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Found 20 hits Enz. Inhib. hit(s) with Target = 'Aspartokinase I' AND taxid = 83333   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aspartokinase I


(Escherichia coli)
BDBM92984
PNG
(L-Norvaline)
Show SMILES CCC[C@H](N)C([O-])=O
Show InChI InChI=1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/p-1/t4-/m0/s1
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3.10E+6n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92985
PNG
(2-Aminobutyrate)
Show SMILES CCC([NH3+])C([O-])=O
Show InChI InChI=1S/C4H9NO2/c1-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)
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5.00E+6n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92999
PNG
(Homoserine phosphate)
Show SMILES N[C@@H](CCOP(O)(O)=O)C([O-])=O
Show InChI InChI=1S/C4H10NO6P/c5-3(4(6)7)1-2-11-12(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/p-1/t3-/m0/s1
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6.00E+6n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92986
PNG
(L-Alanosine)
Show SMILES N[C@@H](CN(O)N=O)C([O-])=O
Show InChI InChI=1S/C3H7N3O4/c4-2(3(7)8)1-6(10)5-9/h2,10H,1,4H2,(H,7,8)/p-1/t2-/m0/s1
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7.50E+6n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM93000
PNG
(DL-2-Amino-5-phosphonovalerate)
Show SMILES NC(CCCP(O)(O)=O)C([O-])=O
Show InChI InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/p-1
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8.40E+6n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92987
PNG
(2,4-Diaminobutanoate)
Show SMILES NCC[C@H](N)C(O)=O
Show InChI InChI=1S/C4H10N2O2/c5-2-1-3(6)4(7)8/h3H,1-2,5-6H2,(H,7,8)/t3-/m0/s1
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1.00E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92988
PNG
(D-aspartate alpha-benzyl ester)
Show SMILES N[C@@H](CC([O-])=O)C(=O)OCc1ccccc1
Show InChI InChI=1S/C11H13NO4/c12-9(6-10(13)14)11(15)16-7-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,14)/p-1/t9-/m0/s1
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1.10E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM93001
PNG
(O-phospho-L-serine)
Show SMILES [NH3+][C@@H](COP([O-])([O-])=O)C([O-])=O
Show InChI InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/p-2/t2-/m0/s1
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1.20E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92989
PNG
(D-aspartate-beta-hydroxamate)
Show SMILES N[C@@H](CC(=O)NO)C([O-])=O
Show InChI InChI=1S/C4H8N2O4/c5-2(4(8)9)1-3(7)6-10/h2,10H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1
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1.60E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92990
PNG
(Aminomalonate)
Show SMILES NC(C([O-])=O)C([O-])=O
Show InChI InChI=1S/C3H5NO4/c4-1(2(5)6)3(7)8/h1H,4H2,(H,5,6)(H,7,8)/p-2
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2.30E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92992
PNG
(L-glutamate gamma-methyl ester)
Show SMILES COC(=O)CC[C@H](N)C([O-])=O
Show InChI InChI=1S/C6H11NO4/c1-11-5(8)3-2-4(7)6(9)10/h4H,2-3,7H2,1H3,(H,9,10)/p-1/t4-/m0/s1
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2.40E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92991
PNG
(L-norleucine)
Show SMILES CCCC[C@H](N)C([O-])=O
Show InChI InChI=1S/C6H13NO2/c1-2-3-4-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)/p-1/t5-/m0/s1
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2.40E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92993
PNG
(DL-Isoserine)
Show SMILES NCC(O)C([O-])=O
Show InChI InChI=1S/C3H7NO3/c4-1-2(5)3(6)7/h2,5H,1,4H2,(H,6,7)/p-1
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3.00E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92994
PNG
(L-Valine)
Show SMILES CC(C)[C@H](N)C([O-])=O
Show InChI InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/p-1/t4-/m0/s1
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3.20E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM17657
PNG
((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Show SMILES N[C@@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
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3.80E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92995
PNG
(D-asparagine)
Show SMILES N[C@H](CC(N)=O)C([O-])=O
Show InChI InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/p-1/t2-/m1/s1
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3.90E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92996
PNG
(3-Aminoglutarate)
Show SMILES NC(CC(O)=O)CC(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(1-4(7)8)2-5(9)10/h3H,1-2,6H2,(H,7,8)(H,9,10)
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4.50E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM93002
PNG
(DL-2-amino-4-phosphonobutyrate)
Show SMILES NC(CCP(O)(O)=O)C([O-])=O
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/p-1
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6.10E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92997
PNG
(L-Aspartic dimethyl ester)
Show SMILES COC(=O)C[C@H](N)C(=O)OC
Show InChI InChI=1S/C6H11NO4/c1-10-5(8)3-4(7)6(9)11-2/h4H,3,7H2,1-2H3/t4-/m0/s1
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7.10E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92998
PNG
(L-alanine)
Show SMILES C[C@H](N)C([O-])=O
Show InChI InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/p-1/t2-/m0/s1
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9.90E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)

More data for this
Ligand-Target Pair