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Compile Data Set for Download or QSAR

Found 31 hits Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 1' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50445006
PNG
(CHEMBL3099943)
Show SMILES O[C@H](COc1cc(O)c(Cl)cc1NC(=O)NC1CC1)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C25H29Cl2N3O5/c26-16-1-4-22-15(9-16)12-25(35-22)5-7-30(8-6-25)13-18(31)14-34-23-11-21(32)19(27)10-20(23)29-24(33)28-17-2-3-17/h1,4,9-11,17-18,31-32H,2-3,5-8,12-14H2,(H2,28,29,33)/t18-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50210979
PNG
((R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O
Show InChI InChI=1S/C26H29ClFN5O4/c1-16-13-32(14-17-2-5-19(28)6-3-17)10-11-33(16)22(34)15-37-21-7-4-18(27)12-20(21)31-24-23(30-9-8-29)25(35)26(24)36/h2-7,12,16,30-31H,8-11,13-15,29H2,1H3/t16-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Tanabe Research Laboratories, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50210977
PNG
((R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O
Show InChI InChI=1S/C24H24ClFN4O4/c1-14-11-29(12-15-2-5-17(26)6-3-15)8-9-30(14)20(31)13-34-19-7-4-16(25)10-18(19)28-22-21(27)23(32)24(22)33/h2-7,10,14,28H,8-9,11-13,27H2,1H3/t14-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Tanabe Research Laboratories, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50210982
PNG
((R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O
Show InChI InChI=1S/C26H28ClFN4O5/c1-16-13-31(14-17-2-5-19(28)6-3-17)9-10-32(16)22(34)15-37-21-7-4-18(27)12-20(21)30-24-23(29-8-11-33)25(35)26(24)36/h2-7,12,16,29-30,33H,8-11,13-15H2,1H3/t16-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Tanabe Research Laboratories, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50210971
PNG
((R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O
Show InChI InChI=1S/C30H36ClFN6O4/c1-20-17-37(18-21-2-5-23(32)6-3-21)14-15-38(20)26(39)19-42-25-7-4-22(31)16-24(25)35-28-27(29(40)30(28)41)34-10-13-36-11-8-33-9-12-36/h2-7,16,20,33-35H,8-15,17-19H2,1H3/t20-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Tanabe Research Laboratories, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50210970
PNG
((R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Show SMILES CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O
Show InChI InChI=1S/C25H26ClFN4O4/c1-15-12-30(13-16-3-6-18(27)7-4-16)9-10-31(15)21(32)14-35-20-8-5-17(26)11-19(20)29-23-22(28-2)24(33)25(23)34/h3-8,11,15,28-29H,9-10,12-14H2,1-2H3/t15-/m1/s1
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n/an/a 49n/an/an/an/an/an/a



Tanabe Research Laboratories, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50445004
PNG
(CHEMBL3099945)
Show SMILES O[C@H](COc1cc(O)ccc1NC(=O)NC1CC1)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C25H30ClN3O5/c26-17-1-6-22-16(11-17)13-25(34-22)7-9-29(10-8-25)14-20(31)15-33-23-12-19(30)4-5-21(23)28-24(32)27-18-2-3-18/h1,4-6,11-12,18,20,30-31H,2-3,7-10,13-15H2,(H2,27,28,32)/t20-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50445005
PNG
(CHEMBL3099944)
Show SMILES COc1ccc(NC(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(Cc4cc(Cl)ccc4O3)CC2)c1
Show InChI InChI=1S/C26H32ClN3O5/c1-33-21-5-6-22(29-25(32)28-19-3-4-19)24(13-21)34-16-20(31)15-30-10-8-26(9-11-30)14-17-12-18(27)2-7-23(17)35-26/h2,5-7,12-13,19-20,31H,3-4,8-11,14-16H2,1H3,(H2,28,29,32)/t20-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50208999
PNG
((R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1NC(N)=O
Show InChI InChI=1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
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n/an/a 59n/an/an/an/an/an/a



Tanabe Research Laboratories, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50435676
PNG
(CHEMBL2391938)
Show SMILES COc1ccc(C(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(Cc4cc(Cl)ccc4O3)CC2)c1
Show InChI InChI=1S/C26H31ClN2O5/c1-32-21-5-6-22(25(31)28-19-3-4-19)24(13-21)33-16-20(30)15-29-10-8-26(9-11-29)14-17-12-18(27)2-7-23(17)34-26/h2,5-7,12-13,19-20,30H,3-4,8-11,14-16H2,1H3,(H,28,31)/t20-/m0/s1
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n/an/a 79n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50210972
PNG
((R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O
Show InChI InChI=1S/C30H35ClFN5O5/c1-20-17-36(18-21-2-5-23(32)6-3-21)10-11-37(20)26(38)19-42-25-7-4-22(31)16-24(25)34-28-27(29(39)30(28)40)33-8-9-35-12-14-41-15-13-35/h2-7,16,20,33-34H,8-15,17-19H2,1H3/t20-/m1/s1
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n/an/a 87n/an/an/an/an/an/a



Tanabe Research Laboratories, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50445003
PNG
(CHEMBL3099946)
Show SMILES COc1ccc(NC(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(Cc4cc(F)ccc4O3)CC2)c1
Show InChI InChI=1S/C26H32FN3O5/c1-33-21-5-6-22(29-25(32)28-19-3-4-19)24(13-21)34-16-20(31)15-30-10-8-26(9-11-30)14-17-12-18(27)2-7-23(17)35-26/h2,5-7,12-13,19-20,31H,3-4,8-11,14-16H2,1H3,(H2,28,29,32)/t20-/m0/s1
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n/an/a 90n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50445002
PNG
(CHEMBL3099947)
Show SMILES O[C@H](COc1cc(O)ccc1NC(=O)NC1CC1)CN1CCC2(Cc3cc(F)ccc3O2)CC1
Show InChI InChI=1S/C25H30FN3O5/c26-17-1-6-22-16(11-17)13-25(34-22)7-9-29(10-8-25)14-20(31)15-33-23-12-19(30)4-5-21(23)28-24(32)27-18-2-3-18/h1,4-6,11-12,18,20,30-31H,2-3,7-10,13-15H2,(H2,27,28,32)/t20-/m0/s1
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n/an/a 101n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50435673
PNG
(CHEMBL2391795)
Show SMILES O[C@H](COc1cc(O)ccc1C(=O)NC1CC1)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C25H29ClN2O5/c26-17-1-6-22-16(11-17)13-25(33-22)7-9-28(10-8-25)14-20(30)15-32-23-12-19(29)4-5-21(23)24(31)27-18-2-3-18/h1,4-6,11-12,18,20,29-30H,2-3,7-10,13-15H2,(H,27,31)/t20-/m0/s1
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n/an/a 114n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50210976
PNG
((R)-3-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O
Show InChI InChI=1S/C30H29ClFN5O4/c1-19-16-36(17-20-4-7-23(32)8-5-20)11-12-37(19)26(38)18-41-25-9-6-22(31)13-24(25)35-28-27(29(39)30(28)40)34-15-21-3-2-10-33-14-21/h2-10,13-14,19,34-35H,11-12,15-18H2,1H3/t19-/m1/s1
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n/an/a 130n/an/an/an/an/an/a



Tanabe Research Laboratories, Inc.

Curated by ChEMBL


Assay Description
Binding affinity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50435671
PNG
(CHEMBL2391793)
Show SMILES CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C23H27ClN2O5/c1-25-22(29)19-4-3-17(27)11-21(19)30-14-18(28)13-26-8-6-23(7-9-26)12-15-10-16(24)2-5-20(15)31-23/h2-5,10-11,18,27-28H,6-9,12-14H2,1H3,(H,25,29)/t18-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50445008
PNG
(CHEMBL3099941)
Show SMILES CNC(=O)Nc1ccc(OC)cc1OC[C@@H](O)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C24H30ClN3O5/c1-26-23(30)27-20-5-4-19(31-2)12-22(20)32-15-18(29)14-28-9-7-24(8-10-28)13-16-11-17(25)3-6-21(16)33-24/h3-6,11-12,18,29H,7-10,13-15H2,1-2H3,(H2,26,27,30)/t18-/m0/s1
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n/an/a 447n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50435690
PNG
(CHEMBL2391803)
Show SMILES O[C@H](COc1cc(O)c(Cl)cc1C(=O)N1CC[C@H](O)C1)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C26H30Cl2N2O6/c27-17-1-2-23-16(9-17)12-26(36-23)4-7-29(8-5-26)13-19(32)15-35-24-11-22(33)21(28)10-20(24)25(34)30-6-3-18(31)14-30/h1-2,9-11,18-19,31-33H,3-8,12-15H2/t18-,19-/m0/s1
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n/an/a 880n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50435684
PNG
(CHEMBL2391794)
Show SMILES CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(Cc3cc(F)ccc3O2)CC1
Show InChI InChI=1S/C23H27FN2O5/c1-25-22(29)19-4-3-17(27)11-21(19)30-14-18(28)13-26-8-6-23(7-9-26)12-15-10-16(24)2-5-20(15)31-23/h2-5,10-11,18,27-28H,6-9,12-14H2,1H3,(H,25,29)/t18-/m0/s1
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n/an/a 890n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50435669
PNG
(CHEMBL2391809)
Show SMILES O[C@H](COc1cc(O)ccc1C(=O)N1CCCCC1)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C27H33ClN2O5/c28-20-4-7-24-19(14-20)16-27(35-24)8-12-29(13-9-27)17-22(32)18-34-25-15-21(31)5-6-23(25)26(33)30-10-2-1-3-11-30/h4-7,14-15,22,31-32H,1-3,8-13,16-18H2/t22-/m0/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50444998
PNG
(CHEMBL3099951)
Show SMILES O[C@H](COc1cccc2OCC(=O)Nc12)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C23H25ClN2O5/c24-16-4-5-18-15(10-16)11-23(31-18)6-8-26(9-7-23)12-17(27)13-29-19-2-1-3-20-22(19)25-21(28)14-30-20/h1-5,10,17,27H,6-9,11-14H2,(H,25,28)/t17-/m0/s1
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n/an/a 1.26E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50445001
PNG
(CHEMBL3099948)
Show SMILES NC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C22H26ClN3O5/c23-15-1-4-19-14(9-15)11-22(31-19)5-7-26(8-6-22)12-17(28)13-30-20-10-16(27)2-3-18(20)25-21(24)29/h1-4,9-10,17,27-28H,5-8,11-13H2,(H3,24,25,29)/t17-/m0/s1
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n/an/a 1.58E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50444999
PNG
(CHEMBL3099950)
Show SMILES NC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C22H25ClFN3O4/c23-15-1-4-19-14(9-15)11-22(31-19)5-7-27(8-6-22)12-17(28)13-30-20-10-16(24)2-3-18(20)26-21(25)29/h1-4,9-10,17,28H,5-8,11-13H2,(H3,25,26,29)/t17-/m0/s1
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n/an/a 1.62E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50445007
PNG
(CHEMBL3099942)
Show SMILES CNC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C23H28ClN3O5/c1-25-22(30)26-19-4-3-17(28)11-21(19)31-14-18(29)13-27-8-6-23(7-9-27)12-15-10-16(24)2-5-20(15)32-23/h2-5,10-11,18,28-29H,6-9,12-14H2,1H3,(H2,25,26,30)/t18-/m0/s1
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n/an/a 1.76E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50444989
PNG
(CHEMBL3099960)
Show SMILES CNC(=O)Nc1ccc(OC)cc1OC[C@@H](O)CN1CCC2(Cc3cc(F)ccc3O2)CC1
Show InChI InChI=1S/C24H30FN3O5/c1-26-23(30)27-20-5-4-19(31-2)12-22(20)32-15-18(29)14-28-9-7-24(8-10-28)13-16-11-17(25)3-6-21(16)33-24/h3-6,11-12,18,29H,7-10,13-15H2,1-2H3,(H2,26,27,30)/t18-/m0/s1
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n/an/a 1.78E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50445000
PNG
(CHEMBL3099949)
Show SMILES NC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C22H26ClN3O4/c23-16-5-6-19-15(11-16)12-22(30-19)7-9-26(10-8-22)13-17(27)14-29-20-4-2-1-3-18(20)25-21(24)28/h1-6,11,17,27H,7-10,12-14H2,(H3,24,25,28)/t17-/m0/s1
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n/an/a 2.11E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50435668
PNG
(CHEMBL2391800)
Show SMILES O[C@H](COc1cc(F)ccc1C(=O)N1CC[C@H](O)C1)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C26H30ClFN2O5/c27-18-1-4-23-17(11-18)13-26(35-23)6-9-29(10-7-26)14-21(32)16-34-24-12-19(28)2-3-22(24)25(33)30-8-5-20(31)15-30/h1-4,11-12,20-21,31-32H,5-10,13-16H2/t20-,21-/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50444995
PNG
(CHEMBL3099954)
Show SMILES O[C@H](COc1cccc2c1[nH]c(=O)[nH]c2=O)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C23H24ClN3O5/c24-15-4-5-18-14(10-15)11-23(32-18)6-8-27(9-7-23)12-16(28)13-31-19-3-1-2-17-20(19)25-22(30)26-21(17)29/h1-5,10,16,28H,6-9,11-13H2,(H2,25,26,29,30)/t16-/m0/s1
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n/an/a>6.00E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50435666
PNG
(CHEMBL2391804)
Show SMILES O[C@H](COc1cc(O)ccc1C(=O)N1CC[C@H](O)C1)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C26H31ClN2O6/c27-18-1-4-23-17(11-18)13-26(35-23)6-9-28(10-7-26)14-21(32)16-34-24-12-19(30)2-3-22(24)25(33)29-8-5-20(31)15-29/h1-4,11-12,20-21,30-32H,5-10,13-16H2/t20-,21-/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50435667
PNG
(CHEMBL2391796)
Show SMILES O[C@H](COc1cc(O)ccc1C(=O)N1CC[C@@H](O)C1)CN1CCC2(Cc3cc(Cl)ccc3O2)CC1
Show InChI InChI=1S/C26H31ClN2O6/c27-18-1-4-23-17(11-18)13-26(35-23)6-9-28(10-7-26)14-21(32)16-34-24-12-19(30)2-3-22(24)25(33)29-8-5-20(31)15-29/h1-4,11-12,20-21,30-32H,5-10,13-16H2/t20-,21+/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at rat CCR1


Citation and Details
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Rattus norvegicus)
BDBM50399208
PNG
(CHEMBL2180528)
Show SMILES CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H27ClN2O2/c1-16(2)21(25-22(27)19-6-4-3-5-7-19)23(28)26-14-12-18(13-15-26)17-8-10-20(24)11-9-17/h3-11,16,18,21H,12-15H2,1-2H3,(H,25,27)/t21-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from CCR1 in rat thioglycolate-elicited peritoneal cells incubated for 60 mins


Citation and Details
More data for this
Ligand-Target Pair