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Compile Data Set for Download or QSAR

Found 49 hits Enz. Inhib. hit(s) with Target = 'CGMP-dependent protein kinase' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 18n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 18n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 18n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Bioorg Med Chem Lett 5: 55-60 (1995)

More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3040
PNG
(23-(3-aminopropyl)-3-methyl-3,13,23-triazahexacycl...)
Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCCN)c3c12
Show InChI InChI=1S/C24H22N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,11-13,25H2,1H3,(H,26,29)
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n/an/a 220n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Bioorg Med Chem Lett 5: 55-60 (1995)

More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3040
PNG
(23-(3-aminopropyl)-3-methyl-3,13,23-triazahexacycl...)
Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCCN)c3c12
Show InChI InChI=1S/C24H22N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,11-13,25H2,1H3,(H,26,29)
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n/an/a 220n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50280868
PNG
(12-(2,3-dihydroxypropyl)-6,7,12,13-tetrahydro-5H-i...)
Show SMILES OCC(O)Cn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4[nH]c3c12
Show InChI InChI=1S/C23H19N3O3/c27-11-12(28)10-26-17-8-4-2-6-14(17)18-15-9-24-23(29)20(15)19-13-5-1-3-7-16(13)25-21(19)22(18)26/h1-8,12,25,27-28H,9-11H2,(H,24,29)
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n/an/a 280n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50280877
PNG
(2-(5-oxo-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrr...)
Show SMILES O=C1NCc2c1c1c3ccccc3[nH]c1c1n(CCC#N)c3ccccc3c21
Show InChI InChI=1S/C23H16N4O/c24-10-5-11-27-17-9-4-2-7-14(17)18-15-12-25-23(28)20(15)19-13-6-1-3-8-16(13)26-21(19)22(18)27/h1-4,6-9,26H,5,11-12H2,(H,25,28)
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n/an/a 320n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50280876
PNG
(12-methyl-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyr...)
Show SMILES Cn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4[nH]c3c12
Show InChI InChI=1S/C21H15N3O/c1-24-15-9-5-3-7-12(15)16-13-10-22-21(25)18(13)17-11-6-2-4-8-14(11)23-19(17)20(16)24/h2-9,23H,10H2,1H3,(H,22,25)
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n/an/a 400n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM10840
PNG
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
Show SMILES Nc1nccc(n1)-c1c[nH]c2ccc(Br)cc12
Show InChI InChI=1S/C12H9BrN4/c13-7-1-2-10-8(5-7)9(6-16-10)11-3-4-15-12(14)17-11/h1-6,16H,(H2,14,15,17)
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PubMed
n/an/a 400n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3036
PNG
(23-[3-(dimethylamino)propyl]-3,13,23-triazahexacyc...)
Show SMILES CN(C)CCCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4[nH]c3c12
Show InChI InChI=1S/C25H24N4O/c1-28(2)12-7-13-29-19-11-6-4-9-16(19)20-17-14-26-25(30)22(17)21-15-8-3-5-10-18(15)27-23(21)24(20)29/h3-6,8-11,27H,7,12-14H2,1-2H3,(H,26,30)
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n/an/a 420n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3036
PNG
(23-[3-(dimethylamino)propyl]-3,13,23-triazahexacyc...)
Show SMILES CN(C)CCCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4[nH]c3c12
Show InChI InChI=1S/C25H24N4O/c1-28(2)12-7-13-29-19-11-6-4-9-16(19)20-17-14-26-25(30)22(17)21-15-8-3-5-10-18(15)27-23(21)24(20)29/h3-6,8-11,27H,7,12-14H2,1-2H3,(H,26,30)
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n/an/a 420n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Bioorg Med Chem Lett 5: 55-60 (1995)

More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM10842
PNG
(3-(2-aminopyrimidin-4-yl)-7-bromo-1H-indol-4-ol | ...)
Show SMILES Nc1nccc(n1)-c1c[nH]c2c(Br)ccc(O)c12
Show InChI InChI=1S/C12H9BrN4O/c13-7-1-2-9(18)10-6(5-16-11(7)10)8-3-4-15-12(14)17-8/h1-5,16,18H,(H2,14,15,17)
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n/an/a 600n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM10843
PNG
(4-(5,6-dibromo-1H-indol-3-yl)pyrimidin-2-amine | M...)
Show SMILES Nc1nccc(n1)-c1c[nH]c2cc(Br)c(Br)cc12
Show InChI InChI=1S/C12H8Br2N4/c13-8-3-6-7(5-17-11(6)4-9(8)14)10-1-2-16-12(15)18-10/h1-5,17H,(H2,15,16,18)
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n/an/a 600n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM2581
PNG
(3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)
Show SMILES O=C1NCc2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)
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n/an/a 650n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50280879
PNG
(12,13-diethyl-6,7,12,13-tetrahydro-5H-indolo[2,3-a...)
Show SMILES CCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(CC)c3c12
Show InChI InChI=1S/C24H21N3O/c1-3-26-17-11-7-5-9-14(17)19-16-13-25-24(28)21(16)20-15-10-6-8-12-18(15)27(4-2)23(20)22(19)26/h5-12H,3-4,13H2,1-2H3,(H,25,28)
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n/an/a 700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50280870
PNG
(12-(2,2-difluoroethyl)-13-methyl-6,7,12,13-tetrahy...)
Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CC(F)F)c3c12
Show InChI InChI=1S/C23H17F2N3O/c1-27-15-8-4-2-6-12(15)19-20-14(10-26-23(20)29)18-13-7-3-5-9-16(13)28(11-17(24)25)22(18)21(19)27/h2-9,17H,10-11H2,1H3,(H,26,29)
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n/an/a 710n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM10841
PNG
(4-(6-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
Show SMILES Nc1nccc(n1)-c1c[nH]c2cc(Br)ccc12
Show InChI InChI=1S/C12H9BrN4/c13-7-1-2-8-9(6-16-11(8)5-7)10-3-4-15-12(14)17-10/h1-6,16H,(H2,14,15,17)
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n/an/a 800n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3039
PNG
(23-[3-(dimethylamino)propyl]-3-methyl-3,13,23-tria...)
Show SMILES CN(C)CCCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(C)c3c12
Show InChI InChI=1S/C26H26N4O/c1-28(2)13-8-14-30-20-12-7-5-10-17(20)21-18-15-27-26(31)23(18)22-16-9-4-6-11-19(16)29(3)24(22)25(21)30/h4-7,9-12H,8,13-15H2,1-3H3,(H,27,31)
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n/an/a 870n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Bioorg Med Chem Lett 5: 55-60 (1995)

More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3039
PNG
(23-[3-(dimethylamino)propyl]-3-methyl-3,13,23-tria...)
Show SMILES CN(C)CCCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(C)c3c12
Show InChI InChI=1S/C26H26N4O/c1-28(2)13-8-14-30-20-12-7-5-10-17(20)21-18-15-27-26(31)23(18)22-16-9-4-6-11-19(16)29(3)24(22)25(21)30/h4-7,9-12H,8,13-15H2,1-3H3,(H,27,31)
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n/an/a 870n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM10839
PNG
(3-(2-aminopyrimidin-4-yl)-6-bromo-1H-indol-4-ol | ...)
Show SMILES Nc1nccc(n1)-c1c[nH]c2cc(Br)cc(O)c12
Show InChI InChI=1S/C12H9BrN4O/c13-6-3-9-11(10(18)4-6)7(5-16-9)8-1-2-15-12(14)17-8/h1-5,16,18H,(H2,14,15,17)
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n/an/a 1.00E+3n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50284317
PNG
(3-(9-methoxy-13-methyl-5,7-dioxo-6,7,12,13-tetrahy...)
Show SMILES COc1ccc2n(CCCC#N)c3c(c4C(=O)NC(=O)c4c4c5ccccc5n(C)c34)c2c1
Show InChI InChI=1S/C26H20N4O3/c1-29-17-8-4-3-7-15(17)19-21-22(26(32)28-25(21)31)20-16-13-14(33-2)9-10-18(16)30(12-6-5-11-27)24(20)23(19)29/h3-4,7-10,13H,5-6,12H2,1-2H3,(H,28,31,32)
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n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3047
PNG
(4-{19-methoxy-23-methyl-12,14-dioxo-3,13,23-triaza...)
Show SMILES COc1ccc2n(C)c3c(c4C(=O)NC(=O)c4c4c5ccccc5n(CCCC#N)c34)c2c1
Show InChI InChI=1S/C26H20N4O3/c1-29-17-10-9-14(33-2)13-16(17)20-22-21(25(31)28-26(22)32)19-15-7-3-4-8-18(15)30(12-6-5-11-27)24(19)23(20)29/h3-4,7-10,13H,5-6,12H2,1-2H3,(H,28,31,32)
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n/an/a 1.00E+3n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50280873
PNG
(2-(13-ethyl-5-oxo-6,7,12,13-tetrahydro-5H-indolo[2...)
Show SMILES CCn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12
Show InChI InChI=1S/C25H20N4O/c1-2-28-18-10-5-4-9-16(18)21-22-17(14-27-25(22)30)20-15-8-3-6-11-19(15)29(13-7-12-26)23(20)24(21)28/h3-6,8-11H,2,7,13-14H2,1H3,(H,27,30)
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n/an/a 1.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3034
PNG
(3-{7,19-dimethoxy-23-methyl-14-oxo-3,13,23-triazah...)
Show SMILES COc1ccc2n(C)c3c(c4C(=O)NCc4c4c5cc(OC)ccc5n(CCC#N)c34)c2c1
Show InChI InChI=1S/C26H22N4O3/c1-29-19-7-5-14(32-2)11-16(19)22-23-18(13-28-26(23)31)21-17-12-15(33-3)6-8-20(17)30(10-4-9-27)25(21)24(22)29/h5-8,11-12H,4,10,13H2,1-3H3,(H,28,31)
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n/an/a 2.00E+3n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Bioorg Med Chem Lett 5: 55-60 (1995)

More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3034
PNG
(3-{7,19-dimethoxy-23-methyl-14-oxo-3,13,23-triazah...)
Show SMILES COc1ccc2n(C)c3c(c4C(=O)NCc4c4c5cc(OC)ccc5n(CCC#N)c34)c2c1
Show InChI InChI=1S/C26H22N4O3/c1-29-19-7-5-14(32-2)11-16(19)22-23-18(13-28-26(23)31)21-17-12-15(33-3)6-8-20(17)30(10-4-9-27)25(21)24(22)29/h5-8,11-12H,4,10,13H2,1-3H3,(H,28,31)
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3048
PNG
(23-[3-(dimethylamino)-2-hydroxypropyl]-3-methyl-3,...)
Show SMILES CN(C)CC(O)Cn1c2ccccc2c2c3C(=O)NC(=O)c3c3c4ccccc4n(C)c3c12
Show InChI InChI=1S/C26H24N4O3/c1-28(2)12-14(31)13-30-18-11-7-5-9-16(18)20-22-21(25(32)27-26(22)33)19-15-8-4-6-10-17(15)29(3)23(19)24(20)30/h4-11,14,31H,12-13H2,1-3H3,(H,27,32,33)
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n/an/a 2.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3048
PNG
(23-[3-(dimethylamino)-2-hydroxypropyl]-3-methyl-3,...)
Show SMILES CN(C)CC(O)Cn1c2ccccc2c2c3C(=O)NC(=O)c3c3c4ccccc4n(C)c3c12
Show InChI InChI=1S/C26H24N4O3/c1-28(2)12-14(31)13-30-18-11-7-5-9-16(18)20-22-21(25(32)27-26(22)33)19-15-8-4-6-10-17(15)29(3)23(19)24(20)30/h4-11,14,31H,12-13H2,1-3H3,(H,27,32,33)
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n/an/a 2.10E+3n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3045
PNG
(3-{19-methoxy-23-methyl-12,14-dioxo-3,13,23-triaza...)
Show SMILES COc1ccc2n(C)c3c(c4C(=O)NC(=O)c4c4c5ccccc5n(CCC#N)c34)c2c1
Show InChI InChI=1S/C25H18N4O3/c1-28-16-9-8-13(32-2)12-15(16)19-21-20(24(30)27-25(21)31)18-14-6-3-4-7-17(14)29(11-5-10-26)23(18)22(19)28/h3-4,6-9,12H,5,11H2,1-2H3,(H,27,30,31)
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n/an/a>3.00E+3n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3044
PNG
(3-{7-methoxy-23-methyl-12,14-dioxo-3,13,23-triazah...)
Show SMILES COc1ccc2n(CCC#N)c3c(c4C(=O)NC(=O)c4c4c5ccccc5n(C)c34)c2c1
Show InChI InChI=1S/C25H18N4O3/c1-28-16-7-4-3-6-14(16)18-20-21(25(31)27-24(20)30)19-15-12-13(32-2)8-9-17(15)29(11-5-10-26)23(19)22(18)28/h3-4,6-9,12H,5,11H2,1-2H3,(H,27,30,31)
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n/an/a>3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3049
PNG
(23-[3-(dimethylamino)-2-hydroxypropyl]-7-methoxy-3...)
Show SMILES COc1ccc2n(C)c3c(c4C(=O)NC(=O)c4c4c5ccccc5n(CC(O)CN(C)C)c34)c2c1
Show InChI InChI=1S/C27H26N4O4/c1-29(2)12-14(32)13-31-19-8-6-5-7-16(19)20-22-23(27(34)28-26(22)33)21-17-11-15(35-4)9-10-18(17)30(3)24(21)25(20)31/h5-11,14,32H,12-13H2,1-4H3,(H,28,33,34)
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n/an/a 4.80E+3n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50284318
PNG
(13-(3-dimethylamino-2-hydroxypropyl)-3-methoxy-12-...)
Show SMILES COc1ccc2n(CC(O)CN(C)C)c3c(c4C(=O)NC(=O)c4c4c5ccccc5n(C)c34)c2c1
Show InChI InChI=1S/C27H26N4O4/c1-29(2)12-14(32)13-31-19-10-9-15(35-4)11-17(19)21-23-22(26(33)28-27(23)34)20-16-7-5-6-8-18(16)30(3)24(20)25(21)31/h5-11,14,32H,12-13H2,1-4H3,(H,28,33,34)
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n/an/a 4.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50280869
PNG
(13-methyl-12-propyl-6,7,12,13-tetrahydro-5H-indolo...)
Show SMILES CCCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(C)c3c12
Show InChI InChI=1S/C24H21N3O/c1-3-12-27-18-11-7-5-9-15(18)19-16-13-25-24(28)21(16)20-14-8-4-6-10-17(14)26(2)22(20)23(19)27/h4-11H,3,12-13H2,1-2H3,(H,25,28)
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n/an/a 5.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50280878
PNG
(12,13-dimethyl-6,7,12,13-tetrahydro-5H-indolo[2,3-...)
Show SMILES Cn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(C)c3c12
Show InChI InChI=1S/C22H17N3O/c1-24-15-9-5-3-7-12(15)17-14-11-23-22(26)19(14)18-13-8-4-6-10-16(13)25(2)21(18)20(17)24/h3-10H,11H2,1-2H3,(H,23,26)
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n/an/a 5.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3033
PNG
(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12
Show InChI InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
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n/an/a 6.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3033
PNG
(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12
Show InChI InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
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n/an/a 6.20E+3n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Bioorg Med Chem Lett 5: 55-60 (1995)

More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3033
PNG
(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Show SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12
Show InChI InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
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n/an/a 6.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3043
PNG
(3-{23-methyl-12,14-dioxo-3,13,23-triazahexacyclo[1...)
Show SMILES Cn1c2ccccc2c2c3C(=O)NC(=O)c3c3c4ccccc4n(CCC#N)c3c12
Show InChI InChI=1S/C24H16N4O2/c1-27-15-9-4-2-7-13(15)17-19-20(24(30)26-23(19)29)18-14-8-3-5-10-16(14)28(12-6-11-25)22(18)21(17)27/h2-5,7-10H,6,12H2,1H3,(H,26,29,30)
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n/an/a 7.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3043
PNG
(3-{23-methyl-12,14-dioxo-3,13,23-triazahexacyclo[1...)
Show SMILES Cn1c2ccccc2c2c3C(=O)NC(=O)c3c3c4ccccc4n(CCC#N)c3c12
Show InChI InChI=1S/C24H16N4O2/c1-27-15-9-4-2-7-13(15)17-19-20(24(30)26-23(19)29)18-14-8-3-5-10-16(14)28(12-6-11-25)22(18)21(17)27/h2-5,7-10H,6,12H2,1H3,(H,26,29,30)
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n/an/a 7.20E+3n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3041
PNG
(23-[3-(dimethylamino)-2-hydroxypropyl]-3-methyl-3,...)
Show SMILES CN(C)CC(O)Cn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(C)c3c12
Show InChI InChI=1S/C26H26N4O2/c1-28(2)13-15(31)14-30-20-11-7-5-9-17(20)21-18-12-27-26(32)23(18)22-16-8-4-6-10-19(16)29(3)24(22)25(21)30/h4-11,15,31H,12-14H2,1-3H3,(H,27,32)
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n/an/a 9.40E+3n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3041
PNG
(23-[3-(dimethylamino)-2-hydroxypropyl]-3-methyl-3,...)
Show SMILES CN(C)CC(O)Cn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4n(C)c3c12
Show InChI InChI=1S/C26H26N4O2/c1-28(2)13-15(31)14-30-20-11-7-5-9-17(20)21-18-12-27-26(32)23(18)22-16-8-4-6-10-19(16)29(3)24(22)25(21)30/h4-11,15,31H,12-14H2,1-3H3,(H,27,32)
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n/an/a 9.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50280874
PNG
(3-(5-oxo-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrr...)
Show SMILES OC(=O)CCn1c2ccccc2c2c3CNC(=O)c3c3c4ccccc4[nH]c3c12
Show InChI InChI=1S/C23H17N3O3/c27-17(28)9-10-26-16-8-4-2-6-13(16)18-14-11-24-23(29)20(14)19-12-5-1-3-7-15(12)25-21(19)22(18)26/h1-8,25H,9-11H2,(H,24,29)(H,27,28)
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n/an/a 2.10E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50284316
PNG
(12-(3-dimethylamino-2-hydroxypropyl)-9-methoxy-13-...)
Show SMILES COc1ccc2n(CC(O)CN(C)C)c3c(c4CNC(=O)c4c4c5ccccc5n(C)c34)c2c1
Show InChI InChI=1S/C27H28N4O3/c1-29(2)13-15(32)14-31-21-10-9-16(34-4)11-18(21)22-19-12-28-27(33)24(19)23-17-7-5-6-8-20(17)30(3)25(23)26(22)31/h5-11,15,32H,12-14H2,1-4H3,(H,28,33)
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n/an/a 2.30E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of cGMP-dependent protein kinase from bovine lung


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM3042
PNG
(23-[3-(dimethylamino)-2-hydroxypropyl]-7-methoxy-3...)
Show SMILES COc1ccc2n(C)c3c(c4C(=O)NCc4c4c5ccccc5n(CC(O)CN(C)C)c34)c2c1
Show InChI InChI=1S/C27H28N4O3/c1-29(2)13-15(32)14-31-21-8-6-5-7-17(21)22-19-12-28-27(33)24(19)23-18-11-16(34-4)9-10-20(18)30(3)25(23)26(22)31/h5-11,15,32H,12-14H2,1-4H3,(H,28,33)
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n/an/a 2.30E+4n/an/an/an/a7.430



Tumor Biology Center



Assay Description
The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM50280867
PNG
(2-(6,13-dimethyl-5-oxo-6,7,12,13-tetrahydro-5H-ind...)
Show SMILES CN1Cc2c(C1=O)c1c3ccccc3n(C)c1c1n(CCC#N)c3ccccc3c21
Show InChI InChI=1S/C25H20N4O/c1-27-14-17-20-16-9-4-6-11-19(16)29(13-7-12-26)24(20)23-21(22(17)25(27)30)15-8-3-5-10-18(15)28(23)2/h3-6,8-11H,7,13-14H2,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM10838
PNG
(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12
Show InChI InChI=1S/C12H10N4O/c13-12-14-5-4-8(16-12)7-6-15-9-2-1-3-10(17)11(7)9/h1-6,15,17H,(H2,13,14,16)
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n/an/a 2.00E+5n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM10844
PNG
(4-(1H-indol-3-yl)pyrimidin-2-amine | Meridianin G)
Show SMILES Nc1nccc(n1)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C12H10N4/c13-12-14-6-5-11(16-12)9-7-15-10-4-2-1-3-8(9)10/h1-7,15H,(H2,13,14,16)
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PubMed
n/an/a 4.00E+5n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM7533
PNG
((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
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n/an/a>1.00E+6n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM10845
PNG
(4-(5-bromo-1H-indol-2-yl)pyrimidin-2-amine | isome...)
Show SMILES Nc1nccc(n1)-c1cc2cc(Br)ccc2[nH]1
Show InChI InChI=1S/C12H9BrN4/c13-8-1-2-9-7(5-8)6-11(16-9)10-3-4-15-12(14)17-10/h1-6,16H,(H2,14,15,17)
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n/an/a>1.00E+6n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Citation and Details
More data for this
Ligand-Target Pair
cGMP-Dependent Protein Kinase


(Bos taurus (bovine))
BDBM10846
PNG
(4-(1H-indol-2-yl)pyrimidin-2-amine | isomeridianin...)
Show SMILES Nc1nccc(n1)-c1cc2ccccc2[nH]1
Show InChI InChI=1S/C12H10N4/c13-12-14-6-5-10(16-12)11-7-8-3-1-2-4-9(8)15-11/h1-7,15H,(H2,13,14,16)
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n/an/a 1.00E+6n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Citation and Details
More data for this
Ligand-Target Pair