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Compile Data Set for Download or QSAR

Found 1639 hits Enz. Inhib. hit(s) with Target = 'CREB-binding protein'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM50443232
PNG
(CHEMBL3086883)
Show SMILES Cc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)cc1O
Show InChI InChI=1S/C18H17N5O3S/c1-12-10-16(15(19)11-17(12)24)22-21-13-5-7-14(8-6-13)27(25,26)23-18-4-2-3-9-20-18/h2-11,24H,19H2,1H3,(H,20,23)
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2.18E+3n/an/an/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Displacement of fluorescein-labeled MS226 from recombinant human CBP bromodomain after 1 hr by fluorescence anisotropy assay


J Med Chem 56: 9251-64 (2013)


Article DOI: 10.1021/jm401334s
BindingDB Entry DOI: 10.7270/Q2ZW1NCF
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50443231
PNG
(CHEMBL3086884)
Show SMILES Cc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)c(C)c1O
Show InChI InChI=1S/C19H19N5O3S/c1-12-11-16(18(20)13(2)19(12)25)23-22-14-6-8-15(9-7-14)28(26,27)24-17-5-3-4-10-21-17/h3-11,25H,20H2,1-2H3,(H,21,24)
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5.12E+3n/an/an/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Displacement of fluorescein-labeled MS226 from recombinant human CBP bromodomain after 1 hr by fluorescence anisotropy assay


J Med Chem 56: 9251-64 (2013)


Article DOI: 10.1021/jm401334s
BindingDB Entry DOI: 10.7270/Q2ZW1NCF
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50443230
PNG
(CHEMBL3086885)
Show SMILES Cc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)c(Cl)c1O
Show InChI InChI=1S/C18H16ClN5O3S/c1-11-10-14(17(20)16(19)18(11)25)23-22-12-5-7-13(8-6-12)28(26,27)24-15-4-2-3-9-21-15/h2-10,25H,20H2,1H3,(H,21,24)
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5.59E+3n/an/an/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Displacement of fluorescein-labeled MS226 from recombinant human CBP bromodomain after 1 hr by fluorescence anisotropy assay


J Med Chem 56: 9251-64 (2013)


Article DOI: 10.1021/jm401334s
BindingDB Entry DOI: 10.7270/Q2ZW1NCF
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50443233
PNG
(CHEMBL3087052)
Show SMILES Cc1cc(cc(C)c1O)N=Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1
Show InChI InChI=1S/C19H18N4O3S/c1-13-11-16(12-14(2)19(13)24)22-21-15-6-8-17(9-7-15)27(25,26)23-18-5-3-4-10-20-18/h3-12,24H,1-2H3,(H,20,23)
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7.15E+3n/an/an/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Displacement of fluorescein-labeled MS226 from recombinant human CBP bromodomain after 1 hr by fluorescence anisotropy assay


J Med Chem 56: 9251-64 (2013)


Article DOI: 10.1021/jm401334s
BindingDB Entry DOI: 10.7270/Q2ZW1NCF
More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50229787
PNG
((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Show SMILES COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Induction of p53-Ser15 phosphorylation in human HCT116 cells after 24 hrs


J Med Chem 52: 7044-53 (2009)


Article DOI: 10.1021/jm900681h
BindingDB Entry DOI: 10.7270/Q2ZK5GRQ
More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50025671
PNG
(CHEMBL583413)
Show SMILES CN1c2ncnn2C(C2=C1c1cc(C)ccc1OC2c1ccc(Br)cc1)c1ccc(Br)cc1
Show InChI InChI=1S/C26H20Br2N4O/c1-15-3-12-21-20(13-15)24-22(25(33-21)17-6-10-19(28)11-7-17)23(16-4-8-18(27)9-5-16)32-26(31(24)2)29-14-30-32/h3-14,23,25H,1-2H3
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Induction of p53-Ser15 phosphorylation in human HCT116 cells after 24 hrs


J Med Chem 52: 7044-53 (2009)


Article DOI: 10.1021/jm900681h
BindingDB Entry DOI: 10.7270/Q2ZK5GRQ
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340748
PNG
(US9763922, Example 274)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCN(CC1)C(C)=O
Show InChI InChI=1S/C26H31F3N8O2/c1-15(38)35-7-4-17(5-8-35)37-23-6-9-36(26(39)30-2)14-20(23)25(33-37)32-22-11-19(24(28)29)18(10-21(22)27)16-12-31-34(3)13-16/h10-13,17,24H,4-9,14H2,1-3H3,(H,30,39)(H,32,33)
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n/an/a 1n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340734
PNG
(3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyrazol-...)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCOCC1
Show InChI InChI=1S/C24H28F3N7O2/c1-28-24(35)33-6-3-21-18(13-33)23(31-34(21)15-4-7-36-8-5-15)30-20-10-17(22(26)27)16(9-19(20)25)14-11-29-32(2)12-14/h9-12,15,22H,3-8,13H2,1-2H3,(H,28,35)(H,30,31)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50229787
PNG
((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)
Show SMILES COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1
Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...


J Med Chem 52: 7044-53 (2009)


Article DOI: 10.1021/jm900681h
BindingDB Entry DOI: 10.7270/Q2ZK5GRQ
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340716
PNG
(1-[3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyraz...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCOCC1
Show InChI InChI=1S/C24H27F3N6O2/c1-14(34)32-6-3-22-19(13-32)24(30-33(22)16-4-7-35-8-5-16)29-21-10-18(23(26)27)17(9-20(21)25)15-11-28-31(2)12-15/h9-12,16,23H,3-8,13H2,1-2H3,(H,29,30)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340730
PNG
(3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyrazol-...)
Show SMILES Cn1cc(cn1)-c1cc(F)c(Nc2nn(C3CCOCC3)c3CCN(Cc23)C(N)=O)cc1C(F)F
Show InChI InChI=1S/C23H26F3N7O2/c1-31-11-13(10-28-31)15-8-18(24)19(9-16(15)21(25)26)29-22-17-12-32(23(27)34)5-2-20(17)33(30-22)14-3-6-35-7-4-14/h8-11,14,21H,2-7,12H2,1H3,(H2,27,34)(H,29,30)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340747
PNG
(3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyrazol-...)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C24H28F3N7O3S/c1-28-24(35)33-6-3-21-18(13-33)23(31-34(21)15-4-7-38(36,37)8-5-15)30-20-10-17(22(26)27)16(9-19(20)25)14-11-29-32(2)12-14/h9-12,15,22H,3-8,13H2,1-2H3,(H,28,35)(H,30,31)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340746
PNG
(US9763922, Example 272)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1ccc(nc1)C(=O)NC)nn2C1CCOCC1
Show InChI InChI=1S/C27H30F3N7O3/c1-31-26(38)21-4-3-15(13-33-21)17-11-20(28)22(12-18(17)24(29)30)34-25-19-14-36(27(39)32-2)8-5-23(19)37(35-25)16-6-9-40-10-7-16/h3-4,11-13,16,24H,5-10,14H2,1-2H3,(H,31,38)(H,32,39)(H,34,35)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340740
PNG
(US9763922, Example 266)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1ccnc(OC)c1)nn2C1CCOCC1
Show InChI InChI=1S/C26H29F3N6O3/c1-30-26(36)34-8-4-22-19(14-34)25(33-35(22)16-5-9-38-10-6-16)32-21-13-18(24(28)29)17(12-20(21)27)15-3-7-31-23(11-15)37-2/h3,7,11-13,16,24H,4-6,8-10,14H2,1-2H3,(H,30,36)(H,32,33)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50025671
PNG
(CHEMBL583413)
Show SMILES CN1c2ncnn2C(C2=C1c1cc(C)ccc1OC2c1ccc(Br)cc1)c1ccc(Br)cc1
Show InChI InChI=1S/C26H20Br2N4O/c1-15-3-12-21-20(13-15)24-22(25(33-21)17-6-10-19(28)11-7-17)23(16-4-8-18(27)9-5-16)32-26(31(24)2)29-14-30-32/h3-14,23,25H,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...


J Med Chem 52: 7044-53 (2009)


Article DOI: 10.1021/jm900681h
BindingDB Entry DOI: 10.7270/Q2ZK5GRQ
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340731
PNG
(US9763922, Example 257)
Show SMILES Cn1cc(cn1)-c1cc(F)c(Nc2nn([C@H]3CCOC3)c3CCN(Cc23)C(N)=O)cc1C(F)F
Show InChI InChI=1S/C22H24F3N7O2/c1-30-9-12(8-27-30)14-6-17(23)18(7-15(14)20(24)25)28-21-16-10-31(22(26)33)4-2-19(16)32(29-21)13-3-5-34-11-13/h6-9,13,20H,2-5,10-11H2,1H3,(H2,26,33)(H,28,29)/t13-/m0/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340735
PNG
(US9763922, Example 261)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2[C@H]1CCOC1
Show InChI InChI=1S/C23H26F3N7O2/c1-27-23(34)32-5-3-20-17(11-32)22(30-33(20)14-4-6-35-12-14)29-19-8-16(21(25)26)15(7-18(19)24)13-9-28-31(2)10-13/h7-10,14,21H,3-6,11-12H2,1-2H3,(H,27,34)(H,29,30)/t14-/m0/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340745
PNG
(US9763922, Example 271)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(cc(c1)S(=O)(=O)N(C)C)-c1cnn(C)c1)nn2C1CCOCC1
Show InChI InChI=1S/C25H34N8O4S/c1-26-25(34)32-8-5-23-22(16-32)24(29-33(23)20-6-9-37-10-7-20)28-19-11-17(18-14-27-31(4)15-18)12-21(13-19)38(35,36)30(2)3/h11-15,20H,5-10,16H2,1-4H3,(H,26,34)(H,28,29)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349503
PNG
(5-[7-(difluoromethyl)-1-[(4R)-4-methyl-2-oxo-1,3,4...)
Show SMILES CNC(=O)c1ccc(cn1)-c1cc2CCCN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C27H27F2N5O2/c1-15-11-24(35)33-20-6-3-7-22(25(20)32-15)34-10-4-5-16-12-18(19(26(28)29)13-23(16)34)17-8-9-21(31-14-17)27(36)30-2/h3,6-9,12-15,26,32H,4-5,10-11H2,1-2H3,(H,30,36)(H,33,35)/t15-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)


Article DOI: 10.1021/jm060653b
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349496
PNG
((difluoromethyl)-5-(1- | US10206931, Example 304)
Show SMILES CN\C=C(/C=N)c1cc2CCN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C23H25F2N5O/c1-13-8-21(31)29-18-4-3-5-19(22(18)28-13)30-7-6-14-9-16(15(11-26)12-27-2)17(23(24)25)10-20(14)30/h3-5,9-13,23,26-28H,6-8H2,1-2H3,(H,29,31)/b15-12+,26-11?/t13-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)


Article DOI: 10.1021/jm060653b
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349498
PNG
(1-methyl-4-[(4R)-4-methyl-2-oxo-1,3,4,5-tetrahydro...)
Show SMILES CN\C=C(/C=N)c1cc2N(C)CCN(c3cccc4NC(=O)C[C@@H](C)Nc34)c2cc1C#N
Show InChI InChI=1S/C24H27N7O/c1-15-9-23(32)29-19-5-4-6-20(24(19)28-15)31-8-7-30(3)21-11-18(17(13-26)14-27-2)16(12-25)10-22(21)31/h4-6,10-11,13-15,26-28H,7-9H2,1-3H3,(H,29,32)/b17-14+,26-13?/t15-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)


Article DOI: 10.1021/jm060653b
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349500
PNG
((R,R)-6-[7-(difluoromethyl)-4-methyl-6-(l-methylpy...)
Show SMILES CN\C=C(/C=N)c1cc2[C@@H](C)CCN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C25H29F2N5O/c1-14-7-8-32(21-6-4-5-20-24(21)30-15(2)9-23(33)31-20)22-11-19(25(26)27)18(10-17(14)22)16(12-28)13-29-3/h4-6,10-15,25,28-30H,7-9H2,1-3H3,(H,31,33)/b16-13+,28-12?/t14-,15+/m0/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)


Article DOI: 10.1021/jm060653b
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349483
PNG
((difluoromethyl)-6-(1- | US10206931, Example 291)
Show SMILES CN\C=C(/C=N)c1cc2CCCN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C24H27F2N5O/c1-14-9-22(32)30-19-6-3-7-20(23(19)29-14)31-8-4-5-15-10-17(16(12-27)13-28-2)18(24(25)26)11-21(15)31/h3,6-7,10-14,24,27-29H,4-5,8-9H2,1-2H3,(H,30,32)/b16-13+,27-12?/t14-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)


Article DOI: 10.1021/jm060653b
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340726
PNG
(1-[3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyraz...)
Show SMILES CCC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCOCC1
Show InChI InChI=1S/C25H29F3N6O2/c1-3-23(35)33-7-4-22-19(14-33)25(31-34(22)16-5-8-36-9-6-16)30-21-11-18(24(27)28)17(10-20(21)26)15-12-29-32(2)13-15/h10-13,16,24H,3-9,14H2,1-2H3,(H,30,31)
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n/an/a 4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349497
PNG
((4R)-6-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl...)
Show SMILES CN\C=C(/C=N)c1cc2CCCN(c2cc1C(F)F)c1nccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C23H26F2N6O/c1-13-8-20(32)30-18-5-6-28-23(21(18)29-13)31-7-3-4-14-9-16(15(11-26)12-27-2)17(22(24)25)10-19(14)31/h5-6,9-13,22,26-27,29H,3-4,7-8H2,1-2H3,(H,30,32)/b15-12+,26-11?/t13-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)


Article DOI: 10.1021/jm060653b
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349484
PNG
(US10206931, Example 292 | oxo-1,3,4,5-tetrahydro-)
Show SMILES CN\C=C(/C=N)c1cc2CCCN(c2cc1C#N)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C24H26N6O/c1-15-9-23(31)29-20-6-3-7-21(24(20)28-15)30-8-4-5-16-10-19(18(13-26)14-27-2)17(12-25)11-22(16)30/h3,6-7,10-11,13-15,26-28H,4-5,8-9H2,1-2H3,(H,29,31)/b18-14+,26-13?/t15-/m1/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)


Article DOI: 10.1021/jm060653b
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340742
PNG
(US9763922, Example 268)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(F)c(cc1F)-c1cnn(C)c1)nn2C1CCOCC1
Show InChI InChI=1S/C23H27F2N7O2/c1-26-23(33)31-6-3-21-17(13-31)22(29-32(21)15-4-7-34-8-5-15)28-20-10-18(24)16(9-19(20)25)14-11-27-30(2)12-14/h9-12,15H,3-8,13H2,1-2H3,(H,26,33)(H,28,29)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340743
PNG
(US9763922, Example 269)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C#N)c(cc1F)-c1cnn(C)c1)nn2C1CCOCC1
Show InChI InChI=1S/C24H27FN8O2/c1-27-24(34)32-6-3-22-19(14-32)23(30-33(22)17-4-7-35-8-5-17)29-21-9-15(11-26)18(10-20(21)25)16-12-28-31(2)13-16/h9-10,12-13,17H,3-8,14H2,1-2H3,(H,27,34)(H,29,30)
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n/an/a 5n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340739
PNG
(US9763922, Example 265)
Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cn(C)nc1C(F)(F)F)nn2C1CCOCC1
Show InChI InChI=1S/C24H27F4N7O2/c1-29-23(36)34-8-5-20-17(13-34)22(32-35(20)15-6-9-37-10-7-15)30-19-4-3-14(11-18(19)25)16-12-33(2)31-21(16)24(26,27)28/h3-4,11-12,15H,5-10,13H2,1-2H3,(H,29,36)(H,30,32)
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349491
PNG
((difluoromethyl)-2- | US10206931, Example 299)
Show SMILES CN\C=C(/C=N)c1cc(F)c(Nc2cccc3NC(=O)C[C@@H](C)Nc23)cc1C(F)F
Show InChI InChI=1S/C21H22F3N5O/c1-11-6-19(30)29-17-5-3-4-16(20(17)27-11)28-18-8-14(21(23)24)13(7-15(18)22)12(9-25)10-26-2/h3-5,7-11,21,25-28H,6H2,1-2H3,(H,29,30)/b12-10+,25-9?/t11-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)


Article DOI: 10.1021/jm060653b
More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50299820
PNG
((+/-)-syn-6,7-Bis(4-bromophenyl)-1-ethoxy-12-methy...)
Show SMILES CCOc1cccc2OC(C3=C(N(C)c4ncnn4C3c3ccc(Br)cc3)c12)c1ccc(Br)cc1
Show InChI InChI=1S/C27H22Br2N4O2/c1-3-34-20-5-4-6-21-22(20)25-23(26(35-21)17-9-13-19(29)14-10-17)24(16-7-11-18(28)12-8-16)33-27(32(25)2)30-15-31-33/h4-15,24,26H,3H2,1-2H3
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n/an/a 6.5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...


J Med Chem 52: 7044-53 (2009)


Article DOI: 10.1021/jm900681h
BindingDB Entry DOI: 10.7270/Q2ZK5GRQ
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340698
PNG
(1-[3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyraz...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1COC1
Show InChI InChI=1S/C22H23F3N6O2/c1-12(32)30-4-3-20-17(9-30)22(28-31(20)14-10-33-11-14)27-19-6-16(21(24)25)15(5-18(19)23)13-7-26-29(2)8-13/h5-8,14,21H,3-4,9-11H2,1-2H3,(H,27,28)
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n/an/a 7n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349501
PNG
((R,S)-6-[7-(difluoromethyl)-3-methyl-6-(1-methylpy...)
Show SMILES CN\C=C(/C=N)c1cc2C[C@H](C)CN(c2cc1C(F)F)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C25H29F2N5O/c1-14-7-16-9-18(17(11-28)12-29-3)19(25(26)27)10-22(16)32(13-14)21-6-4-5-20-24(21)30-15(2)8-23(33)31-20/h4-6,9-12,14-15,25,28-30H,7-8,13H2,1-3H3,(H,31,33)/b17-12+,28-11?/t14-,15+/m0/s1
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)


Article DOI: 10.1021/jm060653b
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340715
PNG
(US9763922, Example 241)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCOC1
Show InChI InChI=1S/C23H25F3N6O2/c1-13(33)31-5-3-21-18(11-31)23(29-32(21)15-4-6-34-12-15)28-20-8-17(22(25)26)16(7-19(20)24)14-9-27-30(2)10-14/h7-10,15,22H,3-6,11-12H2,1-2H3,(H,28,29)
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n/an/a 7n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340763
PNG
(US9763922, Example 289)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(-c3cnn(C)c3)c(c1)C(F)F)nn2C1CCOC1
Show InChI InChI=1S/C23H26F2N6O2/c1-14(32)30-7-5-21-20(12-30)23(28-31(21)17-6-8-33-13-17)27-16-3-4-18(19(9-16)22(24)25)15-10-26-29(2)11-15/h3-4,9-11,17,22H,5-8,12-13H2,1-2H3,(H,27,28)
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n/an/a 8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349486
PNG
(US10206931, Example 294 | methyl-6-(1-)
Show SMILES CN\C=C(/C=N)c1ccc2N(CC[C@H](C)c2c1)c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1S/C24H29N5O/c1-15-9-10-29(21-8-7-17(12-19(15)21)18(13-25)14-26-3)22-6-4-5-20-24(22)27-16(2)11-23(30)28-20/h4-8,12-16,25-27H,9-11H2,1-3H3,(H,28,30)/b18-14+,25-13?/t15-,16+/m0/s1
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n/an/a 9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)


Article DOI: 10.1021/jm060653b
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349504
PNG
((4R)-4-methyl-6-[3-(1-methylpyrazol-1-yl)-8-isoqui...)
Show SMILES CN\C=C(/C=N)c1cc2cccc(-c3cccc4NC(=O)C[C@@H](C)Nc34)c2cn1
Show InChI InChI=1S/C23H23N5O/c1-14-9-22(29)28-20-8-4-7-18(23(20)27-14)17-6-3-5-15-10-21(26-13-19(15)17)16(11-24)12-25-2/h3-8,10-14,24-25,27H,9H2,1-2H3,(H,28,29)/b16-12+,24-11?/t14-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)


Article DOI: 10.1021/jm060653b
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM349488
PNG
(US10206931, Example 296 | methylpyrazol-4-)
Show SMILES CN\C=C(/C=N)c1cccc(Nc2cccc3NC(=O)C[C@@H](C)Nc23)c1
Show InChI InChI=1S/C20H23N5O/c1-13-9-19(26)25-18-8-4-7-17(20(18)23-13)24-16-6-3-5-14(10-16)15(11-21)12-22-2/h3-8,10-13,21-24H,9H2,1-2H3,(H,25,26)/b15-12+,21-11?/t13-/m1/s1
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US Patent
n/an/a 9n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US10206931 (2019)


Article DOI: 10.1021/jm060653b
More data for this
Ligand-Target Pair
CREB-binding protein/p53


(Homo sapiens (Human))
BDBM50299822
PNG
((+/-)-syn-6,7-Bis(4-chlorophenyl)-12-methyl-7,12-d...)
Show SMILES CN1c2ncnn2C(C2=C1c1ccccc1OC2c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H18Cl2N4O/c1-30-23-19-4-2-3-5-20(19)32-24(16-8-12-18(27)13-9-16)21(23)22(31-25(30)28-14-29-31)15-6-10-17(26)11-7-15/h2-14,22,24H,1H3
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n/an/a 9.40n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...


J Med Chem 52: 7044-53 (2009)


Article DOI: 10.1021/jm900681h
BindingDB Entry DOI: 10.7270/Q2ZK5GRQ
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340490
PNG
(US9763922, Example 21)
Show SMILES CNC1=C(CN(CC1)C(C)=O)C(=N)Nc1cc(C)cc(c1)-c1cnn(C)c1
Show InChI InChI=1S/C20H26N6O/c1-13-7-15(16-10-23-25(4)11-16)9-17(8-13)24-20(21)18-12-26(14(2)27)6-5-19(18)22-3/h7-11,22H,5-6,12H2,1-4H3,(H2,21,24)
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340773
PNG
(US9763922, Example 297)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cn(C)nc1C(F)(F)F)nn2[C@@H]1CCOC1
Show InChI InChI=1S/C23H24F4N6O2/c1-13(34)32-7-5-20-17(11-32)22(30-33(20)15-6-8-35-12-15)28-19-4-3-14(9-18(19)24)16-10-31(2)29-21(16)23(25,26)27/h3-4,9-10,15H,5-8,11-12H2,1-2H3,(H,28,30)/t15-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340503
PNG
(1-[3-[2-fluoro-4-[1-methyl-3-(trifluoromethyl)pyra...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cn(C)nc1C(F)(F)F)nn2C
Show InChI InChI=1S/C20H20F4N6O/c1-11(31)30-7-6-17-14(10-30)19(27-29(17)3)25-16-5-4-12(8-15(16)21)13-9-28(2)26-18(13)20(22,23)24/h4-5,8-9H,6-7,10H2,1-3H3,(H,25,27)
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340504
PNG
(US9763922, Example 35)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cn(C)nc1C(C)(F)F)nn2C
Show InChI InChI=1S/C21H24F2N6O/c1-13(30)29-9-8-18-17(12-29)20(26-28(18)4)24-15-7-5-6-14(10-15)16-11-27(3)25-19(16)21(2,22)23/h5-7,10-11H,8-9,12H2,1-4H3,(H,24,26)
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340507
PNG
(US9763922, Example 38)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(F)c(c1)-c1cnn(C)c1)nn2CC1CC1
Show InChI InChI=1S/C22H25FN6O/c1-14(30)28-8-7-21-19(13-28)22(26-29(21)11-15-3-4-15)25-17-5-6-20(23)18(9-17)16-10-24-27(2)12-16/h5-6,9-10,12,15H,3-4,7-8,11,13H2,1-2H3,(H,25,26)
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340509
PNG
(US9763922, Example 40)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cc(ccc1F)-c1cnn(C)c1)nn2CC1CC1
Show InChI InChI=1S/C22H25FN6O/c1-14(30)28-8-7-21-18(13-28)22(26-29(21)11-15-3-4-15)25-20-9-16(5-6-19(20)23)17-10-24-27(2)12-17/h5-6,9-10,12,15H,3-4,7-8,11,13H2,1-2H3,(H,25,26)
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340521
PNG
(US9763922, Example 52)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(-c3cnn(C)c3)c(F)c1)nn2C1CCOC1
Show InChI InChI=1S/C22H25FN6O2/c1-14(30)28-7-5-21-19(12-28)22(26-29(21)17-6-8-31-13-17)25-16-3-4-18(20(23)9-16)15-10-24-27(2)11-15/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340524
PNG
(1-(3-((2-fluoro-4-(1-methyl-3-(trifluoromethyl)-1H...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cn(C)nc1C(F)(F)F)nn2C1CCOC1
Show InChI InChI=1S/C23H24F4N6O2/c1-13(34)32-7-5-20-17(11-32)22(30-33(20)15-6-8-35-12-15)28-19-4-3-14(9-18(19)24)16-10-31(2)29-21(16)23(25,26)27/h3-4,9-10,15H,5-8,11-12H2,1-2H3,(H,28,30)
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340525
PNG
(US9763922, Example 56)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cn(C)nc1C(F)(F)F)nn2C1CCOC1
Show InChI InChI=1S/C23H25F3N6O2/c1-14(33)31-9-7-20-19(12-31)22(29-32(20)17-8-10-34-13-17)27-16-5-3-15(4-6-16)18-11-30(2)28-21(18)23(24,25)26/h3-6,11,17H,7-10,12-13H2,1-2H3,(H,27,29)
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340526
PNG
(US9763922, Example 57)
Show SMILES CN\C=C(/C(=N)C(F)(F)F)c1ccc(NC(=N)C2=C(CCN(C2)C(C)=O)NC2CCOC2)cn1
Show InChI InChI=1S/C22H28F3N7O2/c1-13(33)32-7-5-19(30-15-6-8-34-12-15)17(11-32)21(27)31-14-3-4-18(29-9-14)16(10-28-2)20(26)22(23,24)25/h3-4,9-10,15,26,28,30H,5-8,11-12H2,1-2H3,(H2,27,31)/b16-10-,26-20?
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM340528
PNG
(1-(1-cyclopropyl-3-((3-(1-methyl-1H-pyrazol-4-yl)p...)
Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cnn(C)c1)nn2C1CC1
Show InChI InChI=1S/C21H24N6O/c1-14(28)26-9-8-20-19(13-26)21(24-27(20)18-6-7-18)23-17-5-3-4-15(10-17)16-11-22-25(2)12-16/h3-5,10-12,18H,6-9,13H2,1-2H3,(H,23,24)
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n/an/a 10n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...


US Patent US9763922 (2017)

More data for this
Ligand-Target Pair
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