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Compile Data Set for Download or QSAR

Found 40 hits Enz. Inhib. hit(s) with Target = 'Bromodomain adjacent to zinc finger domain protein 2A' AND taxid = 9606   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078633
PNG
(CHEMBL3415187)
Show SMILES Cn1cc(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C19H17N7/c1-24-10-15(8-22-24)11-26-13-21-18(17-9-23-25(2)12-17)19(26)16-5-3-14(7-20)4-6-16/h3-6,8-10,12-13H,11H2,1-2H3
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n/an/a 130n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148289
PNG
(CHEMBL3770199)
Show SMILES CC(=O)c1cc(-c2ccccc2S(C)(=O)=O)c2cc(CNC(=O)OC(C)(C)C)ccn12
Show InChI InChI=1S/C23H26N2O5S/c1-15(26)19-13-18(17-8-6-7-9-21(17)31(5,28)29)20-12-16(10-11-25(19)20)14-24-22(27)30-23(2,3)4/h6-13H,14H2,1-5H3,(H,24,27)
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n/an/a 160n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148270
PNG
(CHEMBL3739699)
Show SMILES CCCOc1ccn2c(cc(-c3ccccc3S(C)(=O)=O)c2c1)C(C)=O
Show InChI InChI=1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3
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n/an/a 400n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078635
PNG
(CHEMBL3415185)
Show SMILES Cc1cn(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(C#N)c(F)c2)nn1
Show InChI InChI=1S/C18H15FN8/c1-12-8-27(24-23-12)11-26-10-21-17(15-7-22-25(2)9-15)18(26)13-3-4-14(6-20)16(19)5-13/h3-5,7-10H,11H2,1-2H3
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n/an/a 450n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148290
PNG
(CHEMBL3770277)
Show SMILES CC(=O)c1cc(-c2ccccc2S(C)(=O)=O)c2cc(Oc3ccccc3)ccn12
Show InChI InChI=1S/C23H19NO4S/c1-16(25)21-15-20(19-10-6-7-11-23(19)29(2,26)27)22-14-18(12-13-24(21)22)28-17-8-4-3-5-9-17/h3-15H,1-2H3
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n/an/a 550n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148334
PNG
(CHEMBL3770214)
Show SMILES COc1ccn2c(cc(-c3ccccc3S(C)(=O)=O)c2c1)C(C)=O
Show InChI InChI=1S/C18H17NO4S/c1-12(20)16-11-15(17-10-13(23-2)8-9-19(16)17)14-6-4-5-7-18(14)24(3,21)22/h4-11H,1-3H3
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n/an/a 580n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078638
PNG
(CHEMBL3415182)
Show SMILES Cc1cn(CCn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)nn1
Show InChI InChI=1S/C19H18N8/c1-14-11-27(24-23-14)8-7-26-13-21-18(17-10-22-25(2)12-17)19(26)16-5-3-15(9-20)4-6-16/h3-6,10-13H,7-8H2,1-2H3
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n/an/a 600n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148281
PNG
(CHEMBL3770847)
Show SMILES CC(=O)c1cc(-c2ccccc2S(C)(=O)=O)c2ccccn12
Show InChI InChI=1S/C17H15NO3S/c1-12(19)16-11-14(15-8-5-6-10-18(15)16)13-7-3-4-9-17(13)22(2,20)21/h3-11H,1-2H3
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n/an/a 720n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148371
PNG
(CHEMBL3770738)
Show SMILES CC(=O)c1cc(-c2ccccc2S(C)(=O)=O)c2cc(C)ccn12
Show InChI InChI=1S/C18H17NO3S/c1-12-8-9-19-16(13(2)20)11-15(17(19)10-12)14-6-4-5-7-18(14)23(3,21)22/h4-11H,1-3H3
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n/an/a 890n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148282
PNG
(CHEMBL3771216)
Show SMILES CC(=O)c1cc(-c2ccccc2CO)c2cc(C)ccn12
Show InChI InChI=1S/C18H17NO2/c1-12-7-8-19-17(13(2)21)10-16(18(19)9-12)15-6-4-3-5-14(15)11-20/h3-10,20H,11H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078636
PNG
(CHEMBL3415184)
Show SMILES Cc1cn(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2F)C#N)nn1
Show InChI InChI=1S/C18H15FN8/c1-12-8-27(24-23-12)11-26-10-21-17(14-7-22-25(2)9-14)18(26)15-4-3-13(6-20)5-16(15)19/h3-5,7-10H,11H2,1-2H3
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n/an/a 1.01E+3n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148280
PNG
(CHEMBL3771080)
Show SMILES CN(C)c1ccc(cc1)-c1cc(C(C)=O)n2ccccc12
Show InChI InChI=1S/C18H18N2O/c1-13(21)18-12-16(17-6-4-5-11-20(17)18)14-7-9-15(10-8-14)19(2)3/h4-12H,1-3H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148283
PNG
(CHEMBL3770155)
Show SMILES COc1ccn2c(cc(-c3ccccc3CO)c2c1)C(C)=O
Show InChI InChI=1S/C18H17NO3/c1-12(21)17-10-16(15-6-4-3-5-13(15)11-20)18-9-14(22-2)7-8-19(17)18/h3-10,20H,11H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148279
PNG
(CHEMBL3769753)
Show SMILES CC(=O)c1cc(-c2ccc(CO)cc2)c2ccccn12
Show InChI InChI=1S/C17H15NO2/c1-12(20)17-10-15(16-4-2-3-9-18(16)17)14-7-5-13(11-19)6-8-14/h2-10,19H,11H2,1H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078634
PNG
(CHEMBL3415186)
Show SMILES Cc1cn(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)[N+]([O-])=O)nn1
Show InChI InChI=1S/C17H16N8O2/c1-12-8-24(21-20-12)11-23-10-18-16(14-7-19-22(2)9-14)17(23)13-3-5-15(6-4-13)25(26)27/h3-10H,11H2,1-2H3
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n/an/a 1.38E+3n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148278
PNG
(CHEMBL3769588)
Show SMILES COc1ccc(-c2cc(C(C)=O)n3ccccc23)c(CO)c1
Show InChI InChI=1S/C18H17NO3/c1-12(21)18-10-16(17-5-3-4-8-19(17)18)15-7-6-14(22-2)9-13(15)11-20/h3-10,20H,11H2,1-2H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50364107
PNG
(CHEMBL1950956)
Show SMILES CC(=O)c1cc(-c2ccccn2)c2ccccn12
Show InChI InChI=1S/C15H12N2O/c1-11(18)15-10-12(13-6-2-4-8-16-13)14-7-3-5-9-17(14)15/h2-10H,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148284
PNG
(CHEMBL3770449)
Show SMILES CC(=O)c1cc(-c2ccccc2CO)c2cc(ccn12)N1CCOCC1
Show InChI InChI=1S/C21H22N2O3/c1-15(25)20-13-19(18-5-3-2-4-16(18)14-24)21-12-17(6-7-23(20)21)22-8-10-26-11-9-22/h2-7,12-13,24H,8-11,14H2,1H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148277
PNG
(CHEMBL3770410)
Show SMILES CC(=O)c1cc(-c2cccc(c2)C(N)=O)c2ccccn12
Show InChI InChI=1S/C17H14N2O2/c1-11(20)16-10-14(15-7-2-3-8-19(15)16)12-5-4-6-13(9-12)17(18)21/h2-10H,1H3,(H2,18,21)
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n/an/a 1.80E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148276
PNG
(CHEMBL3770112)
Show SMILES CC(=O)c1cc(-c2ccccc2CO)c2ccccn12
Show InChI InChI=1S/C17H15NO2/c1-12(20)17-10-15(16-8-4-5-9-18(16)17)14-7-3-2-6-13(14)11-19/h2-10,19H,11H2,1H3
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n/an/a 1.80E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148275
PNG
(CHEMBL3769769)
Show SMILES CC(=O)c1cc(-c2cccc(O)c2)c2ccccn12
Show InChI InChI=1S/C16H13NO2/c1-11(18)16-10-14(12-5-4-6-13(19)9-12)15-7-2-3-8-17(15)16/h2-10,19H,1H3
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n/an/a 3.30E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078631
PNG
(CHEMBL3415177)
Show SMILES Cc1cn(CCn2cnc(c2-c2ccc(cc2)C#N)-c2ccncc2)nn1
Show InChI InChI=1S/C20H17N7/c1-15-13-27(25-24-15)11-10-26-14-23-19(17-6-8-22-9-7-17)20(26)18-4-2-16(12-21)3-5-18/h2-9,13-14H,10-11H2,1H3
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148288
PNG
(CHEMBL3770493)
Show SMILES CC(=O)c1cc(-c2ccccc2CO)c2cc(Oc3ccccc3)ccn12
Show InChI InChI=1S/C23H19NO3/c1-16(26)22-14-21(20-10-6-5-7-17(20)15-25)23-13-19(11-12-24(22)23)27-18-8-3-2-4-9-18/h2-14,25H,15H2,1H3
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n/an/a 4.10E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148287
PNG
(CHEMBL3771370)
Show SMILES CC(=O)c1cc(-c2ccccc2CO)c2cc(ccn12)C(N)=O
Show InChI InChI=1S/C18H16N2O3/c1-11(22)16-9-15(14-5-3-2-4-13(14)10-21)17-8-12(18(19)23)6-7-20(16)17/h2-9,21H,10H2,1H3,(H2,19,23)
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148274
PNG
(CHEMBL3769490)
Show SMILES CC(=O)c1cc(-c2ccccc2O)c2ccccn12
Show InChI InChI=1S/C16H13NO2/c1-11(18)15-10-13(12-6-2-3-8-16(12)19)14-7-4-5-9-17(14)15/h2-10,19H,1H3
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n/an/a 7.20E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078641
PNG
(CHEMBL3415179)
Show SMILES Cc1cn(CCn2cnc(-c3cncs3)c2-c2ccc(cc2)C#N)nn1
Show InChI InChI=1S/C18H15N7S/c1-13-10-25(23-22-13)7-6-24-11-21-17(16-9-20-12-26-16)18(24)15-4-2-14(8-19)3-5-15/h2-5,9-12H,6-7H2,1H3
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n/an/a 7.80E+3n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148273
PNG
(CHEMBL3769417)
Show SMILES CC(=O)c1cc(-c2cccs2)c2ccccn12
Show InChI InChI=1S/C14H11NOS/c1-10(16)13-9-11(14-6-4-8-17-14)12-5-2-3-7-15(12)13/h2-9H,1H3
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n/an/a 8.60E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148272
PNG
(CHEMBL3770550)
Show SMILES COc1cccc(c1)-c1cc(C(C)=O)n2ccccc12
Show InChI InChI=1S/C17H15NO2/c1-12(19)17-11-15(16-8-3-4-9-18(16)17)13-6-5-7-14(10-13)20-2/h3-11H,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50028142
PNG
(CHEMBL2177300)
Show SMILES C[C@H]1C[C@@H](Nc2ccc(Cl)cc2)c2cc(ccc2N1C(C)=O)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H23ClN2O3/c1-15-13-23(27-21-10-8-20(26)9-11-21)22-14-19(7-12-24(22)28(15)16(2)29)17-3-5-18(6-4-17)25(30)31/h3-12,14-15,23,27H,13H2,1-2H3,(H,30,31)/t15-,23+/m0/s1
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of human BAZ2A by BROMOscan assay


J Med Chem 57: 8111-31 (2014)


Article DOI: 10.1021/jm5010539
BindingDB Entry DOI: 10.7270/Q23R0VGR
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078639
PNG
(CHEMBL3415181)
Show SMILES Cc1cn(CCn2cncc2-c2ccc(cc2)C#N)nn1
Show InChI InChI=1S/C15H14N6/c1-12-10-21(19-18-12)7-6-20-11-17-9-15(20)14-4-2-13(8-16)3-5-14/h2-5,9-11H,6-7H2,1H3
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078640
PNG
(CHEMBL3415180)
Show SMILES Cc1cn(CCn2cnc(-c3cc(C)no3)c2-c2ccc(cc2)C#N)nn1
Show InChI InChI=1S/C19H17N7O/c1-13-9-17(27-23-13)18-19(16-5-3-15(10-20)4-6-16)25(12-21-18)7-8-26-11-14(2)22-24-26/h3-6,9,11-12H,7-8H2,1-2H3
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078630
PNG
(CHEMBL3415178)
Show SMILES Cc1cn(CCn2cnc(c2-c2ccc(cc2)C#N)-c2cccnc2)nn1
Show InChI InChI=1S/C20H17N7/c1-15-13-27(25-24-15)10-9-26-14-23-19(18-3-2-8-22-12-18)20(26)17-6-4-16(11-21)5-7-17/h2-8,12-14H,9-10H2,1H3
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078637
PNG
(CHEMBL3415183)
Show SMILES Cn1cc(cn1)-c1ncn(C)c1-c1ccc(cc1)C#N
Show InChI InChI=1S/C15H13N5/c1-19-10-17-14(13-8-18-20(2)9-13)15(19)12-5-3-11(7-16)4-6-12/h3-6,8-10H,1-2H3
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078632
PNG
(CHEMBL3415176)
Show SMILES Cc1cn(CCn2cnc(c2-c2ccc(cc2)C#N)-c2ccccc2)nn1
Show InChI InChI=1S/C21H18N6/c1-16-14-27(25-24-16)12-11-26-15-23-20(18-5-3-2-4-6-18)21(26)19-9-7-17(13-22)8-10-19/h2-10,14-15H,11-12H2,1H3
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n/an/a 5.10E+4n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Inhibition of BAZ2A (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50098305
PNG
(CHEMBL3590405)
Show SMILES Cc1cncc(c1)-c1ccc(N[C@@H]2CCNC[C@H]2OCC2CCS(=O)(=O)CC2)c2[nH]c(=O)c(C)cc12
Show InChI InChI=1S/C27H34N4O4S/c1-17-11-20(14-29-13-17)21-3-4-24(26-22(21)12-18(2)27(32)31-26)30-23-5-8-28-15-25(23)35-16-19-6-9-36(33,34)10-7-19/h3-4,11-14,19,23,25,28,30H,5-10,15-16H2,1-2H3,(H,31,32)/t23-,25-/m1/s1
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n/an/an/a 3.98E+3n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to BAZ2A in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assay


J Med Chem 58: 6151-78 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00773
BindingDB Entry DOI: 10.7270/Q2FN17Z1
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148270
PNG
(CHEMBL3739699)
Show SMILES CCCOc1ccn2c(cc(-c3ccccc3S(C)(=O)=O)c2c1)C(C)=O
Show InChI InChI=1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli by isothermal titration calorimetric analysis


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50098250
PNG
(CHEMBL3590389)
Show SMILES Cc1cncc(c1)-c1cnc(N[C@@H]2CCNC[C@H]2OCC2CCCCC2)c2[nH]c(=O)c(C)cc12
Show InChI InChI=1S/C27H35N5O2/c1-17-10-20(13-29-12-17)22-14-30-26(25-21(22)11-18(2)27(33)32-25)31-23-8-9-28-15-24(23)34-16-19-6-4-3-5-7-19/h10-14,19,23-24,28H,3-9,15-16H2,1-2H3,(H,30,31)(H,32,33)/t23-,24-/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to BAZ2A in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assay


J Med Chem 58: 6151-78 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00773
BindingDB Entry DOI: 10.7270/Q2FN17Z1
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50078633
PNG
(CHEMBL3415187)
Show SMILES Cn1cc(Cn2cnc(-c3cnn(C)c3)c2-c2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C19H17N7/c1-24-10-15(8-22-24)11-26-13-21-18(17-9-23-25(2)12-17)19(26)16-5-3-14(7-20)4-6-16/h3-6,8-10,12-13H,11H2,1-2H3
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The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to BAZ2A (unknown origin) by isothermal titration calorimetric analysis


J Med Chem 58: 2553-9 (2015)


Article DOI: 10.1021/jm501963e
BindingDB Entry DOI: 10.7270/Q2V69M9B
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50098311
PNG
(CHEMBL3590408)
Show SMILES CN1CC[C@@H](Nc2ncc(-c3cncc(C)c3)c3cc(C)c(=O)[nH]c23)[C@@H](C1)OCC1CCS(=O)(=O)CC1
Show InChI InChI=1S/C27H35N5O4S/c1-17-10-20(13-28-12-17)22-14-29-26(25-21(22)11-18(2)27(33)31-25)30-23-4-7-32(3)15-24(23)36-16-19-5-8-37(34,35)9-6-19/h10-14,19,23-24H,4-9,15-16H2,1-3H3,(H,29,30)(H,31,33)/t23-,24-/m1/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to BAZ2A in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assay


J Med Chem 58: 6151-78 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00773
BindingDB Entry DOI: 10.7270/Q2FN17Z1
More data for this
Ligand-Target Pair
Bromodomain adjacent to zinc finger domain protein 2A


(Homo sapiens)
BDBM50148270
PNG
(CHEMBL3739699)
Show SMILES CCCOc1ccn2c(cc(-c3ccccc3S(C)(=O)=O)c2c1)C(C)=O
Show InChI InChI=1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3
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n/an/an/a 3.16E+3n/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Binding affinity to BAZ2A in human HUT78 cell extract by chemoproteomic competition binding assay


J Med Chem 59: 1410-24 (2016)


Article DOI: 10.1021/acs.jmedchem.5b00209
BindingDB Entry DOI: 10.7270/Q2PK0J09
More data for this
Ligand-Target Pair