BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 116 hits Enz. Inhib. hit(s) with Target = 'Arginase-2, mitochondrial'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
8.5n/an/an/an/an/an/an/an/a



Drexel University

Curated by ChEMBL


Assay Description
Binding affinity to human arginase 2


J Med Chem 54: 5432-43 (2011)


Article DOI: 10.1021/jm200443b
BindingDB Entry DOI: 10.7270/Q2TH8N21
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439247
PNG
(CHEMBL2418831)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C20H29BCl2N2O4/c22-17-6-3-13(9-18(17)23)12-25-15-4-5-16(25)11-14(10-15)20(24,19(26)27)7-1-2-8-21(28)29/h3,6,9,14-16,28-29H,1-2,4-5,7-8,10-12,24H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439246
PNG
(CHEMBL2418830)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C20H30BClN2O4/c22-16-5-3-14(4-6-16)13-24-17-7-8-18(24)12-15(11-17)20(23,19(25)26)9-1-2-10-21(27)28/h3-6,15,17-18,27-28H,1-2,7-13,23H2,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439245
PNG
(CHEMBL2418991)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccc(F)c(F)c1)C(O)=O
Show InChI InChI=1S/C20H29BF2N2O4/c22-17-6-3-13(9-18(17)23)12-25-15-4-5-16(25)11-14(10-15)20(24,19(26)27)7-1-2-8-21(28)29/h3,6,9,14-16,28-29H,1-2,4-5,7-8,10-12,24H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 33n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439244
PNG
(CHEMBL2418829)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H31BN2O4/c22-20(19(24)25,10-4-5-11-21(26)27)16-12-17-8-9-18(13-16)23(17)14-15-6-2-1-3-7-15/h1-3,6-7,16-18,26-27H,4-5,8-14,22H2,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439243
PNG
(CHEMBL2418998)
Show SMILES NC(CCCCB(O)O)(C1CCN(CCCc2ccc(Cl)cc2Cl)CC1)C(O)=O
Show InChI InChI=1S/C20H31BCl2N2O4/c22-17-6-5-15(18(23)14-17)4-3-11-25-12-7-16(8-13-25)20(24,19(26)27)9-1-2-10-21(28)29/h5-6,14,16,28-29H,1-4,7-13,24H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427899
PNG
(CHEMBL2326090)
Show SMILES CN[C@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O
Show InChI InChI=1S/C14H29BN2O4/c1-16-14(13(18)19,7-3-4-9-15(20)21)8-12-17-10-5-2-6-11-17/h16,20-21H,2-12H2,1H3,(H,18,19)/t14-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 67n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439241
PNG
(CHEMBL2418999)
Show SMILES NC(CCCCB(O)O)(C1CCN(CCCc2ccc(cc2)C(F)(F)F)CC1)C(O)=O
Show InChI InChI=1S/C21H32BF3N2O4/c23-21(24,25)18-7-5-16(6-8-18)4-3-13-27-14-9-17(10-15-27)20(26,19(28)29)11-1-2-12-22(30)31/h5-8,17,30-31H,1-4,9-15,26H2,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439242
PNG
(CHEMBL2418828)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2)C(O)=O
Show InChI InChI=1S/C13H25BN2O4/c15-13(12(17)18,5-1-2-6-14(19)20)9-7-10-3-4-11(8-9)16-10/h9-11,16,19-20H,1-8,15H2,(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 85n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427903
PNG
(CHEMBL2326087)
Show SMILES CC(C)NCC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C11H25BN2O4/c1-9(2)14-8-6-11(13,10(15)16)5-3-4-7-12(17)18/h9,14,17-18H,3-8,13H2,1-2H3,(H,15,16)/t11-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439240
PNG
(CHEMBL2418993)
Show SMILES CC(C)CCN1CCC(CC1)C(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C16H33BN2O4/c1-13(2)5-10-19-11-6-14(7-12-19)16(18,15(20)21)8-3-4-9-17(22)23/h13-14,22-23H,3-12,18H2,1-2H3,(H,20,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 230n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439239
PNG
(CHEMBL2418994)
Show SMILES NC(CCCCB(O)O)(C1CCN(Cc2ccccc2)CC1)C(O)=O
Show InChI InChI=1S/C18H29BN2O4/c20-18(17(22)23,10-4-5-11-19(24)25)16-8-12-21(13-9-16)14-15-6-2-1-3-7-15/h1-3,6-7,16,24-25H,4-5,8-14,20H2,(H,22,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 230n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439238
PNG
(CHEMBL2418995)
Show SMILES NC(CCCCB(O)O)(C1CCN(Cc2ccc(Cl)cc2)CC1)C(O)=O
Show InChI InChI=1S/C18H28BClN2O4/c20-16-5-3-14(4-6-16)13-22-11-7-15(8-12-22)18(21,17(23)24)9-1-2-10-19(25)26/h3-6,15,25-26H,1-2,7-13,21H2,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290405
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(2-(3,4- dich...)
Show SMILES N[C@]1(CN(CCNCc2ccc(Cl)c(Cl)c2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C17H26BCl2N3O4/c19-14-4-3-12(8-15(14)20)9-22-6-7-23-10-13(2-1-5-18(26)27)17(21,11-23)16(24)25/h3-4,8,13,22,26-27H,1-2,5-7,9-11,21H2,(H,24,25)/t13-,17-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290404
PNG
((3R,4S)-3-amino-1-(2-(benzylamino)ethyl)-4-(3- bor...)
Show SMILES N[C@]1(CN(CCNCc2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C17H28BN3O4/c19-17(16(22)23)13-21(12-15(17)7-4-8-18(24)25)10-9-20-11-14-5-2-1-3-6-14/h1-3,5-6,15,20,24-25H,4,7-13,19H2,(H,22,23)/t15-,17-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290403
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(((S)-1,2,3,4...)
Show SMILES N[C@]1(CN(C[C@@H]2Cc3ccccc3CN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C18H28BN3O4/c20-18(17(23)24)12-22(10-15(18)6-3-7-19(25)26)11-16-8-13-4-1-2-5-14(13)9-21-16/h1-2,4-5,15-16,21,25-26H,3,6-12,20H2,(H,23,24)/t15-,16-,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290391
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1,3'-bipyrrolid...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C1CCNC1)C(O)=O
Show InChI InChI=1S/C12H24BN3O4/c14-12(11(17)18)8-16(10-3-5-15-6-10)7-9(12)2-1-4-13(19)20/h9-10,15,19-20H,1-8,14H2,(H,17,18)/t9-,10?,12-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290388
PNG
((3R,4S)-3-amino-1-(2-aminoethyl)-4-(3-boronopropyl...)
Show SMILES NCCN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C10H22BN3O4/c12-4-5-14-6-8(2-1-3-11(17)18)10(13,7-14)9(15)16/h8,17-18H,1-7,12-13H2,(H,15,16)/t8-,10-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290385
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(piperidin-2-...)
Show SMILES N[C@]1(CN(CC2CCCCN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O4/c16-14(13(19)20)10-18(9-12-5-1-2-7-17-12)8-11(14)4-3-6-15(21)22/h11-12,17,21-22H,1-10,16H2,(H,19,20)/t11-,12?,14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290380
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(3-(4- carbox...)
Show SMILES N[C@]1(CN(CCCc2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C17H27BN2O4/c19-17(16(21)22)13-20(12-15(17)9-4-10-18(23)24)11-5-8-14-6-2-1-3-7-14/h1-3,6-7,15,23-24H,4-5,8-13,19H2,(H,21,22)/t15-,17-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290378
PNG
((3R,4S)-3-amino-1-(2-aminocyclopentyl)-4-(3- boron...)
Show SMILES NC1CCCC1N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C13H26BN3O4/c15-10-4-1-5-11(10)17-7-9(3-2-6-14(20)21)13(16,8-17)12(18)19/h9-11,20-21H,1-8,15-16H2,(H,18,19)/t9-,10?,11?,13-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290430
PNG
((1S,2S,4R)-1-amino-4-(2-aminoethyl)-2-(3- boronopr...)
Show SMILES NCC[C@H]1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C11H23BN2O4/c13-5-3-8-6-9(2-1-4-12(17)18)11(14,7-8)10(15)16/h8-9,17-18H,1-7,13-14H2,(H,15,16)/t8-,9-,11-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290402
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(2-(pyrrolidi...)
Show SMILES N[C@]1(CN(CCN2CCCC2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O4/c16-14(13(19)20)11-18(9-8-17-6-1-2-7-17)10-12(14)4-3-5-15(21)22/h12,21-22H,1-11,16H2,(H,19,20)/t12-,14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290368
PNG
((2S,3S)-3-amino-2-(3-boronopropyl)tetrahydrofuran-...)
Show SMILES N[C@]1(CCO[C@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H16BNO5/c10-8(7(11)12)3-5-15-6(8)2-1-4-9(13)14/h6,13-14H,1-5,10H2,(H,11,12)/t6-,8-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290428
PNG
((1S,2S,4R)-1-amino-4-(aminomethyl)-2-(3- boronopro...)
Show SMILES NC[C@@H]1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C10H21BN2O4/c12-6-7-4-8(2-1-3-11(16)17)10(13,5-7)9(14)15/h7-8,16-17H,1-6,12-13H2,(H,14,15)/t7-,8+,10+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290427
PNG
((1S,2S,4S)-1-amino-2-(3-boronopropyl)-4- (dimethyl...)
Show SMILES CN(C)[C@H]1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C11H23BN2O4/c1-14(2)9-6-8(4-3-5-12(17)18)11(13,7-9)10(15)16/h8-9,17-18H,3-7,13H2,1-2H3,(H,15,16)/t8-,9-,11-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290426
PNG
((1S,2S,4S)-1-amino-4-(benzylamino)-2-(3- boronopro...)
Show SMILES N[C@]1(C[C@H](C[C@@H]1CCCB(O)O)NCc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H25BN2O4/c18-16(15(20)21)10-14(9-13(16)7-4-8-17(22)23)19-11-12-5-2-1-3-6-12/h1-3,5-6,13-14,19,22-23H,4,7-11,18H2,(H,20,21)/t13-,14-,16-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290423
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((5,7-dichlor...)
Show SMILES N[C@]1(CN(CC2Cc3c(Cl)cc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C18H26BCl2N3O4/c20-13-4-11-7-23-14(6-15(11)16(21)5-13)9-24-8-12(2-1-3-19(27)28)18(22,10-24)17(25)26/h4-5,12,14,23,27-28H,1-3,6-10,22H2,(H,25,26)/t12-,14?,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290421
PNG
((3R,4S)-3-amino-1-(2-amino-3-phenylpropyl)-4-(3- b...)
Show SMILES NC(CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O)Cc1ccccc1
Show InChI InChI=1S/C17H28BN3O4/c19-15(9-13-5-2-1-3-6-13)11-21-10-14(7-4-8-18(24)25)17(20,12-21)16(22)23/h1-3,5-6,14-15,24-25H,4,7-12,19-20H2,(H,22,23)/t14-,15?,17-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290420
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(7-chloro-1,2...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1Cc2ccc(Cl)cc2CN1)C(O)=O
Show InChI InChI=1S/C18H25BClN3O5/c20-14-4-3-11-7-15(22-8-12(11)6-14)16(24)23-9-13(2-1-5-19(27)28)18(21,10-23)17(25)26/h3-4,6,13,15,22,27-28H,1-2,5,7-10,21H2,(H,25,26)/t13-,15?,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290419
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((7-(trifluor...)
Show SMILES N[C@]1(CN(CC2Cc3ccc(cc3CN2)C(F)(F)F)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C19H27BF3N3O4/c21-19(22,23)14-4-3-12-7-16(25-8-13(12)6-14)10-26-9-15(2-1-5-20(29)30)18(24,11-26)17(27)28/h3-4,6,15-16,25,29-30H,1-2,5,7-11,24H2,(H,27,28)/t15-,16?,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290416
PNG
((3R,4S)-3-amino-1-(2-(biphenyl-4-ylamino)ethyl)-4-...)
Show SMILES N[C@]1(CN(CCNc2ccc(cc2)-c2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C22H30BN3O4/c24-22(21(27)28)16-26(15-19(22)7-4-12-23(29)30)14-13-25-20-10-8-18(9-11-20)17-5-2-1-3-6-17/h1-3,5-6,8-11,19,25,29-30H,4,7,12-16,24H2,(H,27,28)/t19-,22-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290415
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((6-chloro-1,...)
Show SMILES N[C@]1(CN(CC2Cc3cc(Cl)ccc3CN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C18H27BClN3O4/c20-15-4-3-12-8-22-16(7-13(12)6-15)10-23-9-14(2-1-5-19(26)27)18(21,11-23)17(24)25/h3-4,6,14,16,22,26-27H,1-2,5,7-11,21H2,(H,24,25)/t14-,16?,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290413
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((7-chloro-1,...)
Show SMILES N[C@]1(CN(CC2Cc3ccc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C18H27BClN3O4/c20-15-4-3-12-7-16(22-8-13(12)6-15)10-23-9-14(2-1-5-19(26)27)18(21,11-23)17(24)25/h3-4,6,14,16,22,26-27H,1-2,5,7-11,21H2,(H,24,25)/t14-,16?,18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290408
PNG
((3R,4S)-3-amino-1-(2-aminocyclohexyl)-4-(3- borono...)
Show SMILES NC1CCCCC1N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C14H28BN3O4/c16-11-5-1-2-6-12(11)18-8-10(4-3-7-15(21)22)14(17,9-18)13(19)20/h10-12,21-22H,1-9,16-17H2,(H,19,20)/t10-,11?,12?,14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427905
PNG
(CHEMBL2326085)
Show SMILES CCN(CC)CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C12H27BN2O4/c1-3-15(4-2)10-8-12(14,11(16)17)7-5-6-9-13(18)19/h18-19H,3-10,14H2,1-2H3,(H,16,17)/t12-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 270n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439237
PNG
(CHEMBL2418996)
Show SMILES NC(CCCCB(O)O)(C1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)C(O)=O
Show InChI InChI=1S/C18H27BCl2N2O4/c20-15-4-3-13(11-16(15)21)12-23-9-5-14(6-10-23)18(22,17(24)25)7-1-2-8-19(26)27/h3-4,11,14,26-27H,1-2,5-10,12,22H2,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427911
PNG
(CHEMBL2326095)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCC1)C(O)=O
Show InChI InChI=1S/C12H25BN2O4/c14-12(11(16)17,5-1-2-7-13(18)19)6-10-15-8-3-4-9-15/h18-19H,1-10,14H2,(H,16,17)/t12-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 310n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427904
PNG
(CHEMBL2326086)
Show SMILES CCCN(C)CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C12H27BN2O4/c1-3-9-15(2)10-7-12(14,11(16)17)6-4-5-8-13(18)19/h18-19H,3-10,14H2,1-2H3,(H,16,17)/t12-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 320n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50439236
PNG
(CHEMBL2418997)
Show SMILES NC(CCCCB(O)O)(C1CCN(CCc2ccc(Cl)cc2Cl)CC1)C(O)=O
Show InChI InChI=1S/C19H29BCl2N2O4/c21-16-4-3-14(17(22)13-16)5-10-24-11-6-15(7-12-24)19(23,18(25)26)8-1-2-9-20(27)28/h3-4,13,15,27-28H,1-2,5-12,23H2,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 330n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427909
PNG
(CHEMBL2326097)
Show SMILES COC[C@@H]1CCCN1CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H29BN2O5/c1-22-11-12-5-4-9-17(12)10-7-14(16,13(18)19)6-2-3-8-15(20)21/h12,20-21H,2-11,16H2,1H3,(H,18,19)/t12-,14+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 340n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427906
PNG
(CHEMBL2326084)
Show SMILES CCN(CCO)CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C12H27BN2O5/c1-2-15(9-10-16)8-6-12(14,11(17)18)5-3-4-7-13(19)20/h16,19-20H,2-10,14H2,1H3,(H,17,18)/t12-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 390n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427913
PNG
(CHEMBL2326093)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCC(O)CC1)C(O)=O
Show InChI InChI=1S/C13H27BN2O5/c15-13(12(18)19,5-1-2-7-14(20)21)6-10-16-8-3-11(17)4-9-16/h11,17,20-21H,1-10,15H2,(H,18,19)/t13-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 420n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427900
PNG
((R)-2-amino-6-borono-2-[2-(piperidin-1-yl)ethyl]he...)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O
Show InChI InChI=1S/C13H27BN2O4/c15-13(12(17)18,6-2-3-8-14(19)20)7-11-16-9-4-1-5-10-16/h19-20H,1-11,15H2,(H,17,18)/t13-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 509n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427907
PNG
(CHEMBL2326099)
Show SMILES N[C@](CCCCB(O)O)(CCN1Cc2ccccc2C1)C(O)=O
Show InChI InChI=1S/C16H25BN2O4/c18-16(15(20)21,7-3-4-9-17(22)23)8-10-19-11-13-5-1-2-6-14(13)12-19/h1-2,5-6,22-23H,3-4,7-12,18H2,(H,20,21)/t16-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 550n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427910
PNG
(CHEMBL2326096)
Show SMILES N[C@](CCCCB(O)O)(CCN1CC[C@@H](CO)C1)C(O)=O
Show InChI InChI=1S/C13H27BN2O5/c15-13(12(18)19,4-1-2-6-14(20)21)5-8-16-7-3-11(9-16)10-17/h11,17,20-21H,1-10,15H2,(H,18,19)/t11-,13-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)


Article DOI: 10.1021/jm400014c
BindingDB Entry DOI: 10.7270/Q2BC40WP
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427911
PNG
(CHEMBL2326095)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCC1)C(O)=O
Show InChI InChI=1S/C12H25BN2O4/c14-12(11(16)17,5-1-2-7-13(18)19)6-10-15-8-3-4-9-15/h18-19H,1-10,14H2,(H,16,17)/t12-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 620n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.024
BindingDB Entry DOI: 10.7270/Q22J6D8K
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM50427911
PNG
(CHEMBL2326095)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCC1)C(O)=O
Show InChI InChI=1S/C12H25BN2O4/c14-12(11(16)17,5-1-2-7-13(18)19)6-10-15-8-3-4-9-15/h18-19H,1-10,14H2,(H,16,17)/t12-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 620n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.092
BindingDB Entry DOI: 10.7270/Q2Z89DT6
More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290389
PNG
(5-((3R,4S)-3-amino-4-(3-boronopropyl)-3-carboxypyr...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)c1cccnc1)C(O)=O
Show InChI InChI=1S/C13H20BN3O4/c15-13(12(18)19)9-17(11-4-2-6-16-7-11)8-10(13)3-1-5-14(20)21/h2,4,6-7,10,20-21H,1,3,5,8-9,15H2,(H,18,19)/t10-,13-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens)
BDBM290425
PNG
((1S,2S,4S)-1,4-diamino-2-(3-boronopropyl)cyclopent...)
Show SMILES CC(OO)[C@]1(N)C[C@@H](N)C[C@@H]1CCCB(O)O
Show InChI InChI=1S/C10H23BN2O4/c1-7(17-16)10(13)6-9(12)5-8(10)3-2-4-11(14)15/h7-9,14-16H,2-6,12-13H2,1H3/t7?,8-,9-,10+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 116 total )  |  Next  |  Last  >>
Jump to: