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Found 273 hits Enz. Inhib. hit(s) with Target = 'CGMP-dependent protein kinase' AND taxid = 5802   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210476
PNG
((2,5-difluorobenzyl)-{4-[7-dimethylaminomethyl-2-(...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2cc(F)ccc2F)n1
Show InChI InChI=1S/C27H23F3N6/c1-35(2)16-17-10-12-36-24(13-17)34-25(18-3-5-20(28)6-4-18)26(36)23-9-11-31-27(33-23)32-15-19-14-21(29)7-8-22(19)30/h3-14H,15-16H2,1-2H3,(H,31,32,33)
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n/an/a 0.0260n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50182369
PNG
(4-(2-(4-fluorophenyl)-7-(1-methylpiperidin-4-yl)H-...)
Show SMILES CN1CCC(CC1)c1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C23H23FN6/c1-29-11-7-15(8-12-29)17-9-13-30-20(14-17)28-21(16-2-4-18(24)5-3-16)22(30)19-6-10-26-23(25)27-19/h2-6,9-10,13-15H,7-8,11-12H2,1H3,(H2,25,26,27)
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n/an/a 0.0400n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against PKG


Bioorg Med Chem Lett 16: 2479-83 (2006)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50182369
PNG
(4-(2-(4-fluorophenyl)-7-(1-methylpiperidin-4-yl)H-...)
Show SMILES CN1CCC(CC1)c1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C23H23FN6/c1-29-11-7-15(8-12-29)17-9-13-30-20(14-17)28-21(16-2-4-18(24)5-3-16)22(30)19-6-10-26-23(25)27-19/h2-6,9-10,13-15H,7-8,11-12H2,1H3,(H2,25,26,27)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50182369
PNG
(4-(2-(4-fluorophenyl)-7-(1-methylpiperidin-4-yl)H-...)
Show SMILES CN1CCC(CC1)c1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C23H23FN6/c1-29-11-7-15(8-12-29)17-9-13-30-20(14-17)28-21(16-2-4-18(24)5-3-16)22(30)19-6-10-26-23(25)27-19/h2-6,9-10,13-15H,7-8,11-12H2,1H3,(H2,25,26,27)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella parasite-specific cGMP-dependent protein kinase


Bioorg Med Chem Lett 19: 1517-21 (2009)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265424
PNG
(2-{4-[3-(2-Aminopyrimidin-4-yl)-2-(4-fluorophenyl)...)
Show SMILES Nc1nccc(n1)-c1c(nc2cc(ccn12)C1CCN(CCO)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H25FN6O/c25-19-3-1-17(2-4-19)22-23(20-5-9-27-24(26)28-20)31-12-8-18(15-21(31)29-22)16-6-10-30(11-7-16)13-14-32/h1-5,8-9,12,15-16,32H,6-7,10-11,13-14H2,(H2,26,27,28)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50168170
PNG
(3-{4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol...)
Show SMILES NCCCN1CCC(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C23H27FN4/c24-20-4-2-19(3-5-20)23-21(17-6-11-26-12-7-17)16-22(27-23)18-8-14-28(15-9-18)13-1-10-25/h2-7,11-12,16,18,27H,1,8-10,13-15,25H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of Eimeria tenella cGMP-dependent protein kinase


Bioorg Med Chem Lett 15: 3296-301 (2005)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50182367
PNG
(4-(2-(4-fluorophenyl)-7-(piperidin-4-yl)H-imidazo[...)
Show SMILES Nc1nccc(n1)-c1c(nc2cc(ccn12)C1CCNCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H21FN6/c23-17-3-1-15(2-4-17)20-21(18-7-11-26-22(24)27-18)29-12-8-16(13-19(29)28-20)14-5-9-25-10-6-14/h1-4,7-8,11-14,25H,5-6,9-10H2,(H2,24,26,27)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50211814
PNG
(4-(2-(4-fluorophenyl)-7-((isopropylamino)methyl)H-...)
Show SMILES CC(C)NCc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N[C@@H](C)c2ccccc2)n1
Show InChI InChI=1S/C29H29FN6/c1-19(2)32-18-21-14-16-36-26(17-21)35-27(23-9-11-24(30)12-10-23)28(36)25-13-15-31-29(34-25)33-20(3)22-7-5-4-6-8-22/h4-17,19-20,32H,18H2,1-3H3,(H,31,33,34)/t20-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Et-PKG


Bioorg Med Chem Lett 17: 3558-61 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50182367
PNG
(4-(2-(4-fluorophenyl)-7-(piperidin-4-yl)H-imidazo[...)
Show SMILES Nc1nccc(n1)-c1c(nc2cc(ccn12)C1CCNCC1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H21FN6/c23-17-3-1-15(2-4-17)20-21(18-7-11-26-22(24)27-18)29-12-8-16(13-19(29)28-20)14-5-9-25-10-6-14/h1-4,7-8,11-14,25H,5-6,9-10H2,(H2,24,26,27)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against PKG


Bioorg Med Chem Lett 16: 2479-83 (2006)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210490
PNG
((2-chlorobenzyl)-{4-[7-dimethylaminomethyl-2-(4-fl...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2ccccc2Cl)n1
Show InChI InChI=1S/C27H24ClFN6/c1-34(2)17-18-12-14-35-24(15-18)33-25(19-7-9-21(29)10-8-19)26(35)23-11-13-30-27(32-23)31-16-20-5-3-4-6-22(20)28/h3-15H,16-17H2,1-2H3,(H,30,31,32)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210479
PNG
((2,6-difluorobenzyl)-{4-[7-dimethylaminomethyl-2-(...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2c(F)cccc2F)n1
Show InChI InChI=1S/C27H23F3N6/c1-35(2)16-17-11-13-36-24(14-17)34-25(18-6-8-19(28)9-7-18)26(36)23-10-12-31-27(33-23)32-15-20-21(29)4-3-5-22(20)30/h3-14H,15-16H2,1-2H3,(H,31,32,33)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210473
PNG
((3,4-difluorobenzyl)-{4-[7-dimethylaminomethyl-2-(...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2ccc(F)c(F)c2)n1
Show InChI InChI=1S/C27H23F3N6/c1-35(2)16-18-10-12-36-24(14-18)34-25(19-4-6-20(28)7-5-19)26(36)23-9-11-31-27(33-23)32-15-17-3-8-21(29)22(30)13-17/h3-14H,15-16H2,1-2H3,(H,31,32,33)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50211811
PNG
(4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(Nc2ccccc2)n1
Show InChI InChI=1S/C26H23FN6/c1-32(2)17-18-13-15-33-23(16-18)31-24(19-8-10-20(27)11-9-19)25(33)22-12-14-28-26(30-22)29-21-6-4-3-5-7-21/h3-16H,17H2,1-2H3,(H,28,29,30)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Et-PKG


Bioorg Med Chem Lett 17: 3558-61 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210495
PNG
(CHEMBL251184 | cyclopropylmethyl{4-[7-dimethylamin...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCC2CC2)n1
Show InChI InChI=1S/C24H25FN6/c1-30(2)15-17-10-12-31-21(13-17)29-22(18-5-7-19(25)8-6-18)23(31)20-9-11-26-24(28-20)27-14-16-3-4-16/h5-13,16H,3-4,14-15H2,1-2H3,(H,26,27,28)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265419
PNG
(4-[7-(1-Dimethylaminobutyl)-2-(4-fluorophenyl)imid...)
Show SMILES CCCC(N(C)C)c1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C23H25FN6/c1-4-5-19(29(2)3)16-11-13-30-20(14-16)28-21(15-6-8-17(24)9-7-15)22(30)18-10-12-26-23(25)27-18/h6-14,19H,4-5H2,1-3H3,(H2,25,26,27)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265425
PNG
(2-{4-[3-(2-Aminopyrimidin-4-yl)-2-(4-fluorophenyl)...)
Show SMILES Nc1nccc(n1)-c1c(nc2cc(ccn12)C1CCN(CCCO)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H27FN6O/c26-20-4-2-18(3-5-20)23-24(21-6-10-28-25(27)29-21)32-14-9-19(16-22(32)30-23)17-7-12-31(13-8-17)11-1-15-33/h2-6,9-10,14,16-17,33H,1,7-8,11-13,15H2,(H2,27,28,29)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210517
PNG
(CHEMBL249527 | {4-[7-dimethylaminomethyl-2-(4-fluo...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2ccc(F)cc2)n1
Show InChI InChI=1S/C27H24F2N6/c1-34(2)17-19-12-14-35-24(15-19)33-25(20-5-9-22(29)10-6-20)26(35)23-11-13-30-27(32-23)31-16-18-3-7-21(28)8-4-18/h3-15H,16-17H2,1-2H3,(H,30,31,32)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265397
PNG
(4-[7-(1-Dimethylaminoethyl)-2-(4-fluorophenyl)imid...)
Show SMILES CC(N(C)C)c1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C21H21FN6/c1-13(27(2)3)15-9-11-28-18(12-15)26-19(14-4-6-16(22)7-5-14)20(28)17-8-10-24-21(23)25-17/h4-13H,1-3H3,(H2,23,24,25)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265430
PNG
(4-[2-(4-Fluorophenyl)-7-(1-phenethylpiperidin-4-yl...)
Show SMILES Nc1nccc(n1)-c1c(nc2cc(ccn12)C1CCN(CCc2ccccc2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C30H29FN6/c31-25-8-6-23(7-9-25)28-29(26-10-15-33-30(32)34-26)37-19-14-24(20-27(37)35-28)22-12-17-36(18-13-22)16-11-21-4-2-1-3-5-21/h1-10,14-15,19-20,22H,11-13,16-18H2,(H2,32,33,34)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50211805
PNG
(4-(7-(((3-(dimethylamino)propyl)(methyl)amino)meth...)
Show SMILES C[C@H](Nc1nccc(n1)-c1c(nc2cc(CN(C)CCCN(C)C)ccn12)-c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C32H36FN7/c1-23(25-9-6-5-7-10-25)35-32-34-17-15-28(36-32)31-30(26-11-13-27(33)14-12-26)37-29-21-24(16-20-40(29)31)22-39(4)19-8-18-38(2)3/h5-7,9-17,20-21,23H,8,18-19,22H2,1-4H3,(H,34,35,36)/t23-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Et-PKG


Bioorg Med Chem Lett 17: 3558-61 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50374578
PNG
(CHEMBL401749)
Show SMILES Fc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)C1CCN(CC2CNCCN2)CC1
Show InChI InChI=1S/C25H30FN5/c26-21-3-1-20(2-4-21)25-23(18-5-9-27-10-6-18)15-24(30-25)19-7-13-31(14-8-19)17-22-16-28-11-12-29-22/h1-6,9-10,15,19,22,28-30H,7-8,11-14,16-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Bioorg Med Chem Lett 18: 2019-22 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50374594
PNG
(CHEMBL444009)
Show SMILES Fc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)C1CCN(CCN2CCC2)CC1
Show InChI InChI=1S/C25H29FN4/c26-22-4-2-21(3-5-22)25-23(19-6-10-27-11-7-19)18-24(28-25)20-8-14-30(15-9-20)17-16-29-12-1-13-29/h2-7,10-11,18,20,28H,1,8-9,12-17H2
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Bioorg Med Chem Lett 18: 2019-22 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210508
PNG
(CHEMBL250791 | cyclopropyl{4-[7-dimethylaminomethy...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NC2CC2)n1
Show InChI InChI=1S/C23H23FN6/c1-29(2)14-15-10-12-30-20(13-15)28-21(16-3-5-17(24)6-4-16)22(30)19-9-11-25-23(27-19)26-18-7-8-18/h3-6,9-13,18H,7-8,14H2,1-2H3,(H,25,26,27)
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n/an/a 0.0800n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210494
PNG
(CHEMBL250601 | {4-[7-dimethylaminomethyl-2-(4-fluo...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2ccccc2C)n1
Show InChI InChI=1S/C28H27FN6/c1-19-6-4-5-7-22(19)17-31-28-30-14-12-24(32-28)27-26(21-8-10-23(29)11-9-21)33-25-16-20(18-34(2)3)13-15-35(25)27/h4-16H,17-18H2,1-3H3,(H,30,31,32)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50182359
PNG
(CHEMBL379059 | N-benzyl-4-(7-((dimethylamino)methy...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2ccccc2)n1
Show InChI InChI=1S/C27H25FN6/c1-33(2)18-20-13-15-34-24(16-20)32-25(21-8-10-22(28)11-9-21)26(34)23-12-14-29-27(31-23)30-17-19-6-4-3-5-7-19/h3-16H,17-18H2,1-2H3,(H,29,30,31)
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n/an/a 0.0810n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against PKG


Bioorg Med Chem Lett 16: 2479-83 (2006)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50182359
PNG
(CHEMBL379059 | N-benzyl-4-(7-((dimethylamino)methy...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2ccccc2)n1
Show InChI InChI=1S/C27H25FN6/c1-33(2)18-20-13-15-34-24(16-20)32-25(21-8-10-22(28)11-9-21)26(34)23-12-14-29-27(31-23)30-17-19-6-4-3-5-7-19/h3-16H,17-18H2,1-2H3,(H,29,30,31)
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n/an/a 0.0810n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Et-PKG


Bioorg Med Chem Lett 17: 3558-61 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210489
PNG
(CHEMBL249526 | {4-[7-dimethylaminomethyl-2-(4-fluo...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2cccc(C)c2)n1
Show InChI InChI=1S/C28H27FN6/c1-19-5-4-6-20(15-19)17-31-28-30-13-11-24(32-28)27-26(22-7-9-23(29)10-8-22)33-25-16-21(18-34(2)3)12-14-35(25)27/h4-16H,17-18H2,1-3H3,(H,30,31,32)
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n/an/a 0.0830n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210493
PNG
(CHEMBL401102 | {4-[7-dimethylaminomethyl-2-(4-fluo...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2ccccc2F)n1
Show InChI InChI=1S/C27H24F2N6/c1-34(2)17-18-12-14-35-24(15-18)33-25(19-7-9-21(28)10-8-19)26(35)23-11-13-30-27(32-23)31-16-20-5-3-4-6-22(20)29/h3-15H,16-17H2,1-2H3,(H,30,31,32)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265397
PNG
(4-[7-(1-Dimethylaminoethyl)-2-(4-fluorophenyl)imid...)
Show SMILES CC(N(C)C)c1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C21H21FN6/c1-13(27(2)3)15-9-11-28-18(12-15)26-19(14-4-6-16(22)7-5-14)20(28)17-8-10-24-21(23)25-17/h4-13H,1-3H3,(H2,23,24,25)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210478
PNG
(CHEMBL249326 | {4-[7-dimethylaminomethyl-2-(4-fluo...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2cccc(F)c2)n1
Show InChI InChI=1S/C27H24F2N6/c1-34(2)17-19-11-13-35-24(15-19)33-25(20-6-8-21(28)9-7-20)26(35)23-10-12-30-27(32-23)31-16-18-4-3-5-22(29)14-18/h3-15H,16-17H2,1-2H3,(H,30,31,32)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265427
PNG
(4-[7-(1-Cyclopropylmethylpiperidin-4-yl)-2-(4-fluo...)
Show SMILES Nc1nccc(n1)-c1c(nc2cc(ccn12)C1CCN(CC2CC2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H27FN6/c27-21-5-3-19(4-6-21)24-25(22-7-11-29-26(28)30-22)33-14-10-20(15-23(33)31-24)18-8-12-32(13-9-18)16-17-1-2-17/h3-7,10-11,14-15,17-18H,1-2,8-9,12-13,16H2,(H2,28,29,30)
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n/an/a 0.0950n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50248496
PNG
(2-(4-(2-(4-fluorophenyl)-3-(pyridin-4-yl)-1H-indol...)
Show SMILES OCCN1CCC(CC1)c1ccc2c(c([nH]c2c1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C26H26FN3O/c27-22-4-1-20(2-5-22)26-25(19-7-11-28-12-8-19)23-6-3-21(17-24(23)29-26)18-9-13-30(14-10-18)15-16-31/h1-8,11-12,17-18,29,31H,9-10,13-16H2
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n/an/a 0.100n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella parasite-specific cGMP-dependent protein kinase


Bioorg Med Chem Lett 19: 1517-21 (2009)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210500
PNG
(CHEMBL251589 | {4-[7-dimethylaminomethyl-2-(4-fluo...)
Show SMILES CCCCCNc1nccc(n1)-c1c(nc2cc(CN(C)C)ccn12)-c1ccc(F)cc1
Show InChI InChI=1S/C25H29FN6/c1-4-5-6-13-27-25-28-14-11-21(29-25)24-23(19-7-9-20(26)10-8-19)30-22-16-18(17-31(2)3)12-15-32(22)24/h7-12,14-16H,4-6,13,17H2,1-3H3,(H,27,28,29)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50195444
PNG
(2-(ethyl((2-(4-fluorophenyl)-3-(2-((S)-1-phenyleth...)
Show SMILES CCN(CCO)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(n1)[C@@H](C)c1ccccc1
Show InChI InChI=1S/C30H30FN5O/c1-3-35(17-18-37)20-22-14-16-36-27(19-22)34-28(24-9-11-25(31)12-10-24)29(36)26-13-15-32-30(33-26)21(2)23-7-5-4-6-8-23/h4-16,19,21,37H,3,17-18,20H2,1-2H3/t21-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella PKG


Bioorg Med Chem Lett 16: 5978-81 (2006)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50211820
PNG
(4-(7-(((2-(azetidin-1-yl)ethyl)(methyl)amino)methy...)
Show SMILES C[C@H](Nc1nccc(n1)-c1c(nc2cc(CN(C)CCN3CCC3)ccn12)-c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C32H34FN7/c1-23(25-7-4-3-5-8-25)35-32-34-15-13-28(36-32)31-30(26-9-11-27(33)12-10-26)37-29-21-24(14-18-40(29)31)22-38(2)19-20-39-16-6-17-39/h3-5,7-15,18,21,23H,6,16-17,19-20,22H2,1-2H3,(H,34,35,36)/t23-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Et-PKG


Bioorg Med Chem Lett 17: 3558-61 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210511
PNG
(4-[2-(2,4-difluorophenyl)-7-dimethylaminomethylimi...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1F)-c1ccnc(N)n1
Show InChI InChI=1S/C20H18F2N6/c1-27(2)11-12-6-8-28-17(9-12)26-18(14-4-3-13(21)10-15(14)22)19(28)16-5-7-24-20(23)25-16/h3-10H,11H2,1-2H3,(H2,23,24,25)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210514
PNG
(CHEMBL399257 | cyclopentyl{4-[7-dimethylaminomethy...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NC2CCCC2)n1
Show InChI InChI=1S/C25H27FN6/c1-31(2)16-17-12-14-32-22(15-17)30-23(18-7-9-19(26)10-8-18)24(32)21-11-13-27-25(29-21)28-20-5-3-4-6-20/h7-15,20H,3-6,16H2,1-2H3,(H,27,28,29)
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n/an/a 0.102n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265421
PNG
(4-[7-(1-Dimethylamino-1-methyl-ethyl)-2-(4-fluorop...)
Show SMILES CN(C)C(C)(C)c1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C22H23FN6/c1-22(2,28(3)4)15-10-12-29-18(13-15)27-19(14-5-7-16(23)8-6-14)20(29)17-9-11-25-21(24)26-17/h5-13H,1-4H3,(H2,24,25,26)
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n/an/a 0.110n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265429
PNG
(4-[7-(1-Benzylpiperidin-4-yl)-2-(4-fluorophenyl)-i...)
Show SMILES Nc1nccc(n1)-c1c(nc2cc(ccn12)C1CCN(Cc2ccccc2)CC1)-c1ccc(F)cc1
Show InChI InChI=1S/C29H27FN6/c30-24-8-6-22(7-9-24)27-28(25-10-14-32-29(31)33-25)36-17-13-23(18-26(36)34-27)21-11-15-35(16-12-21)19-20-4-2-1-3-5-20/h1-10,13-14,17-18,21H,11-12,15-16,19H2,(H2,31,32,33)
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n/an/a 0.110n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265402
PNG
(4-[7-[1-(3,3-Dimethylbutyl)piperidin-4-yl)-2-(4-fl...)
Show SMILES CC(C)(C)CCN1CCC(CC1)c1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C28H33FN6/c1-28(2,3)12-17-34-14-9-19(10-15-34)21-11-16-35-24(18-21)33-25(20-4-6-22(29)7-5-20)26(35)23-8-13-31-27(30)32-23/h4-8,11,13,16,18-19H,9-10,12,14-15,17H2,1-3H3,(H2,30,31,32)
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n/an/a 0.110n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50182362
PNG
(4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C20H19FN6/c1-26(2)12-13-8-10-27-17(11-13)25-18(14-3-5-15(21)6-4-14)19(27)16-7-9-23-20(22)24-16/h3-11H,12H2,1-2H3,(H2,22,23,24)
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n/an/a 0.110n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50195435
PNG
(2-(((2-(4-fluorophenyl)-3-(2-((S)-1-phenylethyl)py...)
Show SMILES C[C@@H](c1ccccc1)c1nccc(n1)-c1c(nc2cc(CN(C)CCO)ccn12)-c1ccc(F)cc1
Show InChI InChI=1S/C29H28FN5O/c1-20(22-6-4-3-5-7-22)29-31-14-12-25(32-29)28-27(23-8-10-24(30)11-9-23)33-26-18-21(13-15-35(26)28)19-34(2)16-17-36/h3-15,18,20,36H,16-17,19H2,1-2H3/t20-/m0/s1
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n/an/a 0.110n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella PKG


Bioorg Med Chem Lett 16: 5978-81 (2006)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50211802
PNG
(2-(((2-(4-fluorophenyl)-3-(2-((S)-1-phenylethylami...)
Show SMILES C[C@H](Nc1nccc(n1)-c1c(nc2cc(CN(C)CCO)ccn12)-c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C29H29FN6O/c1-20(22-6-4-3-5-7-22)32-29-31-14-12-25(33-29)28-27(23-8-10-24(30)11-9-23)34-26-18-21(13-15-36(26)28)19-35(2)16-17-37/h3-15,18,20,37H,16-17,19H2,1-2H3,(H,31,32,33)/t20-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Et-PKG


Bioorg Med Chem Lett 17: 3558-61 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50211812
PNG
(4-(2-(4-fluorophenyl)-7-((isopropyl(methyl)amino)m...)
Show SMILES CC(C)N(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N[C@@H](C)c2ccccc2)n1
Show InChI InChI=1S/C30H31FN6/c1-20(2)36(4)19-22-15-17-37-27(18-22)35-28(24-10-12-25(31)13-11-24)29(37)26-14-16-32-30(34-26)33-21(3)23-8-6-5-7-9-23/h5-18,20-21H,19H2,1-4H3,(H,32,33,34)/t21-/m0/s1
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n/an/a 0.110n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Et-PKG


Bioorg Med Chem Lett 17: 3558-61 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265404
PNG
(4-(7-(1-ethylpiperidin-4-yl)-2-(4-fluorophenyl)imi...)
Show SMILES CCN1CCC(CC1)c1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C24H25FN6/c1-2-30-12-8-16(9-13-30)18-10-14-31-21(15-18)29-22(17-3-5-19(25)6-4-17)23(31)20-7-11-27-24(26)28-20/h3-7,10-11,14-16H,2,8-9,12-13H2,1H3,(H2,26,27,28)
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n/an/a 0.110n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50182362
PNG
(4-(7-((dimethylamino)methyl)-2-(4-fluorophenyl)H-i...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C20H19FN6/c1-26(2)12-13-8-10-27-17(11-13)25-18(14-3-5-15(21)6-4-14)19(27)16-7-9-23-20(22)24-16/h3-11H,12H2,1-2H3,(H2,22,23,24)
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n/an/a 0.110n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against PKG


Bioorg Med Chem Lett 16: 2479-83 (2006)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210486
PNG
((3,5-difluorobenzyl)-{4-[7-dimethylaminomethyl-2-(...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2cc(F)cc(F)c2)n1
Show InChI InChI=1S/C27H23F3N6/c1-35(2)16-17-8-10-36-24(13-17)34-25(19-3-5-20(28)6-4-19)26(36)23-7-9-31-27(33-23)32-15-18-11-21(29)14-22(30)12-18/h3-14H,15-16H2,1-2H3,(H,31,32,33)
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n/an/a 0.110n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265403
PNG
(4-{2-(4-Fluorophenyl)-7-[1-(2-methylpentyl)piperid...)
Show SMILES CCCC(C)CN1CCC(CC1)c1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C28H33FN6/c1-3-4-19(2)18-34-14-10-20(11-15-34)22-12-16-35-25(17-22)33-26(21-5-7-23(29)8-6-21)27(35)24-9-13-31-28(30)32-24/h5-9,12-13,16-17,19-20H,3-4,10-11,14-15,18H2,1-2H3,(H2,30,31,32)
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n/an/a 0.120n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50265426
PNG
(4-[2-(4-Fluorophenyl)-7-(1-isobutylpiperidin-4-yl)...)
Show SMILES CC(C)CN1CCC(CC1)c1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(N)n1
Show InChI InChI=1S/C26H29FN6/c1-17(2)16-32-12-8-18(9-13-32)20-10-14-33-23(15-20)31-24(19-3-5-21(27)6-4-19)25(33)22-7-11-29-26(28)30-22/h3-7,10-11,14-15,17-18H,8-9,12-13,16H2,1-2H3,(H2,28,29,30)
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n/an/a 0.120n/an/an/an/an/an/a



SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase


Eur J Med Chem 43: 1123-51 (2008)

More data for this
Ligand-Target Pair
cGMP-dependent protein kinase


(Eimeria tenella)
BDBM50210488
PNG
((2,3-difluorobenzyl)-{4-[7-dimethylaminomethyl-2-(...)
Show SMILES CN(C)Cc1ccn2c(c(nc2c1)-c1ccc(F)cc1)-c1ccnc(NCc2cccc(F)c2F)n1
Show InChI InChI=1S/C27H23F3N6/c1-35(2)16-17-11-13-36-23(14-17)34-25(18-6-8-20(28)9-7-18)26(36)22-10-12-31-27(33-22)32-15-19-4-3-5-21(29)24(19)30/h3-14H,15-16H2,1-2H3,(H,31,32,33)
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SCYNEXIS, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Eimeria tenella cGMP-dependent protein kinase by Ten_K assay


Eur J Med Chem 42: 1334-57 (2007)

More data for this
Ligand-Target Pair
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