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Found 114 hits Enz. Inhib. hit(s) with Target = 'Calcium-dependent protein kinase 1 (CDPK1)' AND taxid = 5807   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389702
PNG
(CHEMBL2070069 | US9765037, Compound 39)
Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc4cc(OCc5ccc(Cl)cc5)ccc4c3)c12
Show InChI InChI=1S/C28H27ClN6O/c29-23-6-1-19(2-7-23)16-36-24-8-5-20-13-22(4-3-21(20)14-24)26-25-27(30)32-17-33-28(25)35(34-26)15-18-9-11-31-12-10-18/h1-8,13-14,17-18,31H,9-12,15-16H2,(H2,30,32,33)
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n/an/a 0.400n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389700
PNG
(CHEMBL2070067 | US9765037, Compound 38)
Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc4cc(OCc5cccc(Cl)c5)ccc4c3)c12
Show InChI InChI=1S/C28H27ClN6O/c29-23-3-1-2-19(12-23)16-36-24-7-6-20-13-22(5-4-21(20)14-24)26-25-27(30)32-17-33-28(25)35(34-26)15-18-8-10-31-11-9-18/h1-7,12-14,17-18,31H,8-11,15-16H2,(H2,30,32,33)
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n/an/a 0.600n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389698
PNG
(CHEMBL2070065 | US9765037, Compound 37)
Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc4cc(OCc5ccccc5Cl)ccc4c3)c12
Show InChI InChI=1S/C28H27ClN6O/c29-24-4-2-1-3-22(24)16-36-23-8-7-19-13-21(6-5-20(19)14-23)26-25-27(30)32-17-33-28(25)35(34-26)15-18-9-11-31-12-10-18/h1-8,13-14,17-18,31H,9-12,15-16H2,(H2,30,32,33)
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US Patent
n/an/a 0.800n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389696
PNG
(CHEMBL2070063 | US9765037, Compound 34)
Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc4cc(OCc5ccccc5)ccc4c3)c12
Show InChI InChI=1S/C28H28N6O/c29-27-25-26(33-34(28(25)32-18-31-27)16-19-10-12-30-13-11-19)23-7-6-22-15-24(9-8-21(22)14-23)35-17-20-4-2-1-3-5-20/h1-9,14-15,18-19,30H,10-13,16-17H2,(H2,29,31,32)
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n/an/a 2.10n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340945
PNG
(3-tert-butyl-1-(1-methyl-1H-indol-5- yl)imidazo[1,...)
Show SMILES Cn1ccc2cc(ccc12)-c1nc(n2ccnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C19H21N5/c1-19(2,3)18-22-15(16-17(20)21-8-10-24(16)18)13-5-6-14-12(11-13)7-9-23(14)4/h5-11H,1-4H3,(H2,20,21)
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US Patent
n/an/a 2.20n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50383380
PNG
(CHEMBL2030553 | CHEMBL2070047 | US9765037, Compoun...)
Show SMILES COc1ccc2cc(ccc2c1)-c1nn(CC2CCNCC2)c2ncnc(N)c12
Show InChI InChI=1S/C22H24N6O/c1-29-18-5-4-15-10-17(3-2-16(15)11-18)20-19-21(23)25-13-26-22(19)28(27-20)12-14-6-8-24-9-7-14/h2-5,10-11,13-14,24H,6-9,12H2,1H3,(H2,23,25,26)
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n/an/a 2.30n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389734
PNG
(CHEMBL2069950 | US9765037, Compound 20)
Show SMILES CC(C)n1nc(-c2ccc3n(C)ccc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C17H18N6/c1-10(2)23-17-14(16(18)19-9-20-17)15(21-23)12-4-5-13-11(8-12)6-7-22(13)3/h4-10H,1-3H3,(H2,18,19,20)
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n/an/a 3n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389688
PNG
(CHEMBL2069315 | US9765037, Compound 36)
Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc4cc(OCC=C)ccc4c3)c12
Show InChI InChI=1S/C24H26N6O/c1-2-11-31-20-6-5-17-12-19(4-3-18(17)13-20)22-21-23(25)27-15-28-24(21)30(29-22)14-16-7-9-26-10-8-16/h2-6,12-13,15-16,26H,1,7-11,14H2,(H2,25,27,28)
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n/an/a 3.20n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50383381
PNG
(CHEMBL2030554 | CHEMBL2070050 | US9765037, Compoun...)
Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(CC2CCNCC2)c2ncnc(N)c12
Show InChI InChI=1S/C23H26N6O/c1-2-30-19-6-5-16-11-18(4-3-17(16)12-19)21-20-22(24)26-14-27-23(20)29(28-21)13-15-7-9-25-10-8-15/h3-6,11-12,14-15,25H,2,7-10,13H2,1H3,(H2,24,26,27)
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n/an/a 3.5n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389687
PNG
(CHEMBL2070054 | US9765037, Compound 41)
Show SMILES CC(C)n1nc(-c2ccc3cc(OCC=C)ccc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C21H21N5O/c1-4-9-27-17-8-7-14-10-16(6-5-15(14)11-17)19-18-20(22)23-12-24-21(18)26(25-19)13(2)3/h4-8,10-13H,1,9H2,2-3H3,(H2,22,23,24)
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n/an/a 4.10n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389746
PNG
(CHEMBL2070061 | US9765037, Compound 35)
Show SMILES CCCCOc1ccc2cc(ccc2c1)-c1nn(CC2CCNCC2)c2ncnc(N)c12
Show InChI InChI=1S/C25H30N6O/c1-2-3-12-32-21-7-6-18-13-20(5-4-19(18)14-21)23-22-24(26)28-16-29-25(22)31(30-23)15-17-8-10-27-11-9-17/h4-7,13-14,16-17,27H,2-3,8-12,15H2,1H3,(H2,26,28,29)
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n/an/a 4.40n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389690
PNG
(CHEMBL2070056 | US9765037, Compound 33)
Show SMILES CCCOc1ccc2cc(ccc2c1)-c1nn(CC2CCNCC2)c2ncnc(N)c12
Show InChI InChI=1S/C24H28N6O/c1-2-11-31-20-6-5-17-12-19(4-3-18(17)13-20)22-21-23(25)27-15-28-24(21)30(29-22)14-16-7-9-26-10-8-16/h3-6,12-13,15-16,26H,2,7-11,14H2,1H3,(H2,25,27,28)
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n/an/a 4.60n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345739
PNG
(1-isopropyl-3-(6-methoxynaphthalen-2-yl)-1H-pyrazo...)
Show SMILES COc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C19H19N5O/c1-11(2)24-19-16(18(20)21-10-22-19)17(23-24)14-5-4-13-9-15(25-3)7-6-12(13)8-14/h4-11H,1-3H3,(H2,20,21,22)
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n/an/a 5n/an/an/an/an/an/a



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US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389686
PNG
(CHEMBL2070053 | US9765037, Compound 32)
Show SMILES CC(C)Oc1ccc2cc(ccc2c1)-c1nn(CC2CCNCC2)c2ncnc(N)c12
Show InChI InChI=1S/C24H28N6O/c1-15(2)31-20-6-5-17-11-19(4-3-18(17)12-20)22-21-23(25)27-14-28-24(21)30(29-22)13-16-7-9-26-10-8-16/h3-6,11-12,14-16,26H,7-10,13H2,1-2H3,(H2,25,27,28)
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n/an/a 5.10n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340946
PNG
(3-tert-butyl-1-(6-methoxynaphthalen-2- yl)imidazo[...)
Show SMILES COc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C21H22N4O/c1-21(2,3)20-24-17(18-19(22)23-9-10-25(18)20)15-6-5-14-12-16(26-4)8-7-13(14)11-15/h5-12H,1-4H3,(H2,22,23)
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n/an/a 5.30n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389693
PNG
(CHEMBL2070059 | US9765037, Compound 44)
Show SMILES CC(C)COc1ccc2cc(ccc2c1)-c1nn(CC2CCNCC2)c2ncnc(N)c12
Show InChI InChI=1S/C25H30N6O/c1-16(2)14-32-21-6-5-18-11-20(4-3-19(18)12-21)23-22-24(26)28-15-29-25(22)31(30-23)13-17-7-9-27-10-8-17/h3-6,11-12,15-17,27H,7-10,13-14H2,1-2H3,(H2,26,28,29)
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n/an/a 6.70n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340899
PNG
(1-isopropyl-3-(4-methyl-1H-indol-2-yl)-1H- pyrazol...)
Show SMILES CC(C)n1nc(-c2cc3c(C)cccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C17H18N6/c1-9(2)23-17-14(16(18)19-8-20-17)15(22-23)13-7-11-10(3)5-4-6-12(11)21-13/h4-9,21H,1-3H3,(H2,18,19,20)
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n/an/a 7.30n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340881
PNG
(3-isopropyl-1-(naphthalen-2-yl)imidazo[1,5- a]pyra...)
Show SMILES CC(C)c1nc(-c2ccc3ccccc3c2)c2c(N)nccn12
Show InChI InChI=1S/C19H18N4/c1-12(2)19-22-16(17-18(20)21-9-10-23(17)19)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H2,20,21)
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n/an/a 7.80n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345712
PNG
(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-ylmethyl)...)
Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C22H24N6/c23-21-20-19(12-17-6-3-5-16-4-1-2-7-18(16)17)27-28(22(20)26-14-25-21)13-15-8-10-24-11-9-15/h1-7,14-15,24H,8-13H2,(H2,23,25,26)
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n/an/a 9n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345738
PNG
(1-isopropyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]...)
Show SMILES CC(C)n1nc(-c2ccc3ccccc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C18H17N5/c1-11(2)23-18-15(17(19)20-10-21-18)16(22-23)14-8-7-12-5-3-4-6-13(12)9-14/h3-11H,1-2H3,(H2,19,20,21)
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n/an/a 10n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340944
PNG
(3-tert-butyl-1-(6-ethoxynaphthalen-2- yl)imidazo[1...)
Show SMILES CCOc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C
Show InChI InChI=1S/C22H24N4O/c1-5-27-17-9-8-14-12-16(7-6-15(14)13-17)18-19-20(23)24-10-11-26(19)21(25-18)22(2,3)4/h6-13H,5H2,1-4H3,(H2,23,24)
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n/an/a 10.7n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345740
PNG
(3-(6-ethoxynaphthalen-2-yl)-1-isopropyl-1H-pyrazol...)
Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C20H21N5O/c1-4-26-16-8-7-13-9-15(6-5-14(13)10-16)18-17-19(21)22-11-23-20(17)25(24-18)12(2)3/h5-12H,4H2,1-3H3,(H2,21,22,23)
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n/an/a 12n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340947
PNG
(3-tert-butyl-1-(quinolin-3-yl)imidazo[1,5- a]pyraz...)
Show SMILES CC(C)(C)c1nc(-c2cnc3ccccc3c2)c2c(N)nccn12
Show InChI InChI=1S/C19H19N5/c1-19(2,3)18-23-15(16-17(20)21-8-9-24(16)18)13-10-12-6-4-5-7-14(12)22-11-13/h4-11H,1-3H3,(H2,20,21)
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US Patent
n/an/a 12.3n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345725
PNG
(3-(3,4-dichlorophenyl)-1-isopropyl-1H-pyrazolo[3,4...)
Show SMILES CC(C)n1nc(-c2ccc(Cl)c(Cl)c2)c2c(N)ncnc12
Show InChI InChI=1S/C14H13Cl2N5/c1-7(2)21-14-11(13(17)18-6-19-14)12(20-21)8-3-4-9(15)10(16)5-8/h3-7H,1-2H3,(H2,17,18,19)
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n/an/a 13n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340932
PNG
(3-(1-methyl-1H-indol-5-yl)-1-(piperidin-4- ylmethy...)
Show SMILES Cn1ccc2cc(ccc12)-c1nn(CC2CCNCC2)c2ncnc(N)c12
Show InChI InChI=1S/C20H23N7/c1-26-9-6-14-10-15(2-3-16(14)26)18-17-19(21)23-12-24-20(17)27(25-18)11-13-4-7-22-8-5-13/h2-3,6,9-10,12-13,22H,4-5,7-8,11H2,1H3,(H2,21,23,24)
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US Patent
n/an/a 13.4n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50383382
PNG
(CHEMBL2030556 | CHEMBL2069948 | US10172858, Table ...)
Show SMILES CC(C)n1nc(-c2cc3c(Cl)cccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H15ClN6/c1-8(2)23-16-13(15(18)19-7-20-16)14(22-23)12-6-9-10(17)4-3-5-11(9)21-12/h3-8,21H,1-2H3,(H2,18,19,20)
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n/an/a 16.2n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345735
PNG
(1-isopropyl-3-(4-methoxy-3-methylphenyl)-1H-pyrazo...)
Show SMILES COc1ccc(cc1C)-c1nn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C16H19N5O/c1-9(2)21-16-13(15(17)18-8-19-16)14(20-21)11-5-6-12(22-4)10(3)7-11/h5-9H,1-4H3,(H2,17,18,19)
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US Patent
n/an/a 17n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345742
PNG
(1-isopropyl-3-(quinolin-3-yl)-1H-pyrazolo[3,4-d]py...)
Show SMILES CC(C)n1nc(-c2cnc3ccccc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C17H16N6/c1-10(2)23-17-14(16(18)20-9-21-17)15(22-23)12-7-11-5-3-4-6-13(11)19-8-12/h3-10H,1-2H3,(H2,18,20,21)
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n/an/a 20n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345730
PNG
(3-(3,4-dimethylphenyl)-1-isopropyl-1H-pyrazolo[3,4...)
Show SMILES CC(C)n1nc(-c2ccc(C)c(C)c2)c2c(N)ncnc12
Show InChI InChI=1S/C16H19N5/c1-9(2)21-16-13(15(17)18-8-19-16)14(20-21)12-6-5-10(3)11(4)7-12/h5-9H,1-4H3,(H2,17,18,19)
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n/an/a 22n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340930
PNG
(1-isopropyl-3-(6-(pyridin-4- ylmethoxy)naphthalen-...)
Show SMILES CC(C)n1nc(-c2ccc3cc(OCc4ccncc4)ccc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C24H22N6O/c1-15(2)30-24-21(23(25)27-14-28-24)22(29-30)19-4-3-18-12-20(6-5-17(18)11-19)31-13-16-7-9-26-10-8-16/h3-12,14-15H,13H2,1-2H3,(H2,25,27,28)
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US Patent
n/an/a 30.7n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340882
PNG
(3-isopropyl-1-(quinolin-3-yl)imidazo[1,5- a]pyrazi...)
Show SMILES CC(C)c1nc(-c2cnc3ccccc3c2)c2c(N)nccn12
Show InChI InChI=1S/C18H17N5/c1-11(2)18-22-15(16-17(19)20-7-8-23(16)18)13-9-12-5-3-4-6-14(12)21-10-13/h3-11H,1-2H3,(H2,19,20)
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US Patent
n/an/a 32n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340883
PNG
(1-(6-ethoxynaphthalen-2-yl)-3- isopropylimidazo[1,...)
Show SMILES CCOc1ccc2cc(ccc2c1)-c1nc(C(C)C)n2ccnc(N)c12
Show InChI InChI=1S/C21H22N4O/c1-4-26-17-8-7-14-11-16(6-5-15(14)12-17)18-19-20(22)23-9-10-25(19)21(24-18)13(2)3/h5-13H,4H2,1-3H3,(H2,22,23)
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US Patent
n/an/a 33.6n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345713
PNG
(3-(naphthalen-1-ylmethyl)-1-(2-(piperidin-4-yl)eth...)
Show SMILES Nc1ncnc2n(CCC3CCNCC3)nc(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C23H26N6/c24-22-21-20(14-18-6-3-5-17-4-1-2-7-19(17)18)28-29(23(21)27-15-26-22)13-10-16-8-11-25-12-9-16/h1-7,15-16,25H,8-14H2,(H2,24,26,27)
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n/an/a 34n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389695
PNG
(CHEMBL2070062 | US9765037, Compound 40)
Show SMILES CC(C)n1nc(-c2ccc3cc(OCc4ccccc4)ccc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C25H23N5O/c1-16(2)30-25-22(24(26)27-15-28-25)23(29-30)20-9-8-19-13-21(11-10-18(19)12-20)31-14-17-6-4-3-5-7-17/h3-13,15-16H,14H2,1-2H3,(H2,26,27,28)
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US Patent
n/an/a 49.7n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345717
PNG
(1-(1-ethylpiperidin-4-yl)-3-(naphthalen-1-ylmethyl...)
Show SMILES CCN1CCC(CC1)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc12
Show InChI InChI=1S/C23H26N6/c1-2-28-12-10-18(11-13-28)29-23-21(22(24)25-15-26-23)20(27-29)14-17-8-5-7-16-6-3-4-9-19(16)17/h3-9,15,18H,2,10-14H2,1H3,(H2,24,25,26)
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n/an/a 50n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345731
PNG
(3-(4-fluoro-3-methylphenyl)-1-isopropyl-1H-pyrazol...)
Show SMILES CC(C)n1nc(-c2ccc(F)c(C)c2)c2c(N)ncnc12
Show InChI InChI=1S/C15H16FN5/c1-8(2)21-15-12(14(17)18-7-19-15)13(20-21)10-4-5-11(16)9(3)6-10/h4-8H,1-3H3,(H2,17,18,19)
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n/an/a 53n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389689
PNG
(CHEMBL2070055 | US9765037, Compound 12)
Show SMILES CCCOc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C21H23N5O/c1-4-9-27-17-8-7-14-10-16(6-5-15(14)11-17)19-18-20(22)23-12-24-21(18)26(25-19)13(2)3/h5-8,10-13H,4,9H2,1-3H3,(H2,22,23,24)
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n/an/a 53.2n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389694
PNG
(CHEMBL2070060 | US9765037, Compound 42)
Show SMILES CCCCOc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C22H25N5O/c1-4-5-10-28-18-9-8-15-11-17(7-6-16(15)12-18)20-19-21(23)24-13-25-22(19)27(26-20)14(2)3/h6-9,11-14H,4-5,10H2,1-3H3,(H2,23,24,25)
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n/an/a 54n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345711
PNG
(3-(naphthalen-1-ylmethyl)-1-(piperidin-4-yl)-1H-py...)
Show SMILES Nc1ncnc2n(nc(Cc3cccc4ccccc34)c12)C1CCNCC1
Show InChI InChI=1S/C21H22N6/c22-20-19-18(12-15-6-3-5-14-4-1-2-7-17(14)15)26-27(21(19)25-13-24-20)16-8-10-23-11-9-16/h1-7,13,16,23H,8-12H2,(H2,22,24,25)
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n/an/a 56n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389685
PNG
(CHEMBL2070052 | US9765037, Compound 11)
Show SMILES CC(C)Oc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C21H23N5O/c1-12(2)26-21-18(20(22)23-11-24-21)19(25-26)16-6-5-15-10-17(27-13(3)4)8-7-14(15)9-16/h5-13H,1-4H3,(H2,22,23,24)
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n/an/a 57.3n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345704
PNG
(1-(tert-butyl)-3-(naphthalen-2-yl)-1H-pyrazolo[3,4...)
Show SMILES CC(C)(C)n1nc(-c2ccc3ccccc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-9-8-12-6-4-5-7-13(12)10-14/h4-11H,1-3H3,(H2,20,21,22)
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n/an/a 59n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345727
PNG
(1-isopropyl-3-(3-isopropylphenyl)-1H-pyrazolo[3,4-...)
Show SMILES CC(C)c1cccc(c1)-c1nn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C17H21N5/c1-10(2)12-6-5-7-13(8-12)15-14-16(18)19-9-20-17(14)22(21-15)11(3)4/h5-11H,1-4H3,(H2,18,19,20)
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n/an/a 59n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389730
PNG
(CHEMBL2069946 | US10172858, Table 2.7 | US9765037,...)
Show SMILES CC(C)n1nc(-c2cc3ccccc3[nH]2)c2c(N)ncnc12
Show InChI InChI=1S/C16H16N6/c1-9(2)22-16-13(15(17)18-8-19-16)14(21-22)12-7-10-5-3-4-6-11(10)20-12/h3-9,20H,1-2H3,(H2,17,18,19)
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n/an/a 70.4n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345720
PNG
(1-(1-(methylsulfonyl)piperidin-4-yl)-3-(naphthalen...)
Show SMILES CS(=O)(=O)N1CCC(CC1)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc12
Show InChI InChI=1S/C22H24N6O2S/c1-31(29,30)27-11-9-17(10-12-27)28-22-20(21(23)24-14-25-22)19(26-28)13-16-7-4-6-15-5-2-3-8-18(15)16/h2-8,14,17H,9-13H2,1H3,(H2,23,24,25)
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n/an/a 75n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50383374
PNG
(CHEMBL2030555 | CHEMBL2069960 | US9765037, Compoun...)
Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3cnc4ccccc4c3)c12
Show InChI InChI=1S/C20H21N7/c21-19-17-18(15-9-14-3-1-2-4-16(14)23-10-15)26-27(20(17)25-12-24-19)11-13-5-7-22-8-6-13/h1-4,9-10,12-13,22H,5-8,11H2,(H2,21,24,25)
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n/an/a 83.7n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345728
PNG
(1-isopropyl-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-...)
Show SMILES CC(C)n1nc(-c2ccc(C)cc2)c2c(N)ncnc12
Show InChI InChI=1S/C15H17N5/c1-9(2)20-15-12(14(16)17-8-18-15)13(19-20)11-6-4-10(3)5-7-11/h4-9H,1-3H3,(H2,16,17,18)
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n/an/a 87n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340919
PNG
(3-(4-chlorophenyl)-1-(piperidin-4-ylmethyl)-1H- py...)
Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C17H19ClN6/c18-13-3-1-12(2-4-13)15-14-16(19)21-10-22-17(14)24(23-15)9-11-5-7-20-8-6-11/h1-4,10-11,20H,5-9H2,(H2,19,21,22)
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n/an/a 92n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50345734
PNG
(1-isopropyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo...)
Show SMILES COc1cc(cc(OC)c1OC)-c1nn(C(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C17H21N5O3/c1-9(2)22-17-13(16(18)19-8-20-17)14(21-22)10-6-11(23-3)15(25-5)12(7-10)24-4/h6-9H,1-5H3,(H2,18,19,20)
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PC sid
UniChem

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US Patent
n/an/a 93n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM340905
PNG
(1-((1H-imidazol-4-yl)methyl)-3-(naphthalen-1- ylme...)
Show SMILES Nc1ncnc2n(Cc3c[nH]cn3)nc(Cc3cccc4ccccc34)c12
Show InChI InChI=1S/C20H17N7/c21-19-18-17(8-14-6-3-5-13-4-1-2-7-16(13)14)26-27(20(18)25-12-24-19)10-15-9-22-11-23-15/h1-7,9,11-12H,8,10H2,(H,22,23)(H2,21,24,25)
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 93.6n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
Calcium-dependent protein kinase 1 (CDPK1)


(Cryptosporidium parvum)
BDBM50389697
PNG
(CHEMBL2070064 | US9765037, Compound 46)
Show SMILES CC(C)n1nc(-c2ccc3cc(OCc4ccccc4Cl)ccc3c2)c2c(N)ncnc12
Show InChI InChI=1S/C25H22ClN5O/c1-15(2)31-25-22(24(27)28-14-29-25)23(30-31)18-8-7-17-12-20(10-9-16(17)11-18)32-13-19-5-3-4-6-21(19)26/h3-12,14-15H,13H2,1-2H3,(H2,27,28,29)
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 102n/an/an/an/an/an/a



University of Washington Through its Center for Commercialization

US Patent


Assay Description
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...


US Patent US9765037 (2017)

More data for this
Ligand-Target Pair
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