BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 10 hits Enz. Inhib. hit(s) with Target = 'Beta-secretase 2 (BACE2)' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-secretase 2 (BACE2)


(Mus musculus (Mouse))
BDBM165913
PNG
(US9067924, 7)
Show SMILES CC1C(N)=N[C@@](C)(CCS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1/C19H20F2N4O3S/c1-11-17(22)25-19(2,7-8-29(11,27)28)14-9-13(4-5-15(14)21)24-18(26)16-6-3-12(20)10-23-16/h3-6,9-11H,7-8H2,1-2H3,(H2,22,25)(H,24,26)/t11?,19-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 2n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...


US Patent US9067924 (2015)

More data for this
Ligand-Target Pair
Beta-secretase 2 (BACE2)


(Mus musculus (Mouse))
BDBM165910
PNG
(US9067924, 4)
Show SMILES C[C@]1(CCS(=O)(=O)CC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1/C18H18F2N4O3S/c1-18(6-7-28(26,27)10-16(21)24-18)13-8-12(3-4-14(13)20)23-17(25)15-5-2-11(19)9-22-15/h2-5,8-9H,6-7,10H2,1H3,(H2,21,24)(H,23,25)/t18-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 4n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...


US Patent US9067924 (2015)

More data for this
Ligand-Target Pair
Beta-secretase 2 (BACE2)


(Mus musculus (Mouse))
BDBM165909
PNG
(US9067924, 3)
Show SMILES C[C@]1(CCS(=O)(=O)CC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1/C18H18ClFN4O3S/c1-18(6-7-28(26,27)10-16(21)24-18)13-8-12(3-4-14(13)20)23-17(25)15-5-2-11(19)9-22-15/h2-5,8-9H,6-7,10H2,1H3,(H2,21,24)(H,23,25)/t18-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 5n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...


US Patent US9067924 (2015)

More data for this
Ligand-Target Pair
Beta-secretase 2 (BACE2)


(Mus musculus (Mouse))
BDBM165912
PNG
(US9067924, 6)
Show SMILES CC1SCC[C@](C)(N=C1N)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1/C19H20ClFN4OS/c1-11-17(22)25-19(2,7-8-27-11)14-9-13(4-5-15(14)21)24-18(26)16-6-3-12(20)10-23-16/h3-6,9-11H,7-8H2,1-2H3,(H2,22,25)(H,24,26)/t11?,19-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 9n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...


US Patent US9067924 (2015)

More data for this
Ligand-Target Pair
Beta-secretase 2 (BACE2)


(Mus musculus (Mouse))
BDBM165914
PNG
(US9067924, 8)
Show SMILES CC1C(N)=N[C@@](C)(CCS1(=O)=O)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1/C19H20ClFN4O3S/c1-11-17(22)25-19(2,7-8-29(11,27)28)14-9-13(4-5-15(14)21)24-18(26)16-6-3-12(20)10-23-16/h3-6,9-11H,7-8H2,1-2H3,(H2,22,25)(H,24,26)/t11?,19-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 16n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...


US Patent US9067924 (2015)

More data for this
Ligand-Target Pair
Beta-secretase 2 (BACE2)


(Mus musculus (Mouse))
BDBM165911
PNG
(US9067924, 5)
Show SMILES CC1SCC[C@](C)(N=C1N)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1/C19H20F2N4OS/c1-11-17(22)25-19(2,7-8-27-11)14-9-13(4-5-15(14)21)24-18(26)16-6-3-12(20)10-23-16/h3-6,9-11H,7-8H2,1-2H3,(H2,22,25)(H,24,26)/t11?,19-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 21n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...


US Patent US9067924 (2015)

More data for this
Ligand-Target Pair
Beta-secretase 2 (BACE2)


(Mus musculus (Mouse))
BDBM165908
PNG
(US9067924, 2)
Show SMILES C[C@]1(CCSCC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1/C18H18F2N4OS/c1-18(6-7-26-10-16(21)24-18)13-8-12(3-4-14(13)20)23-17(25)15-5-2-11(19)9-22-15/h2-5,8-9H,6-7,10H2,1H3,(H2,21,24)(H,23,25)/t18-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 79n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...


US Patent US9067924 (2015)

More data for this
Ligand-Target Pair
Beta-secretase 2 (BACE2)


(Mus musculus (Mouse))
BDBM165907
PNG
(US9067924, 1)
Show SMILES C[C@]1(CCSCC(N)=N1)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F
Show InChI InChI=1/C18H18ClFN4OS/c1-18(6-7-26-10-16(21)24-18)13-8-12(3-4-14(13)20)23-17(25)15-5-2-11(19)9-22-15/h2-5,8-9H,6-7,10H2,1H3,(H2,21,24)(H,23,25)/t18-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 167n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...


US Patent US9067924 (2015)

More data for this
Ligand-Target Pair
Beta-secretase 2 (BACE2)


(Mus musculus (Mouse))
BDBM165916
PNG
(US9067924, 10)
Show SMILES CC1(C)C(N)=N[C@@](C)(CCS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F
Show InChI InChI=1/C20H22F2N4O3S/c1-19(2)18(23)26-20(3,8-9-30(19,28)29)14-10-13(5-6-15(14)22)25-17(27)16-7-4-12(21)11-24-16/h4-7,10-11H,8-9H2,1-3H3,(H2,23,26)(H,25,27)/t20-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 181n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...


US Patent US9067924 (2015)

More data for this
Ligand-Target Pair
Beta-secretase 2 (BACE2)


(Mus musculus (Mouse))
BDBM165915
PNG
(US9067924, 9)
Show SMILES CC1C(N)=N[C@@](C)(CCS1(=O)=O)c1cc(NC(=O)c2[nH]ncc2Cl)ccc1F
Show InChI InChI=1/C17H19ClFN5O3S/c1-9-15(20)23-17(2,5-6-28(9,26)27)11-7-10(3-4-13(11)19)22-16(25)14-12(18)8-21-24-14/h3-4,7-9H,5-6H2,1-2H3,(H2,20,23)(H,21,24)(H,22,25)/t9?,17-/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 858n/an/an/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...


US Patent US9067924 (2015)

More data for this
Ligand-Target Pair