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Found 48 hits Enz. Inhib. hit(s) with Target = 'Bradykinin B1 receptor' AND taxid = 9986   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50156446
PNG
(CHEMBL359553 | N-{2-[4-(4,5-Dihydro-1H-imidazol-2-...)
Show SMILES O=C(C[C@H]1N(c2ccccc2NC1=O)S(=O)(=O)c1ccc2ccccc2c1)NCCc1ccc(cc1)C1=NCCN1
Show InChI InChI=1S/C31H29N5O4S/c37-29(32-16-15-21-9-11-23(12-10-21)30-33-17-18-34-30)20-28-31(38)35-26-7-3-4-8-27(26)36(28)41(39,40)25-14-13-22-5-1-2-6-24(22)19-25/h1-14,19,28H,15-18,20H2,(H,32,37)(H,33,34)(H,35,38)/t28-/m1/s1
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0.0500n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity of the [35S]- radiolabelled compound to rabbit Bradykinin receptor B1


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50157515
PNG
(4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamino)-pyridi...)
Show SMILES COC(=O)c1c(F)cccc1-c1ccc(cc1)[C@@H](C)Nc1nccc(Cl)c1NC(=O)CC#N
Show InChI InChI=1S/C24H20ClFN4O3/c1-14(29-23-22(18(25)11-13-28-23)30-20(31)10-12-27)15-6-8-16(9-7-15)17-4-3-5-19(26)21(17)24(32)33-2/h3-9,11,13-14H,10H2,1-2H3,(H,28,29)(H,30,31)/t14-/m1/s1
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0.690n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to rabbit bradykinin B1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50157513
PNG
(3-chloro-4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamin...)
Show SMILES COC(=O)c1c(Cl)cccc1-c1ccc(cc1)[C@@H](C)Nc1nccc(Cl)c1NC(=O)CC#N
Show InChI InChI=1S/C24H20Cl2N4O3/c1-14(29-23-22(19(26)11-13-28-23)30-20(31)10-12-27)15-6-8-16(9-7-15)17-4-3-5-18(25)21(17)24(32)33-2/h3-9,11,13-14H,10H2,1-2H3,(H,28,29)(H,30,31)/t14-/m1/s1
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1.10n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to rabbit bradykinin B1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50157509
PNG
(CHEMBL222038 | N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-...)
Show SMILES C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(cc1)-c1cccc(F)c1-c1nc(C)no1
Show InChI InChI=1S/C25H20ClFN6O2/c1-14(30-24-23(19(26)11-13-29-24)32-21(34)10-12-28)16-6-8-17(9-7-16)18-4-3-5-20(27)22(18)25-31-15(2)33-35-25/h3-9,11,13-14H,10H2,1-2H3,(H,29,30)(H,32,34)/t14-/m1/s1
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2.70n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to rabbit bradykinin B1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50157511
PNG
(CHEMBL387638 | N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-...)
Show SMILES C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(cc1)-c1cccc(F)c1-c1nnn(C)n1
Show InChI InChI=1S/C24H20ClFN8O/c1-14(29-24-22(18(25)11-13-28-24)30-20(35)10-12-27)15-6-8-16(9-7-15)17-4-3-5-19(26)21(17)23-31-33-34(2)32-23/h3-9,11,13-14H,10H2,1-2H3,(H,28,29)(H,30,35)/t14-/m1/s1
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3n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to rabbit bradykinin B1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50202412
PNG
(3-Chloro-3'-fluoro-4'-((R)-1-{[1-(2,2,2-trifluoro-...)
Show SMILES COC(=O)c1c(Cl)cccc1-c1ccc([C@@H](C)NC(=O)C2(CC2)NC(=O)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C22H19ClF4N2O4/c1-11(28-19(31)21(8-9-21)29-20(32)22(25,26)27)13-7-6-12(10-16(13)24)14-4-3-5-15(23)17(14)18(30)33-2/h3-7,10-11H,8-9H2,1-2H3,(H,28,31)(H,29,32)/t11-/m1/s1
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7.30n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to rabbit bradykinin B1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50229295
PNG
((R)-N-((R)-1-(5-(5-chloro-3-fluoro-2-(5-methyl-1,2...)
Show SMILES C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1
Show InChI InChI=1S/C20H16ClF5N4O3/c1-8(28-18(31)19(3,32)20(24,25)26)16-14(23)4-10(7-27-16)12-5-11(21)6-13(22)15(12)17-29-9(2)33-30-17/h4-8,32H,1-3H3,(H,28,31)/t8-,19-/m1/s1
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13n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to rabbit bradikinin B1 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50157514
PNG
(CHEMBL221984 | N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-...)
Show SMILES C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(cc1)-c1cccc(F)c1-c1nnnn1C
Show InChI InChI=1S/C24H20ClFN8O/c1-14(29-23-22(18(25)11-13-28-23)30-20(35)10-12-27)15-6-8-16(9-7-15)17-4-3-5-19(26)21(17)24-31-32-33-34(24)2/h3-9,11,13-14H,10H2,1-2H3,(H,28,29)(H,30,35)/t14-/m1/s1
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41.5n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to rabbit bradykinin B1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50156455
PNG
((R)-N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenethyl)-...)
Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)N1[C@H](CC(=O)NCCc2ccc(cc2)C2=NCCN2)C(=O)Nc2ccccc12
Show InChI InChI=1S/C27H25Cl2N5O4S/c28-20-10-9-19(15-21(20)29)39(37,38)34-23-4-2-1-3-22(23)33-27(36)24(34)16-25(35)30-12-11-17-5-7-18(8-6-17)26-31-13-14-32-26/h1-10,15,24H,11-14,16H2,(H,30,35)(H,31,32)(H,33,36)/t24-/m1/s1
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n/an/a 0.260n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rabbit bradykinin B1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50355062
PNG
(CHEMBL1834752)
Show SMILES Cc1nn(-c2ccc(cn2)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc23)c(=O)c2c(F)cccc12
Show InChI InChI=1S/C31H32FN5O2/c1-20-24-8-6-9-26(32)29(24)31(39)37(35-20)28-14-12-23(18-33-28)30(38)34-27-10-5-7-22-17-21(11-13-25(22)27)19-36-15-3-2-4-16-36/h6,8-9,11-14,17-18,27H,2-5,7,10,15-16,19H2,1H3,(H,34,38)/t27-/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rabbit B1 receptor by cellular calcium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50355063
PNG
(CHEMBL1834619)
Show SMILES Cc1nn(-c2ccc(cn2)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc23)c(=O)c2c(Cl)cccc12
Show InChI InChI=1S/C31H32ClN5O2/c1-20-24-8-6-9-26(32)29(24)31(39)37(35-20)28-14-12-23(18-33-28)30(38)34-27-10-5-7-22-17-21(11-13-25(22)27)19-36-15-3-2-4-16-36/h6,8-9,11-14,17-18,27H,2-5,7,10,15-16,19H2,1H3,(H,34,38)/t27-/m1/s1
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n/an/a 1.10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rabbit B1 receptor by cellular calcium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50355057
PNG
(CHEMBL1834751)
Show SMILES Cc1nn(-c2ccc(cn2)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc23)c(=O)c2c(F)ccc(F)c12
Show InChI InChI=1S/C31H31F2N5O2/c1-19-28-24(32)11-12-25(33)29(28)31(40)38(36-19)27-13-9-22(17-34-27)30(39)35-26-7-5-6-21-16-20(8-10-23(21)26)18-37-14-3-2-4-15-37/h8-13,16-17,26H,2-7,14-15,18H2,1H3,(H,35,39)/t26-/m1/s1
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n/an/a 2.20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rabbit B1 receptor by cellular calcium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50157515
PNG
(4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamino)-pyridi...)
Show SMILES COC(=O)c1c(F)cccc1-c1ccc(cc1)[C@@H](C)Nc1nccc(Cl)c1NC(=O)CC#N
Show InChI InChI=1S/C24H20ClFN4O3/c1-14(29-23-22(18(25)11-13-28-23)30-20(31)10-12-27)15-6-8-16(9-7-15)17-4-3-5-19(26)21(17)24(32)33-2/h3-9,11,13-14H,10H2,1-2H3,(H,28,29)(H,30,31)/t14-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activity at rabbit bradykinin B1 receptor assessed by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50157511
PNG
(CHEMBL387638 | N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-...)
Show SMILES C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(cc1)-c1cccc(F)c1-c1nnn(C)n1
Show InChI InChI=1S/C24H20ClFN8O/c1-14(29-24-22(18(25)11-13-28-24)30-20(35)10-12-27)15-6-8-16(9-7-15)17-4-3-5-19(26)21(17)23-31-33-34(2)32-23/h3-9,11,13-14H,10H2,1-2H3,(H,28,29)(H,30,35)/t14-/m1/s1
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n/an/a 3.90n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activity at rabbit bradykinin B1 receptor assessed by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50344100
PNG
(2-((2R)-1-((4-methylphenyl)sulfonyl)-3-oxo-2-piper...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCNC(=O)[C@H]1CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12
Show InChI InChI=1S/C29H38N4O4S/c1-21-8-11-24(12-9-21)38(36,37)33-17-14-30-29(35)27(33)19-28(34)31-26-7-5-6-23-18-22(10-13-25(23)26)20-32-15-3-2-4-16-32/h8-13,18,26-27H,2-7,14-17,19-20H2,1H3,(H,30,35)(H,31,34)/t26-,27-/m1/s1
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n/an/a 4.10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rabbit B1 receptor by cellular calcium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50157513
PNG
(3-chloro-4'-{(R)-1-[4-chloro-3-(2-cyano-acetylamin...)
Show SMILES COC(=O)c1c(Cl)cccc1-c1ccc(cc1)[C@@H](C)Nc1nccc(Cl)c1NC(=O)CC#N
Show InChI InChI=1S/C24H20Cl2N4O3/c1-14(29-23-22(19(26)11-13-28-23)30-20(31)10-12-27)15-6-8-16(9-7-15)17-4-3-5-18(25)21(17)24(32)33-2/h3-9,11,13-14H,10H2,1-2H3,(H,28,29)(H,30,31)/t14-/m1/s1
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n/an/a 7.20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activity at rabbit bradykinin B1 receptor assessed by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50209744
PNG
((R)-3-(4-fluorophenyl)-N-((R)-7-(piperidin-1-ylmet...)
Show SMILES Fc1ccc(cc1)[C@@H](CC(=O)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc12)NS(=O)(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C31H33F4N3O4S/c32-24-10-8-22(9-11-24)28(37-43(40,41)25-6-4-5-23(18-25)31(33,34)35)19-30(39)36-27-13-16-42-29-17-21(7-12-26(27)29)20-38-14-2-1-3-15-38/h4-12,17-18,27-28,37H,1-3,13-16,19-20H2,(H,36,39)/t27-,28-/m1/s1
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n/an/a 10.4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit bradykinin B1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50244617
PNG
((2R,3S)-2,3-dihydroxy-N-((R)-6-(piperidin-1-ylmeth...)
Show SMILES O[C@H](CS(=O)(=O)c1cccc(c1)C(F)(F)F)[C@@H](O)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12
Show InChI InChI=1S/C27H33F3N2O5S/c28-27(29,30)20-7-5-8-21(15-20)38(36,37)17-24(33)25(34)26(35)31-23-9-4-6-19-14-18(10-11-22(19)23)16-32-12-2-1-3-13-32/h5,7-8,10-11,14-15,23-25,33-34H,1-4,6,9,12-13,16-17H2,(H,31,35)/t23-,24-,25-/m1/s1
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n/an/a 11.2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rabbit B1 receptor by cellular calcium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50244617
PNG
((2R,3S)-2,3-dihydroxy-N-((R)-6-(piperidin-1-ylmeth...)
Show SMILES O[C@H](CS(=O)(=O)c1cccc(c1)C(F)(F)F)[C@@H](O)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12
Show InChI InChI=1S/C27H33F3N2O5S/c28-27(29,30)20-7-5-8-21(15-20)38(36,37)17-24(33)25(34)26(35)31-23-9-4-6-19-14-18(10-11-22(19)23)16-32-12-2-1-3-13-32/h5,7-8,10-11,14-15,23-25,33-34H,1-4,6,9,12-13,16-17H2,(H,31,35)/t23-,24-,25-/m1/s1
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n/an/a 11.2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50157509
PNG
(CHEMBL222038 | N-(4-chloro-2-{(R)-1-[3'-fluoro-2'-...)
Show SMILES C[C@@H](Nc1nccc(Cl)c1NC(=O)CC#N)c1ccc(cc1)-c1cccc(F)c1-c1nc(C)no1
Show InChI InChI=1S/C25H20ClFN6O2/c1-14(30-24-23(19(26)11-13-29-24)32-21(34)10-12-28)16-6-8-17(9-7-16)18-4-3-5-20(27)22(18)25-31-15(2)33-35-25/h3-9,11,13-14H,10H2,1-2H3,(H,29,30)(H,32,34)/t14-/m1/s1
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n/an/a 12.3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activity at rabbit bradykinin B1 receptor assessed by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50203200
PNG
((R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-...)
Show SMILES O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCOc2cc(CN3CCCCC3)ccc12
Show InChI InChI=1S/C34H37N3O4S/c38-34(35-31-17-20-41-33-21-25(13-16-30(31)33)24-37-18-7-2-8-19-37)23-32(27-10-3-1-4-11-27)36-42(39,40)29-15-14-26-9-5-6-12-28(26)22-29/h1,3-6,9-16,21-22,31-32,36H,2,7-8,17-20,23-24H2,(H,35,38)/t31-,32-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity at rabbit bradykinin B1 receptor expressed in CHO-D cells assessed as effect on DAK-mediated calcium mobilization


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50355058
PNG
(CHEMBL1834750)
Show SMILES Cc1nn(-c2ccc(cc2)C(=O)N[C@@H]2CCOc3cc(CN4CCCCC4)ccc23)c(=O)c2c(Cl)cccc12
Show InChI InChI=1S/C31H31ClN4O3/c1-20-24-6-5-7-26(32)29(24)31(38)36(34-20)23-11-9-22(10-12-23)30(37)33-27-14-17-39-28-18-21(8-13-25(27)28)19-35-15-3-2-4-16-35/h5-13,18,27H,2-4,14-17,19H2,1H3,(H,33,37)/t27-/m1/s1
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n/an/a 17.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rabbit B1 receptor by cellular calcium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50244566
PNG
((2R,3S)-2,3-dihydroxy-4-(naphthalen-2-ylsulfonyl)-...)
Show SMILES O[C@H](CS(=O)(=O)c1ccc2ccccc2c1)[C@@H](O)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12
Show InChI InChI=1S/C30H36N2O5S/c33-28(20-38(36,37)25-13-12-22-7-2-3-8-23(22)18-25)29(34)30(35)31-27-10-6-9-24-17-21(11-14-26(24)27)19-32-15-4-1-5-16-32/h2-3,7-8,11-14,17-18,27-29,33-34H,1,4-6,9-10,15-16,19-20H2,(H,31,35)/t27-,28-,29-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50244438
PNG
((2R,3S)-4-(3,4-dichlorophenylsulfonyl)-2,3-dihydro...)
Show SMILES O[C@H](CS(=O)(=O)c1ccc(Cl)c(Cl)c1)[C@@H](O)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12
Show InChI InChI=1S/C26H32Cl2N2O5S/c27-21-10-8-19(14-22(21)28)36(34,35)16-24(31)25(32)26(33)29-23-6-4-5-18-13-17(7-9-20(18)23)15-30-11-2-1-3-12-30/h7-10,13-14,23-25,31-32H,1-6,11-12,15-16H2,(H,29,33)/t23-,24-,25-/m1/s1
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n/an/a 20.3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50355064
PNG
(CHEMBL1834616)
Show SMILES Cc1nn(-c2ccc(cc2)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc23)c(=O)c2c(Cl)cccc12
Show InChI InChI=1S/C32H33ClN4O2/c1-21-26-8-6-9-28(33)30(26)32(39)37(35-21)25-14-12-23(13-15-25)31(38)34-29-10-5-7-24-19-22(11-16-27(24)29)20-36-17-3-2-4-18-36/h6,8-9,11-16,19,29H,2-5,7,10,17-18,20H2,1H3,(H,34,38)/t29-/m1/s1
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n/an/a 21.4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rabbit B1 receptor by cellular calcium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360418
PNG
(CHEMBL1934264)
Show SMILES Fc1cccc2occ(-c3ccc(cc3)C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc34)c(=O)c12
Show InChI InChI=1S/C32H31FN2O3/c33-27-7-5-9-29-30(27)31(36)26(20-38-29)22-11-13-23(14-12-22)32(37)34-28-8-4-6-24-18-21(10-15-25(24)28)19-35-16-2-1-3-17-35/h5,7,9-15,18,20,28H,1-4,6,8,16-17,19H2,(H,34,37)/t28-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50244437
PNG
((2R,3S)-4-(4-tert-butylphenylsulfonyl)-2,3-dihydro...)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)C[C@@H](O)[C@@H](O)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12
Show InChI InChI=1S/C30H42N2O5S/c1-30(2,3)23-11-13-24(14-12-23)38(36,37)20-27(33)28(34)29(35)31-26-9-7-8-22-18-21(10-15-25(22)26)19-32-16-5-4-6-17-32/h10-15,18,26-28,33-34H,4-9,16-17,19-20H2,1-3H3,(H,31,35)/t26-,27-,28-/m1/s1
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n/an/a 25.3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360416
PNG
(CHEMBL1934260)
Show SMILES Clc1cccc2occ(-c3ccc(cc3)C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc34)c(=O)c12
Show InChI InChI=1S/C32H31ClN2O3/c33-27-7-5-9-29-30(27)31(36)26(20-38-29)22-11-13-23(14-12-22)32(37)34-28-8-4-6-24-18-21(10-15-25(24)28)19-35-16-2-1-3-17-35/h5,7,9-15,18,20,28H,1-4,6,8,16-17,19H2,(H,34,37)/t28-/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50355059
PNG
(CHEMBL1834620)
Show SMILES Cc1nn(-c2ccc(nc2)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc23)c(=O)c2c(Cl)cccc12
Show InChI InChI=1S/C31H32ClN5O2/c1-20-24-8-6-9-26(32)29(24)31(39)37(35-20)23-12-14-28(33-18-23)30(38)34-27-10-5-7-22-17-21(11-13-25(22)27)19-36-15-3-2-4-16-36/h6,8-9,11-14,17-18,27H,2-5,7,10,15-16,19H2,1H3,(H,34,38)/t27-/m1/s1
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n/an/a 31.1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rabbit B1 receptor by cellular calcium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50244619
PNG
((2R,3S)-4-(3-chlorophenylsulfonyl)-2,3-dihydroxy-N...)
Show SMILES O[C@H](CS(=O)(=O)c1cccc(Cl)c1)[C@@H](O)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12
Show InChI InChI=1S/C26H33ClN2O5S/c27-20-7-5-8-21(15-20)35(33,34)17-24(30)25(31)26(32)28-23-9-4-6-19-14-18(10-11-22(19)23)16-29-12-2-1-3-13-29/h5,7-8,10-11,14-15,23-25,30-31H,1-4,6,9,12-13,16-17H2,(H,28,32)/t23-,24-,25-/m1/s1
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n/an/a 85.9n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360419
PNG
(CHEMBL1934253)
Show SMILES Cc1nn(-c2ccc(cc2)C(=O)N[C@H]2CCCc3cc(CN4CCCCC4)ccc23)c(=O)c2ccccc12
Show InChI InChI=1S/C32H34N4O2/c1-22-27-9-3-4-10-29(27)32(38)36(34-22)26-15-13-24(14-16-26)31(37)33-30-11-7-8-25-20-23(12-17-28(25)30)21-35-18-5-2-6-19-35/h3-4,9-10,12-17,20,30H,2,5-8,11,18-19,21H2,1H3,(H,33,37)/t30-/m0/s1
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n/an/a 98n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360421
PNG
(CHEMBL1934259)
Show SMILES O=C(N[C@H]1CCCc2cc(CN3CCCCC3)ccc12)c1ccc(cc1)-c1coc2ccccc2c1=O
Show InChI InChI=1S/C32H32N2O3/c35-31-27-8-2-3-10-30(27)37-21-28(31)23-12-14-24(15-13-23)32(36)33-29-9-6-7-25-19-22(11-16-26(25)29)20-34-17-4-1-5-18-34/h2-3,8,10-16,19,21,29H,1,4-7,9,17-18,20H2,(H,33,36)/t29-/m0/s1
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n/an/a 122n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360417
PNG
(CHEMBL1934265)
Show SMILES Cc1cccc2occ(-c3ccc(cc3)C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc34)c(=O)c12
Show InChI InChI=1S/C33H34N2O3/c1-22-7-5-10-30-31(22)32(36)28(21-38-30)24-12-14-25(15-13-24)33(37)34-29-9-6-8-26-19-23(11-16-27(26)29)20-35-17-3-2-4-18-35/h5,7,10-16,19,21,29H,2-4,6,8-9,17-18,20H2,1H3,(H,34,37)/t29-/m0/s1
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n/an/a 139n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50244439
PNG
((2R,3S)-4-(2,3-dichlorophenylsulfonyl)-2,3-dihydro...)
Show SMILES O[C@H](CS(=O)(=O)c1cccc(Cl)c1Cl)[C@@H](O)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12
Show InChI InChI=1S/C26H32Cl2N2O5S/c27-20-7-5-9-23(24(20)28)36(34,35)16-22(31)25(32)26(33)29-21-8-4-6-18-14-17(10-11-19(18)21)15-30-12-2-1-3-13-30/h5,7,9-11,14,21-22,25,31-32H,1-4,6,8,12-13,15-16H2,(H,29,33)/t21-,22-,25-/m1/s1
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n/an/a 141n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360424
PNG
(CHEMBL1934255)
Show SMILES Clc1ccc2occ(-c3cccc(c3)C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc34)c(=O)c2c1
Show InChI InChI=1S/C32H31ClN2O3/c33-25-11-13-30-27(18-25)31(36)28(20-38-30)23-6-4-8-24(17-23)32(37)34-29-9-5-7-22-16-21(10-12-26(22)29)19-35-14-2-1-3-15-35/h4,6,8,10-13,16-18,20,29H,1-3,5,7,9,14-15,19H2,(H,34,37)/t29-/m1/s1
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n/an/a>160n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50244618
PNG
((2R,3S)-2,3-dihydroxy-N-((R)-6-(piperidin-1-ylmeth...)
Show SMILES O[C@H](CS(=O)(=O)c1ccc(cc1)C(F)(F)F)[C@@H](O)C(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12
Show InChI InChI=1S/C27H33F3N2O5S/c28-27(29,30)20-8-10-21(11-9-20)38(36,37)17-24(33)25(34)26(35)31-23-6-4-5-19-15-18(7-12-22(19)23)16-32-13-2-1-3-14-32/h7-12,15,23-25,33-34H,1-6,13-14,16-17H2,(H,31,35)/t23-,24-,25-/m1/s1
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n/an/a 210n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit bradykinin B1 receptor expressed in clone CHO-D-/aequorin cells by aquerin based assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360420
PNG
(CHEMBL1934254)
Show SMILES Clc1cccc2occ(-c3cccc(c3)C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc34)c(=O)c12
Show InChI InChI=1S/C32H31ClN2O3/c33-27-10-6-12-29-30(27)31(36)26(20-38-29)23-7-4-9-24(18-23)32(37)34-28-11-5-8-22-17-21(13-14-25(22)28)19-35-15-2-1-3-16-35/h4,6-7,9-10,12-14,17-18,20,28H,1-3,5,8,11,15-16,19H2,(H,34,37)/t28-/m1/s1
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n/an/a 248n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50355070
PNG
(CHEMBL1834749)
Show SMILES Cc1nn(-c2ccc(cc2)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc23)c(=O)c2cccnc12
Show InChI InChI=1S/C31H33N5O2/c1-21-29-27(8-6-16-32-29)31(38)36(34-21)25-13-11-23(12-14-25)30(37)33-28-9-5-7-24-19-22(10-15-26(24)28)20-35-17-3-2-4-18-35/h6,8,10-16,19,28H,2-5,7,9,17-18,20H2,1H3,(H,33,37)/t28-/m1/s1
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n/an/a 342n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of rabbit B1 receptor by cellular calcium flux assay


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360422
PNG
(CHEMBL1934256)
Show SMILES Fc1ccc2occ(-c3cccc(c3)C(=O)N[C@@H]3CCCc4cc(CN5CCCCC5)ccc34)c(=O)c2c1
Show InChI InChI=1S/C32H31FN2O3/c33-25-11-13-30-27(18-25)31(36)28(20-38-30)23-6-4-8-24(17-23)32(37)34-29-9-5-7-22-16-21(10-12-26(22)29)19-35-14-2-1-3-15-35/h4,6,8,10-13,16-18,20,29H,1-3,5,7,9,14-15,19H2,(H,34,37)/t29-/m1/s1
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n/an/a 393n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50209720
PNG
((R)-3-(4-fluorophenyl)-N-((R)-7-(pyrrolidin-1-ylme...)
Show SMILES Fc1ccc(cc1)[C@@H](CC(=O)N[C@@H]1CCOc2cc(CN3CCCC3)ccc12)NS(=O)(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H31F4N3O4S/c31-23-9-7-21(8-10-23)27(36-42(39,40)24-5-3-4-22(17-24)30(32,33)34)18-29(38)35-26-12-15-41-28-16-20(6-11-25(26)28)19-37-13-1-2-14-37/h3-11,16-17,26-27,36H,1-2,12-15,18-19H2,(H,35,38)/t26-,27-/m1/s1
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n/an/a 451n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit bradykinin B1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50355069
PNG
(CHEMBL1835756)
Show SMILES O=C(N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12)c1cccc(c1)-c1coc2ccccc2c1=O
Show InChI InChI=1S/C32H32N2O3/c35-31-27-11-2-3-13-30(27)37-21-28(31)24-8-6-10-25(19-24)32(36)33-29-12-7-9-23-18-22(14-15-26(23)29)20-34-16-4-1-5-17-34/h2-3,6,8,10-11,13-15,18-19,21,29H,1,4-5,7,9,12,16-17,20H2,(H,33,36)/t29-/m1/s1
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n/an/a 476n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360414
PNG
(CHEMBL1934262)
Show SMILES Clc1ccc2c(c1)occ(-c1ccc(cc1)C(=O)N[C@H]1CCCc3cc(CN4CCCCC4)ccc13)c2=O
Show InChI InChI=1S/C32H31ClN2O3/c33-25-12-14-27-30(18-25)38-20-28(31(27)36)22-8-10-23(11-9-22)32(37)34-29-6-4-5-24-17-21(7-13-26(24)29)19-35-15-2-1-3-16-35/h7-14,17-18,20,29H,1-6,15-16,19H2,(H,34,37)/t29-/m0/s1
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n/an/a>800n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360423
PNG
(CHEMBL1934258)
Show SMILES Clc1cccc2c1occ(-c1cccc(c1)C(=O)N[C@@H]1CCCc3cc(CN4CCCCC4)ccc13)c2=O
Show InChI InChI=1S/C32H31ClN2O3/c33-28-11-6-10-26-30(36)27(20-38-31(26)28)23-7-4-9-24(18-23)32(37)34-29-12-5-8-22-17-21(13-14-25(22)29)19-35-15-2-1-3-16-35/h4,6-7,9-11,13-14,17-18,20,29H,1-3,5,8,12,15-16,19H2,(H,34,37)/t29-/m1/s1
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n/an/a>800n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360425
PNG
(CHEMBL1934257)
Show SMILES Clc1ccc2c(c1)occ(-c1cccc(c1)C(=O)N[C@@H]1CCCc3cc(CN4CCCCC4)ccc13)c2=O
Show InChI InChI=1S/C32H31ClN2O3/c33-25-11-13-27-30(18-25)38-20-28(31(27)36)23-6-4-8-24(17-23)32(37)34-29-9-5-7-22-16-21(10-12-26(22)29)19-35-14-2-1-3-15-35/h4,6,8,10-13,16-18,20,29H,1-3,5,7,9,14-15,19H2,(H,34,37)/t29-/m1/s1
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n/an/a>800n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50209726
PNG
((R)-3-(4-fluorophenyl)-N-((R)-7-((2-methoxyethylam...)
Show SMILES COCCNCc1ccc2[C@@H](CCOc2c1)NC(=O)C[C@@H](NS(=O)(=O)c1cccc(c1)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C29H31F4N3O5S/c1-40-14-12-34-18-19-5-10-24-25(11-13-41-27(24)15-19)35-28(37)17-26(20-6-8-22(30)9-7-20)36-42(38,39)23-4-2-3-21(16-23)29(31,32)33/h2-10,15-16,25-26,34,36H,11-14,17-18H2,1H3,(H,35,37)/t25-,26-/m1/s1
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n/an/a 1.69E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit bradykinin B1 receptor


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360413
PNG
(CHEMBL1934261)
Show SMILES Clc1ccc2occ(-c3ccc(cc3)C(=O)N[C@H]3CCCc4cc(CN5CCCCC5)ccc34)c(=O)c2c1
Show InChI InChI=1S/C32H31ClN2O3/c33-25-12-14-30-27(18-25)31(36)28(20-38-30)22-8-10-23(11-9-22)32(37)34-29-6-4-5-24-17-21(7-13-26(24)29)19-35-15-2-1-3-16-35/h7-14,17-18,20,29H,1-6,15-16,19H2,(H,34,37)/t29-/m0/s1
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n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50360415
PNG
(CHEMBL1934263)
Show SMILES Clc1cccc2c1occ(-c1ccc(cc1)C(=O)N[C@H]1CCCc3cc(CN4CCCCC4)ccc13)c2=O
Show InChI InChI=1S/C32H31ClN2O3/c33-28-8-5-7-26-30(36)27(20-38-31(26)28)22-11-13-23(14-12-22)32(37)34-29-9-4-6-24-18-21(10-15-25(24)29)19-35-16-2-1-3-17-35/h5,7-8,10-15,18,20,29H,1-4,6,9,16-17,19H2,(H,34,37)/t29-/m0/s1
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n/an/a>4.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Oryctolagus cuniculus)
BDBM50355083
PNG
(CHEMBL1835762)
Show SMILES Cc1nn(-c2cccc(c2)C(=O)N[C@@H]2CCCc3cc(CN4CCCCC4)ccc23)c(=O)c2ccccc12
Show InChI InChI=1S/C32H34N4O2/c1-22-27-12-3-4-13-29(27)32(38)36(34-22)26-11-7-10-25(20-26)31(37)33-30-14-8-9-24-19-23(15-16-28(24)30)21-35-17-5-2-6-18-35/h3-4,7,10-13,15-16,19-20,30H,2,5-6,8-9,14,17-18,21H2,1H3,(H,33,37)/t30-/m1/s1
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n/an/a>6.47E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rabbit B1 bradykinin receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair