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Compile Data Set for Download or QSAR

Found 162 hits Enz. Inhib. hit(s) with Target = 'Basic fibroblast growth factor' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM142256
PNG
(US8933099, 22)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)
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US Patent
n/an/a 4.5n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM142255
PNG
(US8933099, 21)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C31H35N5O5/c1-32-31(38)36-15-11-24-18-28(27(20-26(24)36)40-17-16-39-3)41-25-8-12-33-29(19-25)34-30(37)23-6-4-21(5-7-23)22-9-13-35(2)14-10-22/h4-8,11-12,15,18-20,22H,9-10,13-14,16-17H2,1-3H3,(H,32,38)(H,33,34,37)
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US Patent
n/an/a 5.10n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM142236
PNG
(US8933099, 2)
Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1
Show InChI InChI=1S/C30H33N5O4/c1-4-34-14-10-21(11-15-34)20-5-7-22(8-6-20)29(36)33-28-18-24(9-13-32-28)39-27-17-23-12-16-35(30(37)31-2)25(23)19-26(27)38-3/h5-9,12-13,16-19,21H,4,10-11,14-15H2,1-3H3,(H,31,37)(H,32,33,36)
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US Patent
n/an/a 6.40n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50000130
PNG
(CHEMBL320550)
Show SMILES OC1C(O)C(NC(=O)COc2ccc(Cl)cc2Cl)OC(C1O)C(O)=O
Show InChI InChI=1S/C14H15Cl2NO8/c15-5-1-2-7(6(16)3-5)24-4-8(18)17-13-11(21)9(19)10(20)12(25-13)14(22)23/h1-3,9-13,19-21H,4H2,(H,17,18)(H,22,23)
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n/an/a 10n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
24% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50000128
PNG
(CHEMBL113091)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)NC1OC(C(O)C(O)C1O)C(O)=O
Show InChI InChI=1S/C16H21NO10/c1-24-7-4-6(5-8(25-2)12(7)26-3)14(21)17-15-11(20)9(18)10(19)13(27-15)16(22)23/h4-5,9-11,13,15,18-20H,1-3H3,(H,17,21)(H,22,23)
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n/an/a 58n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
23% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50421574
PNG
(CHEMBL2303729)
Show SMILES O[C@@H]1[C@H](O)[C@H](OCCN2C(=O)CCC2=O)O[C@H]([C@H]1O)C(O)=O
Show InChI InChI=1S/C12H17NO9/c14-5-1-2-6(15)13(5)3-4-21-12-9(18)7(16)8(17)10(22-12)11(19)20/h7-10,12,16-18H,1-4H2,(H,19,20)/t7-,8-,9-,10+,12+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
25% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50421574
PNG
(CHEMBL2303729)
Show SMILES O[C@@H]1[C@H](O)[C@H](OCCN2C(=O)CCC2=O)O[C@H]([C@H]1O)C(O)=O
Show InChI InChI=1S/C12H17NO9/c14-5-1-2-6(15)13(5)3-4-21-12-9(18)7(16)8(17)10(22-12)11(19)20/h7-10,12,16-18H,1-4H2,(H,19,20)/t7-,8-,9-,10+,12+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
25% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167952
PNG
(1-(4-(3-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Show SMILES COc1cccc(c1)N1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C22H26N4O3/c1-28-19-6-4-5-17(13-19)26-11-9-25(10-12-26)14-18(27)15-29-22-20-7-2-3-8-21(20)23-16-24-22/h2-8,13,16,18,27H,9-12,14-15H2,1H3
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n/an/a 103n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50331095
PNG
(CHEMBL1289494 | Tivozanib)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
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n/an/a 114n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167953
PNG
(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Show SMILES COc1ccc(cc1)N1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C22H26N4O3/c1-28-19-8-6-17(7-9-19)26-12-10-25(11-13-26)14-18(27)15-29-22-20-4-2-3-5-21(20)23-16-24-22/h2-9,16,18,27H,10-15H2,1H3
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n/an/a 122n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167954
PNG
(1-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)-3-...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1/C22H23F3N4O2/c23-22(24,25)16-4-3-5-17(12-16)29-10-8-28(9-11-29)13-18(30)14-31-21-19-6-1-2-7-20(19)26-15-27-21/h1-7,12,15,18,30H,8-11,13-14H2
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n/an/a 145n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167956
PNG
(1-(4-(3,4-Dichlorophenyl)piperazin-1-yl)-3-(quinaz...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C21H22Cl2N4O2/c22-18-6-5-15(11-19(18)23)27-9-7-26(8-10-27)12-16(28)13-29-21-17-3-1-2-4-20(17)24-14-25-21/h1-6,11,14,16,28H,7-10,12-13H2
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n/an/a 178n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167951
PNG
(1-(4-(2-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C22H26N4O3/c1-28-21-9-5-4-8-20(21)26-12-10-25(11-13-26)14-17(27)15-29-22-18-6-2-3-7-19(18)23-16-24-22/h2-9,16-17,27H,10-15H2,1H3
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n/an/a 209n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167957
PNG
(1-(4-(2,4-Dimethylphenyl)piperazin-1-yl)-3-(quinaz...)
Show SMILES Cc1ccc(N2CCN(CC(O)COc3ncnc4ccccc34)CC2)c(C)c1
Show InChI InChI=1/C23H28N4O2/c1-17-7-8-22(18(2)13-17)27-11-9-26(10-12-27)14-19(28)15-29-23-20-5-3-4-6-21(20)24-16-25-23/h3-8,13,16,19,28H,9-12,14-15H2,1-2H3
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n/an/a 222n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167950
PNG
(1-(4-(4-Nitrophenyl)piperazin-1-yl)-3-(quinazolin-...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1/C21H23N5O4/c27-18(14-30-21-19-3-1-2-4-20(19)22-15-23-21)13-24-9-11-25(12-10-24)16-5-7-17(8-6-16)26(28)29/h1-8,15,18,27H,9-14H2
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n/an/a 248n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167945
PNG
(1-(4-Phenylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1/C21H24N4O2/c26-18(15-27-21-19-8-4-5-9-20(19)22-16-23-21)14-24-10-12-25(13-11-24)17-6-2-1-3-7-17/h1-9,16,18,26H,10-15H2
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n/an/a 293n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167949
PNG
(1-(4-(4-Fluorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1/C21H23FN4O2/c22-16-5-7-17(8-6-16)26-11-9-25(10-12-26)13-18(27)14-28-21-19-3-1-2-4-20(19)23-15-24-21/h1-8,15,18,27H,9-14H2
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n/an/a 300n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167948
PNG
(1-(4-(2-Fluorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccccc1F
Show InChI InChI=1/C21H23FN4O2/c22-18-6-2-4-8-20(18)26-11-9-25(10-12-26)13-16(27)14-28-21-17-5-1-3-7-19(17)23-15-24-21/h1-8,15-16,27H,9-14H2
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n/an/a 372n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167955
PNG
(1-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-(quinaz...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1/C21H22Cl2N4O2/c22-17-5-3-7-19(20(17)23)27-10-8-26(9-11-27)12-15(28)13-29-21-16-4-1-2-6-18(16)24-14-25-21/h1-7,14-15,28H,8-13H2
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n/an/a 398n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167947
PNG
(1-(4-(3-Chlorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1/C21H23ClN4O2/c22-16-4-3-5-17(12-16)26-10-8-25(9-11-26)13-18(27)14-28-21-19-6-1-2-7-20(19)23-15-24-21/h1-7,12,15,18,27H,8-11,13-14H2
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n/an/a 402n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167959
PNG
(1-(4-Methylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Show SMILES CN1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C16H22N4O2/c1-19-6-8-20(9-7-19)10-13(21)11-22-16-14-4-2-3-5-15(14)17-12-18-16/h2-5,12-13,21H,6-11H2,1H3
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n/an/a 419n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167958
PNG
(1-(4-Benzylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1/C22H26N4O2/c27-19(16-28-22-20-8-4-5-9-21(20)23-17-24-22)15-26-12-10-25(11-13-26)14-18-6-2-1-3-7-18/h1-9,17,19,27H,10-16H2
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n/an/a 444n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167946
PNG
(1-(4-(2-Chlorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccccc1Cl
Show InChI InChI=1/C21H23ClN4O2/c22-18-6-2-4-8-20(18)26-11-9-25(10-12-26)13-16(27)14-28-21-17-5-1-3-7-19(17)23-15-24-21/h1-8,15-16,27H,9-14H2
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n/an/a 506n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167960
PNG
(1-(4-Ethylpiperazin-1-yl)-3-(quinazolin-4-yloxy)pr...)
Show SMILES CCN1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C17H24N4O2/c1-2-20-7-9-21(10-8-20)11-14(22)12-23-17-15-5-3-4-6-16(15)18-13-19-17/h3-6,13-14,22H,2,7-12H2,1H3
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n/an/a 519n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167961
PNG
(1-(Dimethylamino)-3-(quinazolin-4-yloxy)propan-2-o...)
Show SMILES CN(C)CC(O)COc1ncnc2ccccc12
Show InChI InChI=1/C13H17N3O2/c1-16(2)7-10(17)8-18-13-11-5-3-4-6-12(11)14-9-15-13/h3-6,9-10,17H,7-8H2,1-2H3
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n/an/a 582n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167965
PNG
(1-(2-Methyl-1H-imidazol-1-yl)-3-(quinazolin-4-ylox...)
Show SMILES Cc1nccn1CC(O)COc1ncnc2ccccc12
Show InChI InChI=1/C15H16N4O2/c1-11-16-6-7-19(11)8-12(20)9-21-15-13-4-2-3-5-14(13)17-10-18-15/h2-7,10,12,20H,8-9H2,1H3
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n/an/a 586n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167966
PNG
(1-(4-Methyl-1H-imidazol-1-yl)-3-(quinazolin-4-ylox...)
Show SMILES Cc1cn(CC(O)COc2ncnc3ccccc23)cn1
Show InChI InChI=1/C15H16N4O2/c1-11-6-19(10-18-11)7-12(20)8-21-15-13-4-2-3-5-14(13)16-9-17-15/h2-6,9-10,12,20H,7-8H2,1H3
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n/an/a 592n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167963
PNG
(1-(Piperidin-1-yl)-3-(quinazolin-4-yloxy)propan-2-...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCCCC1
Show InChI InChI=1/C16H21N3O2/c20-13(10-19-8-4-1-5-9-19)11-21-16-14-6-2-3-7-15(14)17-12-18-16/h2-3,6-7,12-13,20H,1,4-5,8-11H2
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n/an/a 593n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167962
PNG
(1-Morpholino-3-(quinazolin-4-yloxy)propan-2-ol (3r...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCOCC1
Show InChI InChI=1/C15H19N3O3/c19-12(9-18-5-7-20-8-6-18)10-21-15-13-3-1-2-4-14(13)16-11-17-15/h1-4,11-12,19H,5-10H2
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n/an/a 602n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167964
PNG
(1-(1H-Imidazol-1-yl)-3-(quinazolin-4-yloxy)propan-...)
Show SMILES OC(COc1ncnc2ccccc12)Cn1ccnc1
Show InChI InChI=1/C14H14N4O2/c19-11(7-18-6-5-15-10-18)8-20-14-12-3-1-2-4-13(12)16-9-17-14/h1-6,9-11,19H,7-8H2
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n/an/a 609n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50182285
PNG
(CHEMBL3819473)
Show SMILES C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CC[C@@H]2[C@@H](O)CC(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1/C24H34F6O3/c1-20-9-7-14(31)11-13(20)3-4-15-16-5-6-18(21(16,2)10-8-17(15)20)19(32)12-22(33,23(25,26)27)24(28,29)30/h3,14-19,31-33H,4-12H2,1-2H3/t14-,15-,16-,17-,18+,19-,20-,21-/s2
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n/an/a 1.00E+4n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FGF2 assessed as reduction in HSPG/FGF2/FGDR interaction by measuring FGF2 mediated A475-CHO-flg-1A-luc cell to CHO-K...


J Med Chem 59: 4651-63 (2016)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50182286
PNG
(CHEMBL3819333)
Show SMILES C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CC[C@@H]2C(O)CC(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1/C24H34F6O3/c1-20-9-7-14(31)11-13(20)3-4-15-16-5-6-18(21(16,2)10-8-17(15)20)19(32)12-22(33,23(25,26)27)24(28,29)30/h3,14-19,31-33H,4-12H2,1-2H3/t14-,15-,16-,17-,18+,19?,20-,21-/s2
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n/an/a 1.00E+4n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FGF2 assessed as reduction in HSPG/FGF2/FGDR interaction by measuring FGF2 mediated A475-CHO-flg-1A-luc cell to CHO-K...


J Med Chem 59: 4651-63 (2016)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50000129
PNG
(CHEMBL112763)
Show SMILES OC1C(O)C(NC(=O)c2ccc(F)c(F)c2)OC(C1O)C(O)=O
Show InChI InChI=1S/C13H13F2NO7/c14-5-2-1-4(3-6(5)15)11(20)16-12-9(19)7(17)8(18)10(23-12)13(21)22/h1-3,7-10,12,17-19H,(H,16,20)(H,21,22)
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n/an/a 1.10E+4n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
25% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50260260
PNG
(Biotin-Ala-(Arg)9 | CID44576236 | [amino({[(1R,2S,...)
Show SMILES NC(=[NH2+])NCC1OC(OC2C(CO)OC(OC3C(O)C(CC([NH+]=C(N)N)C3OC3OC(CNC(N)=[NH2+])C(O)C(O)C3[NH+]=C(N)N)[NH+]=C(N)N)C2O)C(NC(N)=[NH2+])C(O)C1O
Show InChI InChI=1S/C29H58N18O13/c30-24(31)42-2-7-13(50)15(52)10(46-28(38)39)21(55-7)58-18-6(45-27(36)37)1-5(44-26(34)35)12(49)20(18)60-23-17(54)19(9(4-48)57-23)59-22-11(47-29(40)41)16(53)14(51)8(56-22)3-43-25(32)33/h5-23,48-54H,1-4H2,(H4,30,31,42)(H4,32,33,43)(H4,34,35,44)(H4,36,37,45)(H4,38,39,46)(H4,40,41,47)/p+6
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Binding affinity to biotinylated FGF2 in CHO cells by flow cytometry


J Biol Chem 282: 13585-91 (2007)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144519
PNG
(CHEMBL385967 | Sodium sulfated glycoconjugate deri...)
Show SMILES [O-]S(=O)(=O)OCC1OC(OCCNC(=O)CN(Cc2ccccc2)C(=O)COC2C(OS([O-])(=O)=O)OC(COS([O-])(=O)=O)C(OS([O-])(=O)=O)C2OS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C25H38N2O38S8/c28-16(26-6-7-54-24-23(64-72(48,49)50)21(63-71(45,46)47)19(61-69(39,40)41)14(58-24)10-56-66(30,31)32)9-27(8-13-4-2-1-3-5-13)17(29)12-55-22-20(62-70(42,43)44)18(60-68(36,37)38)15(11-57-67(33,34)35)59-25(22)65-73(51,52)53/h1-5,14-15,18-25H,6-12H2,(H,26,28)(H,30,31,32)(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)/p-8
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n/an/an/a 8.50E+4n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144523
PNG
(CHEMBL305519 | Sodium sulfated glycoconjugate deri...)
Show SMILES [O-]S(=O)(=O)OCCN(CC(=O)NC1CCCCC1)C(=O)C1OC(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C16H28N2O23S5/c19-10(17-9-4-2-1-3-5-9)8-18(6-7-36-42(21,22)23)15(20)13-11(38-43(24,25)26)12(39-44(27,28)29)14(40-45(30,31)32)16(37-13)41-46(33,34)35/h9,11-14,16H,1-8H2,(H,17,19)(H,21,22,23)(H,24,25,26)(H,27,28,29)(H,30,31,32)(H,33,34,35)/p-5
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n/an/an/a>8.00E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144525
PNG
(CHEMBL70844 | Sodium sulfated glycoconjugate deriv...)
Show SMILES [O-]S(=O)(=O)OC1OC(C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)C(=O)N(CC(=O)NCc1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C22H26N2O19S4/c25-16(23-11-14-7-3-1-4-8-14)13-24(12-15-9-5-2-6-10-15)21(26)19-17(40-44(27,28)29)18(41-45(30,31)32)20(42-46(33,34)35)22(39-19)43-47(36,37)38/h1-10,17-20,22H,11-13H2,(H,23,25)(H,27,28,29)(H,30,31,32)(H,33,34,35)(H,36,37,38)/p-4
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n/an/an/a 2.06E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144524
PNG
(CHEMBL410472 | Sodium sulfated glycoconjugate deri...)
Show SMILES CC(C)(CC(=O)N(CCOC1OC(COS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)CC(=O)NC1CCCCC1)CC(=O)N(CCOC1OC(COS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)CC(=O)NC1CCCCC1
Show InChI InChI=1S/C39H68N4O40S8/c1-39(2,17-29(46)42(19-27(44)40-23-9-5-3-6-10-23)13-15-72-37-35(82-90(66,67)68)33(80-88(60,61)62)31(78-86(54,55)56)25(76-37)21-74-84(48,49)50)18-30(47)43(20-28(45)41-24-11-7-4-8-12-24)14-16-73-38-36(83-91(69,70)71)34(81-89(63,64)65)32(79-87(57,58)59)26(77-38)22-75-85(51,52)53/h23-26,31-38H,3-22H2,1-2H3,(H,40,44)(H,41,45)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)/p-8
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n/an/an/a 3.40E+4n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144528
PNG
(CHEMBL430625 | Sodium sulfated glycoconjugate deri...)
Show SMILES COC1OC(COCC(=O)N(CCS([O-])(=O)=O)CC(=O)NC2CCCCC2)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C19H34N2O20S4/c1-36-19-18(41-45(33,34)35)17(40-44(30,31)32)16(39-43(27,28)29)13(38-19)10-37-11-15(23)21(7-8-42(24,25)26)9-14(22)20-12-5-3-2-4-6-12/h12-13,16-19H,2-11H2,1H3,(H,20,22)(H,24,25,26)(H,27,28,29)(H,30,31,32)(H,33,34,35)/p-4
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n/an/an/a 5.51E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144521
PNG
(CHEMBL408602 | Sodium sulfated glycoconjugate deri...)
Show SMILES COC1OC(COCC(=O)N(CC(=O)NC2CCCCC2)C2CCC(CC2)N(CC(=O)NC2CCCCC2)C(=O)COCC2OC(OC)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C2OS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C40H68N4O34S6/c1-67-39-37(77-83(61,62)63)35(75-81(55,56)57)33(73-79(49,50)51)27(71-39)19-69-21-31(47)43(17-29(45)41-23-9-5-3-6-10-23)25-13-15-26(16-14-25)44(18-30(46)42-24-11-7-4-8-12-24)32(48)22-70-20-28-34(74-80(52,53)54)36(76-82(58,59)60)38(40(68-2)72-28)78-84(64,65)66/h23-28,33-40H,3-22H2,1-2H3,(H,41,45)(H,42,46)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)/p-6
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n/an/an/a 2.79E+4n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144527
PNG
(CHEMBL308220 | Sodium sulfated glycoconjugate deri...)
Show SMILES COC1OC(COCC(=O)N(CC(=O)NC2CCCCC2)Cc2ccccc2)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C24H36N2O17S3/c1-38-24-23(43-46(35,36)37)22(42-45(32,33)34)21(41-44(29,30)31)18(40-24)14-39-15-20(28)26(12-16-8-4-2-5-9-16)13-19(27)25-17-10-6-3-7-11-17/h2,4-5,8-9,17-18,21-24H,3,6-7,10-15H2,1H3,(H,25,27)(H,29,30,31)(H,32,33,34)(H,35,36,37)/p-3
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n/an/an/a 2.00E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144529
PNG
(CHEMBL70718 | Sodium sulfated glycoconjugate deriv...)
Show SMILES OC1C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)OC1C(=O)N(CC(=O)NC1CCCCC1)Cc1ccccc1
Show InChI InChI=1S/C21H30N2O16S3/c24-15(22-14-9-5-2-6-10-14)12-23(11-13-7-3-1-4-8-13)20(26)18-16(25)17(37-40(27,28)29)19(38-41(30,31)32)21(36-18)39-42(33,34)35/h1,3-4,7-8,14,16-19,21,25H,2,5-6,9-12H2,(H,22,24)(H,27,28,29)(H,30,31,32)(H,33,34,35)/p-3
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n/an/an/a 1.16E+6n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144522
PNG
(CHEMBL430983 | Sodium sulfated glycoconjugate deri...)
Show SMILES CC(=O)N(CC(=O)NCCOC1OC(COS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)Cc1ccccc1
Show InChI InChI=1S/C19H28N2O20S4/c1-12(22)21(9-13-5-3-2-4-6-13)10-15(23)20-7-8-36-19-18(41-45(33,34)35)17(40-44(30,31)32)16(39-43(27,28)29)14(38-19)11-37-42(24,25)26/h2-6,14,16-19H,7-11H2,1H3,(H,20,23)(H,24,25,26)(H,27,28,29)(H,30,31,32)(H,33,34,35)/p-4
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n/an/an/a 2.87E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144520
PNG
(CHEMBL308715 | Sodium sulfated glycoconjugate deri...)
Show SMILES [O-]S(=O)(=O)OC1OC(C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)C(=O)N(Cc1ccccc1)C(C(=O)NC1CCCCC1)c1ccccc1
Show InChI InChI=1S/C27H34N2O19S4/c30-25(28-19-14-8-3-9-15-19)20(18-12-6-2-7-13-18)29(16-17-10-4-1-5-11-17)26(31)23-21(45-49(32,33)34)22(46-50(35,36)37)24(47-51(38,39)40)27(44-23)48-52(41,42)43/h1-2,4-7,10-13,19-24,27H,3,8-9,14-16H2,(H,28,30)(H,32,33,34)(H,35,36,37)(H,38,39,40)(H,41,42,43)/p-4
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n/an/an/a>8.00E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay (No binding)


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50143026
PNG
((6-{benzyl[(cyclohexylcarbamoyl)methyl]carbamoyl}-...)
Show SMILES [O-]S(=O)(=O)OC1OC(C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O)C(=O)N(CC(=O)NC1CCCCC1)Cc1ccccc1
Show InChI InChI=1S/C21H30N2O19S4/c24-15(22-14-9-5-2-6-10-14)12-23(11-13-7-3-1-4-8-13)20(25)18-16(39-43(26,27)28)17(40-44(29,30)31)19(41-45(32,33)34)21(38-18)42-46(35,36)37/h1,3-4,7-8,14,16-19,21H,2,5-6,9-12H2,(H,22,24)(H,26,27,28)(H,29,30,31)(H,32,33,34)(H,35,36,37)/p-4
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n/an/an/a 2.54E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144526
PNG
(CHEMBL386607 | Sodium sulfated glycoconjugate deri...)
Show SMILES COC1OC(COCC(=O)N(CC(=O)NCCOC2OC(COS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C2OS([O-])(=O)=O)Cc2ccccc2)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C26H40N2O35S7/c1-52-25-23(62-69(46,47)48)21(60-67(40,41)42)19(58-65(34,35)36)15(56-25)11-53-13-18(30)28(9-14-5-3-2-4-6-14)10-17(29)27-7-8-54-26-24(63-70(49,50)51)22(61-68(43,44)45)20(59-66(37,38)39)16(57-26)12-55-64(31,32)33/h2-6,15-16,19-26H,7-13H2,1H3,(H,27,29)(H,31,32,33)(H,34,35,36)(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)/p-7
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n/an/an/a 1.60E+4n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50179254
PNG
((2R,3S,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-2-{[(2R,3S,4...)
Show SMILES OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](CO)O[C@H](O[C@H]3[C@H](O)[C@@H](CO)O[C@H](O[C@H]4[C@H](O)[C@@H](CO)O[C@H](O[C@H]5[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]5OCc5ccccc5)[C@H]4O)[C@H]3O)[C@H]2O)[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C37H58O26/c38-6-13-18(43)23(48)25(50)33(55-13)60-29-20(45)15(8-40)56-34(26(29)51)61-30-21(46)16(9-41)57-35(27(30)52)62-31-22(47)17(10-42)58-36(28(31)53)63-32-24(49)19(44)14(7-39)59-37(32)54-11-12-4-2-1-3-5-12/h1-5,13-53H,6-11H2/t13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33-,34-,35-,36-,37+/m1/s1
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n/an/an/a 86n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Binding affinity for FGF2 by BIAcore solution affinity assay


J Med Chem 48: 8229-36 (2005)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50179256
PNG
(6-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d...)
Show SMILES OC[C@H]1O[C@H](NC(=O)CCCCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H]4O)[C@@H]3O)[C@@H]2O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C46H78N4O28S/c51-10-17-27(59)32(64)40(41(70-17)49-24(57)8-2-1-5-9-47-23(56)7-4-3-6-22-25-16(15-79-22)48-46(69)50-25)78-45-36(68)39(30(62)21(14-55)74-45)77-44-35(67)38(29(61)20(13-54)73-44)76-43-34(66)37(28(60)19(12-53)72-43)75-42-33(65)31(63)26(58)18(11-52)71-42/h16-22,25-45,51-55,58-68H,1-15H2,(H,47,56)(H,49,57)(H2,48,50,69)/t16-,17+,18+,19+,20+,21+,22-,25-,26+,27+,28+,29+,30+,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42+,43+,44+,45+/m0/s1
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n/an/an/a 84n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Binding affinity for FGF2 by BIAcore solution affinity assay


J Med Chem 48: 8229-36 (2005)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50179255
PNG
(CHEMBL265885 | N-[(2S,3S,4S,5S,6R)-3-{[(2R,3S,4S,5...)
Show SMILES OC[C@H]1O[C@H](NC(=O)COc2ccccc2)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H]4O)[C@@H]3O)[C@@H]2O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C38H59NO27/c40-6-13-20(47)25(52)33(34(58-13)39-18(45)11-57-12-4-2-1-3-5-12)66-38-29(56)32(23(50)17(10-44)62-38)65-37-28(55)31(22(49)16(9-43)61-37)64-36-27(54)30(21(48)15(8-42)60-36)63-35-26(53)24(51)19(46)14(7-41)59-35/h1-5,13-17,19-38,40-44,46-56H,6-11H2,(H,39,45)/t13-,14-,15-,16-,17-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35-,36-,37-,38-/m1/s1
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n/an/an/a 112n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Binding affinity for FGF2 by BIAcore solution affinity assay


J Med Chem 48: 8229-36 (2005)

More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50179253
PNG
((2R,3S,4S,5S,6R)-2-{[(2R,3S,4S,5R,6R)-2-{[(2R,3S,4...)
Show SMILES CCCCCCCCO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H]3O)[C@@H]2O)[C@@H]1O
Show InChI InChI=1S/C38H68O26/c1-2-3-4-5-6-7-8-55-38-33(25(50)20(45)15(10-40)60-38)64-37-29(54)32(23(48)18(13-43)59-37)63-36-28(53)31(22(47)17(12-42)58-36)62-35-27(52)30(21(46)16(11-41)57-35)61-34-26(51)24(49)19(44)14(9-39)56-34/h14-54H,2-13H2,1H3/t14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35-,36-,37-,38+/m1/s1
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n/an/an/a 68n/an/an/an/an/a



Progen Industries Limited

Curated by ChEMBL


Assay Description
Binding affinity for FGF2 by BIAcore solution affinity assay


J Med Chem 48: 8229-36 (2005)

More data for this
Ligand-Target Pair
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