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Compile Data Set for Download or QSAR

Found 144 hits Enz. Inhib. hit(s) with Target = 'CDK8/Cyclin C'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-C


(Homo sapiens)
BDBM50265275
PNG
(4-(4-iodophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c...)
Show SMILES Ic1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C14H8IN5OS/c15-8-1-3-9(4-2-8)21-11-6-16-7-13-10(11)5-12(22-13)14-17-19-20-18-14/h1-7H,(H,17,18,19,20)
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n/an/a 0.700n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189434
PNG
(CHEMBL3828221)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)-c1nccn1C
Show InChI InChI=1S/C22H18N6/c1-27-10-9-24-22(27)20-8-7-17-11-23-13-19(21(17)26-20)16-5-3-15(4-6-16)18-12-25-28(2)14-18/h3-14H,1-2H3
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n/an/a 0.710n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189415
PNG
(CHEMBL3828637)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4N(C)S(=O)(=O)Cc4c3)c2n1
Show InChI InChI=1S/C18H16N4O3S/c1-19-18(23)15-5-3-12-8-20-9-14(17(12)21-15)11-4-6-16-13(7-11)10-26(24,25)22(16)2/h3-9H,10H2,1-2H3,(H,19,23)
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n/an/a 0.900n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-C


(Homo sapiens)
BDBM50169081
PNG
(CHEMBL3806220)
Show SMILES N#Cc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C15H8N6OS/c16-6-9-1-3-10(4-2-9)22-12-7-17-8-14-11(12)5-13(23-14)15-18-20-21-19-15/h1-5,7-8H,(H,18,19,20,21)
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n/an/a 1n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189428
PNG
(CHEMBL3828458)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)N1CCNC1=O
Show InChI InChI=1S/C21H18N6O/c1-26-13-17(11-24-26)14-2-4-15(5-3-14)18-12-22-10-16-6-7-19(25-20(16)18)27-9-8-23-21(27)28/h2-7,10-13H,8-9H2,1H3,(H,23,28)
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n/an/a 1n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189447
PNG
(CHEMBL3828553)
Show SMILES COC1CN(C1)C(=O)c1ccc2c(N)ncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C23H22N6O2/c1-28-11-16(9-26-28)14-3-5-15(6-4-14)19-10-25-22(24)18-7-8-20(27-21(18)19)23(30)29-12-17(13-29)31-2/h3-11,17H,12-13H2,1-2H3,(H2,24,25)
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n/an/a 1.10n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50265311
PNG
(4-(4-chlorophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3...)
Show SMILES Clc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C14H8ClN5OS/c15-8-1-3-9(4-2-8)21-11-6-16-7-13-10(11)5-12(22-13)14-17-19-20-18-14/h1-7H,(H,17,18,19,20)
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n/an/a 1.10n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50169082
PNG
(CHEMBL3805960)
Show SMILES FC(F)(F)Oc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C15H8F3N5O2S/c16-15(17,18)25-9-3-1-8(2-4-9)24-11-6-19-7-13-10(11)5-12(26-13)14-20-22-23-21-14/h1-7H,(H,20,21,22,23)
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n/an/a 1.10n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50191414
PNG
(CHEMBL3947140)
Show SMILES Cc1n[nH]c2ccc(nc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN4O/c1-11-17-14(22-21-11)8-9-15(20-17)18(24)23-10-2-3-16(23)12-4-6-13(19)7-5-12/h4-9,16H,2-3,10H2,1H3,(H,21,22)/t16-/m0/s1
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n/an/a 1.30n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50191472
PNG
(CHEMBL3956719)
Show SMILES Cc1n[nH]c2ccc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1
Show InChI InChI=1S/C19H18ClN3O/c1-12-16-11-14(6-9-17(16)22-21-12)19(24)23-10-2-3-18(23)13-4-7-15(20)8-5-13/h4-9,11,18H,2-3,10H2,1H3,(H,21,22)/t18-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50169062
PNG
(CHEMBL3805194)
Show SMILES NC(=O)c1cc2c(Oc3ccc(Cl)cc3)cnc(N)c2s1
Show InChI InChI=1S/C14H10ClN3O2S/c15-7-1-3-8(4-2-7)20-10-6-18-13(16)12-9(10)5-11(21-12)14(17)19/h1-6H,(H2,16,18)(H2,17,19)
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n/an/a 1.5n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189417
PNG
(CHEMBL3828116)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)C(N)=O
Show InChI InChI=1S/C19H15N5O/c1-24-11-15(9-22-24)12-2-4-13(5-3-12)16-10-21-8-14-6-7-17(19(20)25)23-18(14)16/h2-11H,1H3,(H2,20,25)
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n/an/a 1.5n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50265309
PNG
(2-(2H-tetrazol-5-yl)-4-(p-tolyloxy)thieno[2,3-c]py...)
Show SMILES Cc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C15H11N5OS/c1-9-2-4-10(5-3-9)21-12-7-16-8-14-11(12)6-13(22-14)15-17-19-20-18-15/h2-8H,1H3,(H,17,18,19,20)
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n/an/a 1.60n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50191373
PNG
(CHEMBL3966985)
Show SMILES Cc1n[nH]c2ccc(cc12)C(=O)N1CC[C@H]1c1ccc(Cl)cc1
Show InChI InChI=1S/C18H16ClN3O/c1-11-15-10-13(4-7-16(15)21-20-11)18(23)22-9-8-17(22)12-2-5-14(19)6-3-12/h2-7,10,17H,8-9H2,1H3,(H,20,21)/t17-/m0/s1
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n/an/a 1.70n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189426
PNG
(CHEMBL3827944)
Show SMILES CC(=O)Nc1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C20H17N5O/c1-13(26)23-19-8-7-16-9-21-11-18(20(16)24-19)15-5-3-14(4-6-15)17-10-22-25(2)12-17/h3-12H,1-2H3,(H,23,24,26)
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n/an/a 1.80n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50154956
PNG
(CHEMBL3775317)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CC[C@@H](O)C2)cc1
Show InChI InChI=1S/C23H23N5O2/c1-27-13-18(12-24-27)16-4-2-15(3-5-16)10-22-20-11-17(6-7-21(20)25-26-22)23(30)28-9-8-19(29)14-28/h2-7,11-13,19,29H,8-10,14H2,1H3,(H,25,26)/t19-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50154942
PNG
(CHEMBL3775076)
Show SMILES Cn1ncc2cc(Cc3n[nH]c4ccc(cc34)C(=O)N3CCC(F)(F)C3)ccc12
Show InChI InChI=1S/C21H19F2N5O/c1-27-19-5-2-13(8-15(19)11-24-27)9-18-16-10-14(3-4-17(16)25-26-18)20(29)28-7-6-21(22,23)12-28/h2-5,8,10-11H,6-7,9,12H2,1H3,(H,25,26)
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n/an/a 2n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50169080
PNG
(CHEMBL3806173)
Show SMILES CC(=O)Nc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C16H12N6O2S/c1-9(23)18-10-2-4-11(5-3-10)24-13-7-17-8-15-12(13)6-14(25-15)16-19-21-22-20-16/h2-8H,1H3,(H,18,23)(H,19,20,21,22)
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n/an/a 2n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189436
PNG
(CHEMBL3827327)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)C(=O)NC1CC1
Show InChI InChI=1S/C23H20N4O/c1-27-14-19(12-25-27)15-2-4-16(5-3-15)22-13-24-11-18-7-6-17(10-21(18)22)23(28)26-20-8-9-20/h2-7,10-14,20H,8-9H2,1H3,(H,26,28)
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n/an/a 2.10n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189427
PNG
(CHEMBL3827470)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)N1CCCC1=O
Show InChI InChI=1S/C22H19N5O/c1-26-14-18(12-24-26)15-4-6-16(7-5-15)19-13-23-11-17-8-9-20(25-22(17)19)27-10-2-3-21(27)28/h4-9,11-14H,2-3,10H2,1H3
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n/an/a 2.40n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50191357
PNG
(CHEMBL3903492)
Show SMILES Cc1n[nH]c2ncc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16(23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-C


(Homo sapiens)
BDBM50169078
PNG
(CHEMBL3804919)
Show SMILES OC(=O)c1cc2c(Oc3ccc(Cl)cc3)cncc2s1
Show InChI InChI=1S/C14H8ClNO3S/c15-8-1-3-9(4-2-8)19-11-6-16-7-13-10(11)5-12(20-13)14(17)18/h1-7H,(H,17,18)
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n/an/a 2.80n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50154955
PNG
(CHEMBL3775321)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CC[C@H](O)C2)cc1
Show InChI InChI=1S/C23H23N5O2/c1-27-13-18(12-24-27)16-4-2-15(3-5-16)10-22-20-11-17(6-7-21(20)25-26-22)23(30)28-9-8-19(29)14-28/h2-7,11-13,19,29H,8-10,14H2,1H3,(H,25,26)/t19-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50264866
PNG
(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C21H14N6O2S/c22-20(28)14-3-1-12(2-4-14)13-5-7-15(8-6-13)29-17-10-23-11-19-16(17)9-18(30-19)21-24-26-27-25-21/h1-11H,(H2,22,28)(H,24,25,26,27)
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n/an/a 3n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50191371
PNG
(CHEMBL3939280)
Show SMILES Nc1n[nH]c2ccc(cc12)C(=O)N1CCC[C@H]1c1ccc(Br)cc1
Show InChI InChI=1S/C18H17BrN4O/c19-13-6-3-11(4-7-13)16-2-1-9-23(16)18(24)12-5-8-15-14(10-12)17(20)22-21-15/h3-8,10,16H,1-2,9H2,(H3,20,21,22)/t16-/m0/s1
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n/an/a 3.10n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189423
PNG
(CHEMBL3828523)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)C(=O)N1CCCC1
Show InChI InChI=1S/C23H21N5O/c1-27-15-19(13-25-27)16-4-6-17(7-5-16)20-14-24-12-18-8-9-21(26-22(18)20)23(29)28-10-2-3-11-28/h4-9,12-15H,2-3,10-11H2,1H3
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n/an/a 3.5n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189420
PNG
(CHEMBL3827799)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)C(=O)N1CCC1
Show InChI InChI=1S/C22H19N5O/c1-26-14-18(12-24-26)15-3-5-16(6-4-15)19-13-23-11-17-7-8-20(25-21(17)19)22(28)27-9-2-10-27/h3-8,11-14H,2,9-10H2,1H3
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n/an/a 3.60n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189412
PNG
(CHEMBL3827983)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C20H17N5O/c1-21-20(26)18-8-7-15-9-22-11-17(19(15)24-18)14-5-3-13(4-6-14)16-10-23-25(2)12-16/h3-12H,1-2H3,(H,21,26)
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n/an/a 3.60n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50191443
PNG
(CHEMBL3938208)
Show SMILES Cc1ncc2sc(nn12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClN4OS/c1-10-18-9-14-21(10)19-15(23-14)16(22)20-8-2-3-13(20)11-4-6-12(17)7-5-11/h4-7,9,13H,2-3,8H2,1H3/t13-/m0/s1
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n/an/a 3.80n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-C


(Homo sapiens)
BDBM50154960
PNG
(CHEMBL3775123)
Show SMILES Cn1ncc2cc(Cc3n[nH]c4ccc(cc34)C(=O)N3CC(O)C3)ccc12
Show InChI InChI=1S/C20H19N5O2/c1-24-19-5-2-12(6-14(19)9-21-24)7-18-16-8-13(3-4-17(16)22-23-18)20(27)25-10-15(26)11-25/h2-6,8-9,15,26H,7,10-11H2,1H3,(H,22,23)
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n/an/a 4n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50155241
PNG
(CHEMBL3774885)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CCOCC2)cc1
Show InChI InChI=1S/C23H23N5O2/c1-27-15-19(14-24-27)17-4-2-16(3-5-17)12-22-20-13-18(6-7-21(20)25-26-22)23(29)28-8-10-30-11-9-28/h2-7,13-15H,8-12H2,1H3,(H,25,26)
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n/an/a 4n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50155239
PNG
(CHEMBL3775935)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CCCC2)cc1
Show InChI InChI=1S/C23H23N5O/c1-27-15-19(14-24-27)17-6-4-16(5-7-17)12-22-20-13-18(8-9-21(20)25-26-22)23(29)28-10-2-3-11-28/h4-9,13-15H,2-3,10-12H2,1H3,(H,25,26)
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n/an/a 4n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50154965
PNG
(CHEMBL3775423)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CC(O)C2)cc1
Show InChI InChI=1S/C22H21N5O2/c1-26-11-17(10-23-26)15-4-2-14(3-5-15)8-21-19-9-16(6-7-20(19)24-25-21)22(29)27-12-18(28)13-27/h2-7,9-11,18,28H,8,12-13H2,1H3,(H,24,25)
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n/an/a 4n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50154941
PNG
(CHEMBL3775024)
Show SMILES Cn1ncc2cc(Cc3n[nH]c4ccc(cc34)C(=O)N3CC[C@H](O)C3)ccc12
Show InChI InChI=1S/C21H21N5O2/c1-25-20-5-2-13(8-15(20)11-22-25)9-19-17-10-14(3-4-18(17)23-24-19)21(28)26-7-6-16(27)12-26/h2-5,8,10-11,16,27H,6-7,9,12H2,1H3,(H,23,24)/t16-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50169079
PNG
(CHEMBL3805857)
Show SMILES NC(=O)c1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C15H10N6O2S/c16-14(22)8-1-3-9(4-2-8)23-11-6-17-7-13-10(11)5-12(24-13)15-18-20-21-19-15/h1-7H,(H2,16,22)(H,18,19,20,21)
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n/an/a 4.40n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189435
PNG
(CHEMBL3828003)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C21H18N4O/c1-22-21(26)16-7-8-17-10-23-12-20(19(17)9-16)15-5-3-14(4-6-15)18-11-24-25(2)13-18/h3-13H,1-2H3,(H,22,26)
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n/an/a 4.5n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189442
PNG
(CHEMBL3828503)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)N1CCOC1=O
Show InChI InChI=1S/C22H18N4O2/c1-25-14-18(12-24-25)15-2-4-16(5-3-15)21-13-23-11-17-6-7-19(10-20(17)21)26-8-9-28-22(26)27/h2-7,10-14H,8-9H2,1H3
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n/an/a 4.60n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189418
PNG
(CHEMBL3827482)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(nc12)C(O)=O
Show InChI InChI=1S/C19H14N4O2/c1-23-11-15(9-21-23)12-2-4-13(5-3-12)16-10-20-8-14-6-7-17(19(24)25)22-18(14)16/h2-11H,1H3,(H,24,25)
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n/an/a 4.70n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50163795
PNG
(CHEMBL3798382)
Show SMILES Cn1ncc2cc(ccc12)-c1cnc(N)c(Cl)c1N1CCC2(CCNC2=O)CC1
Show InChI InChI=1S/C21H23ClN6O/c1-27-16-3-2-13(10-14(16)11-26-27)15-12-25-19(23)17(22)18(15)28-8-5-21(6-9-28)4-7-24-20(21)29/h2-3,10-12H,4-9H2,1H3,(H2,23,25)(H,24,29)
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n/an/a 4.90n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to human CDK8 (1 to 464 amino acid residues)/Cyclin C (1 to 283 amino acid residues) by reporter displacement assay


J Med Chem 59: 1078-101 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01685
BindingDB Entry DOI: 10.7270/Q29025P6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-C


(Homo sapiens)
BDBM50189439
PNG
(CHEMBL3827699)
Show SMILES CC(=O)Nc1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2c1
Show InChI InChI=1S/C21H18N4O/c1-14(26)24-19-8-7-17-10-22-12-21(20(17)9-19)16-5-3-15(4-6-16)18-11-23-25(2)13-18/h3-13H,1-2H3,(H,24,26)
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n/an/a 4.90n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50191467
PNG
(CHEMBL3911320)
Show SMILES Nc1n[nH]c2ccc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1
Show InChI InChI=1S/C18H17ClN4O/c19-13-6-3-11(4-7-13)16-2-1-9-23(16)18(24)12-5-8-15-14(10-12)17(20)22-21-15/h3-8,10,16H,1-2,9H2,(H3,20,21,22)/t16-/m0/s1
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n/an/a 4.90n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50155240
PNG
(CHEMBL3775773)
Show SMILES Cn1cc(cn1)-c1ccc(Cc2n[nH]c3ccc(cc23)C(=O)N2CCC(F)(F)C2)cc1
Show InChI InChI=1S/C23H21F2N5O/c1-29-13-18(12-26-29)16-4-2-15(3-5-16)10-21-19-11-17(6-7-20(19)27-28-21)22(31)30-9-8-23(24,25)14-30/h2-7,11-13H,8-10,14H2,1H3,(H,27,28)
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n/an/a 5n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assay


Bioorg Med Chem Lett 26: 1443-51 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.062
BindingDB Entry DOI: 10.7270/Q2NZ89G6
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50105215
PNG
(4-(4-Cyano-phenoxy)-thieno[2,3-c]pyridine-2-carbox...)
Show SMILES NC(=O)c1cc2c(Oc3ccc(cc3)C#N)cncc2s1
Show InChI InChI=1S/C15H9N3O2S/c16-6-9-1-3-10(4-2-9)20-12-7-18-8-14-11(12)5-13(21-14)15(17)19/h1-5,7-8H,(H2,17,19)
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n/an/a 5.10n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189447
PNG
(CHEMBL3828553)
Show SMILES COC1CN(C1)C(=O)c1ccc2c(N)ncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C23H22N6O2/c1-28-11-16(9-26-28)14-3-5-15(6-4-14)19-10-25-22(24)18-7-8-20(27-21(18)19)23(30)29-12-17(13-29)31-2/h3-11,17H,12-13H2,1-2H3,(H2,24,25)
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n/an/a 5.10n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Binding affinity to human CDK8 (1 to 464 residues)/cyclin C (1 to 283 residues) by reporter probe displacement assay


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189421
PNG
(CHEMBL3827118)
Show SMILES COC1CN(C1)C(=O)c1ccc2cncc(-c3ccc(cc3)-c3cnn(C)c3)c2n1
Show InChI InChI=1S/C23H21N5O2/c1-27-12-18(10-25-27)15-3-5-16(6-4-15)20-11-24-9-17-7-8-21(26-22(17)20)23(29)28-13-19(14-28)30-2/h3-12,19H,13-14H2,1-2H3
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n/an/a 5.20n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50169071
PNG
(CHEMBL3806024)
Show SMILES CNC(=O)c1cc2c(Oc3ccc(I)cc3)cncc2s1
Show InChI InChI=1S/C15H11IN2O2S/c1-17-15(19)13-6-11-12(7-18-8-14(11)21-13)20-10-4-2-9(16)3-5-10/h2-8H,1H3,(H,17,19)
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n/an/a 5.30n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-C


(Homo sapiens)
BDBM50189416
PNG
(CHEMBL3828575)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4NS(=O)(=O)Cc4c3)c2n1
Show InChI InChI=1S/C17H14N4O3S/c1-18-17(22)15-5-3-11-7-19-8-13(16(11)20-15)10-2-4-14-12(6-10)9-25(23,24)21-14/h2-8,21H,9H2,1H3,(H,18,22)
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n/an/a 5.30n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
CDK8/Cyclin C


(Homo sapiens)
BDBM50191469
PNG
(CHEMBL3895703)
Show SMILES CNc1n[nH]c2ccc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1
Show InChI InChI=1S/C19H19ClN4O/c1-21-18-15-11-13(6-9-16(15)22-23-18)19(25)24-10-2-3-17(24)12-4-7-14(20)8-5-12/h4-9,11,17H,2-3,10H2,1H3,(H2,21,22,23)/t17-/m0/s1
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n/an/a 5.40n/an/an/an/an/an/a



Merck KGaA

Curated by ChEMBL


Assay Description
Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...


J Med Chem 59: 9337-9349 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00597
BindingDB Entry DOI: 10.7270/Q2K64M1C
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50189413
PNG
(CHEMBL3827774)
Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4n(C)ncc4c3)c2n1
Show InChI InChI=1S/C18H15N5O/c1-19-18(24)15-5-3-12-8-20-10-14(17(12)22-15)11-4-6-16-13(7-11)9-21-23(16)2/h3-10H,1-2H3,(H,19,24)
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n/an/a 5.40n/an/an/an/an/an/a



The Institute of Cancer Research

Curated by ChEMBL


Assay Description
Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...


ACS Med Chem Lett 7: 573-8 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00022
BindingDB Entry DOI: 10.7270/Q2N87CRB
More data for this
Ligand-Target Pair
Cyclin-C


(Homo sapiens)
BDBM50169083
PNG
(CHEMBL3805667)
Show SMILES Fc1ccc(Oc2cncc3sc(cc23)-c2nnn[nH]2)cc1
Show InChI InChI=1S/C14H8FN5OS/c15-8-1-3-9(4-2-8)21-11-6-16-7-13-10(11)5-12(22-13)14-17-19-20-18-14/h1-7H,(H,17,18,19,20)
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n/an/a 5.5n/an/an/an/an/an/a



Genentech, Inc

Curated by ChEMBL


Assay Description
Inhibition of full length human recombinant His-tagged CDK8/Cyclin C expressed in baculovirus expression system by fluorescence polarization assay


ACS Med Chem Lett 7: 223-8 (2016)


Article DOI: 10.1021/acsmedchemlett.5b00278
BindingDB Entry DOI: 10.7270/Q29G5PPC
More data for this
Ligand-Target Pair
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