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Compile Data Set for Download or QSAR

Found 2554 hits Enz. Inhib. hit(s) with Target = 'Basic fibroblast growth factor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM3443
PNG
(1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyr...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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45.2n/an/an/an/an/an/an/an/a



Parke-Davis Pharmaceutical Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 286: 569-77 (1998)


BindingDB Entry DOI: 10.7270/Q2C24TZQ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50206819
PNG
(CHEMBL3893914)
Show SMILES Cc1cc(Nc2cc(C)c(C#N)c(NCCOc3ccc(C)nc3)n2)n[nH]1
Show InChI InChI=1S/C19H21N7O/c1-12-8-17(23-18-9-14(3)25-26-18)24-19(16(12)10-20)21-6-7-27-15-5-4-13(2)22-11-15/h4-5,8-9,11H,6-7H2,1-3H3,(H3,21,23,24,25,26)
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80n/an/an/an/an/an/an/an/a



CXS Corporation

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 (unknown origin)


Bioorg Med Chem Lett 26: 5860-5862 (2016)


Article DOI: 10.1016/j.bmcl.2016.11.020
BindingDB Entry DOI: 10.7270/Q2WS8W80
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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350n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to FGFR1 (unknown origin)


Eur J Med Chem 82: 139-51 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.051
BindingDB Entry DOI: 10.7270/Q2F1918D
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>4.74E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of FGFR


Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
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8.02E+3n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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>1.00E+4n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM286987
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-2-((cyclopr...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H34Cl2N6O4/c1-4-23(38)36-12-10-35(11-13-36)8-5-9-37-27-19(17-33-29(34-27)32-16-18-6-7-18)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-15,17-18H,1,5-13,16H2,2-3H3,(H,32,33,34)
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n/an/a 0.100n/an/an/an/an/a25



Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50065454
PNG
(CHEBI:63453 | CHEMBL3348846)
Show SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1
Show InChI InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+
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n/an/a<0.200n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 in human KG1 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assay


Bioorg Med Chem Lett 26: 2594-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.028
BindingDB Entry DOI: 10.7270/Q20C4XNM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50166610
PNG
(CHEMBL3800526)
Show SMILES COc1cc(CCc2cc(Nc3ncnc4cc(ccc34)N3CCN4CCCCC4C3)n[nH]2)cc(OC)c1
Show InChI InChI=1S/C29H35N7O2/c1-37-24-13-20(14-25(17-24)38-2)6-7-21-15-28(34-33-21)32-29-26-9-8-22(16-27(26)30-19-31-29)36-12-11-35-10-4-3-5-23(35)18-36/h8-9,13-17,19,23H,3-7,10-12,18H2,1-2H3,(H2,30,31,32,33,34)
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n/an/a<0.200n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 in human KG1 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assay


Bioorg Med Chem Lett 26: 2594-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.028
BindingDB Entry DOI: 10.7270/Q20C4XNM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50189870
PNG
(CHEMBL3827818)
Show SMILES CC(Oc1ccc2[nH]nc(-c3nc4cc(ccc4[nH]3)N3CCOCC3)c2c1)c1c(Cl)cncc1Cl
Show InChI InChI=1S/C25H22Cl2N6O2/c1-14(23-18(26)12-28-13-19(23)27)35-16-3-5-20-17(11-16)24(32-31-20)25-29-21-4-2-15(10-22(21)30-25)33-6-8-34-9-7-33/h2-5,10-14H,6-9H2,1H3,(H,29,30)(H,31,32)
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n/an/a 0.200n/an/an/an/an/an/a



East China University of Science& Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA


J Med Chem 59: 6690-708 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00056
BindingDB Entry DOI: 10.7270/Q2474CT3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50189872
PNG
(CHEMBL3827492)
Show SMILES CC(Oc1ccc2[nH]nc(-c3nc4cc(NCCN(C)C)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl
Show InChI InChI=1S/C25H25Cl2N7O/c1-14(23-18(26)12-28-13-19(23)27)35-16-5-7-20-17(11-16)24(33-32-20)25-30-21-6-4-15(10-22(21)31-25)29-8-9-34(2)3/h4-7,10-14,29H,8-9H2,1-3H3,(H,30,31)(H,32,33)
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n/an/a 0.300n/an/an/an/an/an/a



East China University of Science& Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA


J Med Chem 59: 6690-708 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00056
BindingDB Entry DOI: 10.7270/Q2474CT3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM286978
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2-chloro...)
Show SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(NCC(C)(C)O)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H37ClN6O5/c1-6-24(37)35-12-10-34(11-13-35)8-7-9-36-26-19(17-31-28(33-26)32-18-29(2,3)39)14-22(27(36)38)21-15-20(40-4)16-23(41-5)25(21)30/h6,14-17,39H,1,7-13,18H2,2-5H3,(H,31,32,33)
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n/an/a 0.300n/an/an/an/an/a25



Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50189781
PNG
(CHEMBL3828009)
Show SMILES C[C@@H](Oc1ccc2[nH]nc(\C=C\c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl
Show InChI InChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1
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n/an/a 0.300n/an/an/an/an/an/a



East China University of Science& Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA


J Med Chem 59: 6690-708 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00056
BindingDB Entry DOI: 10.7270/Q2474CT3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM130859
PNG
(US8829199, 114)
Show SMILES CC1CCC(C)N1Cc1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc2nc(C)nc2c1
Show InChI InChI=1S/C27H29N7O/c1-15-4-5-16(2)33(15)14-18-6-8-22-19(10-18)11-25(32-22)26(35)21-13-29-34(27(21)28)20-7-9-23-24(12-20)31-17(3)30-23/h6-13,15-16,32H,4-5,14,28H2,1-3H3,(H,30,31)
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n/an/a 0.320n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM286391
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NC(C)C)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C28H34Cl2N6O4/c1-6-22(37)35-12-10-34(11-13-35)8-7-9-36-26-18(16-31-28(33-26)32-17(2)3)14-19(27(36)38)23-24(29)20(39-4)15-21(40-5)25(23)30/h6,14-17H,1,7-13H2,2-5H3,(H,31,32,33)
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n/an/a 0.400n/an/an/an/an/a25



Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM287008
PNG
(8-(2-((1-acryloylazetidin-3-yl)oxy)ethyl)-6-(2,6-d...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C24H25Cl2N5O5/c1-5-18(32)30-11-14(12-30)36-7-6-31-22-13(10-28-24(27-2)29-22)8-15(23(31)33)19-20(25)16(34-3)9-17(35-4)21(19)26/h5,8-10,14H,1,6-7,11-12H2,2-4H3,(H,27,28,29)
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n/an/a 0.400n/an/an/an/an/a25



Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50189785
PNG
(CHEMBL3828439)
Show SMILES CC(Oc1ccc2[nH]nc(-c3nc4cc(ccc4[nH]3)N(C)C(=O)CN(C)C)c2c1)c1c(Cl)cncc1Cl
Show InChI InChI=1S/C26H25Cl2N7O2/c1-14(24-18(27)11-29-12-19(24)28)37-16-6-8-20-17(10-16)25(33-32-20)26-30-21-7-5-15(9-22(21)31-26)35(4)23(36)13-34(2)3/h5-12,14H,13H2,1-4H3,(H,30,31)(H,32,33)
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n/an/a 0.400n/an/an/an/an/an/a



East China University of Science& Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA


J Med Chem 59: 6690-708 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00056
BindingDB Entry DOI: 10.7270/Q2474CT3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM194880
PNG
(US9206184, 61)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(-c2cnco2)c(CN2CCNCC2)n2ncnc(N)c12
Show InChI InChI=1S/C24H25N7O2S/c1-14-7-15-9-19(34-23(15)17(8-14)32-2)21-20(18-10-27-13-33-18)16(11-30-5-3-26-4-6-30)31-22(21)24(25)28-12-29-31/h7-10,12-13,26H,3-6,11H2,1-2H3,(H2,25,28,29)
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n/an/a 0.5n/an/an/an/a7.022



BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07SH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50166610
PNG
(CHEMBL3800526)
Show SMILES COc1cc(CCc2cc(Nc3ncnc4cc(ccc34)N3CCN4CCCCC4C3)n[nH]2)cc(OC)c1
Show InChI InChI=1S/C29H35N7O2/c1-37-24-13-20(14-25(17-24)38-2)6-7-21-15-28(34-33-21)32-29-26-9-8-22(16-27(26)30-19-31-29)36-12-11-35-10-4-3-5-23(35)18-36/h8-9,13-17,19,23H,3-7,10-12,18H2,1-2H3,(H2,30,31,32,33,34)
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n/an/a<0.5n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 in human H1581 cells assessed as suppression of cell proliferation after 72 hrs by SRB/CCK-8 assay


Bioorg Med Chem Lett 26: 2594-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.028
BindingDB Entry DOI: 10.7270/Q20C4XNM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM194837
PNG
(US9206184, 18 | US9206184, 19)
Show SMILES CCOCc1c(CN2CCNCC2)n2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C24H30N6O2S/c1-4-32-13-17-18(12-29-7-5-26-6-8-29)30-22(24(25)27-14-28-30)21(17)20-11-16-9-15(2)10-19(31-3)23(16)33-20/h9-11,14,26H,4-8,12-13H2,1-3H3,(H2,25,27,28)
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n/an/a 0.5n/an/an/an/a7.022



BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07SH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM287005
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCO)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C27H32Cl2N6O5/c1-4-21(37)34-11-9-33(10-12-34)7-5-8-35-25-17(16-31-27(32-25)30-6-13-36)14-18(26(35)38)22-23(28)19(39-2)15-20(40-3)24(22)29/h4,14-16,36H,1,5-13H2,2-3H3,(H,30,31,32)
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Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50189873
PNG
(CHEMBL3827725)
Show SMILES COCCNc1ccc2[nH]c(nc2c1)-c1n[nH]c2ccc(OC(C)c3c(Cl)cncc3Cl)cc12
Show InChI InChI=1S/C24H22Cl2N6O2/c1-13(22-17(25)11-27-12-18(22)26)34-15-4-6-19-16(10-15)23(32-31-19)24-29-20-5-3-14(9-21(20)30-24)28-7-8-33-2/h3-6,9-13,28H,7-8H2,1-2H3,(H,29,30)(H,31,32)
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East China University of Science& Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA


J Med Chem 59: 6690-708 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00056
BindingDB Entry DOI: 10.7270/Q2474CT3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM286984
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)
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Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50065454
PNG
(CHEBI:63453 | CHEMBL3348846)
Show SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1
Show InChI InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+
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East China University of Science& Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA


J Med Chem 59: 6690-708 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00056
BindingDB Entry DOI: 10.7270/Q2474CT3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM130860
PNG
(US8829199, 115)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3cc(CN4CCCC(F)C4)ccc3[nH]2)c1N
Show InChI InChI=1S/C26H26FN7O/c1-15-30-22-7-5-19(11-23(22)31-15)34-26(28)20(12-29-34)25(35)24-10-17-9-16(4-6-21(17)32-24)13-33-8-2-3-18(27)14-33/h4-7,9-12,18,32H,2-3,8,13-14,28H2,1H3,(H,30,31)
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Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM194844
PNG
(US9206184, 25)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCC2CC2)c(CN2CCNCC2)n2ncnc(N)c12
Show InChI InChI=1S/C26H32N6O2S/c1-16-9-18-11-22(35-25(18)21(10-16)33-2)23-19(14-34-13-17-3-4-17)20(12-31-7-5-28-6-8-31)32-24(23)26(27)29-15-30-32/h9-11,15,17,28H,3-8,12-14H2,1-2H3,(H2,27,29,30)
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n/an/a 0.700n/an/an/an/a7.022



BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07SH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM287015
PNG
((R)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C29H34Cl2N6O5/c1-4-23(38)36-11-9-35(10-12-36)7-5-8-37-27-18(16-32-29(34-27)33-19-6-13-42-17-19)14-20(28(37)39)24-25(30)21(40-2)15-22(41-3)26(24)31/h4,14-16,19H,1,5-13,17H2,2-3H3,(H,32,33,34)/t19-/m1/s1
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Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM287006
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCC3CCOCC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C31H38Cl2N6O5/c1-4-25(40)38-12-10-37(11-13-38)8-5-9-39-29-21(19-35-31(36-29)34-18-20-6-14-44-15-7-20)16-22(30(39)41)26-27(32)23(42-2)17-24(43-3)28(26)33/h4,16-17,19-20H,1,5-15,18H2,2-3H3,(H,34,35,36)
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Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50322535
PNG
(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
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n/an/a 0.700n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Inhibition of FGFR1 (unknown origin)


Bioorg Med Chem Lett 24: 5639-43 (2014)


Article DOI: 10.1016/j.bmcl.2014.10.078
BindingDB Entry DOI: 10.7270/Q2765GZ3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM194837
PNG
(US9206184, 18 | US9206184, 19)
Show SMILES CCOCc1c(CN2CCNCC2)n2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C24H30N6O2S/c1-4-32-13-17-18(12-29-7-5-26-6-8-29)30-22(24(25)27-14-28-30)21(17)20-11-16-9-15(2)10-19(31-3)23(16)33-20/h9-11,14,26H,4-8,12-13H2,1-3H3,(H2,25,27,28)
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BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07SH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM286381
PNG
(8-(2-((1-acryloylpiperidin-3-yl)oxy)ethyl)-6-(2,6-...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CCCN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H29Cl2N5O5/c1-5-20(34)32-8-6-7-16(14-32)38-10-9-33-24-15(13-30-26(29-2)31-24)11-17(25(33)35)21-22(27)18(36-3)12-19(37-4)23(21)28/h5,11-13,16H,1,6-10,14H2,2-4H3,(H,29,30,31)
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Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM287058
PNG
((R)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-...)
Show SMILES COC[C@@H](C)Nc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C29H36Cl2N6O5/c1-6-23(38)36-12-10-35(11-13-36)8-7-9-37-27-19(16-32-29(34-27)33-18(2)17-40-3)14-20(28(37)39)24-25(30)21(41-4)15-22(42-5)26(24)31/h6,14-16,18H,1,7-13,17H2,2-5H3,(H,32,33,34)/t18-/m1/s1
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Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50065454
PNG
(CHEBI:63453 | CHEMBL3348846)
Show SMILES COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1
Show InChI InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+
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Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR1 (unknown origin) using (Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA


Bioorg Med Chem Lett 26: 2594-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.04.028
BindingDB Entry DOI: 10.7270/Q20C4XNM
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM287508
PNG
(8-(2-((1-acryloylazetidin-3-yl)(methyl)amino)ethyl...)
Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCN(C)C3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C26H30Cl2N6O4/c1-6-20(35)33-13-16(14-33)32(3)8-9-34-24-15(12-30-26(31-24)29-7-2)10-17(25(34)36)21-22(27)18(37-4)11-19(38-5)23(21)28/h6,10-12,16H,1,7-9,13-14H2,2-5H3,(H,29,30,31)
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Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM286995
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3ccccc3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C31H32Cl2N6O4/c1-4-25(40)38-15-13-37(14-16-38)11-8-12-39-29-20(19-34-31(36-29)35-21-9-6-5-7-10-21)17-22(30(39)41)26-27(32)23(42-2)18-24(43-3)28(26)33/h4-7,9-10,17-19H,1,8,11-16H2,2-3H3,(H,34,35,36)
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Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50189868
PNG
(CHEMBL3828465)
Show SMILES CC(Oc1ccc2[nH]nc(-c3nc4cc(ccc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1)c1c(Cl)cncc1Cl
Show InChI InChI=1S/C31H33Cl2N7O/c1-19(29-24(32)17-34-18-25(29)33)41-22-6-8-26-23(16-22)30(38-37-26)31-35-27-7-5-21(15-28(27)36-31)40-13-9-20(10-14-40)39-11-3-2-4-12-39/h5-8,15-20H,2-4,9-14H2,1H3,(H,35,36)(H,37,38)
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n/an/a 0.800n/an/an/an/an/an/a



East China University of Science& Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA


J Med Chem 59: 6690-708 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00056
BindingDB Entry DOI: 10.7270/Q2474CT3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM130811
PNG
(US8829199, 40)
Show SMILES Cc1nc2ccc(cc2n1)-n1ncc(C(=O)c2cc3ccc(OCC4(C)COC4)cc3[nH]2)c1N
Show InChI InChI=1S/C25H24N6O3/c1-14-28-19-6-4-16(8-21(19)29-14)31-24(26)18(10-27-31)23(32)22-7-15-3-5-17(9-20(15)30-22)34-13-25(2)11-33-12-25/h3-10,30H,11-13,26H2,1-2H3,(H,28,29)
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n/an/a 0.810n/an/an/an/an/an/a



Chugai Seiyaku Kabushiki Kaisha; F. Hoffmann-La Roche AG

US Patent


Assay Description
The FGFR1-inhibiting activity was measured based on the activity to inhibit phosphorylation of the biotinylated peptide EGPWLEEEEEAYGWMDF by the huma...


US Patent US8829199 (2014)


BindingDB Entry DOI: 10.7270/Q26T0KB8
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM194845
PNG
(US9206184, 26)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COC2CCC2)c(CN2CCNCC2)n2ncnc(N)c12
Show InChI InChI=1S/C26H32N6O2S/c1-16-10-17-12-22(35-25(17)21(11-16)33-2)23-19(14-34-18-4-3-5-18)20(13-31-8-6-28-7-9-31)32-24(23)26(27)29-15-30-32/h10-12,15,18,28H,3-9,13-14H2,1-2H3,(H2,27,29,30)
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n/an/a 0.900n/an/an/an/a7.022



BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07SH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM194841
PNG
(US9206184, 22)
Show SMILES COc1cc(C)cc2cc(sc12)-c1c(COCCO)c(CN2CCNCC2)n2ncnc(N)c12
Show InChI InChI=1S/C24H30N6O3S/c1-15-9-16-11-20(34-23(16)19(10-15)32-2)21-17(13-33-8-7-31)18(12-29-5-3-26-4-6-29)30-22(21)24(25)27-14-28-30/h9-11,14,26,31H,3-8,12-13H2,1-2H3,(H2,25,27,28)
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n/an/a 0.900n/an/an/an/a7.022



BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07SH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM194836
PNG
(US9206184, 17)
Show SMILES COCc1c(CN2CCNCC2)n2ncnc(N)c2c1-c1cc2cc(C)cc(OC)c2s1
Show InChI InChI=1S/C23H28N6O2S/c1-14-8-15-10-19(32-22(15)18(9-14)31-3)20-16(12-30-2)17(11-28-6-4-25-5-7-28)29-21(20)23(24)26-13-27-29/h8-10,13,25H,4-7,11-12H2,1-3H3,(H2,24,26,27)
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n/an/a 0.900n/an/an/an/a7.022



BAYER INTELLECTUAL PROPERTY GmbH

US Patent


Assay Description
For the assay, 50 nl of each stock solution of the test compound in DMSO was pipetted into a black, low-volume 384-well microtiter plate (Greiner Bio...


US Patent US9206184 (2015)


BindingDB Entry DOI: 10.7270/Q2SN07SH
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 0.900n/an/an/an/an/an/a



Novartis Institute for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR1


J Med Chem 54: 7066-83 (2011)


Article DOI: 10.1021/jm2006222
BindingDB Entry DOI: 10.7270/Q22N52N1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM287529
PNG
(8-(2-((1-acryloylazetidin-3-yl)amino)ethyl)-6-(2,6...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCNC3CN(C3)C(=O)C=C)c2n1
Show InChI InChI=1S/C24H26Cl2N6O4/c1-5-18(33)31-11-14(12-31)28-6-7-32-22-13(10-29-24(27-2)30-22)8-15(23(32)34)19-20(25)16(35-3)9-17(36-4)21(19)26/h5,8-10,14,28H,1,6-7,11-12H2,2-4H3,(H,27,29,30)
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n/an/a 0.900n/an/an/an/an/a25



Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50189787
PNG
(CHEMBL3827178)
Show SMILES C[C@@H](Oc1ccc2[nH]nc(-c3nc4cc(ccc4[nH]3)N3CCN(C)CC3)c2c1)c1c(Cl)cncc1Cl
Show InChI InChI=1S/C26H25Cl2N7O/c1-15(24-19(27)13-29-14-20(24)28)36-17-4-6-21-18(12-17)25(33-32-21)26-30-22-5-3-16(11-23(22)31-26)35-9-7-34(2)8-10-35/h3-6,11-15H,7-10H2,1-2H3,(H,30,31)(H,32,33)/t15-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



East China University of Science& Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA


J Med Chem 59: 6690-708 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00056
BindingDB Entry DOI: 10.7270/Q2474CT3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM286992
PNG
(8-(2-((1-acryloylpiperidin-4-yl)oxy)ethyl)-6-(2,6-...)
Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCOC3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C27H31Cl2N5O5/c1-5-21(35)33-9-7-17(8-10-33)39-12-11-34-25-16(15-31-27(32-25)30-6-2)13-18(26(34)36)22-23(28)19(37-3)14-20(38-4)24(22)29/h5,13-15,17H,1,6-12H2,2-4H3,(H,30,31,32)
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n/an/a 0.900n/an/an/an/an/a25



Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM287048
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@H]3CC[C@H](O)CC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C31H38Cl2N6O5/c1-4-25(41)38-14-12-37(13-15-38)10-5-11-39-29-19(18-34-31(36-29)35-20-6-8-21(40)9-7-20)16-22(30(39)42)26-27(32)23(43-2)17-24(44-3)28(26)33/h4,16-18,20-21,40H,1,5-15H2,2-3H3,(H,34,35,36)/t20-,21-
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Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM287044
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCOC(C)C)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O
Show InChI InChI=1S/C30H38Cl2N6O5/c1-6-24(39)37-13-11-36(12-14-37)9-7-10-38-28-20(18-34-30(35-28)33-8-15-43-19(2)3)16-21(29(38)40)25-26(31)22(41-4)17-23(42-5)27(25)32/h6,16-19H,1,7-15H2,2-5H3,(H,33,34,35)
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n/an/a 0.900n/an/an/an/an/a25



Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM286999
PNG
(8-((1-((4-acryloylpiperazin-1-yl)methyl)cyclopropy...)
Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CC3(CN4CCN(CC4)C(=O)C=C)CC3)c2n1
Show InChI InChI=1S/C28H32Cl2N6O4/c1-5-21(37)35-10-8-34(9-11-35)15-28(6-7-28)16-36-25-17(14-32-27(31-2)33-25)12-18(26(36)38)22-23(29)19(39-3)13-20(40-4)24(22)30/h5,12-14H,1,6-11,15-16H2,2-4H3,(H,31,32,33)
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n/an/a 0.900n/an/an/an/an/a25



Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM286998
PNG
(8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...)
Show SMILES CCNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1
Show InChI InChI=1S/C27H32Cl2N6O4/c1-5-21(36)34-12-10-33(11-13-34)8-7-9-35-25-17(16-31-27(32-25)30-6-2)14-18(26(35)37)22-23(28)19(38-3)15-20(39-4)24(22)29/h5,14-16H,1,6-13H2,2-4H3,(H,30,31,32)
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n/an/a 0.900n/an/an/an/an/a25



Principia Biopharma, Inc.

US Patent


Assay Description
A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...


US Patent US9567334 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50329427
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H13N5O/c16-14(21)10-8-12(11-6-7-18-15(17)20-11)19-13(10)9-4-2-1-3-5-9/h1-8,19H,(H2,16,21)(H2,17,18,20)
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n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50355393
PNG
(CHEMBL1834657 | US9434697, BGJ398)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1
Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)
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n/an/a 1n/an/an/an/a7.525



EISAI R&D MANAGEMENT CO., LTD.

US Patent


Assay Description
Recombinant FGFR1 (2.5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μM, FGFR1 substrate); Pol...


US Patent US9434697 (2016)


BindingDB Entry DOI: 10.7270/Q2K07351
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
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