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Compile Data Set for Download or QSAR

Found 34 hits Enz. Inhib. hit(s) with Target = 'Calcium sensing receptor' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193410
PNG
(CHEMBL536975 | N-[(1S,2S)-2-((R)-1-naphthalen-1-yl...)
Show SMILES C[C@@H](N[C@H]1CCCC[C@@H]1NC(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C26H27F3N2O2/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)30-23-11-4-5-12-24(23)31-25(32)19-13-15-20(16-14-19)33-26(27,28)29/h2-3,6-10,13-17,23-24,30H,4-5,11-12H2,1H3,(H,31,32)/t17-,23+,24+/m1/s1
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n/an/a 250n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50346036
PNG
(CHEMBL1198855 | Ronacaleret)
Show SMILES CC(C)(CC1Cc2ccccc2C1)NC[C@@H](O)COc1cc(CCC(O)=O)cc(F)c1F
Show InChI InChI=1S/C25H31F2NO4/c1-25(2,13-17-9-18-5-3-4-6-19(18)10-17)28-14-20(29)15-32-22-12-16(7-8-23(30)31)11-21(26)24(22)27/h3-6,11-12,17,20,28-29H,7-10,13-15H2,1-2H3,(H,30,31)/t20-/m1/s1
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n/an/a 320n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Negative allosteric modulator activity at rat calcium sensing receptor expressed in HEK cells


Bioorg Med Chem Lett 19: 3328-32 (2009)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193411
PNG
(3,4-dichloro-N-((1S,2S)-2-((R)-1-(naphthalen-1-yl)...)
Show SMILES C[C@@H](N[C@H]1CCCC[C@@H]1NC(=O)c1ccc(Cl)c(Cl)c1)c1cccc2ccccc12
Show InChI InChI=1S/C25H26Cl2N2O/c1-16(19-10-6-8-17-7-2-3-9-20(17)19)28-23-11-4-5-12-24(23)29-25(30)18-13-14-21(26)22(27)15-18/h2-3,6-10,13-16,23-24,28H,4-5,11-12H2,1H3,(H,29,30)/t16-,23+,24+/m1/s1
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n/an/a 330n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50161093
PNG
((R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthale...)
Show SMILES CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N
Show InChI InChI=1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1
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n/an/a 460n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50161093
PNG
((R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthale...)
Show SMILES CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc1cccc(Cl)c1C#N
Show InChI InChI=1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1
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n/an/a 530n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptor


Bioorg Med Chem Lett 15: 5478-82 (2005)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193408
PNG
(CHEMBL556781 | N-((1R,2R)-2-((R)-1-(naphthalen-1-y...)
Show SMILES C[C@@H](N[C@@H]1CCCC[C@H]1NC(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C26H27F3N2O2/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)30-23-11-4-5-12-24(23)31-25(32)19-13-15-20(16-14-19)33-26(27,28)29/h2-3,6-10,13-17,23-24,30H,4-5,11-12H2,1H3,(H,31,32)/t17-,23-,24-/m1/s1
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n/an/a 900n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193408
PNG
(CHEMBL556781 | N-((1R,2R)-2-((R)-1-(naphthalen-1-y...)
Show SMILES C[C@@H](N[C@@H]1CCCC[C@H]1NC(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C26H27F3N2O2/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)30-23-11-4-5-12-24(23)31-25(32)19-13-15-20(16-14-19)33-26(27,28)29/h2-3,6-10,13-17,23-24,30H,4-5,11-12H2,1H3,(H,31,32)/t17-,23-,24-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50175371
PNG
(3-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(naphthalen...)
Show SMILES CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)[C@H]1CCCN1Cc1cccc(c1)C#N
Show InChI InChI=1S/C28H33N3O/c1-28(2,17-21-12-13-24-9-3-4-10-25(24)16-21)30-19-27(32)26-11-6-14-31(26)20-23-8-5-7-22(15-23)18-29/h3-5,7-10,12-13,15-16,26-27,30,32H,6,11,14,17,19-20H2,1-2H3/t26-,27-/m1/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptor


Bioorg Med Chem Lett 15: 5478-82 (2005)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50175365
PNG
(2-fluoro-6-(((R)-2-((R)-1-hydroxy-2-(2-methyl-1-(n...)
Show SMILES CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)[C@H]1CCCN1Cc1cccc(F)c1O
Show InChI InChI=1S/C27H33FN2O2/c1-27(2,16-19-12-13-20-7-3-4-8-21(20)15-19)29-17-25(31)24-11-6-14-30(24)18-22-9-5-10-23(28)26(22)32/h3-5,7-10,12-13,15,24-25,29,31-32H,6,11,14,16-18H2,1-2H3/t24-,25-/m1/s1
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n/an/a 2.56E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of extracellular calcium-induced inositol triphosphate generation in rat MTC cells expressing calcium-sensing receptor


Bioorg Med Chem Lett 15: 5478-82 (2005)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193412
PNG
(CHEMBL537427 | N-[(1S,2S)-2-((R)-1-naphthalen-1-yl...)
Show SMILES C[C@@H](N[C@H]1CCCC[C@@H]1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C25H27F3N2O3S/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)29-23-11-4-5-12-24(23)30-34(31,32)20-15-13-19(14-16-20)33-25(26,27)28/h2-3,6-10,13-17,23-24,29-30H,4-5,11-12H2,1H3/t17-,23+,24+/m1/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193407
PNG
(CHEMBL537426 | N1-[4-(trifluoromethoxy)benzenesulf...)
Show SMILES CC(N[C@@H]1CCCC[C@H]1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12
Show InChI InChI=1S/C25H27F3N2O3S/c1-17(21-10-6-8-18-7-2-3-9-22(18)21)29-23-11-4-5-12-24(23)30-34(31,32)20-15-13-19(14-16-20)33-25(26,27)28/h2-3,6-10,13-17,23-24,29-30H,4-5,11-12H2,1H3/t17?,23-,24-/m1/s1
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n/an/a 5.40E+3n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50193413
PNG
(4-methoxy-N-((1R,2R)-2-(1-(naphthalen-1-yl)ethylam...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@@H]1CCCC[C@H]1NC(C)c1cccc2ccccc12
Show InChI InChI=1S/C25H30N2O3S/c1-18(22-11-7-9-19-8-3-4-10-23(19)22)26-24-12-5-6-13-25(24)27-31(28,29)21-16-14-20(30-2)15-17-21/h3-4,7-11,14-18,24-27H,5-6,12-13H2,1-2H3/t18?,24-,25-/m1/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation


J Med Chem 49: 5119-28 (2006)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50133682
PNG
(CHEMBL3633656)
Show SMILES COc1ccc(cc1)-c1[nH]c2ccccc2c1C(=O)CN(C)CC(=O)N1CCOCC1
Show InChI InChI=1S/C24H27N3O4/c1-26(16-22(29)27-11-13-31-14-12-27)15-21(28)23-19-5-3-4-6-20(19)25-24(23)17-7-9-18(30-2)10-8-17/h3-10,25H,11-16H2,1-2H3
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n/an/a 5.62E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50133682
PNG
(CHEMBL3633656)
Show SMILES COc1ccc(cc1)-c1[nH]c2ccccc2c1C(=O)CN(C)CC(=O)N1CCOCC1
Show InChI InChI=1S/C24H27N3O4/c1-26(16-22(29)27-11-13-31-14-12-27)15-21(28)23-19-5-3-4-6-20(19)25-24(23)17-7-9-18(30-2)10-8-17/h3-10,25H,11-16H2,1-2H3
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n/an/a 5.62E+4n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50133685
PNG
(CHEMBL3633663)
Show SMILES O=C(CN1CCCC(C1)C(=O)N1CCOCC1)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1/C26H29N3O3/c30-23(18-28-12-6-9-20(17-28)26(31)29-13-15-32-16-14-29)24-21-10-4-5-11-22(21)27-25(24)19-7-2-1-3-8-19/h1-5,7-8,10-11,20,27H,6,9,12-18H2
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n/an/a 2.40E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50133685
PNG
(CHEMBL3633663)
Show SMILES O=C(CN1CCCC(C1)C(=O)N1CCOCC1)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1/C26H29N3O3/c30-23(18-28-12-6-9-20(17-28)26(31)29-13-15-32-16-14-29)24-21-10-4-5-11-22(21)27-25(24)19-7-2-1-3-8-19/h1-5,7-8,10-11,20,27H,6,9,12-18H2
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n/an/a 2.40E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50133676
PNG
(CHEMBL3633650)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H25N3O3/c1-25(16-21(28)26-11-13-29-14-12-26)15-20(27)22-18-9-5-6-10-19(18)24-23(22)17-7-3-2-4-8-17/h2-10,24H,11-16H2,1H3
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n/an/a 3.16E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50133676
PNG
(CHEMBL3633650)
Show SMILES CN(CC(=O)N1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H25N3O3/c1-25(16-21(28)26-11-13-29-14-12-26)15-20(27)22-18-9-5-6-10-19(18)24-23(22)17-7-3-2-4-8-17/h2-10,24H,11-16H2,1H3
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n/an/a 3.16E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50133679
PNG
(CHEMBL3633665)
Show SMILES CN(CCN1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H27N3O2/c1-25(11-12-26-13-15-28-16-14-26)17-21(27)22-19-9-5-6-10-20(19)24-23(22)18-7-3-2-4-8-18/h2-10,24H,11-17H2,1H3
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n/an/a 3.47E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50133679
PNG
(CHEMBL3633665)
Show SMILES CN(CCN1CCOCC1)CC(=O)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C23H27N3O2/c1-25(11-12-26-13-15-28-16-14-26)17-21(27)22-19-9-5-6-10-20(19)24-23(22)18-7-3-2-4-8-18/h2-10,24H,11-17H2,1H3
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n/an/a 3.47E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at rat CaSR expressed in HEK293 cells assessed as inhibition of Ca2+-induced inositol monophosphate accumulation after 1 hr by FR...


J Med Chem 58: 8938-51 (2015)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50140175
PNG
(CHEMBL3753729)
Show SMILES C[C@@H](NCc1cc2c(cccc2[nH]1)-c1ccccc1)c1cccc2ccccc12
Show InChI InChI=1/C27H24N2/c1-19(23-14-7-12-21-11-5-6-13-24(21)23)28-18-22-17-26-25(15-8-16-27(26)29-22)20-9-3-2-4-10-20/h2-17,19,28-29H,18H2,1H3/t19-/s2
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n/an/an/an/a 136n/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...


Bioorg Med Chem 24: 554-69 (2016)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50140173
PNG
(CHEMBL3753306)
Show SMILES C[C@@H](NCc1cc2cccc([N+]([O-])=O)c2[nH]1)c1cccc2ccccc12
Show InChI InChI=1/C21H19N3O2/c1-14(18-10-4-7-15-6-2-3-9-19(15)18)22-13-17-12-16-8-5-11-20(24(25)26)21(16)23-17/h2-12,14,22-23H,13H2,1H3/t14-/s2
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CNRS

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...


Bioorg Med Chem 24: 554-69 (2016)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50140170
PNG
(CHEMBL3754639)
Show SMILES C[C@@H](NCc1cc2c(O)cccc2[nH]1)c1cccc2ccccc12
Show InChI InChI=1/C21H20N2O/c1-14(17-9-4-7-15-6-2-3-8-18(15)17)22-13-16-12-19-20(23-16)10-5-11-21(19)24/h2-12,14,22-24H,13H2,1H3/t14-/s2
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n/an/an/an/a 102n/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...


Bioorg Med Chem 24: 554-69 (2016)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50139127
PNG
(CHEMBL3753595)
Show SMILES C[C@@H](NCc1cc2cc(O)ccc2[nH]1)c1cccc2ccccc12
Show InChI InChI=1/C21H20N2O/c1-14(19-8-4-6-15-5-2-3-7-20(15)19)22-13-17-11-16-12-18(24)9-10-21(16)23-17/h2-12,14,22-24H,13H2,1H3/t14-/s2
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CNRS

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...


Bioorg Med Chem 24: 554-69 (2016)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50139126
PNG
(CHEMBL3753320)
Show SMILES CC(NCc1cc2ccccc2[nH]1)c1ccc(F)c2ccccc12
Show InChI InChI=1/C21H19FN2/c1-14(17-10-11-20(22)19-8-4-3-7-18(17)19)23-13-16-12-15-6-2-5-9-21(15)24-16/h2-12,14,23-24H,13H2,1H3
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n/an/an/an/a 131n/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...


Bioorg Med Chem 24: 554-69 (2016)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50404271
PNG
(CHEMBL2092942)
Show SMILES C[C@@H](NCc1cc2ccccc2[nH]1)c1cccc2ccccc12
Show InChI InChI=1S/C21H20N2/c1-15(19-11-6-9-16-7-2-4-10-20(16)19)22-14-18-13-17-8-3-5-12-21(17)23-18/h2-13,15,22-23H,14H2,1H3/t15-/m1/s1
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n/an/an/an/a 132n/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...


Bioorg Med Chem 24: 554-69 (2016)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50140175
PNG
(CHEMBL3753729)
Show SMILES C[C@@H](NCc1cc2c(cccc2[nH]1)-c1ccccc1)c1cccc2ccccc12
Show InChI InChI=1/C27H24N2/c1-19(23-14-7-12-21-11-5-6-13-24(21)23)28-18-22-17-26-25(15-8-16-27(26)29-22)20-9-3-2-4-10-20/h2-17,19,28-29H,18H2,1H3/t19-/s2
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n/an/an/an/a 135n/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...


Bioorg Med Chem 24: 554-69 (2016)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50140173
PNG
(CHEMBL3753306)
Show SMILES C[C@@H](NCc1cc2cccc([N+]([O-])=O)c2[nH]1)c1cccc2ccccc12
Show InChI InChI=1/C21H19N3O2/c1-14(18-10-4-7-15-6-2-3-9-19(15)18)22-13-17-12-16-8-5-11-20(24(25)26)21(16)23-17/h2-12,14,22-23H,13H2,1H3/t14-/s2
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CNRS

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...


Bioorg Med Chem 24: 554-69 (2016)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50140170
PNG
(CHEMBL3754639)
Show SMILES C[C@@H](NCc1cc2c(O)cccc2[nH]1)c1cccc2ccccc12
Show InChI InChI=1/C21H20N2O/c1-14(17-9-4-7-15-6-2-3-8-18(15)17)22-13-16-12-19-20(23-16)10-5-11-21(19)24/h2-12,14,22-24H,13H2,1H3/t14-/s2
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n/an/an/an/a 102n/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...


Bioorg Med Chem 24: 554-69 (2016)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50139127
PNG
(CHEMBL3753595)
Show SMILES C[C@@H](NCc1cc2cc(O)ccc2[nH]1)c1cccc2ccccc12
Show InChI InChI=1/C21H20N2O/c1-14(19-8-4-6-15-5-2-3-7-20(15)19)22-13-17-11-16-12-18(24)9-10-21(16)23-17/h2-12,14,22-24H,13H2,1H3/t14-/s2
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CNRS

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...


Bioorg Med Chem 24: 554-69 (2016)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50139126
PNG
(CHEMBL3753320)
Show SMILES CC(NCc1cc2ccccc2[nH]1)c1ccc(F)c2ccccc12
Show InChI InChI=1/C21H19FN2/c1-14(17-10-11-20(22)19-8-4-3-7-18(17)19)23-13-16-12-15-6-2-5-9-21(15)24-16/h2-12,14,23-24H,13H2,1H3
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CNRS

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...


Bioorg Med Chem 24: 554-69 (2016)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50404271
PNG
(CHEMBL2092942)
Show SMILES C[C@@H](NCc1cc2ccccc2[nH]1)c1cccc2ccccc12
Show InChI InChI=1S/C21H20N2/c1-15(19-11-6-9-16-7-2-4-10-20(16)19)22-14-18-13-17-8-3-5-12-21(17)23-18/h2-13,15,22-23H,14H2,1H3/t15-/m1/s1
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n/an/an/an/a 132n/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Agonist activity at rat brain CaSR expressed in CHO cells assessed as inositol phosphate production in presence of 3 mM extracellular Ca2+ by IP-one ...


Bioorg Med Chem 24: 554-69 (2016)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50404271
PNG
(CHEMBL2092942)
Show SMILES C[C@@H](NCc1cc2ccccc2[nH]1)c1cccc2ccccc12
Show InChI InChI=1S/C21H20N2/c1-15(19-11-6-9-16-7-2-4-10-20(16)19)22-14-18-13-17-8-3-5-12-21(17)23-18/h2-13,15,22-23H,14H2,1H3/t15-/m1/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



UPR 2301 Centre National de la Recherche Scientifique

Curated by ChEMBL


Assay Description
Ability to stimulate [3H]inositol phosphates accumulation in CHO cells expressing rat Calcium sensing receptor (CaSR) at 2 mM [Ca2+]


Bioorg Med Chem Lett 14: 3345-9 (2004)

More data for this
Ligand-Target Pair
Calcium sensing receptor


(Rattus norvegicus)
BDBM50147700
PNG
((1H-Indol-2-ylmethyl)-(1-naphthalen-1-yl-ethyl)-am...)
Show SMILES CC(NCc1cc2ccccc2[nH]1)c1cccc2ccccc12
Show InChI InChI=1S/C21H20N2/c1-15(19-11-6-9-16-7-2-4-10-20(16)19)22-14-18-13-17-8-3-5-12-21(17)23-18/h2-13,15,22-23H,14H2,1H3
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n/an/an/an/a 1.30E+3n/an/an/an/a



UPR 2301 Centre National de la Recherche Scientifique

Curated by ChEMBL


Assay Description
Ability to stimulate [3H]inositol phosphates accumulation in CHO cells expressing rat Calcium sensing receptor (CaSR) at 2 mM [Ca2+]


Bioorg Med Chem Lett 14: 3345-9 (2004)

More data for this
Ligand-Target Pair