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Compile Data Set for Download or QSAR

Found 71 hits Enz. Inhib. hit(s) with Target = 'Casein kinase I isoform alpha' AND taxid = 9823   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426312
PNG
(CHEMBL2321951)
Show SMILES COC(=O)c1ccc2[nH]c(C3C(=O)Nc4ccccc34)c(N=O)c2c1
Show InChI InChI=1S/C18H13N3O4/c1-25-18(23)9-6-7-13-11(8-9)15(21-24)16(19-13)14-10-4-2-3-5-12(10)20-17(14)22/h2-8,14,19H,1H3,(H,20,22)
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n/an/a 300n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426336
PNG
(CHEMBL2321952)
Show SMILES OC(=O)c1ccc2[nH]c(C3C(=O)Nc4ccccc34)c(N=O)c2c1
Show InChI InChI=1S/C17H11N3O4/c21-16-13(9-3-1-2-4-11(9)19-16)15-14(20-24)10-7-8(17(22)23)5-6-12(10)18-15/h1-7,13,18H,(H,19,21)(H,22,23)
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TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426310
PNG
(CHEMBL2321967)
Show SMILES COC(=O)c1ccc2N\C(C(=O)c2c1)=C1/C(=O)Nc2ccccc12
Show InChI InChI=1S/C18H12N2O4/c1-24-18(23)9-6-7-13-11(8-9)16(21)15(19-13)14-10-4-2-3-5-12(10)20-17(14)22/h2-8,19H,1H3,(H,20,22)/b15-14-
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TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426334
PNG
(CHEMBL2321948)
Show SMILES Brc1cccc2C(C(=O)Nc12)=C1Nc2ccc(CN=O)cc2C1=O
Show InChI InChI=1S/C17H10BrN3O3/c18-11-3-1-2-9-13(17(23)21-14(9)11)15-16(22)10-6-8(7-19-24)4-5-12(10)20-15/h1-6,20H,7H2,(H,21,23)
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TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426313
PNG
(CHEMBL2321959)
Show SMILES OC(=O)c1ccc2c(N=O)c([nH]c2c1)C1C(=O)Nc2ccccc12
Show InChI InChI=1S/C17H11N3O4/c21-16-13(9-3-1-2-4-11(9)19-16)15-14(20-24)10-6-5-8(17(22)23)7-12(10)18-15/h1-7,13,18H,(H,19,21)(H,22,23)
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TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM7401
PNG
((2 Z,3 E)-6-Bromoindirubin-3 -oxime | (3E)-6-bromo...)
Show SMILES Brc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,13,18H,(H,19,21)
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n/an/a 1.20E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426314
PNG
(CHEMBL2321968)
Show SMILES OC(=O)c1ccc2N\C(C(=O)c2c1)=C1/C(=O)Nc2ccccc12
Show InChI InChI=1S/C17H10N2O4/c20-15-10-7-8(17(22)23)5-6-12(10)18-14(15)13-9-3-1-2-4-11(9)19-16(13)21/h1-7,18H,(H,19,21)(H,22,23)/b14-13-
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n/an/a 1.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426330
PNG
(CHEMBL2321974)
Show SMILES OC(=O)c1ccc2C(=O)\C(Nc2c1)=C1\C(=O)Nc2ccccc12
Show InChI InChI=1S/C17H10N2O4/c20-15-10-6-5-8(17(22)23)7-12(10)18-14(15)13-9-3-1-2-4-11(9)19-16(13)21/h1-7,18H,(H,19,21)(H,22,23)/b14-13-
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n/an/a 1.70E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426335
PNG
(CHEMBL2321878)
Show SMILES OC(=O)c1ccc2[nH]c(C3C(=O)Nc4c3cccc4C(F)(F)F)c(N=O)c2c1
Show InChI InChI=1S/C18H10F3N3O4/c19-18(20,21)10-3-1-2-8-12(16(25)23-13(8)10)15-14(24-28)9-6-7(17(26)27)4-5-11(9)22-15/h1-6,12,22H,(H,23,25)(H,26,27)
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n/an/a 4.20E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426339
PNG
(CHEMBL2321961)
Show SMILES COC(=O)c1ccc2c(N=O)c([nH]c2c1)C1C(=O)Nc2c1cccc2C(F)(F)F
Show InChI InChI=1S/C19H12F3N3O4/c1-29-18(27)8-5-6-9-12(7-8)23-16(15(9)25-28)13-10-3-2-4-11(19(20,21)22)14(10)24-17(13)26/h2-7,13,23H,1H3,(H,24,26)
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n/an/a 5.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426315
PNG
(CHEMBL2321962)
Show SMILES OC(=O)c1ccc2c(N=O)c([nH]c2c1)C1C(=O)Nc2c1cccc2Br
Show InChI InChI=1S/C17H10BrN3O4/c18-10-3-1-2-9-12(16(22)20-13(9)10)15-14(21-25)8-5-4-7(17(23)24)6-11(8)19-15/h1-6,12,19H,(H,20,22)(H,23,24)
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n/an/a 7.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426331
PNG
(CHEMBL2321965)
Show SMILES Brc1cccc2C(C(=O)Nc12)c1[nH]c2ccc(CN=O)cc2c1N=O
Show InChI InChI=1S/C17H11BrN4O3/c18-11-3-1-2-9-13(17(23)21-14(9)11)16-15(22-25)10-6-8(7-19-24)4-5-12(10)20-16/h1-6,13,20H,7H2,(H,21,23)
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n/an/a 7.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426333
PNG
(CHEMBL2321945)
Show SMILES OC(=O)c1ccc2C(=O)\C(Nc2c1)=C1\C(=O)Nc2c1cccc2Br
Show InChI InChI=1S/C17H9BrN2O4/c18-10-3-1-2-9-12(16(22)20-13(9)10)14-15(21)8-5-4-7(17(23)24)6-11(8)19-14/h1-6,19H,(H,20,22)(H,23,24)/b14-12-
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n/an/a 9.30E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM7287
PNG
(8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octad...)
Show SMILES O=C1Cc2c([nH]c3ccccc23)-c2ccccc2N1
Show InChI InChI=1S/C16H12N2O/c19-15-9-12-10-5-1-3-7-13(10)18-16(12)11-6-2-4-8-14(11)17-15/h1-8,18H,9H2,(H,17,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Trinity College

Curated by ChEMBL


Assay Description
Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting


Bioorg Med Chem Lett 20: 4940-4 (2010)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM7266
PNG
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
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Trinity College

Curated by ChEMBL


Assay Description
Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting


Bioorg Med Chem Lett 20: 4940-4 (2010)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50346235
PNG
(9-azapaullone | CHEMBL1782168)
Show SMILES O=C1Cc2c([nH]c3ccncc23)-c2ccccc2N1
Show InChI InChI=1S/C15H11N3O/c19-14-7-10-11-8-16-6-5-13(11)18-15(10)9-3-1-2-4-12(9)17-14/h1-6,8,18H,7H2,(H,17,19)
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Trinity College

Curated by ChEMBL


Assay Description
Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting


Bioorg Med Chem Lett 20: 4940-4 (2010)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50346236
PNG
(9-Benzyl-6-oxo-5,6,7,12-tetrahydro-5,12-diaza-9-az...)
Show SMILES O=C1Cc2c([nH+]c3ccn(Cc4ccccc4)cc23)-c2ccccc2N1
Show InChI InChI=1S/C22H17N3O/c26-21-12-17-18-14-25(13-15-6-2-1-3-7-15)11-10-20(18)24-22(17)16-8-4-5-9-19(16)23-21/h1-11,14H,12-13H2,(H,23,26)/p+1
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Trinity College

Curated by ChEMBL


Assay Description
Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting


Bioorg Med Chem Lett 20: 4940-4 (2010)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50346237
PNG
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)
Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19)
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Trinity College

Curated by ChEMBL


Assay Description
Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting


Bioorg Med Chem Lett 20: 4940-4 (2010)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50393109
PNG
(CHEMBL2153264)
Show SMILES Nc1nc2c(nccc2[nH]1)-c1ccccn1
Show InChI InChI=1S/C11H9N5/c12-11-15-8-4-6-14-9(10(8)16-11)7-3-1-2-5-13-7/h1-6H,(H3,12,15,16)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Macquarie University

Curated by ChEMBL


Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


J Med Chem 54: 2492-503 (2011)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50431995
PNG
(CHEMBL2348725)
Show SMILES O=C(Nc1n[nH]c(=O)c2ccccc12)c1ccccc1
Show InChI InChI=1S/C15H11N3O2/c19-14(10-6-2-1-3-7-10)16-13-11-8-4-5-9-12(11)15(20)18-17-13/h1-9H,(H,18,20)(H,16,17,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50431996
PNG
(CHEMBL2348724)
Show SMILES Nc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C8H7N3O/c9-7-5-3-1-2-4-6(5)8(12)11-10-7/h1-4H,(H2,9,10)(H,11,12)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50431997
PNG
(CHEMBL2348723)
Show SMILES CC(C)C(=O)Nc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C12H13N3O2/c1-7(2)11(16)13-10-8-5-3-4-6-9(8)12(17)15-14-10/h3-7H,1-2H3,(H,15,17)(H,13,14,16)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50431998
PNG
(CHEMBL2348745)
Show SMILES CC(=O)Nc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C10H9N3O2/c1-6(14)11-9-7-4-2-3-5-8(7)10(15)13-12-9/h2-5H,1H3,(H,13,15)(H,11,12,14)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50431999
PNG
(CHEMBL2348744)
Show SMILES O=C(Cc1ccccc1)Nc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C16H13N3O2/c20-14(10-11-6-2-1-3-7-11)17-15-12-8-4-5-9-13(12)16(21)19-18-15/h1-9H,10H2,(H,19,21)(H,17,18,20)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432000
PNG
(CHEMBL2348743)
Show SMILES CCCCCC(=O)Nc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C14H17N3O2/c1-2-3-4-9-12(18)15-13-10-7-5-6-8-11(10)14(19)17-16-13/h5-8H,2-4,9H2,1H3,(H,17,19)(H,15,16,18)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432001
PNG
(CHEMBL2348742)
Show SMILES CC(C)C(=O)N(C(=O)C(C)C)c1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C16H19N3O3/c1-9(2)15(21)19(16(22)10(3)4)13-11-7-5-6-8-12(11)14(20)18-17-13/h5-10H,1-4H3,(H,18,20)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432002
PNG
(CHEMBL2348741)
Show SMILES CC(=O)N(C(C)=O)c1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C12H11N3O3/c1-7(16)15(8(2)17)11-9-5-3-4-6-10(9)12(18)14-13-11/h3-6H,1-2H3,(H,14,18)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432003
PNG
(CHEMBL2348740)
Show SMILES Clc1nnc(NC(=O)Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C16H12ClN3O/c17-15-12-8-4-5-9-13(12)16(20-19-15)18-14(21)10-11-6-2-1-3-7-11/h1-9H,10H2,(H,18,20,21)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432004
PNG
(CHEMBL2348739)
Show SMILES Clc1nnc(N(C(=O)Cc2ccccc2)C(=O)Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H18ClN3O2/c25-23-19-13-7-8-14-20(19)24(27-26-23)28(21(29)15-17-9-3-1-4-10-17)22(30)16-18-11-5-2-6-12-18/h1-14H,15-16H2
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432005
PNG
(CHEMBL2348738)
Show SMILES CCCCCC(=O)N(C(=O)CCCCC)c1nnc(Cl)c2ccccc12
Show InChI InChI=1S/C20H26ClN3O2/c1-3-5-7-13-17(25)24(18(26)14-8-6-4-2)20-16-12-10-9-11-15(16)19(21)22-23-20/h9-12H,3-8,13-14H2,1-2H3
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432006
PNG
(CHEMBL2348737)
Show SMILES O=C(Nc1cc(-c2ccccc2)c(=O)[nH]n1)c1ccccc1
Show InChI InChI=1S/C17H13N3O2/c21-16(13-9-5-2-6-10-13)18-15-11-14(17(22)20-19-15)12-7-3-1-4-8-12/h1-11H,(H,20,22)(H,18,19,21)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432007
PNG
(CHEMBL2348736)
Show SMILES Clc1nnc(NC(=O)c2ccccc2)cc1-c1ccccc1
Show InChI InChI=1S/C17H12ClN3O/c18-16-14(12-7-3-1-4-8-12)11-15(20-21-16)19-17(22)13-9-5-2-6-10-13/h1-11H,(H,19,20,22)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432008
PNG
(CHEMBL2348735)
Show SMILES Nc1cc(-c2ccccc2)c(=O)[nH]n1
Show InChI InChI=1S/C10H9N3O/c11-9-6-8(10(14)13-12-9)7-4-2-1-3-5-7/h1-6H,(H2,11,12)(H,13,14)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432009
PNG
(CHEMBL2348734)
Show SMILES CC(=O)Nc1cc(-c2ccccc2)c(=O)[nH]n1
Show InChI InChI=1S/C12H11N3O2/c1-8(16)13-11-7-10(12(17)15-14-11)9-5-3-2-4-6-9/h2-7H,1H3,(H,15,17)(H,13,14,16)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432010
PNG
(CHEMBL2348733)
Show SMILES Nc1n[nH]c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C10H9N3O/c11-10-8(6-9(14)12-13-10)7-4-2-1-3-5-7/h1-6H,(H2,11,13)(H,12,14)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432011
PNG
(CHEMBL2348732)
Show SMILES CC(=O)Nc1n[nH]c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C12H11N3O2/c1-8(16)13-12-10(7-11(17)14-15-12)9-5-3-2-4-6-9/h2-7H,1H3,(H,14,17)(H,13,15,16)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432012
PNG
(CHEMBL2348731)
Show SMILES CN1CCC(CC1)Nc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C14H18N4O/c1-18-8-6-10(7-9-18)15-13-11-4-2-3-5-12(11)14(19)17-16-13/h2-5,10H,6-9H2,1H3,(H,15,16)(H,17,19)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432013
PNG
(CHEMBL2348730)
Show SMILES O=c1[nH]nc(NCCN2CCCCC2)c2ccccc12
Show InChI InChI=1S/C15H20N4O/c20-15-13-7-3-2-6-12(13)14(17-18-15)16-8-11-19-9-4-1-5-10-19/h2-3,6-7H,1,4-5,8-11H2,(H,16,17)(H,18,20)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432014
PNG
(CHEMBL2348729)
Show SMILES CCCNc1n[nH]c(=O)c2ccccc12
Show InChI InChI=1S/C11H13N3O/c1-2-7-12-10-8-5-3-4-6-9(8)11(15)14-13-10/h3-6H,2,7H2,1H3,(H,12,13)(H,14,15)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432015
PNG
(CHEMBL2348728)
Show SMILES O=c1[nH]nc(NCc2ccccc2)c2ccccc12
Show InChI InChI=1S/C15H13N3O/c19-15-13-9-5-4-8-12(13)14(17-18-15)16-10-11-6-2-1-3-7-11/h1-9H,10H2,(H,16,17)(H,18,19)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432016
PNG
(CHEMBL2348727)
Show SMILES CN1CCC(CC1)Nc1cc(-c2ccccc2)c(=O)[nH]n1
Show InChI InChI=1S/C16H20N4O/c1-20-9-7-13(8-10-20)17-15-11-14(16(21)19-18-15)12-5-3-2-4-6-12/h2-6,11,13H,7-10H2,1H3,(H,17,18)(H,19,21)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432017
PNG
(CHEMBL2348726)
Show SMILES O=c1cc(c(NCCN2CCCCC2)n[nH]1)-c1ccccc1
Show InChI InChI=1S/C17H22N4O/c22-16-13-15(14-7-3-1-4-8-14)17(20-19-16)18-9-12-21-10-5-2-6-11-21/h1,3-4,7-8,13H,2,5-6,9-12H2,(H,18,20)(H,19,22)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432018
PNG
(CHEMBL2348750)
Show SMILES O=c1[nH]nc(NCCN2CCCCC2)cc1-c1ccccc1
Show InChI InChI=1S/C17H22N4O/c22-17-15(14-7-3-1-4-8-14)13-16(19-20-17)18-9-12-21-10-5-2-6-11-21/h1,3-4,7-8,13H,2,5-6,9-12H2,(H,18,19)(H,20,22)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50432019
PNG
(CHEMBL2348749)
Show SMILES CCCNc1n[nH]c(=O)cc1-c1ccccc1
Show InChI InChI=1S/C13H15N3O/c1-2-8-14-13-11(9-12(17)15-16-13)10-6-4-3-5-7-10/h3-7,9H,2,8H2,1H3,(H,14,16)(H,15,17)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50431992
PNG
(CHEMBL2348748)
Show SMILES CCCNc1cc(-c2ccccc2)c(=O)[nH]n1
Show InChI InChI=1S/C13H15N3O/c1-2-8-14-12-9-11(13(17)16-15-12)10-6-4-3-5-7-10/h3-7,9H,2,8H2,1H3,(H,14,15)(H,16,17)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50431993
PNG
(CHEMBL2348747)
Show SMILES O=c1cc(c(NCc2ccccc2)n[nH]1)-c1ccccc1
Show InChI InChI=1S/C17H15N3O/c21-16-11-15(14-9-5-2-6-10-14)17(20-19-16)18-12-13-7-3-1-4-8-13/h1-11H,12H2,(H,18,20)(H,19,21)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50431994
PNG
(CHEMBL2348746)
Show SMILES O=c1[nH]nc(NCc2ccccc2)cc1-c1ccccc1
Show InChI InChI=1S/C17H15N3O/c21-17-15(14-9-5-2-6-10-14)11-16(19-20-17)18-12-13-7-3-1-4-8-13/h1-11H,12H2,(H,18,19)(H,20,21)
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Universit£ de Strasbourg

Curated by ChEMBL


Assay Description
Inhibition of pig brain CK1 using RRKHAAIGpSAYSITA as substrate after 30 mins by scintillation counting analysis in presence of [gamma-33P]ATP


Bioorg Med Chem Lett 23: 2007-13 (2013)

More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426332
PNG
(CHEMBL2321964)
Show SMILES OCc1ccc2[nH]c(C3C(=O)Nc4c3cccc4Br)c(N=O)c2c1
Show InChI InChI=1S/C17H12BrN3O3/c18-11-3-1-2-9-13(17(23)20-14(9)11)16-15(21-24)10-6-8(7-22)4-5-12(10)19-16/h1-6,13,19,22H,7H2,(H,20,23)
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TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426316
PNG
(CHEMBL2321963)
Show SMILES OC(=O)c1ccc2c(N=O)c([nH]c2c1)C1C(=O)Nc2c1cccc2C(F)(F)F
Show InChI InChI=1S/C18H10F3N3O4/c19-18(20,21)10-3-1-2-9-12(16(25)23-13(9)10)15-14(24-28)8-5-4-7(17(26)27)6-11(8)22-15/h1-6,12,22H,(H,23,25)(H,26,27)
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TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase I isoform alpha


(Sus scrofa)
BDBM50426317
PNG
(CHEMBL2321960)
Show SMILES COC(=O)c1ccc2c(N=O)c([nH]c2c1)C1C(=O)Nc2c1cccc2Br
Show InChI InChI=1S/C18H12BrN3O4/c1-26-18(24)8-5-6-9-12(7-8)20-16(15(9)22-25)13-10-3-2-4-11(19)14(10)21-17(13)23/h2-7,13,20H,1H3,(H,21,23)
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UniChem

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Article
n/an/a>1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate


Citation and Details
More data for this
Ligand-Target Pair
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