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Compile Data Set for Download or QSAR

Found 1977 hits Enz. Inhib. hit(s) with Target = 'Arachidonate 5-lipoxygenase' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50016673
PNG
(CHEMBL52896 | N-Hydroxy-N-methyl-2-[4-(quinolin-2-...)
Show SMILES CN(O)C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1
Show InChI InChI=1S/C19H18N2O3/c1-21(23)19(22)12-14-6-10-17(11-7-14)24-13-16-9-8-15-4-2-3-5-18(15)20-16/h2-11,23H,12-13H2,1H3
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800n/an/an/an/an/an/an/an/a



Rorer Central Research

Curated by ChEMBL


Assay Description
Invitro inhibitory activity against polymorphonuclear leukocyte 5-lipoxygenase


J Med Chem 32: 1836-42 (1989)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042977
PNG
(1-(2,5-Diethoxy-phenyl)-3-(3,4-dihydroxy-phenyl)-p...)
Show SMILES CCOc1ccc(OCC)c(c1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C19H20O5/c1-3-23-14-7-10-19(24-4-2)15(12-14)16(20)8-5-13-6-9-17(21)18(22)11-13/h5-12,21-22H,3-4H2,1-2H3/b8-5+
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n/an/a 2.40n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042951
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(5-ethoxy-2-methoxy-phe...)
Show SMILES CCOc1ccc(OC)c(c1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C18H18O5/c1-3-23-13-6-9-18(22-2)14(11-13)15(19)7-4-12-5-8-16(20)17(21)10-12/h4-11,20-21H,3H2,1-2H3/b7-4+
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n/an/a 3.80n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042962
PNG
((E)-3-(3,4-Dihydroxy-phenyl)-1-(4-hydroxy-phenyl)-...)
Show SMILES Oc1ccc(cc1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H12O4/c16-12-5-3-11(4-6-12)13(17)7-1-10-2-8-14(18)15(19)9-10/h1-9,16,18-19H/b7-1+
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n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of 5-lipoxygenase in rat RBL1 cells


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042981
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(2-hydroxy-5-isopropyl-...)
Show SMILES CC(C)c1ccc(O)c(c1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C18H18O4/c1-11(2)13-5-8-16(20)14(10-13)15(19)6-3-12-4-7-17(21)18(22)9-12/h3-11,20-22H,1-2H3/b6-3+
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n/an/a 4n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042962
PNG
((E)-3-(3,4-Dihydroxy-phenyl)-1-(4-hydroxy-phenyl)-...)
Show SMILES Oc1ccc(cc1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H12O4/c16-12-5-3-11(4-6-12)13(17)7-1-10-2-8-14(18)15(19)9-10/h1-9,16,18-19H/b7-1+
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Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042979
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(3-hydroxy-phenyl)-prop...)
Show SMILES Oc1cccc(c1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H12O4/c16-12-3-1-2-11(9-12)13(17)6-4-10-5-7-14(18)15(19)8-10/h1-9,16,18-19H/b6-4+
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n/an/a 4.20n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042979
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(3-hydroxy-phenyl)-prop...)
Show SMILES Oc1cccc(c1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H12O4/c16-12-3-1-2-11(9-12)13(17)6-4-10-5-7-14(18)15(19)8-10/h1-9,16,18-19H/b6-4+
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TBA

Assay Description
Inhibition of 5-lipoxygenase in rat RBL1 cells


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50406422
PNG
(CHEMBL2115381)
Show SMILES CCCCCCCCCCCCCCCCCCOC1C(=O)O[C@H](C(O)CO)C1=O
Show InChI InChI=1S/C24H44O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29-23-21(27)22(20(26)19-25)30-24(23)28/h20,22-23,25-26H,2-19H2,1H3/t20?,22-,23?/m1/s1
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n/an/a 4.30n/an/an/an/an/an/a



Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
Reduction of lipid peroxide formed in rat brain homogenates.


J Med Chem 34: 267-76 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042949
PNG
((E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl...)
Show SMILES Oc1ccc(C(=O)\C=C\c2ccc(O)c(O)c2)c(O)c1
Show InChI InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
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n/an/a 4.60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of 5-lipoxygenase in rat RBL1 cells


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042949
PNG
((E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl...)
Show SMILES Oc1ccc(C(=O)\C=C\c2ccc(O)c(O)c2)c(O)c1
Show InChI InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
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n/an/a 4.60n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042964
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(4-dimethylamino-phenyl...)
Show SMILES CN(C)c1ccc(cc1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C17H17NO3/c1-18(2)14-7-5-13(6-8-14)15(19)9-3-12-4-10-16(20)17(21)11-12/h3-11,20-21H,1-2H3/b9-3+
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n/an/a 4.70n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50006805
PNG
(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)
Show SMILES CC(C)c1ccc2n(Cc3ccc(Cl)cc3)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c2c1
Show InChI InChI=1S/C27H34ClNO2S/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18/h8-14,17H,15-16H2,1-7H3,(H,30,31)
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n/an/a 5n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
The compound was tested for inhibitory activity against 5-lipoxygenase translocation inhibitor in rat RBL-2H3 cells


J Med Chem 35: 2501-24 (1992)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50283416
PNG
(4-[7-(2,3-Dihydroxy-phenyl)-heptyloxy]-2-hydroxy-3...)
Show SMILES CCCc1c(O)c(ccc1OCCCCCCCc1cccc(O)c1O)C(O)=O
Show InChI InChI=1S/C23H30O6/c1-2-9-17-20(14-13-18(22(17)26)23(27)28)29-15-7-5-3-4-6-10-16-11-8-12-19(24)21(16)25/h8,11-14,24-26H,2-7,9-10,15H2,1H3,(H,27,28)
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n/an/a 5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cells


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042971
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(5-ethoxy-2-hydroxy-phe...)
Show SMILES CCOc1ccc(O)c(c1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C17H16O5/c1-2-22-12-5-8-15(19)13(10-12)14(18)6-3-11-4-7-16(20)17(21)9-11/h3-10,19-21H,2H2,1H3/b6-3+
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n/an/a 5.30n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50283408
PNG
(4-[5-(2,3-Dihydroxy-phenyl)-pentyloxy]-2-hydroxy-3...)
Show SMILES CCCc1c(O)c(ccc1OCCCCCc1cccc(O)c1O)C(O)=O
Show InChI InChI=1S/C21H26O6/c1-2-7-15-18(12-11-16(20(15)24)21(25)26)27-13-5-3-4-8-14-9-6-10-17(22)19(14)23/h6,9-12,22-24H,2-5,7-8,13H2,1H3,(H,25,26)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cells


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042945
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(3-methoxy-phenyl)-prop...)
Show SMILES COc1cccc(c1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C16H14O4/c1-20-13-4-2-3-12(10-13)14(17)7-5-11-6-8-15(18)16(19)9-11/h2-10,18-19H,1H3/b7-5+
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n/an/a 6.5n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50004679
PNG
(2-Benzyl-naphthalen-1-ol | 2-Benzyl-naphthalen-1-o...)
Show SMILES Oc1c(Cc2ccccc2)ccc2ccccc12
Show InChI InChI=1S/C17H14O/c18-17-15(12-13-6-2-1-3-7-13)11-10-14-8-4-5-9-16(14)17/h1-11,18H,12H2
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Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042968
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(2,5-dimethoxy-phenyl)-...)
Show SMILES COc1ccc(OC)c(c1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C17H16O5/c1-21-12-5-8-17(22-2)13(10-12)14(18)6-3-11-4-7-15(19)16(20)9-11/h3-10,19-20H,1-2H3/b6-3+
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Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50010968
PNG
(3-(2,5-Dimethyl-3,6-dioxo-4-pyridin-3-ylmethyl-cyc...)
Show SMILES CCOC(=O)C=Cc1c(O)c(=C)c(Cc2cccnc2)c(O)c1=C
Show InChI InChI=1S/C19H19NO4/c1-4-24-17(21)8-7-15-12(2)19(23)16(13(3)18(15)22)10-14-6-5-9-20-11-14/h5-9,11,22-23H,2-4,10H2,1H3
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Takeda Chemical Industries, Ltd.

Curated by ChEMBL


Assay Description
The concentration required to reduce by 50% the amount of LTB4 formed by RBL-1 cells


J Med Chem 34: 267-76 (1991)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50000534
PNG
(2-Phenethyl-6-[3-(pyridin-4-ylsulfanyl)-propyl]-2,...)
Show SMILES Oc1cc2CC(CCc3ccccc3)Oc2cc1CCCSc1ccncc1
Show InChI InChI=1S/C24H25NO2S/c26-23-16-20-15-21(9-8-18-5-2-1-3-6-18)27-24(20)17-19(23)7-4-14-28-22-10-12-25-13-11-22/h1-3,5-6,10-13,16-17,21,26H,4,7-9,14-15H2
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n/an/a 8n/an/an/an/an/an/a



Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against arachidonic acid in rat 5-lipoxygenase.


J Med Chem 35: 1299-318 (1992)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042973
PNG
(1-(4-Chloro-phenyl)-3-(3,4-dihydroxy-phenyl)-prope...)
Show SMILES Oc1ccc(\C=C\C(=O)c2ccc(Cl)cc2)cc1O
Show InChI InChI=1S/C15H11ClO3/c16-12-5-3-11(4-6-12)13(17)7-1-10-2-8-14(18)15(19)9-10/h1-9,18-19H/b7-1+
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n/an/a 8.5n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50025312
PNG
(2-(3,4-Dihydroxy-phenyl)-5-hydroxy-7-methoxy-6-(3-...)
Show SMILES COc1cc2oc(cc(=O)c2c(O)c1OCCC(C)C)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C21H22O7/c1-11(2)6-7-27-21-18(26-3)10-17-19(20(21)25)15(24)9-16(28-17)12-4-5-13(22)14(23)8-12/h4-5,8-11,22-23,25H,6-7H2,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.


J Med Chem 29: 2256-62 (1986)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042991
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(4-hydroxy-3-methoxy-ph...)
Show SMILES COc1cc(ccc1O)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C16H14O5/c1-21-16-9-11(4-7-14(16)19)12(17)5-2-10-3-6-13(18)15(20)8-10/h2-9,18-20H,1H3/b5-2+
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n/an/a 9n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042960
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(3-dimethylamino-phenyl...)
Show SMILES CN(C)c1cccc(c1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C17H17NO3/c1-18(2)14-5-3-4-13(11-14)15(19)8-6-12-7-9-16(20)17(21)10-12/h3-11,20-21H,1-2H3/b8-6+
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n/an/a 9.80n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042950
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(2,4-dimethoxy-phenyl)-...)
Show SMILES COc1ccc(C(=O)\C=C\c2ccc(O)c(O)c2)c(OC)c1
Show InChI InChI=1S/C17H16O5/c1-21-12-5-6-13(17(10-12)22-2)14(18)7-3-11-4-8-15(19)16(20)9-11/h3-10,19-20H,1-2H3/b7-3+
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Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50048999
PNG
(CHEMBL82292 | N-Hydroxy-N-methyl-3-(11-oxo-6,11-di...)
Show SMILES CN(O)C(=O)CCc1ccc2OCc3ccccc3C(=O)c2c1
Show InChI InChI=1S/C18H17NO4/c1-19(22)17(20)9-7-12-6-8-16-15(10-12)18(21)14-5-3-2-4-13(14)11-23-16/h2-6,8,10,22H,7,9,11H2,1H3
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Hoechst-Roussel Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatant


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM22372
PNG
(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Show SMILES C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+
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TBA

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cells


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50076649
PNG
(CHEMBL369848 | N-{1-methyl-3-[1-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)-n1nc(cc1-c1ccc(Cl)cc1)C#CC(C)N(O)C(N)=O
Show InChI InChI=1S/C21H19ClN4O3/c1-14(26(28)21(23)27)3-8-17-13-20(15-4-6-16(22)7-5-15)25(24-17)18-9-11-19(29-2)12-10-18/h4-7,9-14,28H,1-2H3,(H2,23,27)
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The R.W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase(5-LO) using broken rat barophilic leukemia cells (RBL-1)


Bioorg Med Chem Lett 9: 979-84 (1999)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50025315
PNG
(2-(3,4-Dihydroxy-phenyl)-5-hydroxy-7-methoxy-6-oct...)
Show SMILES CCCCCCCCOc1c(OC)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C24H28O7/c1-3-4-5-6-7-8-11-30-24-21(29-2)14-20-22(23(24)28)18(27)13-19(31-20)15-9-10-16(25)17(26)12-15/h9-10,12-14,25-26,28H,3-8,11H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.


J Med Chem 29: 2256-62 (1986)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042952
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(2-hydroxy-5-isopropoxy...)
Show SMILES CC(C)Oc1ccc(O)c(c1)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C18H18O5/c1-11(2)23-13-5-8-16(20)14(10-13)15(19)6-3-12-4-7-17(21)18(22)9-12/h3-11,20-22H,1-2H3/b6-3+
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Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50012730
PNG
(5-(1-Hydroxy-naphthalen-2-yl)-pentanoic acid ethyl...)
Show SMILES CCOC(=O)CCCCc1ccc2ccccc2c1O
Show InChI InChI=1S/C17H20O3/c1-2-20-16(18)10-6-4-8-14-12-11-13-7-3-5-9-15(13)17(14)19/h3,5,7,9,11-12,19H,2,4,6,8,10H2,1H3
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E. I. du Pont de Nemours and Company, Inc.

Curated by ChEMBL


Assay Description
Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line


J Med Chem 33: 360-70 (1990)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50025322
PNG
(6-Decyloxy-2-(3,4-dihydroxy-phenyl)-5-hydroxy-7-me...)
Show SMILES CCCCCCCCCCOc1c(OC)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C26H32O7/c1-3-4-5-6-7-8-9-10-13-32-26-23(31-2)16-22-24(25(26)30)20(29)15-21(33-22)17-11-12-18(27)19(28)14-17/h11-12,14-16,27-28,30H,3-10,13H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.


J Med Chem 29: 2256-62 (1986)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042953
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(5-isopropoxy-2-methoxy...)
Show SMILES COc1ccc(OC(C)C)cc1C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C19H20O5/c1-12(2)24-14-6-9-19(23-3)15(11-14)16(20)7-4-13-5-8-17(21)18(22)10-13/h4-12,21-22H,1-3H3/b7-4+
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Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50025291
PNG
(2-(3,4-Dihydroxy-phenyl)-6-hexyloxy-5,7-dimethoxy-...)
Show SMILES CCCCCCOc1c(OC)cc2oc(cc(=O)c2c1OC)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C23H26O7/c1-4-5-6-7-10-29-22-20(27-2)13-19-21(23(22)28-3)17(26)12-18(30-19)14-8-9-15(24)16(25)11-14/h8-9,11-13,24-25H,4-7,10H2,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.


J Med Chem 29: 2256-62 (1986)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50025286
PNG
(2-(3,4-Dihydroxy-phenyl)-5-hexyloxy-6,7-dimethoxy-...)
Show SMILES CCCCCCOc1c(OC)c(OC)cc2oc(cc(=O)c12)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C23H26O7/c1-4-5-6-7-10-29-23-21-17(26)12-18(14-8-9-15(24)16(25)11-14)30-19(21)13-20(27-2)22(23)28-3/h8-9,11-13,24-25H,4-7,10H2,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.


J Med Chem 29: 2256-62 (1986)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042972
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(2-hydroxy-4-methoxy-ph...)
Show SMILES COc1ccc(C(=O)\C=C\c2ccc(O)c(O)c2)c(O)c1
Show InChI InChI=1S/C16H14O5/c1-21-11-4-5-12(15(19)9-11)13(17)6-2-10-3-7-14(18)16(20)8-10/h2-9,18-20H,1H3/b6-2+
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Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50025278
PNG
(6-Butoxy-2-(3,4-dihydroxy-phenyl)-5-hydroxy-7-meth...)
Show SMILES CCCCOc1c(OC)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C20H20O7/c1-3-4-7-26-20-17(25-2)10-16-18(19(20)24)14(23)9-15(27-16)11-5-6-12(21)13(22)8-11/h5-6,8-10,21-22,24H,3-4,7H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.


J Med Chem 29: 2256-62 (1986)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50025328
PNG
(2-(3,4-Dihydroxy-phenyl)-6,7-dimethoxy-5-(3-methyl...)
Show SMILES COc1cc2oc(cc(=O)c2c(OCCC(C)C)c1OC)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C22H24O7/c1-12(2)7-8-28-22-20-16(25)10-17(13-5-6-14(23)15(24)9-13)29-18(20)11-19(26-3)21(22)27-4/h5-6,9-12,23-24H,7-8H2,1-4H3
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TBA

Curated by ChEMBL


Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.


J Med Chem 29: 2256-62 (1986)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042990
PNG
((E)-3-(3'',4''-Dihydroxyphenyl)-1-(3',4',5'-trimet...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C18H18O6/c1-22-16-9-12(10-17(23-2)18(16)24-3)13(19)6-4-11-5-7-14(20)15(21)8-11/h4-10,20-21H,1-3H3/b6-4+
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Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042989
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(2,5-dimethyl-phenyl)-p...)
Show SMILES Cc1ccc(C)c(c1)C(=O)C=Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C17H16O3/c1-11-3-4-12(2)14(9-11)15(18)7-5-13-6-8-16(19)17(20)10-13/h3-10,19-20H,1-2H3
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Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50041161
PNG
(1-(4-Chloro-benzyl)-2-[2,2-dimethyl-3-(1H-tetrazol...)
Show SMILES CC1Cc2c(OCc3ccc(cn3)-c3ccccc3)ccc3n(Cc4ccc(Cl)cc4)c(CC(C)(C)Cc4nnn[nH]4)c(S1)c23
Show InChI InChI=1S/C36H35ClN6OS/c1-23-17-29-32(44-22-28-14-11-26(20-38-28)25-7-5-4-6-8-25)16-15-30-34(29)35(45-23)31(18-36(2,3)19-33-39-41-42-40-33)43(30)21-24-9-12-27(37)13-10-24/h4-16,20,23H,17-19,21-22H2,1-3H3,(H,39,40,41,42)
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Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Tested for inhibition of 5-HPETE production by rat 5-LO; value ranges from 16-36 nM


J Med Chem 36: 2771-87 (1993)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50045673
PNG
(1-(4-Chloro-benzyl)-2-[2,2-dimethyl-3-(1H-tetrazol...)
Show SMILES CC1Cc2c(CCc3ccc(cn3)-c3ccccc3)ccc3n(Cc4ccc(Cl)cc4)c(CC(C)(C)Cc4nnn[nH]4)c(S1)c23
Show InChI InChI=1S/C37H37ClN6S/c1-24-19-31-27(11-16-30-17-12-28(22-39-30)26-7-5-4-6-8-26)13-18-32-35(31)36(45-24)33(20-37(2,3)21-34-40-42-43-41-34)44(32)23-25-9-14-29(38)15-10-25/h4-10,12-15,17-18,22,24H,11,16,19-21,23H2,1-3H3,(H,40,41,42,43)
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Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
In vitro test for inhibition of 5-lipoxygenase in cell-free preparations from rat PMN leukocytes


J Med Chem 36: 2771-87 (1993)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50025307
PNG
(6-Decyloxy-2-(3,4-dihydroxy-phenyl)-5,7-dimethoxy-...)
Show SMILES CCCCCCCCCCOc1c(OC)cc2oc(cc(=O)c2c1OC)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C27H34O7/c1-4-5-6-7-8-9-10-11-14-33-26-24(31-2)17-23-25(27(26)32-3)21(30)16-22(34-23)18-12-13-19(28)20(29)15-18/h12-13,15-17,28-29H,4-11,14H2,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.


J Med Chem 29: 2256-62 (1986)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50000536
PNG
(6-Allyl-2-phenethyl-2,3-dihydro-benzofuran-5-ol | ...)
Show SMILES Oc1cc2CC(CCc3ccccc3)Oc2cc1CC=C
Show InChI InChI=1S/C19H20O2/c1-2-6-15-13-19-16(12-18(15)20)11-17(21-19)10-9-14-7-4-3-5-8-14/h2-5,7-8,12-13,17,20H,1,6,9-11H2
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n/an/a 17n/an/an/an/an/an/a



Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL


Assay Description
Tested for its inhibitory activity against arachidonic acid in rat 5-lipoxygenase.


J Med Chem 35: 1299-318 (1992)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50408417
PNG
(CHEMBL2113724)
Show SMILES CCCCN(O)C(=O)Nc1cc(cc(OC)c1OCCSc1ccc(Cl)c(Cl)c1)[C@@H]1CC[C@H](O1)c1cc(OC)c(OC)c(OC)c1
Show InChI InChI=1S/C33H40Cl2N2O8S/c1-6-7-12-37(39)33(38)36-25-15-20(16-28(40-2)31(25)44-13-14-46-22-8-9-23(34)24(35)19-22)26-10-11-27(45-26)21-17-29(41-3)32(43-5)30(18-21)42-4/h8-9,15-19,26-27,39H,6-7,10-14H2,1-5H3,(H,36,38)/t26-,27-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



University of Virginia

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase mediated conversion of [14C]-arachidonic acid to leukotrienes in RBL-2H3 cells


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50041161
PNG
(1-(4-Chloro-benzyl)-2-[2,2-dimethyl-3-(1H-tetrazol...)
Show SMILES CC1Cc2c(OCc3ccc(cn3)-c3ccccc3)ccc3n(Cc4ccc(Cl)cc4)c(CC(C)(C)Cc4nnn[nH]4)c(S1)c23
Show InChI InChI=1S/C36H35ClN6OS/c1-23-17-29-32(44-22-28-14-11-26(20-38-28)25-7-5-4-6-8-25)16-15-30-34(29)35(45-23)31(18-36(2,3)19-33-39-41-42-40-33)43(30)21-24-9-12-27(37)13-10-24/h4-16,20,23H,17-19,21-22H2,1-3H3,(H,39,40,41,42)
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n/an/a 17n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
In vitro test for inhibition of 5-lipoxygenase in cell-free preparations from rat PMN leukocytes


J Med Chem 36: 2771-87 (1993)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042959
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(2,4-dimethyl-phenyl)-p...)
Show SMILES Cc1ccc(C(=O)C=Cc2ccc(O)c(O)c2)c(C)c1
Show InChI InChI=1S/C17H16O3/c1-11-3-6-14(12(2)9-11)15(18)7-4-13-5-8-16(19)17(20)10-13/h3-10,19-20H,1-2H3
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n/an/a 17n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50025309
PNG
(5-Decyloxy-2-(3,4-dihydroxy-phenyl)-6,7-dimethoxy-...)
Show SMILES CCCCCCCCCCOc1c(OC)c(OC)cc2oc(cc(=O)c12)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C27H34O7/c1-4-5-6-7-8-9-10-11-14-33-27-25-21(30)16-22(18-12-13-19(28)20(29)15-18)34-23(25)17-24(31-2)26(27)32-3/h12-13,15-17,28-29H,4-11,14H2,1-3H3
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n/an/a 18n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.


J Med Chem 29: 2256-62 (1986)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50042985
PNG
(3-(3,4-Dihydroxy-phenyl)-1-(3,4-dimethoxy-phenyl)-...)
Show SMILES COc1ccc(cc1OC)C(=O)\C=C\c1ccc(O)c(O)c1
Show InChI InChI=1S/C17H16O5/c1-21-16-8-5-12(10-17(16)22-2)13(18)6-3-11-4-7-14(19)15(20)9-11/h3-10,19-20H,1-2H3/b6-3+
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n/an/a 18n/an/an/an/an/an/a



Tokushima Bunri University

Curated by ChEMBL


Assay Description
In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined


J Med Chem 36: 3904-9 (1994)

More data for this
Ligand-Target Pair
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