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Compile Data Set for Download or QSAR

Found 6100 hits Enz. Inhib. hit(s) with Target = 'Carbonic anhydrase 9 (CA IX)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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0.0600n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase-9 preincubated for 15 mins by stopped flow CO2 dehydration method


Bioorg Med Chem 24: 104-12 (2016)


Article DOI: 10.1016/j.bmc.2015.11.031
BindingDB Entry DOI: 10.7270/Q2222XRQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50531530
PNG
(CHEMBL4590200)
Show SMILES NS(=O)(=O)c1cc(cs1)-c1nc(no1)C1CC1
Show InChI InChI=1S/C9H9N3O3S2/c10-17(13,14)7-3-6(4-16-7)9-11-8(12-15-9)5-1-2-5/h3-5H,1-2H2,(H2,10,13,14)
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0.0890n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay


Eur J Med Chem 164: 92-105 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.049
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50153970
PNG
(4-(4,6-Diethoxy-[1,3,5]triazin-2-ylamino)-benzenes...)
Show SMILES CCOc1nc(Nc2ccc(cc2)S(N)(=O)=O)nc(OCC)n1
Show InChI InChI=1S/C13H17N5O4S/c1-3-21-12-16-11(17-13(18-12)22-4-2)15-9-5-7-10(8-6-9)23(14,19)20/h5-8H,3-4H2,1-2H3,(H2,14,19,20)(H,15,16,17,18)
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0.120n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21


Bioorg Med Chem Lett 14: 5427-33 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.087
BindingDB Entry DOI: 10.7270/Q2XD12DQ
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50517085
PNG
(CHEMBL4545711)
Show SMILES NS(=O)(=O)c1nnc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)s1
Show InChI InChI=1S/C10H7ClF3N5O3S2/c11-6-2-1-4(3-5(6)10(12,13)14)16-7(20)17-8-18-19-9(23-8)24(15,21)22/h1-3H,(H2,15,21,22)(H2,16,17,18,20)
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0.130n/an/an/an/an/an/an/an/a



University of Florence

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay


Eur J Med Chem 182: (2019)


Article DOI: 10.1016/j.ejmech.2019.111600
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50531505
PNG
(CHEMBL4560251)
Show SMILES COc1ccccc1-c1noc(n1)-c1csc(c1)S(N)(=O)=O
Show InChI InChI=1S/C13H11N3O4S2/c1-19-10-5-3-2-4-9(10)12-15-13(20-16-12)8-6-11(21-7-8)22(14,17)18/h2-7H,1H3,(H2,14,17,18)
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0.130n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay


Eur J Med Chem 164: 92-105 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.049
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50153971
PNG
(4-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-benzenes...)
Show SMILES NS(=O)(=O)c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1
Show InChI InChI=1S/C9H7Cl2N5O2S/c10-7-14-8(11)16-9(15-7)13-5-1-3-6(4-2-5)19(12,17)18/h1-4H,(H2,12,17,18)(H,13,14,15,16)
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0.150n/an/an/an/an/an/an/an/a



University of Namur

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay


Bioorg Med Chem 17: 553-7 (2009)


Article DOI: 10.1016/j.bmc.2008.11.071
BindingDB Entry DOI: 10.7270/Q28K790B
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50153971
PNG
(4-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-benzenes...)
Show SMILES NS(=O)(=O)c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1
Show InChI InChI=1S/C9H7Cl2N5O2S/c10-7-14-8(11)16-9(15-7)13-5-1-3-6(4-2-5)19(12,17)18/h1-4H,(H2,12,17,18)(H,13,14,15,16)
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0.150n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration method


Bioorg Med Chem 19: 3105-19 (2011)


Article DOI: 10.1016/j.bmc.2011.04.005
BindingDB Entry DOI: 10.7270/Q2FF3SQ6
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50153971
PNG
(4-(4,6-Dichloro-[1,3,5]triazin-2-ylamino)-benzenes...)
Show SMILES NS(=O)(=O)c1ccc(Nc2nc(Cl)nc(Cl)n2)cc1
Show InChI InChI=1S/C9H7Cl2N5O2S/c10-7-14-8(11)16-9(15-7)13-5-1-3-6(4-2-5)19(12,17)18/h1-4H,(H2,12,17,18)(H,13,14,15,16)
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0.150n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21


Bioorg Med Chem Lett 14: 5427-33 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.087
BindingDB Entry DOI: 10.7270/Q2XD12DQ
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50504750
PNG
(CHEMBL4536202)
Show SMILES COC(=O)c1nn(-c2ccc(cc2)S(N)(=O)=O)c2nc3cc(cc(-c4ccc(cc4)[N+]([O-])=O)c3c(=O)n12)-c1cccs1
Show InChI InChI=1S/C27H18N6O7S2/c1-40-26(35)24-30-32(17-8-10-19(11-9-17)42(28,38)39)27-29-21-14-16(22-3-2-12-41-22)13-20(23(21)25(34)31(24)27)15-4-6-18(7-5-15)33(36)37/h2-14H,1H3,(H2,28,38,39)
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0.160n/an/an/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase-9 incubated for 15 mins by stopped flow CO2 hydrase assay


Eur J Med Chem 185: (2020)


Article DOI: 10.1016/j.ejmech.2019.111843
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50146823
PNG
(CHEMBL3764718)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C14H12N2O2S/c15-19(17,18)13-4-1-10(2-5-13)11-3-6-14-12(9-11)7-8-16-14/h1-9,16H,(H2,15,17,18)
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0.170n/an/an/an/an/an/an/an/a



Universit£ de Reims Champagne-Ardenne

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay


J Med Chem 59: 721-32 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01771
BindingDB Entry DOI: 10.7270/Q2K0764T
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM210938
PNG
(4-(3-quinolinyl)-benzenesulfonamide (4p))
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1cnc2ccccc2c1
Show InChI InChI=1S/C15H12N2O2S/c16-20(18,19)14-7-5-11(6-8-14)13-9-12-3-1-2-4-15(12)17-10-13/h1-10H,(H2,16,18,19)
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0.180n/an/an/an/an/an/an/an/a



Universit£ de Reims Champagne-Ardenne

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay


J Med Chem 59: 721-32 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01771
BindingDB Entry DOI: 10.7270/Q2K0764T
More data for this
Ligand-Target Pair
Carbonic anhydrase 9 (CA IX)


(Homo sapiens (Human))
BDBM210935
PNG
(4-(phenyl)-bezenesulfonamide (4a))
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C12H11NO2S/c13-16(14,15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,(H2,13,14,15)
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0.200n/an/an/an/an/an/an/an/a



University of Florida



Assay Description
CA-catalyzed CO2 hydration activity methods were published previously by Cornelio et al. as part of a larger series of benzenesulfonamide-based inhib...


Chembiochem 18: 213-222 (2017)


Article DOI: 10.1002/cbic.201600513
BindingDB Entry DOI: 10.7270/Q27H1HFC
More data for this
Ligand-Target Pair
Carbonic anhydrase 9 (CA IX)


(Homo sapiens (Human))
BDBM210938
PNG
(4-(3-quinolinyl)-benzenesulfonamide (4p))
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1cnc2ccccc2c1
Show InChI InChI=1S/C15H12N2O2S/c16-20(18,19)14-7-5-11(6-8-14)13-9-12-3-1-2-4-15(12)17-10-13/h1-10H,(H2,16,18,19)
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0.200n/an/an/an/an/an/an/an/a



University of Florida



Assay Description
CA-catalyzed CO2 hydration activity methods were published previously by Cornelio et al. as part of a larger series of benzenesulfonamide-based inhib...


Chembiochem 18: 213-222 (2017)


Article DOI: 10.1002/cbic.201600513
BindingDB Entry DOI: 10.7270/Q27H1HFC
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM210935
PNG
(4-(phenyl)-bezenesulfonamide (4a))
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C12H11NO2S/c13-16(14,15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,(H2,13,14,15)
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0.210n/an/an/an/an/an/an/an/a



Universit£ de Reims Champagne-Ardenne

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay


J Med Chem 59: 721-32 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01771
BindingDB Entry DOI: 10.7270/Q2K0764T
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50146833
PNG
(CHEMBL3763841)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1cc2ccccc2s1
Show InChI InChI=1S/C14H11NO2S2/c15-19(16,17)12-7-5-10(6-8-12)14-9-11-3-1-2-4-13(11)18-14/h1-9H,(H2,15,16,17)
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0.210n/an/an/an/an/an/an/an/a



Universit£ de Reims Champagne-Ardenne

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay


J Med Chem 59: 721-32 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01771
BindingDB Entry DOI: 10.7270/Q2K0764T
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50146600
PNG
(CHEMBL3763914)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C16H13NO2S/c17-20(18,19)16-9-7-13(8-10-16)15-6-5-12-3-1-2-4-14(12)11-15/h1-11H,(H2,17,18,19)
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0.220n/an/an/an/an/an/an/an/a



Universit£ de Reims Champagne-Ardenne

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay


J Med Chem 59: 721-32 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01771
BindingDB Entry DOI: 10.7270/Q2K0764T
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50531512
PNG
(CHEMBL4552118)
Show SMILES NS(=O)(=O)c1cc(cs1)-c1nc(no1)-c1ccccc1
Show InChI InChI=1S/C12H9N3O3S2/c13-20(16,17)10-6-9(7-19-10)12-14-11(15-18-12)8-4-2-1-3-5-8/h1-7H,(H2,13,16,17)
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0.240n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay


Eur J Med Chem 164: 92-105 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.049
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50523342
PNG
(CHEMBL4527427)
Show SMILES Cc1nn(-c2ccc(cc2)S(N)(=O)=O)c(=O)c2ccccc12
Show InChI InChI=1S/C15H13N3O3S/c1-10-13-4-2-3-5-14(13)15(19)18(17-10)11-6-8-12(9-7-11)22(16,20)21/h2-9H,1H3,(H2,16,20,21)
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0.240n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of membrane bound human CA 9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay


Eur J Med Chem 168: 301-314 (2019)


Article DOI: 10.1016/j.ejmech.2019.02.044
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50146825
PNG
(CHEMBL3765197)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1cn(c2ccccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H16N2O4S2/c21-27(23,24)16-12-10-15(11-13-16)19-14-22(20-9-5-4-8-18(19)20)28(25,26)17-6-2-1-3-7-17/h1-14H,(H2,21,23,24)
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0.240n/an/an/an/an/an/an/an/a



Universit£ de Reims Champagne-Ardenne

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay


J Med Chem 59: 721-32 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01771
BindingDB Entry DOI: 10.7270/Q2K0764T
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50492476
PNG
(CHEMBL1518649)
Show SMILES COc1ccc(CC(=O)NCCc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C17H20N2O4S/c1-23-15-6-2-14(3-7-15)12-17(20)19-11-10-13-4-8-16(9-5-13)24(18,21)22/h2-9H,10-12H2,1H3,(H,19,20)(H2,18,21,22)
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0.25n/an/an/an/an/an/an/an/a



Bezmialem Vakif University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 5228-32 (2013)


Article DOI: 10.1016/j.bmc.2013.06.029
BindingDB Entry DOI: 10.7270/Q2CJ8HFM
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50334346
PNG
(4-(3-(2-cyanophenyl)ureido)benzenesulfonamide | 4-...)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2C#N)cc1
Show InChI InChI=1S/C14H12N4O3S/c15-9-10-3-1-2-4-13(10)18-14(19)17-11-5-7-12(8-6-11)22(16,20)21/h1-8H,(H2,16,20,21)(H2,17,18,19)
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0.300n/an/an/an/an/an/an/an/a



Universita` degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of tumor-associated human carbonic anhydrase 9 preincubated for 15 min by CO2 hydration assay


J Med Chem 54: 1896-902 (2011)


Article DOI: 10.1021/jm101541x
BindingDB Entry DOI: 10.7270/Q2CC110M
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50334346
PNG
(4-(3-(2-cyanophenyl)ureido)benzenesulfonamide | 4-...)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Nc2ccccc2C#N)cc1
Show InChI InChI=1S/C14H12N4O3S/c15-9-10-3-1-2-4-13(10)18-14(19)17-11-5-7-12(8-6-11)22(16,20)21/h1-8H,(H2,16,20,21)(H2,17,18,19)
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0.300n/an/an/an/an/an/an/an/a



BC Cancer Agency



Assay Description
The inhibition constants (Ki) of FEC to four human CA isoenzymes I, II, IX and XII were determined by CA catalyzed CO2 hydration assays following pre...


J Enzyme Inhib Med Chem 29: 249-55 (2014)


Article DOI: 10.3109/14756366.2013.773994
BindingDB Entry DOI: 10.7270/Q2VM4B6X
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50531507
PNG
(CHEMBL4464320)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1noc(n1)-c1ccccn1
Show InChI InChI=1S/C13H10N4O3S/c14-21(18,19)10-6-4-9(5-7-10)12-16-13(20-17-12)11-3-1-2-8-15-11/h1-8H,(H2,14,18,19)
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0.310n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay


Eur J Med Chem 164: 92-105 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.049
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50492471
PNG
(CHEMBL2402764)
Show SMILES COc1ccc(CC(=O)Nc2nnc(s2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C11H12N4O4S2/c1-19-8-4-2-7(3-5-8)6-9(16)13-10-14-15-11(20-10)21(12,17)18/h2-5H,6H2,1H3,(H2,12,17,18)(H,13,14,16)
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0.310n/an/an/an/an/an/an/an/a



Bezmialem Vakif University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 5228-32 (2013)


Article DOI: 10.1016/j.bmc.2013.06.029
BindingDB Entry DOI: 10.7270/Q2CJ8HFM
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50523351
PNG
(CHEMBL4592596)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1ncc2ccccc2c1=O
Show InChI InChI=1S/C14H11N3O3S/c15-21(19,20)12-7-5-11(6-8-12)17-14(18)13-4-2-1-3-10(13)9-16-17/h1-9H,(H2,15,19,20)
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0.320n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of membrane bound human CA 9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay


Eur J Med Chem 168: 301-314 (2019)


Article DOI: 10.1016/j.ejmech.2019.02.044
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50492464
PNG
(CHEMBL2402768)
Show SMILES COc1ccc(CC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C15H16N2O4S/c1-21-13-6-2-11(3-7-13)10-15(18)17-12-4-8-14(9-5-12)22(16,19)20/h2-9H,10H2,1H3,(H,17,18)(H2,16,19,20)
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0.320n/an/an/an/an/an/an/an/a



Bezmialem Vakif University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 5228-32 (2013)


Article DOI: 10.1016/j.bmc.2013.06.029
BindingDB Entry DOI: 10.7270/Q2CJ8HFM
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50428850
PNG
(CHEMBL2337539)
Show SMILES CC(=O)C1=NN(\C(S1)=C(/C#N)C(=O)Nc1ccc(cc1)S(N)(=O)=O)c1ccccc1
Show InChI InChI=1S/C19H15N5O4S2/c1-12(25)18-23-24(14-5-3-2-4-6-14)19(29-18)16(11-20)17(26)22-13-7-9-15(10-8-13)30(21,27)28/h2-10H,1H3,(H,22,26)(H2,21,27,28)/b19-16-
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0.330n/an/an/an/an/an/an/an/a



Salman Bin Abdulaziz University

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1396-403 (2013)


Article DOI: 10.1016/j.bmc.2012.12.004
BindingDB Entry DOI: 10.7270/Q2GM88N1
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50153964
PNG
(4-((4,6-diethoxy-1,3,5-triazin-2-ylamino)methyl)be...)
Show SMILES CCOc1nc(NCc2ccc(cc2)S(N)(=O)=O)nc(OCC)n1
Show InChI InChI=1S/C14H19N5O4S/c1-3-22-13-17-12(18-14(19-13)23-4-2)16-9-10-5-7-11(8-6-10)24(15,20)21/h5-8H,3-4,9H2,1-2H3,(H2,15,20,21)(H,16,17,18,19)
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0.340n/an/an/an/an/an/an/an/a



University of Namur

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay


Bioorg Med Chem 17: 553-7 (2009)


Article DOI: 10.1016/j.bmc.2008.11.071
BindingDB Entry DOI: 10.7270/Q28K790B
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50153964
PNG
(4-((4,6-diethoxy-1,3,5-triazin-2-ylamino)methyl)be...)
Show SMILES CCOc1nc(NCc2ccc(cc2)S(N)(=O)=O)nc(OCC)n1
Show InChI InChI=1S/C14H19N5O4S/c1-3-22-13-17-12(18-14(19-13)23-4-2)16-9-10-5-7-11(8-6-10)24(15,20)21/h5-8H,3-4,9H2,1-2H3,(H2,15,20,21)(H,16,17,18,19)
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0.340n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21


Bioorg Med Chem Lett 14: 5427-33 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.087
BindingDB Entry DOI: 10.7270/Q2XD12DQ
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50531524
PNG
(CHEMBL4551727)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1noc(n1)-c1cccs1
Show InChI InChI=1S/C12H9N3O3S2/c13-20(16,17)9-5-3-8(4-6-9)11-14-12(18-15-11)10-2-1-7-19-10/h1-7H,(H2,13,16,17)
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0.360n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay


Eur J Med Chem 164: 92-105 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.049
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50146831
PNG
(CHEMBL3763167)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1cc2ccccc2o1
Show InChI InChI=1S/C14H11NO3S/c15-19(16,17)12-7-5-10(6-8-12)14-9-11-3-1-2-4-13(11)18-14/h1-9H,(H2,15,16,17)
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0.370n/an/an/an/an/an/an/an/a



Universit£ de Reims Champagne-Ardenne

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by CO2 hydration-based stopped flow assay


J Med Chem 59: 721-32 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01771
BindingDB Entry DOI: 10.7270/Q2K0764T
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50531513
PNG
(CHEMBL4525976)
Show SMILES NS(=O)(=O)c1cc(cs1)-c1nc(no1)-c1ccccn1
Show InChI InChI=1S/C11H8N4O3S2/c12-20(16,17)9-5-7(6-19-9)11-14-10(15-18-11)8-3-1-2-4-13-8/h1-6H,(H2,12,16,17)
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0.390n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay


Eur J Med Chem 164: 92-105 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.049
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50395391
PNG
(CHEMBL2164737)
Show SMILES NS(=O)(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C21H23N5O7S3/c22-34(28,29)19-9-1-15(2-10-19)13-14-24-21(27)16-3-5-17(6-4-16)25-35(30,31)20-11-7-18(8-12-20)26-36(23,32)33/h1-12,25-26H,13-14H2,(H,24,27)(H2,22,28,29)(H2,23,32,33)
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0.400n/an/an/an/an/an/an/an/a



Istituto di Biostrutture e Bioimmagini-CNR

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CA9 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay


J Med Chem 55: 6776-83 (2012)


Article DOI: 10.1021/jm300818k
BindingDB Entry DOI: 10.7270/Q2736S2H
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50492460
PNG
(CHEMBL2402776)
Show SMILES COc1ccc(CC(=O)Nc2ccc(cc2Cl)S(N)(=O)=O)cc1
Show InChI InChI=1S/C15H15ClN2O4S/c1-22-11-4-2-10(3-5-11)8-15(19)18-14-7-6-12(9-13(14)16)23(17,20)21/h2-7,9H,8H2,1H3,(H,18,19)(H2,17,20,21)
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0.410n/an/an/an/an/an/an/an/a



Bezmialem Vakif University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 5228-32 (2013)


Article DOI: 10.1016/j.bmc.2013.06.029
BindingDB Entry DOI: 10.7270/Q2CJ8HFM
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50492465
PNG
(CHEMBL2402767)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2Br)cc1
Show InChI InChI=1S/C14H13BrN2O3S/c15-13-4-2-1-3-10(13)9-14(18)17-11-5-7-12(8-6-11)21(16,19)20/h1-8H,9H2,(H,17,18)(H2,16,19,20)
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0.440n/an/an/an/an/an/an/an/a



Bezmialem Vakif University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 5228-32 (2013)


Article DOI: 10.1016/j.bmc.2013.06.029
BindingDB Entry DOI: 10.7270/Q2CJ8HFM
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50531500
PNG
(CHEMBL4559832)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1noc(n1)-c1ccncc1
Show InChI InChI=1S/C13H10N4O3S/c14-21(18,19)11-3-1-9(2-4-11)12-16-13(20-17-12)10-5-7-15-8-6-10/h1-8H,(H2,14,18,19)
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0.440n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay


Eur J Med Chem 164: 92-105 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.049
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50492477
PNG
(CHEMBL2402758)
Show SMILES COc1ccc(CC(=O)NCc2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C16H18N2O4S/c1-22-14-6-2-12(3-7-14)10-16(19)18-11-13-4-8-15(9-5-13)23(17,20)21/h2-9H,10-11H2,1H3,(H,18,19)(H2,17,20,21)
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0.450n/an/an/an/an/an/an/an/a



Bezmialem Vakif University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 5228-32 (2013)


Article DOI: 10.1016/j.bmc.2013.06.029
BindingDB Entry DOI: 10.7270/Q2CJ8HFM
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50523350
PNG
(CHEMBL4434778)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1nc(ccc1=O)-c1ccccc1O
Show InChI InChI=1S/C16H13N3O4S/c17-24(22,23)12-7-5-11(6-8-12)19-16(21)10-9-14(18-19)13-3-1-2-4-15(13)20/h1-10,20H,(H2,17,22,23)
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0.460n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of membrane bound human CA 9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay


Eur J Med Chem 168: 301-314 (2019)


Article DOI: 10.1016/j.ejmech.2019.02.044
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50523332
PNG
(CHEMBL4569531)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1ncc(N2CCCCCC2)c(Cl)c1=O
Show InChI InChI=1S/C16H19ClN4O3S/c17-15-14(20-9-3-1-2-4-10-20)11-19-21(16(15)22)12-5-7-13(8-6-12)25(18,23)24/h5-8,11H,1-4,9-10H2,(H2,18,23,24)
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0.490n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of membrane bound human CA 9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay


Eur J Med Chem 168: 301-314 (2019)


Article DOI: 10.1016/j.ejmech.2019.02.044
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50334361
PNG
(4-(3-(2-isopropylphenyl)ureido)benzenesulfonamide ...)
Show SMILES CC(C)c1ccccc1NC(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C16H19N3O3S/c1-11(2)14-5-3-4-6-15(14)19-16(20)18-12-7-9-13(10-8-12)23(17,21)22/h3-11H,1-2H3,(H2,17,21,22)(H2,18,19,20)
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0.5n/an/an/an/an/an/an/an/a



University of Florida College of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 for 15 mins by stopped flow CO2 hydration assay


Bioorg Med Chem 24: 976-81 (2016)


Article DOI: 10.1016/j.bmc.2016.01.019
BindingDB Entry DOI: 10.7270/Q2445P9F
More data for this
Ligand-Target Pair
Carbonic anhydrase 9


(Homo sapiens (Human))
BDBM50334361
PNG
(4-(3-(2-isopropylphenyl)ureido)benzenesulfonamide ...)
Show SMILES CC(C)c1ccccc1NC(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C16H19N3O3S/c1-11(2)14-5-3-4-6-15(14)19-16(20)18-12-7-9-13(10-8-12)23(17,21)22/h3-11H,1-2H3,(H2,17,21,22)(H2,18,19,20)
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0.5n/an/an/an/an/an/an/an/a



Universita` degli Studi di Firenze

Curated by ChEMBL


Assay Description
Inhibition of tumor-associated human carbonic anhydrase 9 preincubated for 15 min by CO2 hydration assay


J Med Chem 54: 1896-902 (2011)


Article DOI: 10.1021/jm101541x
BindingDB Entry DOI: 10.7270/Q2CC110M
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50251369
PNG
(CHEMBL4084006)
Show SMILES NS(=O)(=O)c1nnc(\N=C\c2cccc(\C=N\c3nnc(s3)S(N)(=O)=O)c2)s1
Show InChI InChI=1S/C12H10N8O4S4/c13-27(21,22)11-19-17-9(25-11)15-5-7-2-1-3-8(4-7)6-16-10-18-20-12(26-10)28(14,23)24/h1-6H,(H2,13,21,22)(H2,14,23,24)/b15-5+,16-6+
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0.5n/an/an/an/an/an/an/an/a



Adiyaman University

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 incubated for 10 mins by stopped flow CO2 hydrase assay


Bioorg Med Chem 25: 3093-3097 (2017)


Article DOI: 10.1016/j.bmc.2017.03.063
BindingDB Entry DOI: 10.7270/Q25T3NXJ
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50492474
PNG
(CHEMBL2402753)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2Br)c(Br)c1
Show InChI InChI=1S/C14H12Br2N2O3S/c15-11-4-2-1-3-9(11)7-14(19)18-13-6-5-10(8-12(13)16)22(17,20)21/h1-6,8H,7H2,(H,18,19)(H2,17,20,21)
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0.520n/an/an/an/an/an/an/an/a



Bezmialem Vakif University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 5228-32 (2013)


Article DOI: 10.1016/j.bmc.2013.06.029
BindingDB Entry DOI: 10.7270/Q2CJ8HFM
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50492467
PNG
(CHEMBL2402756)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)Cc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C15H15ClN2O3S/c16-13-5-1-11(2-6-13)9-15(19)18-10-12-3-7-14(8-4-12)22(17,20)21/h1-8H,9-10H2,(H,18,19)(H2,17,20,21)
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0.530n/an/an/an/an/an/an/an/a



Bezmialem Vakif University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 5228-32 (2013)


Article DOI: 10.1016/j.bmc.2013.06.029
BindingDB Entry DOI: 10.7270/Q2CJ8HFM
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50531527
PNG
(CHEMBL4462653)
Show SMILES Cc1nc(no1)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C9H9N3O3S/c1-6-11-9(12-15-6)7-2-4-8(5-3-7)16(10,13)14/h2-5H,1H3,(H2,10,13,14)
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0.530n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 9 assessed as reduction in CO2 hydration after 15 mins by phenol red staining-based stopped flow assay


Eur J Med Chem 164: 92-105 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.049
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50341403
PNG
(CHEMBL4173265)
Show SMILES NS(=O)(=O)c1ccc(Nc2ncc3C(=O)CCCc3n2)cc1
Show InChI InChI=1S/C14H14N4O3S/c15-22(20,21)10-6-4-9(5-7-10)17-14-16-8-11-12(18-14)2-1-3-13(11)19/h4-8H,1-3H2,(H2,15,20,21)(H,16,17,18)
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0.550n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay


J Med Chem 61: 5765-5770 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00670
BindingDB Entry DOI: 10.7270/Q2DB84F9
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50469139
PNG
(CHEMBL4292479)
Show SMILES COc1ccc([Se]Cc2cnc([se]2)-c2ccc(cc2)S(N)(=O)=O)cc1
Show InChI InChI=1S/C17H16N2O3SSe2/c1-22-13-4-8-15(9-5-13)24-11-16-10-19-17(25-16)12-2-6-14(7-3-12)23(18,20)21/h2-10H,11H2,1H3,(H2,18,20,21)
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0.550n/an/an/an/an/an/an/an/a



Department of University of Florence

Curated by ChEMBL


Assay Description
Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay


Eur J Med Chem 157: 1214-1222 (2018)


Article DOI: 10.1016/j.ejmech.2018.08.096
BindingDB Entry DOI: 10.7270/Q2RR21ZR
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50523344
PNG
(CHEMBL4566532)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1ncc(cc1=O)N1CCCCCC1
Show InChI InChI=1S/C16H20N4O3S/c17-24(22,23)15-7-5-13(6-8-15)20-16(21)11-14(12-18-20)19-9-3-1-2-4-10-19/h5-8,11-12H,1-4,9-10H2,(H2,17,22,23)
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0.560n/an/an/an/an/an/an/an/a



Saint Petersburg State University

Curated by ChEMBL


Assay Description
Inhibition of membrane bound human CA 9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay


Eur J Med Chem 168: 301-314 (2019)


Article DOI: 10.1016/j.ejmech.2019.02.044
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50492456
PNG
(CHEMBL2402760)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2ccccc2Br)cc1
Show InChI InChI=1S/C16H17BrN2O3S/c17-15-4-2-1-3-13(15)11-16(20)19-10-9-12-5-7-14(8-6-12)23(18,21)22/h1-8H,9-11H2,(H,19,20)(H2,18,21,22)
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0.570n/an/an/an/an/an/an/an/a



Bezmialem Vakif University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant carbonic anhydrase 9 preincubated for 10 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 5228-32 (2013)


Article DOI: 10.1016/j.bmc.2013.06.029
BindingDB Entry DOI: 10.7270/Q2CJ8HFM
More data for this
Ligand-Target Pair
Carbonic anhydrases; II & IX


(Homo sapiens (Human))
BDBM50341402
PNG
(CHEMBL4167173)
Show SMILES NS(=O)(=O)c1ccc(cc1)-n1ncc2CCc3ncncc3-c12
Show InChI InChI=1S/C15H13N5O2S/c16-23(21,22)12-4-2-11(3-5-12)20-15-10(7-19-20)1-6-14-13(15)8-17-9-18-14/h2-5,7-9H,1,6H2,(H2,16,21,22)
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0.570n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of recombinant human CA9 preincubated for 15 mins by phenol red dye-based stopped-flow CO2 hydration assay


J Med Chem 61: 5765-5770 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00670
BindingDB Entry DOI: 10.7270/Q2DB84F9
More data for this
Ligand-Target Pair
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