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Found 235 hits Enz. Inhib. hit(s) with Target = 'Arachidonate 5-lipoxygenase' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50038649
PNG
(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)
Show SMILES CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc(Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27)
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n/an/a 180n/an/an/an/an/an/a



Merckle GmbH

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine PMNL cell assay.


J Med Chem 37: 1894-7 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50038646
PNG
(2-(6-(4-tert-butylphenyl)-2,2-dimethyl-7-phenyl-2,...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1c(CC(O)=O)n2CC(C)(C)Cc2c1-c1ccccc1
Show InChI InChI=1S/C27H31NO2/c1-26(2,3)20-13-11-19(12-14-20)24-21(15-23(29)30)28-17-27(4,5)16-22(28)25(24)18-9-7-6-8-10-18/h6-14H,15-17H2,1-5H3,(H,29,30)
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n/an/a 180n/an/an/an/an/an/a



Merckle GmbH

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine PMNL cell assay.


J Med Chem 37: 1894-7 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50038647
PNG
(CHEMBL56161 | [2-(4-Methoxy-phenyl)-6,6-dimethyl-1...)
Show SMILES COc1ccc(cc1)-c1c(CC(O)=O)n2CC(C)(C)Cc2c1-c1ccccc1
Show InChI InChI=1S/C24H25NO3/c1-24(2)14-20-23(16-7-5-4-6-8-16)22(17-9-11-18(28-3)12-10-17)19(13-21(26)27)25(20)15-24/h4-12H,13-15H2,1-3H3,(H,26,27)
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n/an/a 240n/an/an/an/an/an/a



Merckle GmbH

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine PMNL cell assay.


J Med Chem 37: 1894-7 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043362
PNG
(1,8-Dihydroxy-10-[2-(3,4,5-trihydroxy-phenyl)-acet...)
Show SMILES Oc1cccc2C(C(=O)Cc3cc(O)c(O)c(O)c3)c3cccc(O)c3C(=O)c12
Show InChI InChI=1S/C22H16O7/c23-13-5-1-3-11-18(12-4-2-6-14(24)20(12)22(29)19(11)13)15(25)7-10-8-16(26)21(28)17(27)9-10/h1-6,8-9,18,23-24,26-28H,7H2
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n/an/a 300n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043360
PNG
(1,8-Dihydroxy-10-(4-phenyl-butyryl)-10H-anthracen-...)
Show SMILES Oc1cccc2C(C(=O)CCCc3ccccc3)c3cccc(O)c3C(=O)c12
Show InChI InChI=1S/C24H20O4/c25-18(12-4-9-15-7-2-1-3-8-15)21-16-10-5-13-19(26)22(16)24(28)23-17(21)11-6-14-20(23)27/h1-3,5-8,10-11,13-14,21,26-27H,4,9,12H2
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n/an/a 300n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM32020
PNG
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Show SMILES CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043353
PNG
(1,8-Dihydroxy-10-(3,4,5-trihydroxy-benzylidene)-10...)
Show SMILES Oc1cc(C=C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc(O)c1O
Show InChI InChI=1S/C21H14O6/c22-14-5-1-3-11-13(7-10-8-16(24)20(26)17(25)9-10)12-4-2-6-15(23)19(12)21(27)18(11)14/h1-9,22-26H
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n/an/a 400n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059631
PNG
(6-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)CCCCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C21H23NO5/c1-22(27)17(24)9-4-2-3-6-13-10-11-15-12-14-7-5-8-16(23)18(14)21(26)19(15)20(13)25/h5,7-8,10-11,23,25,27H,2-4,6,9,12H2,1H3
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n/an/a 400n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50004677
PNG
(Acetic acid 4-acetoxy-6-chloro-2,3-dimethoxy-napht...)
Show SMILES COc1c(OC)c(OC(C)=O)c2cc(Cl)ccc2c1OC(C)=O
Show InChI InChI=1S/C16H15ClO6/c1-8(18)22-13-11-6-5-10(17)7-12(11)14(23-9(2)19)16(21-4)15(13)20-3/h5-7H,1-4H3
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n/an/a 500n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine polymorphonuclear leukocytes


J Med Chem 37: 1660-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043357
PNG
(1,8-Dihydroxy-10-(3-phenyl-propionyl)-10H-anthrace...)
Show SMILES Oc1cccc2C(C(=O)CCc3ccccc3)c3cccc(O)c3C(=O)c12
Show InChI InChI=1S/C23H18O4/c24-17-10-4-8-15-20(19(26)13-12-14-6-2-1-3-7-14)16-9-5-11-18(25)22(16)23(27)21(15)17/h1-11,20,24-25H,12-13H2
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n/an/a 500n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043371
PNG
(1,8-Dihydroxy-10-[2-(4-methoxy-phenyl)-acetyl]-10H...)
Show SMILES COc1ccc(CC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc1
Show InChI InChI=1S/C23H18O5/c1-28-14-10-8-13(9-11-14)12-19(26)20-15-4-2-6-17(24)21(15)23(27)22-16(20)5-3-7-18(22)25/h2-11,20,24-25H,12H2,1H3
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n/an/a 500n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50004677
PNG
(Acetic acid 4-acetoxy-6-chloro-2,3-dimethoxy-napht...)
Show SMILES COc1c(OC)c(OC(C)=O)c2cc(Cl)ccc2c1OC(C)=O
Show InChI InChI=1S/C16H15ClO6/c1-8(18)22-13-11-6-5-10(17)7-12(11)14(23-9(2)19)16(21-4)15(13)20-3/h5-7H,1-4H3
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Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043352
PNG
(10-(3,4-Dihydroxy-benzylidene)-1,8-dihydroxy-10H-a...)
Show SMILES Oc1ccc(C=C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc1O
Show InChI InChI=1S/C21H14O5/c22-15-8-7-11(10-18(15)25)9-14-12-3-1-5-16(23)19(12)21(26)20-13(14)4-2-6-17(20)24/h1-10,22-25H
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Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059608
PNG
(5-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)CCCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C20H21NO5/c1-21(26)16(23)8-3-2-5-12-9-10-14-11-13-6-4-7-15(22)17(13)20(25)18(14)19(12)24/h4,6-7,9-10,22,24,26H,2-3,5,8,11H2,1H3
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n/an/a 500n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50387594
PNG
(CHEMBL2057741)
Show SMILES OC(=O)c1sc2c(Cl)cccc2c1O
Show InChI InChI=1S/C9H5ClO3S/c10-5-3-1-2-4-6(11)8(9(12)13)14-7(4)5/h1-3,11H,(H,12,13)
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n/an/a 510n/an/an/an/an/an/a



University of Hamburg

Curated by ChEMBL


Assay Description
Inhibition of bovine 5-LOX assessed as inhibition of calcium ionophore A23187-induced leukotrine B4 formation by reversed phase HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50041799
PNG
(1,8-Dihydroxy-2-[3-(3,4,5-trihydroxy-phenyl)-propy...)
Show SMILES Oc1cc(CCCc2ccc3Cc4cccc(O)c4C(=O)c3c2O)cc(O)c1O
Show InChI InChI=1S/C23H20O6/c24-16-6-2-5-14-11-15-8-7-13(21(27)20(15)23(29)19(14)16)4-1-3-12-9-17(25)22(28)18(26)10-12/h2,5-10,24-28H,1,3-4,11H2
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n/an/a 600n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine polymorphonuclear leukocytes


J Med Chem 37: 1660-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043355
PNG
(10-[2-(4-Benzyloxy-phenyl)-acetyl]-1,8-dihydroxy-1...)
Show SMILES Oc1cccc2C(C(=O)Cc3ccc(OCc4ccccc4)cc3)c3cccc(O)c3C(=O)c12
Show InChI InChI=1S/C29H22O5/c30-23-10-4-8-21-26(22-9-5-11-24(31)28(22)29(33)27(21)23)25(32)16-18-12-14-20(15-13-18)34-17-19-6-2-1-3-7-19/h1-15,26,30-31H,16-17H2
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n/an/a 600n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059616
PNG
(3-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)CCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C18H17NO5/c1-19(24)14(21)8-7-10-5-6-12-9-11-3-2-4-13(20)15(11)18(23)16(12)17(10)22/h2-6,20,22,24H,7-9H2,1H3
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n/an/a 600n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059604
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)CCCc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C19H19NO5/c1-20(25)15(22)7-3-4-11-8-9-13-10-12-5-2-6-14(21)16(12)19(24)17(13)18(11)23/h2,5-6,8-9,21,23,25H,3-4,7,10H2,1H3
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n/an/a 600n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059599
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)c1ccc(Cc2ccc3Cc4cccc(O)c4C(=O)c3c2O)cc1
Show InChI InChI=1S/C23H19NO5/c1-24(29)23(28)14-7-5-13(6-8-14)11-17-10-9-16-12-15-3-2-4-18(25)19(15)22(27)20(16)21(17)26/h2-10,25-26,29H,11-12H2,1H3
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n/an/a 700n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50038649
PNG
(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)
Show SMILES CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc(Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27)
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n/an/a 760n/an/an/an/an/an/a



University of Hamburg

Curated by ChEMBL


Assay Description
Inhibition of bovine 5-LOX assessed as inhibition of calcium ionophore A23187-induced leukotrine B4 formation by reversed phase HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50041780
PNG
(2-(2,5-Dihydroxy-benzyl)-1,8-dihydroxy-10H-anthrac...)
Show SMILES Oc1ccc(O)c(Cc2ccc3Cc4cccc(O)c4C(=O)c3c2O)c1
Show InChI InChI=1S/C21H16O5/c22-15-6-7-16(23)14(10-15)9-13-5-4-12-8-11-2-1-3-17(24)18(11)21(26)19(12)20(13)25/h1-7,10,22-25H,8-9H2
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n/an/a 900n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine polymorphonuclear leukocytes


J Med Chem 37: 1660-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50387596
PNG
(CHEMBL2057740)
Show SMILES OC(=O)c1sc2cc(Cl)ccc2c1O
Show InChI InChI=1S/C9H5ClO3S/c10-4-1-2-5-6(3-4)14-8(7(5)11)9(12)13/h1-3,11H,(H,12,13)
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n/an/a 970n/an/an/an/an/an/a



University of Hamburg

Curated by ChEMBL


Assay Description
Inhibition of bovine 5-LOX assessed as inhibition of calcium ionophore A23187-induced leukotrine B4 formation by reversed phase HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50041782
PNG
(3-(2,5-Dihydroxy-benzyl)-1,8-dihydroxy-10H-anthrac...)
Show SMILES Oc1ccc(O)c(Cc2cc(O)c3C(=O)c4c(O)cccc4Cc3c2)c1
Show InChI InChI=1S/C21H16O5/c22-15-4-5-16(23)13(10-15)6-11-7-14-9-12-2-1-3-17(24)19(12)21(26)20(14)18(25)8-11/h1-5,7-8,10,22-25H,6,9H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine polymorphonuclear leukocytes


J Med Chem 37: 1660-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043373
PNG
(10-[2-(3,4-Dihydroxy-phenyl)-acetyl]-1,8-dihydroxy...)
Show SMILES Oc1ccc(CC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc1O
Show InChI InChI=1S/C22H16O6/c23-14-8-7-11(9-17(14)26)10-18(27)19-12-3-1-5-15(24)20(12)22(28)21-13(19)4-2-6-16(21)25/h1-9,19,23-26H,10H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomes


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043363
PNG
(1,8-Dihydroxy-10-[3-(4-hydroxy-phenyl)-propionyl]-...)
Show SMILES Oc1ccc(CCC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc1
Show InChI InChI=1S/C23H18O5/c24-14-10-7-13(8-11-14)9-12-19(27)20-15-3-1-5-17(25)21(15)23(28)22-16(20)4-2-6-18(22)26/h1-8,10-11,20,24-26H,9,12H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043368
PNG
(1,8-Dihydroxy-10-[3-(4-methoxy-phenyl)-propionyl]-...)
Show SMILES COc1ccc(CCC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc1
Show InChI InChI=1S/C24H20O5/c1-29-15-11-8-14(9-12-15)10-13-20(27)21-16-4-2-6-18(25)22(16)24(28)23-17(21)5-3-7-19(23)26/h2-9,11-12,21,25-26H,10,13H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM32020
PNG
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Show SMILES CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomes


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059627
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES CN(O)C(=O)Cc1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C17H15NO5/c1-18(23)13(20)8-11-6-5-10-7-9-3-2-4-12(19)14(9)17(22)15(10)16(11)21/h2-6,19,21,23H,7-8H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50059634
PNG
(2-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES OC(=O)C(Cc1ccccc1)c1ccc2Cc3cccc(O)c3C(=O)c2c1O
Show InChI InChI=1S/C23H18O5/c24-18-8-4-7-14-12-15-9-10-16(21(25)20(15)22(26)19(14)18)17(23(27)28)11-13-5-2-1-3-6-13/h1-10,17,24-25H,11-12H2,(H,27,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Westfälische Wilhelms-Universität Münster

Curated by ChEMBL


Assay Description
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leu...


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50038653
PNG
(2-(2,2-dimethyl-6-(4-nitrophenyl)-7-phenyl-2,3-dih...)
Show SMILES CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc(cc1)[N+]([O-])=O)-c1ccccc1
Show InChI InChI=1S/C23H22N2O4/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(18(12-20(26)27)24(19)14-23)16-8-10-17(11-9-16)25(28)29/h3-11H,12-14H2,1-2H3,(H,26,27)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Merckle GmbH

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine PMNL cell assay.


J Med Chem 37: 1894-7 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50038654
PNG
(2-(6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrr...)
Show SMILES OC(=O)Cc1c(c(c2CCCn12)-c1ccccc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H18ClNO2/c22-16-10-8-15(9-11-16)21-18(13-19(24)25)23-12-4-7-17(23)20(21)14-5-2-1-3-6-14/h1-3,5-6,8-11H,4,7,12-13H2,(H,24,25)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Merckle GmbH

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine PMNL cell assay.


J Med Chem 37: 1894-7 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50038645
PNG
(CHEMBL55414 | [6,6-Dimethyl-2-(4-phenoxy-phenyl)-1...)
Show SMILES CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc(Oc2ccccc2)cc1)-c1ccccc1
Show InChI InChI=1S/C29H27NO3/c1-29(2)18-25-28(20-9-5-3-6-10-20)27(24(17-26(31)32)30(25)19-29)21-13-15-23(16-14-21)33-22-11-7-4-8-12-22/h3-16H,17-19H2,1-2H3,(H,31,32)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Merckle GmbH

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine PMNL cell assay.


J Med Chem 37: 1894-7 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50038655
PNG
(CHEMBL54485 | [2-(3,4-Dichloro-phenyl)-6,6-dimethy...)
Show SMILES CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc(Cl)c(Cl)c1)-c1ccccc1
Show InChI InChI=1S/C23H21Cl2NO2/c1-23(2)12-19-21(14-6-4-3-5-7-14)22(15-8-9-16(24)17(25)10-15)18(11-20(27)28)26(19)13-23/h3-10H,11-13H2,1-2H3,(H,27,28)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Merckle GmbH

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine PMNL cell assay.


J Med Chem 37: 1894-7 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50038657
PNG
(CHEMBL301693 | [2-(3-Chloro-phenyl)-6,6-dimethyl-1...)
Show SMILES CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1cccc(Cl)c1)-c1ccccc1
Show InChI InChI=1S/C23H22ClNO2/c1-23(2)13-19-21(15-7-4-3-5-8-15)22(16-9-6-10-17(24)11-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Merckle GmbH

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine PMNL cell assay.


J Med Chem 37: 1894-7 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50038656
PNG
(CHEMBL54486 | [6,6-Dimethyl-1-phenyl-2-(2,3,4-tric...)
Show SMILES CC1(C)Cc2c(c(c(CC(O)=O)n2C1)-c1ccc(Cl)c(Cl)c1Cl)-c1ccccc1
Show InChI InChI=1S/C23H20Cl3NO2/c1-23(2)11-17-19(13-6-4-3-5-7-13)20(16(10-18(28)29)27(17)12-23)14-8-9-15(24)22(26)21(14)25/h3-9H,10-12H2,1-2H3,(H,28,29)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Merckle GmbH

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine PMNL cell assay.


J Med Chem 37: 1894-7 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50041774
PNG
(1,8-Dihydroxy-2-[3-(4-hydroxy-phenyl)-propyl]-10H-...)
Show SMILES Oc1ccc(CCCc2ccc3Cc4cccc(O)c4C(=O)c3c2O)cc1
Show InChI InChI=1S/C23H20O4/c24-18-11-7-14(8-12-18)3-1-4-15-9-10-17-13-16-5-2-6-19(25)20(16)23(27)21(17)22(15)26/h2,5-12,24-26H,1,3-4,13H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine polymorphonuclear leukocytes


J Med Chem 37: 1660-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50041803
PNG
(4-(1,8-Dihydroxy-9-oxo-9,10-dihydro-anthracen-2-yl...)
Show SMILES OC(=O)c1ccc(Cc2ccc3Cc4cccc(O)c4C(=O)c3c2O)cc1
Show InChI InChI=1S/C22H16O5/c23-17-3-1-2-14-11-15-8-9-16(20(24)19(15)21(25)18(14)17)10-12-4-6-13(7-5-12)22(26)27/h1-9,23-24H,10-11H2,(H,26,27)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine polymorphonuclear leukocytes


J Med Chem 37: 1660-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50041806
PNG
(3-(3,4-Dihydroxy-benzyl)-1,8-dihydroxy-10H-anthrac...)
Show SMILES Oc1ccc(Cc2cc(O)c3C(=O)c4c(O)cccc4Cc3c2)cc1O
Show InChI InChI=1S/C21H16O5/c22-15-5-4-11(8-17(15)24)6-12-7-14-10-13-2-1-3-16(23)19(13)21(26)20(14)18(25)9-12/h1-5,7-9,22-25H,6,10H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase in bovine polymorphonuclear leukocytes


J Med Chem 37: 1660-9 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043357
PNG
(1,8-Dihydroxy-10-(3-phenyl-propionyl)-10H-anthrace...)
Show SMILES Oc1cccc2C(C(=O)CCc3ccccc3)c3cccc(O)c3C(=O)c12
Show InChI InChI=1S/C23H18O4/c24-17-10-4-8-15-20(19(26)13-12-14-6-2-1-3-7-14)16-9-5-11-18(25)22(16)23(27)21(15)17/h1-11,20,24-25H,12-13H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomes


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043367
PNG
(10-[2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-acetyl]...)
Show SMILES CC(C)(C)c1cc(CC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc(c1O)C(C)(C)C
Show InChI InChI=1S/C30H32O5/c1-29(2,3)19-13-16(14-20(27(19)34)30(4,5)6)15-23(33)24-17-9-7-11-21(31)25(17)28(35)26-18(24)10-8-12-22(26)32/h7-14,24,31-32,34H,15H2,1-6H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomes


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043359
PNG
(1,8-Dihydroxy-10-[2-(4-hydroxy-phenyl)-acetyl]-10H...)
Show SMILES Oc1ccc(CC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc1
Show InChI InChI=1S/C22H16O5/c23-13-9-7-12(8-10-13)11-18(26)19-14-3-1-5-16(24)20(14)22(27)21-15(19)4-2-6-17(21)25/h1-10,19,23-25H,11H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomes


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043364
PNG
(1,8-Dihydroxy-10-(5-phenyl-pentanoyl)-10H-anthrace...)
Show SMILES Oc1cccc2C(C(=O)CCCCc3ccccc3)c3cccc(O)c3C(=O)c12
Show InChI InChI=1S/C25H22O4/c26-19(13-5-4-10-16-8-2-1-3-9-16)22-17-11-6-14-20(27)23(17)25(29)24-18(22)12-7-15-21(24)28/h1-3,6-9,11-12,14-15,22,27-28H,4-5,10,13H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043366
PNG
(10-[3-(4-Benzyloxy-phenyl)-propionyl]-1,8-dihydrox...)
Show SMILES Oc1cccc2C(C(=O)CCc3ccc(OCc4ccccc4)cc3)c3cccc(O)c3C(=O)c12
Show InChI InChI=1S/C30H24O5/c31-24-10-4-8-22-27(23-9-5-11-25(32)29(23)30(34)28(22)24)26(33)17-14-19-12-15-21(16-13-19)35-18-20-6-2-1-3-7-20/h1-13,15-16,27,31-32H,14,17-18H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043353
PNG
(1,8-Dihydroxy-10-(3,4,5-trihydroxy-benzylidene)-10...)
Show SMILES Oc1cc(C=C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc(O)c1O
Show InChI InChI=1S/C21H14O6/c22-14-5-1-3-11-13(7-10-8-16(24)20(26)17(25)9-10)12-4-2-6-15(23)19(12)21(27)18(11)14/h1-9,22-26H
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomes


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043356
PNG
(1,8-Dihydroxy-10-[2-(4-nitro-phenyl)-acetyl]-10H-a...)
Show SMILES Oc1cccc2C(C(=O)Cc3ccc(cc3)[N+]([O-])=O)c3cccc(O)c3C(=O)c12
Show InChI InChI=1S/C22H15NO6/c24-16-5-1-3-14-19(15-4-2-6-17(25)21(15)22(27)20(14)16)18(26)11-12-7-9-13(10-8-12)23(28)29/h1-10,19,24-25H,11H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomes


J Med Chem 36: 4099-107 (1994)

More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50052464
PNG
(1,8-Dihydroxy-10-(4-hydroxy-phenylsulfanyl)-10H-an...)
Show SMILES Oc1ccc(SC2c3cccc(O)c3C(=O)c3c(O)cccc23)cc1
Show InChI InChI=1S/C20H14O4S/c21-11-7-9-12(10-8-11)25-20-13-3-1-5-15(22)17(13)19(24)18-14(20)4-2-6-16(18)23/h1-10,20-23H
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Tested for inhibition of 5-lipoxygenase as inhibition of 5-HETE and LTB4 biosynthesis in bovine PMNL


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50052457
PNG
(1,8-Dihydroxy-10-(2-hydroxy-ethylsulfanyl)-10H-ant...)
Show SMILES OCCSC1c2cccc(O)c2C(=O)c2c(O)cccc12
Show InChI InChI=1S/C16H14O4S/c17-7-8-21-16-9-3-1-5-11(18)13(9)15(20)14-10(16)4-2-6-12(14)19/h1-6,16-19H,7-8H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Tested for inhibition of 5-lipoxygenase as inhibition of 5-HETE and LTB4 biosynthesis in bovine PMNL


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50052462
PNG
(10-(2-Amino-phenylsulfanyl)-1,8-dihydroxy-10H-anth...)
Show SMILES Nc1ccccc1SC1c2cccc(O)c2C(=O)c2c(O)cccc12
Show InChI InChI=1S/C20H15NO3S/c21-13-7-1-2-10-16(13)25-20-11-5-3-8-14(22)17(11)19(24)18-12(20)6-4-9-15(18)23/h1-10,20,22-23H,21H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Tested for inhibition of 5-lipoxygenase as inhibition of 5-HETE and LTB4 biosynthesis in bovine PMNL


Citation and Details
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50052466
PNG
(3-(4,5-Dihydroxy-10-oxo-9,10-dihydro-anthracen-9-y...)
Show SMILES OC(=O)CCSC1c2cccc(O)c2C(=O)c2c(O)cccc12
Show InChI InChI=1S/C17H14O5S/c18-11-5-1-3-9-14(11)16(22)15-10(4-2-6-12(15)19)17(9)23-8-7-13(20)21/h1-6,17-19H,7-8H2,(H,20,21)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Tested for inhibition of 5-lipoxygenase as inhibition of 5-HETE and LTB4 biosynthesis in bovine PMNL


Citation and Details
More data for this
Ligand-Target Pair
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