BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 57 hits Enz. Inhib. hit(s) with Target = 'Calcium channel (Type N)' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium channel (Type N)


()
BDBM84745
PNG
(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Show SMILES CNCC[C@H](Oc1cccc2ccccc12)c1cccs1
Show InChI InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by PDSP Ki Database




Neuropsychopharmacology 25: 871-80 (2001)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM82071
PNG
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)
Show SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

DrugBank
KEGG
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
1.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by PDSP Ki Database




Neuropsychopharmacology 25: 871-80 (2001)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50022784
PNG
((R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine...)
Show SMILES CNCCC(Oc1ccccc1C)c1ccccc1
Show InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.00E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by PDSP Ki Database




Neuropsychopharmacology 27: 699-711 (2002)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50035398
PNG
((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)
Show SMILES CN1CCC[C@H]1c1cc(C)no1
Show InChI InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




J Pharmacol Exp Ther 270: 310-8 (1994)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50049750
PNG
((S)-3-(azetidin-2-ylmethoxy)pyridine | 3-((S)-1-Az...)
Show SMILES C(Oc1cccnc1)[C@@H]1CCN1
Show InChI InChI=1S/C9H12N2O/c1-2-9(6-10-4-1)12-7-8-3-5-11-8/h1-2,4,6,8,11H,3,5,7H2/t8-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




Neuropharmacology 35: 725-34 (1996)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Pudue Pharma Discovery Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 306: 377-86 (2003)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50386813
PNG
(CHEMBL2047726)
Show SMILES FC(F)(F)c1cccc(CN2C[C@@H]3CC[C@H](NC(=O)C(C4CCCCC4)C4CCCCC4)[C@@H]3C2)c1
Show InChI InChI=1S/C29H41F3N2O/c30-29(31,32)24-13-7-8-20(16-24)17-34-18-23-14-15-26(25(23)19-34)33-28(35)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h7-8,13,16,21-23,25-27H,1-6,9-12,14-15,17-19H2,(H,33,35)/t23-,25+,26-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 40.7n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat Cav2.2 expressed in HEK293 cells under inactivating depolarizing conditions at holding potential of -115mV and stepped to 0 mV once...


Bioorg Med Chem 20: 4128-39 (2012)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50386813
PNG
(CHEMBL2047726)
Show SMILES FC(F)(F)c1cccc(CN2C[C@@H]3CC[C@H](NC(=O)C(C4CCCCC4)C4CCCCC4)[C@@H]3C2)c1
Show InChI InChI=1S/C29H41F3N2O/c30-29(31,32)24-13-7-8-20(16-24)17-34-18-23-14-15-26(25(23)19-34)33-28(35)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h7-8,13,16,21-23,25-27H,1-6,9-12,14-15,17-19H2,(H,33,35)/t23-,25+,26-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 41n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat Cav2.2 expressed in HEK293 cells under inactivating depolarizing conditions at holding potential of -115mV and stepped to 0 mV once...


Bioorg Med Chem 20: 4128-39 (2012)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50438747
PNG
(CHEMBL2414787)
Show SMILES CC(C)N[C@@H](CC(C)(C)C)C(=O)N[C@H]1CC[C@@H]2CN(C[C@H]12)S(=O)(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H36F3N3O3S/c1-15(2)28-21(12-23(3,4)5)22(31)29-20-11-6-16-13-30(14-19(16)20)34(32,33)18-9-7-17(8-10-18)24(25,26)27/h7-10,15-16,19-21,28H,6,11-14H2,1-5H3,(H,29,31)/t16-,19+,20+,21+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 340n/an/an/an/an/an/a



Neuroscience Research, AbbVie, 1 N Waukegan Road, North Chicago, IL 60064, United States. xenia.b.searle@abbvie.com

Curated by ChEMBL


Assay Description
Inhibition of rat N-type Cav2.2 channel expressed in HEK293 cells under hyperpolarized condition by whole cell patch-clamp manual electrophysiology a...


Bioorg Med Chem Lett 23: 4857-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434732
PNG
(CHEMBL2385364)
Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](CCCCO)CN1
Show InChI InChI=1S/C22H30N2O/c1-18-17-24(21(16-23-18)14-8-9-15-25)22(19-10-4-2-5-11-19)20-12-6-3-7-13-20/h2-7,10-13,18,21-23,25H,8-9,14-17H2,1H3/t18-,21-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 850n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50438746
PNG
(CHEMBL2414771)
Show SMILES CN[C@@H](CC(C)C)C(=O)N[C@H]1CC[C@@H]2CN(C[C@H]12)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H30F3N3O/c1-13(2)10-19(25-3)20(28)26-18-9-4-14-11-27(12-17(14)18)16-7-5-15(6-8-16)21(22,23)24/h5-8,13-14,17-19,25H,4,9-12H2,1-3H3,(H,26,28)/t14-,17+,18+,19+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Neuroscience Research, AbbVie, 1 N Waukegan Road, North Chicago, IL 60064, United States. xenia.b.searle@abbvie.com

Curated by ChEMBL


Assay Description
Inhibition of rat N-type Cav2.2 channel expressed in HEK293 cells under depolarized condition by whole cell patch-clamp manual electrophysiology assa...


Bioorg Med Chem Lett 23: 4857-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434737
PNG
(CHEMBL2385359)
Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](CCCCO[Si](C)(C)C(C)(C)C)CN1
Show InChI InChI=1S/C28H44N2OSi/c1-23-22-30(27(24-15-9-7-10-16-24)25-17-11-8-12-18-25)26(21-29-23)19-13-14-20-31-32(5,6)28(2,3)4/h7-12,15-18,23,26-27,29H,13-14,19-22H2,1-6H3/t23-,26-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.07E+3n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434738
PNG
(CHEMBL2385358)
Show SMILES CCCCC[C@@H]1CN[C@H](C)CN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H32N2/c1-3-4-7-16-22-17-24-19(2)18-25(22)23(20-12-8-5-9-13-20)21-14-10-6-11-15-21/h5-6,8-15,19,22-24H,3-4,7,16-18H2,1-2H3/t19-,22-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434735
PNG
(CHEMBL2385361)
Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](CCCO[Si](C)(C)C(C)(C)C)CN1S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C34H48N2O3SSi/c1-27-20-22-32(23-21-27)40(37,38)36-26-31(19-14-24-39-41(6,7)34(3,4)5)35(25-28(36)2)33(29-15-10-8-11-16-29)30-17-12-9-13-18-30/h8-13,15-18,20-23,28,31,33H,14,19,24-26H2,1-7H3/t28-,31-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434742
PNG
(CHEMBL2385371)
Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](Cc2ccccc2)CN1
Show InChI InChI=1S/C25H28N2/c1-20-19-27(24(18-26-20)17-21-11-5-2-6-12-21)25(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,20,24-26H,17-19H2,1H3/t20-,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.34E+3n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50438746
PNG
(CHEMBL2414771)
Show SMILES CN[C@@H](CC(C)C)C(=O)N[C@H]1CC[C@@H]2CN(C[C@H]12)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H30F3N3O/c1-13(2)10-19(25-3)20(28)26-18-9-4-14-11-27(12-17(14)18)16-7-5-15(6-8-16)21(22,23)24/h5-8,13-14,17-19,25H,4,9-12H2,1-3H3,(H,26,28)/t14-,17+,18+,19+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 4.40E+3n/an/an/an/an/an/a



Neuroscience Research, AbbVie, 1 N Waukegan Road, North Chicago, IL 60064, United States. xenia.b.searle@abbvie.com

Curated by ChEMBL


Assay Description
Inhibition of rat N-type Cav2.2 channel expressed in HEK293 cells under hyperpolarized condition by whole cell patch-clamp manual electrophysiology a...


Bioorg Med Chem Lett 23: 4857-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434734
PNG
(CHEMBL2385362)
Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](CCCCO[Si](C)(C)C(C)(C)C)CN1S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C35H50N2O3SSi/c1-28-21-23-33(24-22-28)41(38,39)37-27-32(20-14-15-25-40-42(6,7)35(3,4)5)36(26-29(37)2)34(30-16-10-8-11-17-30)31-18-12-9-13-19-31/h8-13,16-19,21-24,29,32,34H,14-15,20,25-27H2,1-7H3/t29-,32-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.70E+3n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434741
PNG
(CHEMBL2385372)
Show SMILES C[C@@H]1CN(Cc2ccccc2)[C@H](CCCCO[Si](C)(C)C(C)(C)C)CN1
Show InChI InChI=1S/C22H40N2OSi/c1-19-17-24(18-20-12-8-7-9-13-20)21(16-23-19)14-10-11-15-25-26(5,6)22(2,3)4/h7-9,12-13,19,21,23H,10-11,14-18H2,1-6H3/t19-,21-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.85E+3n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434747
PNG
(CHEMBL2385366)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)[C@H](Cc2ccccc2)CN1
Show InChI InChI=1S/C19H23FN2/c1-15-13-22(14-17-7-9-18(20)10-8-17)19(12-21-15)11-16-5-3-2-4-6-16/h2-10,15,19,21H,11-14H2,1H3/t15-,19-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 8.37E+3n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434731
PNG
(CHEMBL2385365)
Show SMILES C[C@@H]1CN(Cc2ccccc2)[C@H](CCCCO)CN1
Show InChI InChI=1S/C16H26N2O/c1-14-12-18(13-15-7-3-2-4-8-15)16(11-17-14)9-5-6-10-19/h2-4,7-8,14,16-17,19H,5-6,9-13H2,1H3/t14-,16-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 9.60E+3n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434740
PNG
(CHEMBL2385356)
Show SMILES CCCCC[C@@H]1CN[C@H](C)CN1Cc1ccccc1
Show InChI InChI=1S/C17H28N2/c1-3-4-6-11-17-12-18-15(2)13-19(17)14-16-9-7-5-8-10-16/h5,7-10,15,17-18H,3-4,6,11-14H2,1-2H3/t15-,17-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 9.84E+3n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434744
PNG
(CHEMBL2385369)
Show SMILES C[C@@H]1CN(Cc2ccccc2)[C@H](Cc2ccccc2)CN1
Show InChI InChI=1S/C19H24N2/c1-16-14-21(15-18-10-6-3-7-11-18)19(13-20-16)12-17-8-4-2-5-9-17/h2-11,16,19-20H,12-15H2,1H3/t16-,19-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434745
PNG
(CHEMBL2385368)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)[C@H](Cc2ccccc2)CN1C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C33H33FN2O/c1-25-22-35(23-27-17-19-30(34)20-18-27)31(21-26-11-5-2-6-12-26)24-36(25)33(37)32(28-13-7-3-8-14-28)29-15-9-4-10-16-29/h2-20,25,31-32H,21-24H2,1H3/t25-,31-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434733
PNG
(CHEMBL2385363)
Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](CCCCO[Si](C)(C)C(C)(C)C)CN1S(=O)(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C35H47F3N2O3SSi/c1-27-25-39(33(28-15-9-7-10-16-28)29-17-11-8-12-18-29)31(19-13-14-24-43-45(5,6)34(2,3)4)26-40(27)44(41,42)32-22-20-30(21-23-32)35(36,37)38/h7-12,15-18,20-23,27,31,33H,13-14,19,24-26H2,1-6H3/t27-,31-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434736
PNG
(CHEMBL2385360)
Show SMILES C[C@@H]1CN(C(c2ccccc2)c2ccccc2)[C@H](CCCO[Si](C)(C)C(C)(C)C)CN1
Show InChI InChI=1S/C27H42N2OSi/c1-22-21-29(25(20-28-22)18-13-19-30-31(5,6)27(2,3)4)26(23-14-9-7-10-15-23)24-16-11-8-12-17-24/h7-12,14-17,22,25-26,28H,13,18-21H2,1-6H3/t22-,25-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434739
PNG
(CHEMBL2385357)
Show SMILES CCCCCCCCC[C@@H]1CN[C@H](C)CN1Cc1ccccc1
Show InChI InChI=1S/C21H36N2/c1-3-4-5-6-7-8-12-15-21-16-22-19(2)17-23(21)18-20-13-10-9-11-14-20/h9-11,13-14,19,21-22H,3-8,12,15-18H2,1-2H3/t19-,21-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434743
PNG
(CHEMBL2385370)
Show SMILES C[C@@H]1CN(Cc2ccccc2)[C@H](Cc2ccccc2)CN1S(=O)(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H27F3N2O2S/c1-20-17-30(18-22-10-6-3-7-11-22)24(16-21-8-4-2-5-9-21)19-31(20)34(32,33)25-14-12-23(13-15-25)26(27,28)29/h2-15,20,24H,16-19H2,1H3/t20-,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50434746
PNG
(CHEMBL2385367)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)[C@H](Cc2ccccc2)CN1S(=O)(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H26F4N2O2S/c1-19-16-31(17-21-7-11-23(27)12-8-21)24(15-20-5-3-2-4-6-20)18-32(19)35(33,34)25-13-9-22(10-14-25)26(28,29)30/h2-14,19,24H,15-18H2,1H3/t19-,24-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



University of British Columbia

Curated by ChEMBL


Assay Description
Inhibition of rat brain Cav2.2 N-type channel expressed in HEK cells after 20 mins by FLIPR assay


Bioorg Med Chem Lett 23: 3257-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50438747
PNG
(CHEMBL2414787)
Show SMILES CC(C)N[C@@H](CC(C)(C)C)C(=O)N[C@H]1CC[C@@H]2CN(C[C@H]12)S(=O)(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H36F3N3O3S/c1-15(2)28-21(12-23(3,4)5)22(31)29-20-11-6-16-13-30(14-19(16)20)34(32,33)18-9-7-17(8-10-18)24(25,26)27/h7-10,15-16,19-21,28H,6,11-14H2,1-5H3,(H,29,31)/t16-,19+,20+,21+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 1.04E+4n/an/an/an/an/an/a



Neuroscience Research, AbbVie, 1 N Waukegan Road, North Chicago, IL 60064, United States. xenia.b.searle@abbvie.com

Curated by ChEMBL


Assay Description
Inhibition of rat N-type Cav2.2 channel expressed in HEK293 cells under depolarized condition by whole cell patch-clamp manual electrophysiology assa...


Bioorg Med Chem Lett 23: 4857-61 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50444089
PNG
(CHEMBL3092995)
Show SMILES NS(=O)(=O)NC[C@H]1COc2cc(Cl)ccc2O1
Show InChI InChI=1S/C9H11ClN2O4S/c10-6-1-2-8-9(3-6)15-5-7(16-8)4-12-17(11,13)14/h1-3,7,12H,4-5H2,(H2,11,13,14)/t7-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 3.40E+4n/an/an/an/an/an/a



Research& Development, Janssen Pharmaceutical Companies of Johnson& Johnson

Curated by ChEMBL


Assay Description
Inhibition of rat Cav2.2-mediated calcium flux expressed in HEK cells by FDSS assay


J Med Chem 56: 9019-30 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50444089
PNG
(CHEMBL3092995)
Show SMILES NS(=O)(=O)NC[C@H]1COc2cc(Cl)ccc2O1
Show InChI InChI=1S/C9H11ClN2O4S/c10-6-1-2-8-9(3-6)15-5-7(16-8)4-12-17(11,13)14/h1-3,7,12H,4-5H2,(H2,11,13,14)/t7-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
Article
PubMed
n/an/a 7.00E+4n/an/an/an/an/an/a



Research& Development, Janssen Pharmaceutical Companies of Johnson& Johnson

Curated by ChEMBL


Assay Description
Inhibition of rat Cav2.2-mediated calcium flux expressed in HEK cells at 0.07 Hz by whole-cell patch-clamp assay


J Med Chem 56: 9019-30 (2013)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50259131
PNG
(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Show SMILES NS(=O)(=O)NCc1csc2ccccc12
Show InChI InChI=1S/C9H10N2O2S2/c10-15(12,13)11-5-7-6-14-9-4-2-1-3-8(7)9/h1-4,6,11H,5H2,(H2,10,12,13)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 1.33E+5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of rat Cav2.2 channel expressed in 0.07 Hz frequency-stimulated HEK cells by whole-cell patch-clamp technique


J Med Chem 52: 7528-36 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50295701
PNG
(CHEMBL565078 | N-(3-{4-[(6-Phenoxy-benzothiazol-2-...)
Show SMILES NC(N)=NCCCOc1ccc(CNc2nc3ccc(Oc4ccccc4)cc3s2)cc1
Show InChI InChI=1S/C24H25N5O2S/c25-23(26)27-13-4-14-30-18-9-7-17(8-10-18)16-28-24-29-21-12-11-20(15-22(21)32-24)31-19-5-2-1-3-6-19/h1-3,5-12,15H,4,13-14,16H2,(H,28,29)(H4,25,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 5.80E+3n/an/an/an/a



CSIRO Molecular and Health Technologies

Curated by ChEMBL


Assay Description
Inhibition of rat neuronal Cav2.2 channel


Bioorg Med Chem Lett 19: 2763-5 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50295698
PNG
(2-(3-Amino-propoxy)-N-(6-phenoxy-benzothiazol-2-yl...)
Show SMILES NCCCOc1ccccc1C(=O)Nc1nc2ccc(Oc3ccccc3)cc2s1
Show InChI InChI=1S/C23H21N3O3S/c24-13-6-14-28-20-10-5-4-9-18(20)22(27)26-23-25-19-12-11-17(15-21(19)30-23)29-16-7-2-1-3-8-16/h1-5,7-12,15H,6,13-14,24H2,(H,25,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



CSIRO Molecular and Health Technologies

Curated by ChEMBL


Assay Description
Inhibition of rat neuronal Cav2.2 channel


Bioorg Med Chem Lett 19: 2763-5 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50295697
PNG
(2-(3-aminopropoxy)-N-(4-(3-(diaminomethyleneamino)...)
Show SMILES NCCCOc1ccccc1C(=O)N(Cc1ccc(OCCCN=C(N)N)cc1)c1nc2ccc(Oc3ccc(O)cc3)cc2s1
Show InChI InChI=1S/C34H36N6O5S/c35-17-3-19-44-30-6-2-1-5-28(30)32(42)40(22-23-7-11-25(12-8-23)43-20-4-18-38-33(36)37)34-39-29-16-15-27(21-31(29)46-34)45-26-13-9-24(41)10-14-26/h1-2,5-16,21,41H,3-4,17-20,22,35H2,(H4,36,37,38)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.78E+3n/an/an/an/a



CSIRO Molecular and Health Technologies

Curated by ChEMBL


Assay Description
Inhibition of rat neuronal Cav2.2 channel


Bioorg Med Chem Lett 19: 2763-5 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50295696
PNG
(2-(3-aminopropoxy)-N-(4-(3-(diaminomethyleneamino)...)
Show SMILES NCCCOc1ccccc1C(=O)N(Cc1ccc(OCCCN=C(N)N)cc1)c1nc2ccc(Oc3ccccc3)cc2s1
Show InChI InChI=1S/C34H36N6O4S/c35-18-6-20-43-30-11-5-4-10-28(30)32(41)40(23-24-12-14-25(15-13-24)42-21-7-19-38-33(36)37)34-39-29-17-16-27(22-31(29)45-34)44-26-8-2-1-3-9-26/h1-5,8-17,22H,6-7,18-21,23,35H2,(H4,36,37,38)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 3.08E+3n/an/an/an/a



CSIRO Molecular and Health Technologies

Curated by ChEMBL


Assay Description
Inhibition of rat neuronal Cav2.2 channel


Bioorg Med Chem Lett 19: 2763-5 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50295695
PNG
(2-(3-aminopropoxy)-N-(4-(3-aminopropoxy)benzyl)-N-...)
Show SMILES NCCCOc1ccc(CN(C(=O)c2ccccc2OCCCN)c2nc3ccc(Oc4ccc(O)cc4)cc3s2)cc1
Show InChI InChI=1S/C33H34N4O5S/c34-17-3-19-40-25-11-7-23(8-12-25)22-37(32(39)28-5-1-2-6-30(28)41-20-4-18-35)33-36-29-16-15-27(21-31(29)43-33)42-26-13-9-24(38)10-14-26/h1-2,5-16,21,38H,3-4,17-20,22,34-35H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 3.18E+3n/an/an/an/a



CSIRO Molecular and Health Technologies

Curated by ChEMBL


Assay Description
Inhibition of rat neuronal Cav2.2 channel


Bioorg Med Chem Lett 19: 2763-5 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50295707
PNG
(2-(3-(4-((2,2-diphenylethylamino)methyl)phenoxy)pr...)
Show SMILES NC(N)=NCCCOc1ccc(CNCC(c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C25H30N4O/c26-25(27)29-16-7-17-30-23-14-12-20(13-15-23)18-28-19-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-6,8-15,24,28H,7,16-19H2,(H4,26,27,29)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.20E+4n/an/an/an/a



CSIRO Molecular and Health Technologies

Curated by ChEMBL


Assay Description
Inhibition of rat neuronal Cav2.2 channel


Bioorg Med Chem Lett 19: 2763-5 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50295706
PNG
(3-{4-[(2,2-Diphenyl-ethylamino)-methyl]-phenoxy}-p...)
Show SMILES NCCCOc1ccc(CNCC(c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C24H28N2O/c25-16-7-17-27-23-14-12-20(13-15-23)18-26-19-24(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-6,8-15,24,26H,7,16-19,25H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



CSIRO Molecular and Health Technologies

Curated by ChEMBL


Assay Description
Inhibition of rat neuronal Cav2.2 channel


Bioorg Med Chem Lett 19: 2763-5 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50295705
PNG
(2-(3-(4-((benzhydrylamino)methyl)phenoxy)propyl)gu...)
Show SMILES NC(N)=NCCCOc1ccc(CNC(c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C24H28N4O/c25-24(26)27-16-7-17-29-22-14-12-19(13-15-22)18-28-23(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-6,8-15,23,28H,7,16-18H2,(H4,25,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2.30E+4n/an/an/an/a



CSIRO Molecular and Health Technologies

Curated by ChEMBL


Assay Description
Inhibition of rat neuronal Cav2.2 channel


Bioorg Med Chem Lett 19: 2763-5 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50295704
PNG
(3-{4-[(Benzhydryl-amino)-methyl]-phenoxy}-propylam...)
Show SMILES NCCCOc1ccc(CNC(c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C23H26N2O/c24-16-7-17-26-22-14-12-19(13-15-22)18-25-23(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-6,8-15,23,25H,7,16-18,24H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a>1.00E+5n/an/an/an/a



CSIRO Molecular and Health Technologies

Curated by ChEMBL


Assay Description
Inhibition of rat neuronal Cav2.2 channel


Bioorg Med Chem Lett 19: 2763-5 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50295703
PNG
(2-(3-(4-((4-phenoxyphenylamino)methyl)phenoxy)prop...)
Show SMILES NC(N)=NCCCOc1ccc(CNc2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C23H26N4O2/c24-23(25)26-15-4-16-28-20-11-7-18(8-12-20)17-27-19-9-13-22(14-10-19)29-21-5-2-1-3-6-21/h1-3,5-14,27H,4,15-17H2,(H4,24,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 2.10E+4n/an/an/an/a



CSIRO Molecular and Health Technologies

Curated by ChEMBL


Assay Description
Inhibition of rat neuronal Cav2.2 channel


Bioorg Med Chem Lett 19: 2763-5 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50295702
PNG
(CHEMBL552193 | [4-(3-Amino-propoxy)-benzyl]-(4-phe...)
Show SMILES NCCCOc1ccc(CNc2ccc(Oc3ccccc3)cc2)cc1
Show InChI InChI=1S/C22H24N2O2/c23-15-4-16-25-20-11-7-18(8-12-20)17-24-19-9-13-22(14-10-19)26-21-5-2-1-3-6-21/h1-3,5-14,24H,4,15-17,23H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 3.40E+4n/an/an/an/a



CSIRO Molecular and Health Technologies

Curated by ChEMBL


Assay Description
Inhibition of rat neuronal Cav2.2 channel


Bioorg Med Chem Lett 19: 2763-5 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50304191
PNG
(2-(6-Aminohexanamido)-5-(3-aminopropoxy)-N-(4-phen...)
Show SMILES NCCCCCC(=O)Nc1ccc(OCCCN)cc1C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H34N4O4/c29-17-6-2-5-10-27(33)32-26-16-15-24(35-19-7-18-30)20-25(26)28(34)31-21-11-13-23(14-12-21)36-22-8-3-1-4-9-22/h1,3-4,8-9,11-16,20H,2,5-7,10,17-19,29-30H2,(H,31,34)(H,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.07E+5n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]GVIA from Cav2.2 channel in rat brain by scintillation counting


Bioorg Med Chem 17: 6659-70 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50304190
PNG
(2-(5-Aminopentanamido)-5-(3-aminopropoxy)-N-(4-phe...)
Show SMILES NCCCCC(=O)Nc1ccc(OCCCN)cc1C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H32N4O4/c28-16-5-4-9-26(32)31-25-15-14-23(34-18-6-17-29)19-24(25)27(33)30-20-10-12-22(13-11-20)35-21-7-2-1-3-8-21/h1-3,7-8,10-15,19H,4-6,9,16-18,28-29H2,(H,30,33)(H,31,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 7.70E+4n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]GVIA from Cav2.2 channel in rat brain by scintillation counting


Bioorg Med Chem 17: 6659-70 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50304189
PNG
(CHEMBL593380 | N-(4-(4-Fluorophenoxy)phenyl)-2-(8-...)
Show SMILES NC(N)=NCCCCCCCC(=O)Nc1ccc(OCCCN=C(N)N)cc1C(=O)Nc1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C32H41FN8O4/c33-22-8-12-24(13-9-22)45-25-14-10-23(11-15-25)40-30(43)27-21-26(44-20-6-19-39-32(36)37)16-17-28(27)41-29(42)7-4-2-1-3-5-18-38-31(34)35/h8-17,21H,1-7,18-20H2,(H,40,43)(H,41,42)(H4,34,35,38)(H4,36,37,39)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 6.00E+3n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]GVIA from Cav2.2 channel in rat brain by scintillation counting


Bioorg Med Chem 17: 6659-70 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50304188
PNG
(2-(8-Guanidinooctanamido)-5-(3-guanidinopropoxy)-N...)
Show SMILES NC(N)=NCCCCCCCC(=O)Nc1ccc(OCCCN=C(N)N)cc1C(=O)Nc1ccc(Oc2ccc(O)cc2)cc1
Show InChI InChI=1S/C32H42N8O5/c33-31(34)37-18-5-3-1-2-4-7-29(42)40-28-17-16-26(44-20-6-19-38-32(35)36)21-27(28)30(43)39-22-8-12-24(13-9-22)45-25-14-10-23(41)11-15-25/h8-17,21,41H,1-7,18-20H2,(H,39,43)(H,40,42)(H4,33,34,37)(H4,35,36,38)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.60E+4n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]GVIA from Cav2.2 channel in rat brain by scintillation counting


Bioorg Med Chem 17: 6659-70 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50304187
PNG
(2-(5-Guanidino-octanamido)-5-(3-guanidinobutoxy)-N...)
Show SMILES NC(N)=NCCCCCCCC(=O)Nc1ccc(OCCCCN=C(N)N)cc1C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C33H44N8O4/c34-32(35)38-20-8-3-1-2-7-13-30(42)41-29-19-18-27(44-22-10-9-21-39-33(36)37)23-28(29)31(43)40-24-14-16-26(17-15-24)45-25-11-5-4-6-12-25/h4-6,11-12,14-19,23H,1-3,7-10,13,20-22H2,(H,40,43)(H,41,42)(H4,34,35,38)(H4,36,37,39)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.50E+4n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]GVIA from Cav2.2 channel in rat brain by scintillation counting


Bioorg Med Chem 17: 6659-70 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50304186
PNG
(2-(5-Guanidinohexanamido)-5-(3-guanidinobutoxy)-N-...)
Show SMILES NC(N)=NCCCCCC(=O)Nc1ccc(OCCCCN=C(N)N)cc1C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C31H40N8O4/c32-30(33)36-18-6-2-5-11-28(40)39-27-17-16-25(42-20-8-7-19-37-31(34)35)21-26(27)29(41)38-22-12-14-24(15-13-22)43-23-9-3-1-4-10-23/h1,3-4,9-10,12-17,21H,2,5-8,11,18-20H2,(H,38,41)(H,39,40)(H4,32,33,36)(H4,34,35,37)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.70E+4n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]GVIA from Cav2.2 channel in rat brain by scintillation counting


Bioorg Med Chem 17: 6659-70 (2009)

More data for this
Ligand-Target Pair
Calcium channel (Type N)


()
BDBM50304185
PNG
(2-(5-Guanidino-octanamido)-5-(3-guanidinopropoxy)-...)
Show SMILES NC(N)=NCCCCCCCC(=O)Nc1ccc(OCCCN=C(N)N)cc1C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C32H42N8O4/c33-31(34)37-19-8-3-1-2-7-12-29(41)40-28-18-17-26(43-21-9-20-38-32(35)36)22-27(28)30(42)39-23-13-15-25(16-14-23)44-24-10-5-4-6-11-24/h4-6,10-11,13-18,22H,1-3,7-9,12,19-21H2,(H,39,42)(H,40,41)(H4,33,34,37)(H4,35,36,38)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1.30E+4n/an/an/an/a



The University of Queensland

Curated by ChEMBL


Assay Description
Displacement of [125I]GVIA from Cav2.2 channel in rat brain by scintillation counting


Bioorg Med Chem 17: 6659-70 (2009)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 57 total )  |  Next  |  Last  >>
Jump to: