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Found 17 hits Enz. Inhib. hit(s) with Target = 'Calcium-activated potassium channel subunit alpha-1' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50412339
PNG
(CHEMBL496460)
Show SMILES COc1ccc(Br)cc1C1Sc2ccc(cc2NC1=O)C(F)(F)F
Show InChI InChI=1S/C16H11BrF3NO2S/c1-23-12-4-3-9(17)7-10(12)14-15(22)21-11-6-8(16(18,19)20)2-5-13(11)24-14/h2-7,14H,1H3,(H,21,22)
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n/an/a 39.8n/an/an/an/an/an/a



Universit£ degli Studi di Pisa

Curated by ChEMBL


Assay Description
Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50412337
PNG
(CHEMBL498516)
Show SMILES COc1ccc(Br)cc1C1Sc2ccc(cc2N(C)C1=O)C(F)(F)F
Show InChI InChI=1S/C17H13BrF3NO2S/c1-22-12-7-9(17(19,20)21)3-6-14(12)25-15(16(22)23)11-8-10(18)4-5-13(11)24-2/h3-8,15H,1-2H3
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n/an/a 617n/an/an/an/an/an/a



Universit£ degli Studi di Pisa

Curated by ChEMBL


Assay Description
Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50347497
PNG
(CHEMBL384903)
Show SMILES Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
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n/an/a 4.37E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50347497
PNG
(CHEMBL384903)
Show SMILES Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
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n/an/a 5.01E+3n/an/an/an/an/an/a



Universit£ degli Studi di Pisa

Curated by ChEMBL


Assay Description
Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50347497
PNG
(CHEMBL384903)
Show SMILES Oc1ccc(cc1-n1c2ccc(cc2[nH]c1=O)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
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n/an/a 5.13E+3n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50412335
PNG
(CHEMBL498702)
Show SMILES COc1ccc(Br)cc1[C@@H](O)[C@H]1Sc2ccc(cc2NC1=O)C(F)(F)F
Show InChI InChI=1S/C17H13BrF3NO3S/c1-25-12-4-3-9(18)7-10(12)14(23)15-16(24)22-11-6-8(17(19,20)21)2-5-13(11)26-15/h2-7,14-15,23H,1H3,(H,22,24)/t14-,15-/m1/s1
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n/an/a 6.31E+3n/an/an/an/an/an/a



Universit£ degli Studi di Pisa

Curated by ChEMBL


Assay Description
Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50412334
PNG
(CHEMBL525555)
Show SMILES COc1ccc(Br)cc1C1Sc2ccccc2NC1=O
Show InChI InChI=1S/C15H12BrNO2S/c1-19-12-7-6-9(16)8-10(12)14-15(18)17-11-4-2-3-5-13(11)20-14/h2-8,14H,1H3,(H,17,18)
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n/an/a 1.58E+4n/an/an/an/an/an/a



Universit£ degli Studi di Pisa

Curated by ChEMBL


Assay Description
Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50413656
PNG
(CHEMBL511502)
Show SMILES Cc1c(nnn1Cc1ccccc1O)C(=O)Nc1ccccc1
Show InChI InChI=1S/C17H16N4O2/c1-12-16(17(23)18-14-8-3-2-4-9-14)19-20-21(12)11-13-7-5-6-10-15(13)22/h2-10,22H,11H2,1H3,(H,18,23)
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n/an/a 1.78E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50412110
PNG
(CHEMBL454860)
Show SMILES COc1ccc(cc1NC(=O)Cc1ccccc1O)[N+]([O-])=O
Show InChI InChI=1S/C15H14N2O5/c1-22-14-7-6-11(17(20)21)9-12(14)16-15(19)8-10-4-2-3-5-13(10)18/h2-7,9,18H,8H2,1H3,(H,16,19)
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n/an/a 1.82E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50412109
PNG
(CHEMBL455120)
Show SMILES Cc1cc(ccc1NC(=O)Cc1ccccc1O)[N+]([O-])=O
Show InChI InChI=1S/C15H14N2O4/c1-10-8-12(17(20)21)6-7-13(10)16-15(19)9-11-4-2-3-5-14(11)18/h2-8,18H,9H2,1H3,(H,16,19)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50413657
PNG
(CHEMBL511864)
Show SMILES Cc1c(nnn1Cc1ccccc1O)C(=O)Nc1ccccc1O
Show InChI InChI=1S/C17H16N4O3/c1-11-16(17(24)18-13-7-3-5-9-15(13)23)19-20-21(11)10-12-6-2-4-8-14(12)22/h2-9,22-23H,10H2,1H3,(H,18,24)
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n/an/a 2.04E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50413658
PNG
(CHEMBL517023)
Show SMILES Cc1c(nnn1Cc1ccccc1O)C(=O)NCc1ccccc1O
Show InChI InChI=1S/C18H18N4O3/c1-12-17(18(25)19-10-13-6-2-4-8-15(13)23)20-21-22(12)11-14-7-3-5-9-16(14)24/h2-9,23-24H,10-11H2,1H3,(H,19,25)
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n/an/a 2.19E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Activation of BK channel in Wistar rat thoracic aorta assessed as relaxation of KCl-induced contraction


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50412336
PNG
(CHEMBL526824)
Show SMILES COc1ccccc1C1CNc2cc(ccc2S1)C(F)(F)F
Show InChI InChI=1S/C16H14F3NOS/c1-21-13-5-3-2-4-11(13)15-9-20-12-8-10(16(17,18)19)6-7-14(12)22-15/h2-8,15,20H,9H2,1H3
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n/an/a 2.24E+4n/an/an/an/an/an/a



Universit£ degli Studi di Pisa

Curated by ChEMBL


Assay Description
Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50412108
PNG
(CHEMBL455121)
Show SMILES Oc1ccccc1CC(=O)Nc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C14H12N2O4/c17-13-4-2-1-3-10(13)9-14(18)15-11-5-7-12(8-6-11)16(19)20/h1-8,17H,9H2,(H,15,18)
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n/an/a 2.29E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50412111
PNG
(CHEMBL452258)
Show SMILES COc1ccccc1CC(=O)Nc1cc(C)ccc1O
Show InChI InChI=1S/C16H17NO3/c1-11-7-8-14(18)13(9-11)17-16(19)10-12-5-3-4-6-15(12)20-2/h3-9,18H,10H2,1-2H3,(H,17,19)
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n/an/a 2.45E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50412107
PNG
(CHEMBL452008)
Show SMILES Fc1ccccc1NC(=O)Cc1ccccc1C(F)(F)F
Show InChI InChI=1S/C15H11F4NO/c16-12-7-3-4-8-13(12)20-14(21)9-10-5-1-2-6-11(10)15(17,18)19/h1-8H,9H2,(H,20,21)
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n/an/a 2.75E+4n/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Induction of BK channel mediated vasorelaxation activity in Kcl-induced contraction in Wistar rat aorta


Citation and Details
More data for this
Ligand-Target Pair
Calcium-activated potassium channel subunit alpha-1


(Rattus norvegicus)
BDBM50412338
PNG
(CHEMBL525920)
Show SMILES COc1c(Br)cc(Br)cc1C1Sc2ccc(cc2NC1=O)C(F)(F)F
Show InChI InChI=1S/C16H10Br2F3NO2S/c1-24-13-9(5-8(17)6-10(13)18)14-15(23)22-11-4-7(16(19,20)21)2-3-12(11)25-14/h2-6,14H,1H3,(H,22,23)
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n/an/a 5.01E+4n/an/an/an/an/an/a



Universit£ degli Studi di Pisa

Curated by ChEMBL


Assay Description
Activation of large-conductance calcium-activated potassium channel-mediated vasorelaxation in endothelium-denuded normotensive Wistar rat thoracic a...


Citation and Details
More data for this
Ligand-Target Pair