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Found 15 hits Enz. Inhib. hit(s) with Target = 'Aurora B/Incenp' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora B/Incenp


(Homo sapiens (Human))
BDBM47224
PNG
(US9073917, 2-inventive)
Show SMILES CCc1[nH]cc2[C@@H](C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C26H24N4O2/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)/t23-/s2
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US Patent
n/an/a 1n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The effect of the compounds of the invention on the activity of the enzyme PDE3 was evaluated by the company CEREP (Le bois I'Evêque, 86600 Celle...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167515
PNG
(US9073917, 12- comparative)
Show SMILES CCOC(=O)c1[nH]cc2[C@@H](c3ccc(Sc4nc5ccccc5[nH]4)o3)C3=C(CCCC3=O)Nc12
Show InChI InChI=1/C25H22N4O4S/c1-2-32-24(31)23-22-13(12-26-23)20(21-16(27-22)8-5-9-17(21)30)18-10-11-19(33-18)34-25-28-14-6-3-4-7-15(14)29-25/h3-4,6-7,10-12,20,26-27H,2,5,8-9H2,1H3,(H,28,29)/t20-/s2
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US Patent
n/an/a 3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167506
PNG
(US9073917, 1-inventive)
Show SMILES CCc1[nH]cc2C(C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C26H24N4O2/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)
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US Patent
n/an/a 4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167510
PNG
(US9073917, 7- comparative)
Show SMILES CCc1[nH]cc2C(C3=C(CC(C)(C)CC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C28H28N4O2/c1-4-19-26-18(15-29-19)24(25-22(30-26)13-28(2,3)14-23(25)33)16-8-7-9-17(12-16)34-27-31-20-10-5-6-11-21(20)32-27/h5-12,15,24,29-30H,4,13-14H2,1-3H3,(H,31,32)
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US Patent
n/an/a 4n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167507
PNG
(US9073917, 4- comparative)
Show SMILES CCc1[nH]cc2C(C3=C(CCCC3=O)Nc12)c1cccc(Sc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C26H24N4OS/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)
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US Patent
n/an/a 6n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167508
PNG
(US9073917, 5- comparative)
Show SMILES O=C1CCCC2=C1C(c1c[nH]nc1N2)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C23H19N5O2/c29-19-10-4-9-18-21(19)20(15-12-24-28-22(15)25-18)13-5-3-6-14(11-13)30-23-26-16-7-1-2-8-17(16)27-23/h1-3,5-8,11-12,20H,4,9-10H2,(H,26,27)(H2,24,25,28)
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US Patent
n/an/a 6n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167512
PNG
(US9073917, 11- comparative | US9073917, 9- compara...)
Show SMILES CCc1[nH]cc2C(C3=C(CNCC3=O)Nc12)c1cccc(Sc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C25H23N5OS/c1-2-17-24-16(11-27-17)22(23-20(28-24)12-26-13-21(23)31)14-6-5-7-15(10-14)32-25-29-18-8-3-4-9-19(18)30-25/h3-11,22,26-28H,2,12-13H2,1H3,(H,29,30)
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US Patent
n/an/a 8n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167513
PNG
(US9073917, 10- comparative)
Show SMILES CC1(C)CC(=O)C2=C(C1)Nc1n[nH]cc1C2c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C25H23N5O2/c1-25(2)11-19-22(20(31)12-25)21(16-13-26-30-23(16)27-19)14-6-5-7-15(10-14)32-24-28-17-8-3-4-9-18(17)29-24/h3-10,13,21H,11-12H2,1-2H3,(H,28,29)(H2,26,27,30)
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US Patent
n/an/a 9n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167516
PNG
(US9073917, 13- comparative)
Show SMILES CCOC(=O)c1[nH]cc2C(c3ccc(Sc4nc5cccc(OC)c5[nH]4)o3)C3=C(CCCC3=O)Nc12
Show InChI InChI=1/C26H24N4O5S/c1-3-34-25(32)24-22-13(12-27-24)20(21-14(28-22)6-4-8-16(21)31)17-10-11-19(35-17)36-26-29-15-7-5-9-18(33-2)23(15)30-26/h5,7,9-12,20,27-28H,3-4,6,8H2,1-2H3,(H,29,30)
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US Patent
n/an/a 10n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167509
PNG
(US9073917, 6- comparative)
Show SMILES O=C1CNCC2=C1C(c1c[nH]nc1N2)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C22H18N6O2/c29-18-11-23-10-17-20(18)19(14-9-24-28-21(14)25-17)12-4-3-5-13(8-12)30-22-26-15-6-1-2-7-16(15)27-22/h1-9,19,23H,10-11H2,(H,26,27)(H2,24,25,28)
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US Patent
n/an/a 13n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167511
PNG
(US9073917, 8- comparative)
Show SMILES CCc1[nH]cc2C(C3=C(CC(C)(C)CC3=O)Nc12)c1cccc(Sc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C28H28N4OS/c1-4-19-26-18(15-29-19)24(25-22(30-26)13-28(2,3)14-23(25)33)16-8-7-9-17(12-16)34-27-31-20-10-5-6-11-21(20)32-27/h5-12,15,24,29-30H,4,13-14H2,1-3H3,(H,31,32)
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US Patent
n/an/a 21n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM167512
PNG
(US9073917, 11- comparative | US9073917, 9- compara...)
Show SMILES CCc1[nH]cc2C(C3=C(CNCC3=O)Nc12)c1cccc(Sc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C25H23N5OS/c1-2-17-24-16(11-27-17)22(23-20(28-24)12-26-13-21(23)31)14-6-5-7-15(10-14)32-25-29-18-8-3-4-9-19(18)30-25/h3-11,22,26-28H,2,12-13H2,1H3,(H,29,30)
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US Patent
n/an/a 107n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The capacity to inhibit the kinase activity of the enzyme is estimated by measuring the residual kinase activity of the enzyme in the presence of dif...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM60452
PNG
(US9073917, 3-comparative)
Show SMILES CCc1[nH]cc2[C@H](C3=C(CCCC3=O)Nc12)c1cccc(Oc2nc3ccccc3[nH]2)c1
Show InChI InChI=1/C26H24N4O2/c1-2-18-25-17(14-27-18)23(24-21(28-25)11-6-12-22(24)31)15-7-5-8-16(13-15)32-26-29-19-9-3-4-10-20(19)30-26/h3-5,7-10,13-14,23,27-28H,2,6,11-12H2,1H3,(H,29,30)/t23-/s2
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US Patent
n/an/a 3.80E+3n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The effect of the compounds of the invention on the activity of the enzyme PDE3 was evaluated by the company CEREP (Le bois I'Evêque, 86600 Celle...


US Patent US9073917 (2015)

More data for this
Ligand-Target Pair
Aurora B/INCENP


(Homo sapiens (Human))
BDBM50419247
PNG
(CHEMBL1835071 | US8470835, 1)
Show SMILES Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1
Show InChI InChI=1S/C17H22N6O2/c1-10-2-4-11(5-3-10)21-16-12(15(19)24)8-20-17(23-16)22-14-6-7-25-9-13(14)18/h2-5,8,13-14H,6-7,9,18H2,1H3,(H2,19,24)(H2,20,21,22,23)/t13-,14+/m0/s1
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MMDB
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US Patent
n/an/a 2.00E+4n/an/an/an/an/an/a



Glaxo Group Limited

US Patent


Assay Description
Recombinant human Aurora B (2-344) was expressed as a Flag-6His-Thr-tagged protein. The activity of Aurora B was assessed using a Fluorescence Polar...


US Patent US8470835 (2013)

More data for this
Ligand-Target Pair
Aurora B/Incenp


(Homo sapiens (Human))
BDBM50183019
PNG
(CHEMBL3819210)
Show SMILES Cc1cc(ccc1C(=O)NC1CC1)-c1cnn2c(NCC3CCOCC3)nc(Oc3ccccc3)nc12
Show InChI InChI=1S/C28H30N6O3/c1-18-15-20(7-10-23(18)26(35)31-21-8-9-21)24-17-30-34-25(24)32-28(37-22-5-3-2-4-6-22)33-27(34)29-16-19-11-13-36-14-12-19/h2-7,10,15,17,19,21H,8-9,11-14,16H2,1H3,(H,31,35)(H,29,32,33)
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PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged Aurora B/full length recombinant human N-terminal GST-tagged INCENP (821-end residues) expressed in baculo...


Bioorg Med Chem Lett 26: 3562-6 (2016)

More data for this
Ligand-Target Pair