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Found 11 hits Enz. Inhib. hit(s) with Target = 'Carbonic Anhydrase II Mutant (F131V)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12013
PNG
(4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE | CHEMBL...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C14H14N2O3S/c15-20(18,19)13-8-6-12(7-9-13)14(17)16-10-11-4-2-1-3-5-11/h1-9H,10H2,(H,16,17)(H2,15,18,19)
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PubMed
n/an/an/a 5.60n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12023
PNG
(2,3,4,5,6-pentafluoro-SBB | 4-(AMINOSULFONYL)-N-[(...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C14H9F5N2O3S/c15-9-8(10(16)12(18)13(19)11(9)17)5-21-14(22)6-1-3-7(4-2-6)25(20,23)24/h1-4H,5H2,(H,21,22)(H2,20,23,24)
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PubMed
n/an/an/a 2n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12018
PNG
(2,5-difluoro-SBB | 4-(AMINOSULFONYL)-N-[(2,5-DIFLU...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1cc(F)ccc1F
Show InChI InChI=1S/C14H12F2N2O3S/c15-11-3-6-13(16)10(7-11)8-18-14(19)9-1-4-12(5-2-9)22(17,20)21/h1-7H,8H2,(H,18,19)(H2,17,20,21)
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PubMed
n/an/an/a 2.20n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12019
PNG
(2,6-difluoro-SBB | 4-(AMINOSULFONYL)-N-[(2,6-DIFLU...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1c(F)cccc1F
Show InChI InChI=1S/C14H12F2N2O3S/c15-12-2-1-3-13(16)11(12)8-18-14(19)9-4-6-10(7-5-9)22(17,20)21/h1-7H,8H2,(H,18,19)(H2,17,20,21)
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PubMed
n/an/an/a 3.90n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12016
PNG
(2,3-difluoro-SBB | 4-(AMINOSULFONYL)-N-[(2,3-DIFLU...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1cccc(F)c1F
Show InChI InChI=1S/C14H12F2N2O3S/c15-12-3-1-2-10(13(12)16)8-18-14(19)9-4-6-11(7-5-9)22(17,20)21/h1-7H,8H2,(H,18,19)(H2,17,20,21)
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PubMed
n/an/an/a 1.60n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12015
PNG
(4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZA...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C14H13FN2O3S/c15-12-5-1-10(2-6-12)9-17-14(18)11-3-7-13(8-4-11)21(16,19)20/h1-8H,9H2,(H,17,18)(H2,16,19,20)
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n/an/an/a 3.30n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12014
PNG
(2-fluoro-SBB | 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENY...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1ccccc1F
Show InChI InChI=1S/C14H13FN2O3S/c15-13-4-2-1-3-11(13)9-17-14(18)10-5-7-12(8-6-10)21(16,19)20/h1-8H,9H2,(H,17,18)(H2,16,19,20)
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PubMed
n/an/an/a 2.30n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12020
PNG
(2,3,4-trifluoro-SBB | 4-(AMINOSULFONYL)-N-[(2,3,4-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1ccc(F)c(F)c1F
Show InChI InChI=1S/C14H11F3N2O3S/c15-11-6-3-9(12(16)13(11)17)7-19-14(20)8-1-4-10(5-2-8)23(18,21)22/h1-6H,7H2,(H,19,20)(H2,18,21,22)
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PubMed
n/an/an/a 3.80n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12021
PNG
(2,4,6-trifluoro-SBB | 4-(AMINOSULFONYL)-N-[(2,4,6-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1c(F)cc(F)cc1F
Show InChI InChI=1S/C14H11F3N2O3S/c15-9-5-12(16)11(13(17)6-9)7-19-14(20)8-1-3-10(4-2-8)23(18,21)22/h1-6H,7H2,(H,19,20)(H2,18,21,22)
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PubMed
n/an/an/a 3.90n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12022
PNG
(3,4,5-trifluoro-SBB | 4-(AMINOSULFONYL)-N-[(3,4,5-...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C14H11F3N2O3S/c15-11-5-8(6-12(16)13(11)17)7-19-14(20)9-1-3-10(4-2-9)23(18,21)22/h1-6H,7H2,(H,19,20)(H2,18,21,22)
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PubMed
n/an/an/a 3.90n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic Anhydrase II Mutant (F131V)


(Homo sapiens (human))
BDBM12017
PNG
(2,4-difluoro-SBB | 4-(AMINOSULFONYL)-N-[(2,4-DIFLU...)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=O)NCc1ccc(F)cc1F
Show InChI InChI=1S/C14H12F2N2O3S/c15-11-4-1-10(13(16)7-11)8-18-14(19)9-2-5-12(6-3-9)22(17,20)21/h1-7H,8H2,(H,18,19)(H2,17,20,21)
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PubMed
n/an/an/a 3.30n/an/an/a7.437



University of Pennsylvania



Assay Description
Inhibitor binding to CA II was determined using a fluorescence competition assay. Displacement of dansylamide and binding of the inhibitor was determ...


J Am Chem Soc 123: 9620-7 (2001)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)