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Found 23 hits Enz. Inhib. hit(s) with Target = 'Bradykinin B2 receptor' AND taxid = 9986   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407803
PNG
(CHEMBL2372276 | NPC-567)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)[C@@H]1CCCN1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C65H94N20O13/c66-42(22-10-28-73-62(67)68)54(89)80-46(35-40-18-6-2-7-19-40)56(91)78-43(23-11-29-74-63(69)70)59(94)84-32-15-27-51(84)60(95)83-31-14-26-50(83)58(93)76-37-52(87)77-45(34-39-16-4-1-5-17-39)55(90)81-48(38-86)53(88)49-25-13-33-85(49)65(98)82-47(36-41-20-8-3-9-21-41)57(92)79-44(61(96)97)24-12-30-75-64(71)72/h1-9,16-21,42-51,86H,10-15,22-38,66H2,(H,76,93)(H,77,87)(H,78,91)(H,79,92)(H,80,89)(H,81,90)(H,82,98)(H,96,97)(H4,67,68,73)(H4,69,70,74)(H4,71,72,75)/t42-,43-,44+,45-,46+,47-,48-,49-,50-,51-/m0/s1
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n/an/an/a 7.41E+3n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407817
PNG
(CHEMBL294278)
Show SMILES NCCCC(=O)NC(Cc1cccs1)C(=O)N1Cc2ccccc2CC1C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C36H50N8O6S/c37-15-5-14-31(45)41-27(20-25-11-7-17-51-25)33(47)43-21-24-10-2-1-8-22(24)18-30(43)34(48)44-28-13-4-3-9-23(28)19-29(44)32(46)42-26(35(49)50)12-6-16-40-36(38)39/h1-2,7-8,10-11,17,23,26-30H,3-6,9,12-16,18-21,37H2,(H,41,45)(H,42,46)(H,49,50)(H4,38,39,40)
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n/an/an/a 251n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407796
PNG
(CHEMBL2369400)
Show SMILES NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C36H48N8O6/c37-20-31(45)41-27(17-22-9-2-1-3-10-22)33(47)43-21-25-13-5-4-11-23(25)18-30(43)34(48)44-28-15-7-6-12-24(28)19-29(44)32(46)42-26(35(49)50)14-8-16-40-36(38)39/h1-5,9-11,13,24,26-30H,6-8,12,14-21,37H2,(H,41,45)(H,42,46)(H,49,50)(H4,38,39,40)/t24?,26-,27-,28?,29-,30-/m0/s1
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n/an/an/a 851n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407797
PNG
(CHEMBL2028840)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](Cc2ccccc2)NC(=O)CNC1=O
Show InChI InChI=1S/C36H46N8O5/c37-36(38)39-16-8-14-26-32(46)40-20-31(45)41-27(17-22-9-2-1-3-10-22)34(48)43-21-25-13-5-4-11-23(25)18-30(43)35(49)44-28-15-7-6-12-24(28)19-29(44)33(47)42-26/h1-5,9-11,13,24,26-30H,6-8,12,14-21H2,(H,40,46)(H,41,45)(H,42,47)(H4,37,38,39)/t24?,26-,27-,28?,29-,30+/m0/s1
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n/an/an/a 117n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407798
PNG
(CHEMBL2028838)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](Cc2cccs2)NC(=O)CNC1=O
Show InChI InChI=1S/C34H44N8O5S/c35-34(36)37-13-5-11-24-30(44)38-18-29(43)39-25(17-23-10-6-14-48-23)32(46)41-19-22-9-2-1-7-20(22)15-28(41)33(47)42-26-12-4-3-8-21(26)16-27(42)31(45)40-24/h1-2,6-7,9-10,14,21,24-28H,3-5,8,11-13,15-19H2,(H,38,44)(H,39,43)(H,40,45)(H4,35,36,37)/t21?,24-,25-,26?,27-,28+/m0/s1
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n/an/an/a 40.7n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407799
PNG
(CHEMBL2028844)
Show SMILES C[C@@H]1NC(=O)CCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC1=O
Show InChI InChI=1S/C35H51N9O7/c1-20-30(47)42-25(19-45)33(50)43-18-23-10-3-2-8-21(23)16-28(43)34(51)44-26-12-5-4-9-22(26)17-27(44)32(49)41-24(11-6-15-39-35(36)37)31(48)38-14-7-13-29(46)40-20/h2-3,8,10,20,22,24-28,45H,4-7,9,11-19H2,1H3,(H,38,48)(H,40,46)(H,41,49)(H,42,47)(H4,36,37,39)/t20-,22?,24-,25-,26?,27-,28+/m0/s1
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n/an/an/a 309n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407800
PNG
(CHEMBL2028837)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](Cc2cccs2)NC(=O)[C@H](CCCNC(N)=N)NC1=O
Show InChI InChI=1S/C38H53N11O5S/c39-37(40)43-15-5-12-26-33(51)47-28(20-25-11-7-17-55-25)35(53)48-21-24-10-2-1-8-22(24)18-31(48)36(54)49-29-14-4-3-9-23(29)19-30(49)34(52)46-27(32(50)45-26)13-6-16-44-38(41)42/h1-2,7-8,10-11,17,23,26-31H,3-6,9,12-16,18-21H2,(H,45,50)(H,46,52)(H,47,51)(H4,39,40,43)(H4,41,42,44)/t23?,26-,27-,28-,29?,30-,31+/m0/s1
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n/an/an/a 75.9n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407801
PNG
(CHEMBL2028843)
Show SMILES C[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C1=O
Show InChI InChI=1S/C43H56N10O6/c1-25-41(58)52-24-29-13-3-2-10-26(29)21-36(52)42(59)53-34-16-7-5-12-28(34)22-35(53)40(57)51-32(15-8-19-47-43(44)45)38(55)46-18-9-17-37(54)50-33(39(56)48-25)23-30-20-27-11-4-6-14-31(27)49-30/h2-4,6,10-11,13-14,20,25,28,32-36,49H,5,7-9,12,15-19,21-24H2,1H3,(H,46,55)(H,48,56)(H,50,54)(H,51,57)(H4,44,45,47)/t25-,28?,32-,33-,34?,35-,36+/m0/s1
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n/an/an/a 490n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407802
PNG
(CHEMBL2028835)
Show SMILES NCCCC[C@@H]1N[C@@H](Cc2cccs2)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2C3CCCCC3C[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1=O
Show InChI InChI=1S/C38H53N9O5S/c39-16-6-5-13-27-33(48)45-34(49)28(14-7-17-42-38(40)41)44-35(50)31-20-24-10-3-4-15-30(24)47(31)37(52)32-19-23-9-1-2-11-25(23)22-46(32)36(51)29(43-27)21-26-12-8-18-53-26/h1-2,8-9,11-12,18,24,27-32,43H,3-7,10,13-17,19-22,39H2,(H,44,50)(H4,40,41,42)(H,45,48,49)/t24?,27-,28-,29-,30?,31-,32+/m0/s1
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n/an/an/a 145n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407804
PNG
(CHEMBL406472)
Show SMILES NC(=N)NCCCCCC(=O)NC(Cc1cccs1)C(=O)N1Cc2ccccc2CC1C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C39H56N10O6S/c40-38(41)44-17-7-1-2-16-33(50)46-29(22-27-13-9-19-56-27)35(52)48-23-26-12-4-3-10-24(26)20-32(48)36(53)49-30-15-6-5-11-25(30)21-31(49)34(51)47-28(37(54)55)14-8-18-45-39(42)43/h3-4,9-10,12-13,19,25,28-32H,1-2,5-8,11,14-18,20-23H2,(H,46,50)(H,47,51)(H,54,55)(H4,40,41,44)(H4,42,43,45)
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n/an/an/a 3.39E+3n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407805
PNG
(CHEMBL2028839)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](Cc2cccs2)NC(=O)CCCNC1=O
Show InChI InChI=1S/C36H48N8O5S/c37-36(38)40-16-5-12-26-32(46)39-15-6-14-31(45)41-27(20-25-11-7-17-50-25)34(48)43-21-24-10-2-1-8-22(24)18-30(43)35(49)44-28-13-4-3-9-23(28)19-29(44)33(47)42-26/h1-2,7-8,10-11,17,23,26-30H,3-6,9,12-16,18-21H2,(H,39,46)(H,41,45)(H,42,47)(H4,37,38,40)/t23?,26-,27-,28?,29-,30+/m0/s1
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n/an/an/a 324n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407806
PNG
(CHEMBL304374)
Show SMILES NCCCCCCCCCC(=O)NC(Cc1cccs1)C(=O)N1Cc2ccccc2CC1C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C42H62N8O6S/c43-21-11-5-3-1-2-4-6-20-37(51)47-33(26-31-17-13-23-57-31)39(53)49-27-30-16-8-7-14-28(30)24-36(49)40(54)50-34-19-10-9-15-29(34)25-35(50)38(52)48-32(41(55)56)18-12-22-46-42(44)45/h7-8,13-14,16-17,23,29,32-36H,1-6,9-12,15,18-22,24-27,43H2,(H,47,51)(H,48,52)(H,55,56)(H4,44,45,46)
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n/an/an/a 468n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407807
PNG
(CHEMBL2028841)
Show SMILES C[C@@H]1NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C1=O
Show InChI InChI=1S/C30H42N8O5/c1-17-28(42)37-16-20-9-3-2-7-18(20)13-24(37)29(43)38-22-11-5-4-8-19(22)14-23(38)27(41)36-21(10-6-12-33-30(31)32)26(40)34-15-25(39)35-17/h2-3,7,9,17,19,21-24H,4-6,8,10-16H2,1H3,(H,34,40)(H,35,39)(H,36,41)(H4,31,32,33)/t17-,19?,21-,22?,23-,24+/m0/s1
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n/an/an/a 240n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407808
PNG
(CHEMBL2028847)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)CCCNC1=O
Show InChI InChI=1S/C42H55N9O7/c43-42(44)46-18-7-14-30-37(54)45-17-8-16-36(53)49-22-28-12-3-1-9-25(28)19-33(49)38(55)48-31(24-52)40(57)50-23-29-13-4-2-10-26(29)20-35(50)41(58)51-32-15-6-5-11-27(32)21-34(51)39(56)47-30/h1-4,9-10,12-13,27,30-35,52H,5-8,11,14-24H2,(H,45,54)(H,47,56)(H,48,55)(H4,43,44,46)/t27?,30-,31-,32?,33-,34-,35+/m0/s1
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n/an/an/a 437n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407809
PNG
(CHEMBL2028846)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CCCNC1=O)c1ccccc1
Show InChI InChI=1S/C40H53N9O7/c41-40(42)44-19-8-15-28-35(52)43-18-9-17-33(51)47-34(24-10-2-1-3-11-24)37(54)46-29(23-50)38(55)48-22-27-14-5-4-12-25(27)20-32(48)39(56)49-30-16-7-6-13-26(30)21-31(49)36(53)45-28/h1-5,10-12,14,26,28-32,34,50H,6-9,13,15-23H2,(H,43,52)(H,45,53)(H,46,54)(H,47,51)(H4,41,42,44)/t26?,28-,29-,30?,31-,32+,34-/m0/s1
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n/an/an/a 537n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407810
PNG
(CHEMBL2028848)
Show SMILES C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC1=O
Show InChI InChI=1S/C38H51N9O7S/c1-21-32(49)44-27(18-25-11-7-15-55-25)34(51)45-28(20-48)36(53)46-19-24-10-3-2-8-22(24)16-31(46)37(54)47-29-13-5-4-9-23(29)17-30(47)35(52)43-26(33(50)42-21)12-6-14-41-38(39)40/h2-3,7-8,10-11,15,21,23,26-31,48H,4-6,9,12-14,16-20H2,1H3,(H,42,50)(H,43,52)(H,44,49)(H,45,51)(H4,39,40,41)/t21-,23?,26-,27-,28-,29?,30-,31+/m0/s1
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n/an/an/a 75.9n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407811
PNG
(CHEMBL2369364)
Show SMILES N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1cccs1)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C38H55N11O6S/c39-26(12-5-15-44-37(40)41)32(50)47-28(20-25-11-7-17-56-25)34(52)48-21-24-10-2-1-8-22(24)18-31(48)35(53)49-29-14-4-3-9-23(29)19-30(49)33(51)46-27(36(54)55)13-6-16-45-38(42)43/h1-2,7-8,10-11,17,23,26-31H,3-6,9,12-16,18-21,39H2,(H,46,51)(H,47,50)(H,54,55)(H4,40,41,44)(H4,42,43,45)/t23?,26-,27-,28-,29?,30-,31-/m0/s1
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n/an/an/a 794n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407812
PNG
(CHEMBL2028849)
Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C(=O)[C@H](CO)NC(=O)[C@H](Cc2cccs2)NC(=O)CCCNC1=O
Show InChI InChI=1S/C39H53N9O7S/c40-39(41)43-16-5-12-27-34(51)42-15-6-14-33(50)44-28(20-26-11-7-17-56-26)35(52)46-29(22-49)37(54)47-21-25-10-2-1-8-23(25)18-32(47)38(55)48-30-13-4-3-9-24(30)19-31(48)36(53)45-27/h1-2,7-8,10-11,17,24,27-32,49H,3-6,9,12-16,18-22H2,(H,42,51)(H,44,50)(H,45,53)(H,46,52)(H4,40,41,43)/t24?,27-,28-,29-,30?,31-,32+/m0/s1
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n/an/an/a 45.7n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407813
PNG
(CHEMBL2369392)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N1C2CCCCC2C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C37H50N8O7/c38-26(17-22-9-2-1-3-10-22)32(47)43-28(21-46)34(49)44-20-25-13-5-4-11-23(25)18-31(44)35(50)45-29-15-7-6-12-24(29)19-30(45)33(48)42-27(36(51)52)14-8-16-41-37(39)40/h1-5,9-11,13,24,26-31,46H,6-8,12,14-21,38H2,(H,42,48)(H,43,47)(H,51,52)(H4,39,40,41)/t24?,26-,27-,28-,29?,30-,31-/m0/s1
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n/an/an/a 912n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407814
PNG
(CHEMBL2028836)
Show SMILES CN1CC(=O)N[C@@H](Cc2cccs2)C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N2C3CCCCC3C[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C1=O
Show InChI InChI=1S/C35H46N8O5S/c1-41-20-30(44)39-26(18-24-11-7-15-49-24)33(47)42-19-23-10-3-2-8-21(23)16-29(42)34(48)43-27-13-5-4-9-22(27)17-28(43)31(45)40-25(32(41)46)12-6-14-38-35(36)37/h2-3,7-8,10-11,15,22,25-29H,4-6,9,12-14,16-20H2,1H3,(H,39,44)(H,40,45)(H4,36,37,38)/t22?,25-,26-,27?,28-,29+/m0/s1
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n/an/an/a 219n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407815
PNG
(CHEMBL65100)
Show SMILES NCCCC(=O)NC(Cc1ccccc1)C(=O)N1Cc2ccccc2CC1C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C38H52N8O6/c39-18-8-17-33(47)43-29(20-24-10-2-1-3-11-24)35(49)45-23-27-14-5-4-12-25(27)21-32(45)36(50)46-30-16-7-6-13-26(30)22-31(46)34(48)44-28(37(51)52)15-9-19-42-38(40)41/h1-5,10-12,14,26,28-32H,6-9,13,15-23,39H2,(H,43,47)(H,44,48)(H,51,52)(H4,40,41,42)
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n/an/an/a 363n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407816
PNG
(CHEMBL63532)
Show SMILES NC(=N)NCCCCC(=O)NC(Cc1cccs1)C(=O)N1Cc2ccccc2CC1C(=O)N1C2CCCCC2CC1C(=O)NC(CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C38H54N10O6S/c39-37(40)43-16-6-5-15-32(49)45-28(21-26-12-8-18-55-26)34(51)47-22-25-11-2-1-9-23(25)19-31(47)35(52)48-29-14-4-3-10-24(29)20-30(48)33(50)46-27(36(53)54)13-7-17-44-38(41)42/h1-2,8-9,11-12,18,24,27-31H,3-7,10,13-17,19-22H2,(H,45,49)(H,46,50)(H,53,54)(H4,39,40,43)(H4,41,42,44)
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n/an/an/a 3.02E+3n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair
Bradykinin B2 receptor


(Oryctolagus cuniculus)
BDBM50407795
PNG
(CHEMBL2028845)
Show SMILES C[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)CCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CC3CCCCC3N2C(=O)[C@H]2Cc3ccccc3CN2C1=O
Show InChI InChI=1S/C39H53N9O6S/c1-23-37(53)47-22-26-11-3-2-9-24(26)19-32(47)38(54)48-30-14-5-4-10-25(30)20-31(48)36(52)46-28(13-6-17-43-39(40)41)34(50)42-16-7-15-33(49)45-29(35(51)44-23)21-27-12-8-18-55-27/h2-3,8-9,11-12,18,23,25,28-32H,4-7,10,13-17,19-22H2,1H3,(H,42,50)(H,44,51)(H,45,49)(H,46,52)(H4,40,41,43)/t23-,25?,28-,29-,30?,31-,32+/m0/s1
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n/an/an/a 63.1n/an/an/an/an/a



Institute de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.


Citation and Details
More data for this
Ligand-Target Pair