-21(34-30-22)17-12-28-32(13-17)14-20(33)31(2)3/h4-7,10-13,19H,8-9,14H2,1-3H3,(H2,25,26,27)/t24-/s2
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n/an/a 4.80E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of FLAP in calcimycin-stimulated mouse whole blood assessed as inhibition of LTB4 synthesis preincubated for 15 mins followed by calcimyci...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50145509
PNG
((E)-1,3-Di-thiophen-2-yl-propenone | CHEMBL88104)
Show SMILES O=C(\C=C\c1cccs1)c1cccs1
Show InChI InChI=1S/C11H8OS2/c12-10(11-4-2-8-14-11)6-5-9-3-1-7-13-9/h1-8H/b6-5+
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n/an/a 4.80E+3n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibitory activity against murine lipoxygenase-2.


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50128344
PNG
(CHEMBL3629177)
Show SMILES COc1ccc(Nc2nc3cc(NC(=O)CCCCOc4ccc(cc4)C(\N)=N\O)ccc3o2)cc1
Show InChI InChI=1S/C26H27N5O5/c1-34-20-12-7-18(8-13-20)29-26-30-22-16-19(9-14-23(22)36-26)28-24(32)4-2-3-15-35-21-10-5-17(6-11-21)25(27)31-33/h5-14,16,33H,2-4,15H2,1H3,(H2,27,31)(H,28,32)(H,29,30)
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n/an/a 4.90E+3n/an/an/an/an/an/a



Sookmyung Women's University

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassay


Bioorg Med Chem 23: 7069-78 (2015)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50329398
PNG
(CHEMBL1269649 | N-(2-Ethylphenyl)-5-methylbenzo[d]...)
Show SMILES CCc1ccccc1Nc1nc2cc(C)ccc2o1
Show InChI InChI=1S/C16H16N2O/c1-3-12-6-4-5-7-13(12)17-16-18-14-10-11(2)8-9-15(14)19-16/h4-10H,3H2,1-2H3,(H,17,18)
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n/an/a 5.66E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassay


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50145518
PNG
((E)-3-Thiophen-3-yl-1-thiophen-2-yl-propenone | CH...)
Show SMILES O=C(\C=C\c1ccsc1)c1cccs1
Show InChI InChI=1S/C11H8OS2/c12-10(11-2-1-6-14-11)4-3-9-5-7-13-8-9/h1-8H/b4-3+
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n/an/a 5.90E+3n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibitory activity against murine lipoxygenase-2.


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50145515
PNG
((E)-3-(3-Methyl-thiophen-2-yl)-1-pyridin-2-yl-prop...)
Show SMILES Cc1ccsc1\C=C\C(=O)c1ccccn1
Show InChI InChI=1S/C13H11NOS/c1-10-7-9-16-13(10)6-5-12(15)11-4-2-3-8-14-11/h2-9H,1H3/b6-5+
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n/an/a 6.51E+3n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibitory activity against murine lipoxygenase-2.


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50329400
PNG
(CHEMBL1269704 | N-(3-Methoxyphenyl)-5-methylbenzo[...)
Show SMILES COc1cccc(Nc2nc3cc(C)ccc3o2)c1
Show InChI InChI=1S/C15H14N2O2/c1-10-6-7-14-13(8-10)17-15(19-14)16-11-4-3-5-12(9-11)18-2/h3-9H,1-2H3,(H,16,17)
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n/an/a 6.83E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassay


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50329399
PNG
(6-Methyl-N-(4-(methylthio)phenyl)benzo[d]oxazol-2-...)
Show SMILES CSc1ccc(Nc2nc3cc(C)ccc3o2)cc1
Show InChI InChI=1S/C15H14N2OS/c1-10-3-8-14-13(9-10)17-15(18-14)16-11-4-6-12(19-2)7-5-11/h3-9H,1-2H3,(H,16,17)
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n/an/a 7.31E+3n/an/an/an/an/an/a



Ewha Womans University

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassay


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50145506
PNG
((E)-1-(5-Chloro-thiophen-2-yl)-3-furan-2-yl-propen...)
Show SMILES Clc1ccc(s1)C(=O)\C=C\c1ccco1
Show InChI InChI=1S/C11H7ClO2S/c12-11-6-5-10(15-11)9(13)4-3-8-2-1-7-14-8/h1-7H/b4-3+
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n/an/a 7.52E+3n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibitory activity against murine lipoxygenase-2.


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Mus musculus)
BDBM50145507
PNG
((E)-1-Pyridin-2-yl-3-thiophen-3-yl-propenone | CHE...)
Show SMILES O=C(\C=C\c1ccsc1)c1ccccn1
Show InChI InChI=1S/C12H9NOS/c14-12(11-3-1-2-7-13-11)5-4-10-6-8-15-9-10/h1-9H/b5-4+
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n/an/a 7.60E+3n/an/an/an/an/an/a



Yeungnam University

Curated by ChEMBL


Assay Description
Inhibitory activity against murine lipoxygenase-2.


Citation and Details
More data for this
Ligand-Target Pair
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