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Found 1290 hits Enz. Inhib. hit(s) with Target = 'Casein kinase II' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34046
PNG
(iodinated benzimidazole, 9a)
Show SMILES CCc1nc2c(I)c(I)c(I)c(I)c2[nH]1
Show InChI InChI=1S/C9H6I4N2/c1-2-3-14-8-6(12)4(10)5(11)7(13)9(8)15-3/h2H2,1H3,(H,14,15)
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PubMed
19 -45.8n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34038
PNG
(4,5,6,7-tetraiodobenzimidazole (TIBI), 1a)
Show SMILES Ic1c(I)c(I)c2[nH]cnc2c1I
Show InChI InChI=1S/C7H2I4N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)
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PubMed
23 -45.4n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34044
PNG
(iodinated benzimidazole, 7a)
Show SMILES Cc1nc2c(I)c(I)c(I)c(I)c2[nH]1
Show InChI InChI=1S/C8H4I4N2/c1-2-13-7-5(11)3(9)4(10)6(12)8(7)14-2/h1H3,(H,13,14)
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24 -45.2n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34051
PNG
(iodinated benzimidazole, 14)
Show SMILES OCCNc1nc2c(I)c(I)c(I)c(I)c2[nH]1
Show InChI InChI=1S/C9H7I4N3O/c10-3-4(11)6(13)8-7(5(3)12)15-9(16-8)14-1-2-17/h17H,1-2H2,(H2,14,15,16)
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27 -44.9n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34052
PNG
(iodinated benzimidazole, 15)
Show SMILES Ic1c(I)c(I)c2[nH]c(=S)[nH]c2c1I
Show InChI InChI=1S/C7H2I4N2S/c8-1-2(9)4(11)6-5(3(1)10)12-7(14)13-6/h(H2,12,13,14)
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50 -43.3n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34054
PNG
(iodinated benzimidazole, 17)
Show SMILES Ic1c(I)c(I)c2[nH]c(=O)[nH]c2c1I
Show InChI InChI=1S/C7H2I4N2O/c8-1-2(9)4(11)6-5(3(1)10)12-7(14)13-6/h(H2,12,13,14)
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50 -43.3n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34053
PNG
(iodinated benzimidazole, 16)
Show SMILES OC(=O)CSc1nc2c(I)c(I)c(I)c(I)c2[nH]1
Show InChI InChI=1S/C9H4I4N2O2S/c10-3-4(11)6(13)8-7(5(3)12)14-9(15-8)18-1-2(16)17/h1H2,(H,14,15)(H,16,17)
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54 -43.2n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34048
PNG
(iodinated benzimidazole, 11a)
Show SMILES FC(F)(F)C(F)(F)c1nc2c(I)c(I)c(I)c(I)c2[nH]1
Show InChI InChI=1S/C9HF5I4N2/c10-8(11,9(12,13)14)7-19-5-3(17)1(15)2(16)4(18)6(5)20-7/h(H,19,20)
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70 -42.5n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34043
PNG
(iodinated benzimidazole, 6a)
Show SMILES Brc1c(I)c(Br)c2nc[nH]c2c1I
Show InChI InChI=1S/C7H2Br2I2N2/c8-2-4(10)3(9)6-7(5(2)11)13-1-12-6/h1H,(H,12,13)
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75 -42.3n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34050
PNG
(iodinated benzimidazole, 13a)
Show SMILES Brc1nc2c(I)c(I)c(I)c(I)c2[nH]1
Show InChI InChI=1S/C7HBrI4N2/c8-7-13-5-3(11)1(9)2(10)4(12)6(5)14-7/h(H,13,14)
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90 -41.8n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34040
PNG
(iodinated benzimidazole, 3a)
Show SMILES Brc1c(I)c(I)c2[nH]cnc2c1I
Show InChI InChI=1S/C7H2BrI3N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)
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100 -41.6n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34049
PNG
(iodinated benzimidazole, 12a)
Show SMILES Clc1nc2c(I)c(I)c(I)c(I)c2[nH]1
Show InChI InChI=1S/C7HClI4N2/c8-7-13-5-3(11)1(9)2(10)4(12)6(5)14-7/h(H,13,14)
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120 -41.1n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34047
PNG
(iodinated benzimidazole, 10a)
Show SMILES FC(F)(F)c1nc2c(I)c(I)c(I)c(I)c2[nH]1
Show InChI InChI=1S/C8HF3I4N2/c9-8(10,11)7-16-5-3(14)1(12)2(13)4(15)6(5)17-7/h(H,16,17)
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120 -41.1n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34056
PNG
(iodinated benzimidazole, 23)
Show SMILES NC(=O)Cn1cnc2c(I)c(I)c(I)c(I)c12
Show InChI InChI=1S/C9H5I4N3O/c10-4-5(11)7(13)9-8(6(4)12)15-2-16(9)1-3(14)17/h2H,1H2,(H2,14,17)
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130 -40.9n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34055
PNG
(iodinated benzimidazole, 21)
Show SMILES OC(=O)Cn1cnc2c(I)c(I)c(I)c(I)c12
Show InChI InChI=1S/C9H4I4N2O2/c10-4-5(11)7(13)9-8(6(4)12)14-2-15(9)1-3(16)17/h2H,1H2,(H,16,17)
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140 -40.7n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34058
PNG
(iodinated benzimidazole, 27)
Show SMILES NNC(=O)Cn1cnc2c(I)c(I)c(I)c(I)c12
Show InChI InChI=1S/C9H6I4N4O/c10-4-5(11)7(13)9-8(6(4)12)15-2-17(9)1-3(18)16-14/h2H,1,14H2,(H,16,18)
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160 -40.3n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34039
PNG
(iodinated benzimidazole, 2a)
Show SMILES Clc1c(I)c(I)c2nc[nH]c2c1I
Show InChI InChI=1S/C7H2ClI3N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)
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160 -40.3n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34057
PNG
(iodinated benzimidazole, 25)
Show SMILES CNC(=O)Cn1cnc2c(I)c(I)c(I)c(I)c12
Show InChI InChI=1S/C10H7I4N3O/c1-15-4(18)2-17-3-16-9-7(13)5(11)6(12)8(14)10(9)17/h3H,2H2,1H3,(H,15,18)
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180 -40.0n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34045
PNG
(iodinated benzimidazole, 8a)
Show SMILES Cc1nc2c(I)c(Cl)c(Cl)c(I)c2[nH]1
Show InChI InChI=1S/C8H4Cl2I2N2/c1-2-13-7-5(11)3(9)4(10)6(12)8(7)14-2/h1H3,(H,13,14)
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330 -38.5n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34041
PNG
(iodinated benzimidazole, 4a)
Show SMILES Clc1c(Cl)c(I)c2[nH]cnc2c1I
Show InChI InChI=1S/C7H2Cl2I2N2/c8-2-3(9)5(11)7-6(4(2)10)12-1-13-7/h1H,(H,12,13)
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460 -37.6n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34042
PNG
(iodinated benzimidazole, 5a)
Show SMILES Clc1c(I)c(Cl)c2nc[nH]c2c1I
Show InChI InChI=1S/C7H2Cl2I2N2/c8-2-4(10)3(9)6-7(5(2)11)13-1-12-6/h1H,(H,12,13)
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590 -37.0n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34059
PNG
(brominated benzimidazole, 20)
Show SMILES OC(=O)Cn1cnc2c(Br)c(Br)c(Br)c(Br)c12
Show InChI InChI=1S/C9H4Br4N2O2/c10-4-5(11)7(13)9-8(6(4)12)14-2-15(9)1-3(16)17/h2H,1H2,(H,16,17)
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1.34E+3 -34.9n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34060
PNG
(brominated benzimidazole, 22)
Show SMILES NC(=O)Cn1cnc2c(Br)c(Br)c(Br)c(Br)c12
Show InChI InChI=1S/C9H5Br4N3O/c10-4-5(11)7(13)9-8(6(4)12)15-2-16(9)1-3(14)17/h2H,1H2,(H2,14,17)
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1.45E+3 -34.7n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34062
PNG
(brominated benzimidazole, 26)
Show SMILES NNC(=O)Cn1cnc2c(Br)c(Br)c(Br)c(Br)c12
Show InChI InChI=1S/C9H6Br4N4O/c10-4-5(11)7(13)9-8(6(4)12)15-2-17(9)1-3(18)16-14/h2H,1,14H2,(H,16,18)
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1.51E+3 -34.6n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein Kinase II


(Rattus norvegicus (Rat))
BDBM34061
PNG
(brominated benzimidazole, 24)
Show SMILES CNC(=O)Cn1cnc2c(Br)c(Br)c(Br)c(Br)c12
Show InChI InChI=1S/C10H7Br4N3O/c1-15-4(18)2-17-3-16-9-7(13)5(11)6(12)8(14)10(9)17/h3H,2H2,1H3,(H,15,18)
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1.91E+3 -34.0n/an/an/an/an/a7.537



University of Padova



Assay Description
Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...


Citation and Details
More data for this
Ligand-Target Pair
Casein kinase II alpha (prime)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM15211
PNG
(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Show SMILES Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1
Show InChI InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+
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1.37E+5n/an/an/an/an/an/an/an/a



Institute for Biochemistry

Curated by ChEMBL


Assay Description
Inhibitory constant against bovine CK2


J Biol Chem 271: 26157-64 (1996)

More data for this
Ligand-Target Pair
Casein kinase II alpha (prime)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50366348
PNG
(CHEMBL1233654)
Show SMILES C[C@H]1CNCCN1S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3/t11-/m0/s1
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7.80E+5n/an/an/an/an/an/an/an/a



Institute for Biochemistry

Curated by ChEMBL


Assay Description
Inhibitory constant against CK2


J Biol Chem 271: 26157-64 (1996)

More data for this
Ligand-Target Pair
Casein kinase II alpha (prime)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM15210
PNG
(CHEMBL148333 | H-8 | Lopac-M-9656 | N-(2-methylami...)
Show SMILES CNCCNS(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C12H15N3O2S/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12/h2-6,9,13,15H,7-8H2,1H3
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9.50E+5n/an/an/an/an/an/an/an/a



Institute for Biochemistry

Curated by ChEMBL


Assay Description
Inhibitory constant against CK2


J Biol Chem 271: 26157-64 (1996)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218843
PNG
(US9303033, A1, Example 5)
Show SMILES Nc1cc(Nc2cccc(Cl)c2)nc2c(\C=C3/NC(=O)NC3=O)cnn12
Show InChI InChI=1S/C16H12ClN7O2/c17-9-2-1-3-10(5-9)20-13-6-12(18)24-14(22-13)8(7-19-24)4-11-15(25)23-16(26)21-11/h1-7H,18H2,(H,20,22)(H2,21,23,25,26)/b11-4-
PDB

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n/an/a<0.100n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219949
PNG
(US9303033, Z43, Table 50A, Compound 31)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)cc(NCc3ccccc3-c3ccccc3)nc12
Show InChI InChI=1S/C26H23N7O2/c34-25-21(30-26(35)32-25)12-18-15-28-33-23(29-19-10-11-19)13-22(31-24(18)33)27-14-17-8-4-5-9-20(17)16-6-2-1-3-7-16/h1-9,12-13,15,19,29H,10-11,14H2,(H,27,31)(H2,30,32,34,35)/b21-12-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219950
PNG
(US9303033, A44, Table 50A, Compound 32)
Show SMILES Fc1ccc(Br)c(CNc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c1
Show InChI InChI=1S/C20H17BrFN7O2/c21-14-4-1-12(22)5-10(14)8-23-16-7-17(25-13-2-3-13)29-18(27-16)11(9-24-29)6-15-19(30)28-20(31)26-15/h1,4-7,9,13,25H,2-3,8H2,(H,23,27)(H2,26,28,30,31)/b15-6-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219952
PNG
(US9303033, C44, Table 50A, Compound 34)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1/C19H23N7O3/c27-13-5-3-11(4-6-13)21-15-8-16(22-12-1-2-12)26-17(24-15)10(9-20-26)7-14-18(28)25-19(29)23-14/h7-9,11-13,22,27H,1-6H2,(H,21,24)(H2,23,25,28,29)/b14-7-/t11-,13-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219818
PNG
(US9303033, X40, Table 43A, Compound 53 | US9303033...)
Show SMILES Clc1c(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)cccc1OCCN1CCOCC1
Show InChI InChI=1S/C25H27ClN8O4/c26-22-17(2-1-3-19(22)38-11-8-33-6-9-37-10-7-33)29-20-13-21(28-16-4-5-16)34-23(31-20)15(14-27-34)12-18-24(35)32-25(36)30-18/h1-3,12-14,16,28H,4-11H2,(H,29,31)(H2,30,32,35,36)/b18-12-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219870
PNG
(US9303033, Y40, Table 43A, Compound 54)
Show SMILES Cc1ccc(Cl)c(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c1
Show InChI InChI=1S/C20H18ClN7O2/c1-10-2-5-13(21)14(6-10)24-16-8-17(23-12-3-4-12)28-18(26-16)11(9-22-28)7-15-19(29)27-20(30)25-15/h2,5-9,12,23H,3-4H2,1H3,(H,24,26)(H2,25,27,29,30)/b15-7-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219871
PNG
(US9303033, Z40, Table 43A, Compound 55)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)cc1
Show InChI InChI=1S/C25H29N9O2/c1-2-32-9-11-33(12-10-32)19-7-5-17(6-8-19)27-21-14-22(28-18-3-4-18)34-23(30-21)16(15-26-34)13-20-24(35)31-25(36)29-20/h5-8,13-15,18,28H,2-4,9-12H2,1H3,(H,27,30)(H2,29,31,35,36)/b20-13-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219872
PNG
(US9303033, A41, Table 43A, Compound 56)
Show SMILES Clc1cc(ccc1Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)N1CCOCC1
Show InChI InChI=1S/C23H23ClN8O3/c24-16-10-15(31-5-7-35-8-6-31)3-4-17(16)27-19-11-20(26-14-1-2-14)32-21(29-19)13(12-25-32)9-18-22(33)30-23(34)28-18/h3-4,9-12,14,26H,1-2,5-8H2,(H,27,29)(H2,28,30,33,34)/b18-9-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219873
PNG
(US9303033, B41, Table 43A, Compound 57)
Show SMILES CC(C)(C)OC(=O)NCc1ccc(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)cc1
Show InChI InChI=1S/C25H28N8O4/c1-25(2,3)37-24(36)26-12-14-4-6-16(7-5-14)28-19-11-20(29-17-8-9-17)33-21(31-19)15(13-27-33)10-18-22(34)32-23(35)30-18/h4-7,10-11,13,17,29H,8-9,12H2,1-3H3,(H,26,36)(H,28,31)(H2,30,32,34,35)/b18-10-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219874
PNG
(US9303033, C41, Table 43A, Compound 58)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)cc1
Show InChI InChI=1S/C28H33N9O4/c1-28(2,3)41-27(40)36-12-10-35(11-13-36)20-8-6-18(7-9-20)30-22-15-23(31-19-4-5-19)37-24(33-22)17(16-29-37)14-21-25(38)34-26(39)32-21/h6-9,14-16,19,31H,4-5,10-13H2,1-3H3,(H,30,33)(H2,32,34,38,39)/b21-14-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219875
PNG
(US9303033, D41, Table 43A, Compound 59)
Show SMILES COc1ccc(F)cc1Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C20H18FN7O3/c1-31-15-5-2-11(21)7-13(15)24-16-8-17(23-12-3-4-12)28-18(26-16)10(9-22-28)6-14-19(29)27-20(30)25-14/h2,5-9,12,23H,3-4H2,1H3,(H,24,26)(H2,25,27,29,30)/b14-6-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219876
PNG
(US9303033, E41, Table 43A, Compound 60)
Show SMILES COc1ccc(C)cc1Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C21H21N7O3/c1-11-3-6-16(31-2)14(7-11)24-17-9-18(23-13-4-5-13)28-19(26-17)12(10-22-28)8-15-20(29)27-21(30)25-15/h3,6-10,13,23H,4-5H2,1-2H3,(H,24,26)(H2,25,27,29,30)/b15-8-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219877
PNG
(US9303033, F41, Table 43A, Compound 61)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)c1ccc(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)cc1
Show InChI InChI=1S/C29H34N8O4/c1-29(2,3)41-28(40)36-12-10-18(11-13-36)17-4-6-20(7-5-17)31-23-15-24(32-21-8-9-21)37-25(34-23)19(16-30-37)14-22-26(38)35-27(39)33-22/h4-7,14-16,18,21,32H,8-13H2,1-3H3,(H,31,34)(H2,33,35,38,39)/b22-14-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219878
PNG
(US9303033, G41, Table 43A, Compound 62)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)cc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C23H25N9O2/c33-22-18(28-23(34)30-22)11-14-13-25-32-20(27-16-1-2-16)12-19(29-21(14)32)26-15-3-5-17(6-4-15)31-9-7-24-8-10-31/h3-6,11-13,16,24,27H,1-2,7-10H2,(H,26,29)(H2,28,30,33,34)/b18-11-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219879
PNG
(US9303033, H41, Table 43A, Compound 63)
Show SMILES NCc1ccc(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)cc1
Show InChI InChI=1S/C20H20N8O2/c21-9-11-1-3-13(4-2-11)23-16-8-17(24-14-5-6-14)28-18(26-16)12(10-22-28)7-15-19(29)27-20(30)25-15/h1-4,7-8,10,14,24H,5-6,9,21H2,(H,23,26)(H2,25,27,29,30)/b15-7-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219880
PNG
(US9303033, I41, Table 43A, Compound 64)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)cc(Nc3ccc(cc3)C3CCNCC3)nc12
Show InChI InChI=1S/C24H26N8O2/c33-23-19(29-24(34)31-23)11-16-13-26-32-21(28-18-5-6-18)12-20(30-22(16)32)27-17-3-1-14(2-4-17)15-7-9-25-10-8-15/h1-4,11-13,15,18,25,28H,5-10H2,(H,27,30)(H2,29,31,33,34)/b19-11-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219881
PNG
(US9303033, J41, Table 44A, Compound 1)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c(F)c1
Show InChI InChI=1S/C25H26FN9O3/c1-33-6-8-34(9-7-33)24(37)14-2-5-18(17(26)10-14)29-20-12-21(28-16-3-4-16)35-22(31-20)15(13-27-35)11-19-23(36)32-25(38)30-19/h2,5,10-13,16,28H,3-4,6-9H2,1H3,(H,29,31)(H2,30,32,36,38)/b19-11-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219882
PNG
(US9303033, K41, Table 44A, Compound 2)
Show SMILES Fc1cc(ccc1Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)C(=O)NC1CC1
Show InChI InChI=1S/C23H21FN8O3/c24-15-7-11(21(33)27-14-4-5-14)1-6-16(15)28-18-9-19(26-13-2-3-13)32-20(30-18)12(10-25-32)8-17-22(34)31-23(35)29-17/h1,6-10,13-14,26H,2-5H2,(H,27,33)(H,28,30)(H2,29,31,34,35)/b17-8-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219883
PNG
(US9303033, L41, Table 44A, Compound 3)
Show SMILES Fc1cc(ccc1Nc1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)C(=O)N1CCCNCC1
Show InChI InChI=1S/C25H26FN9O3/c26-17-10-14(24(37)34-8-1-6-27-7-9-34)2-5-18(17)30-20-12-21(29-16-3-4-16)35-22(32-20)15(13-28-35)11-19-23(36)33-25(38)31-19/h2,5,10-13,16,27,29H,1,3-4,6-9H2,(H,30,32)(H2,31,33,36,38)/b19-11-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219884
PNG
(US9303033, M41, Table 44A, Compound 4)
Show SMILES CN1CCC(CC1)NC(=O)c1ccc(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c(F)c1
Show InChI InChI=1S/C26H28FN9O3/c1-35-8-6-17(7-9-35)30-24(37)14-2-5-19(18(27)10-14)31-21-12-22(29-16-3-4-16)36-23(33-21)15(13-28-36)11-20-25(38)34-26(39)32-20/h2,5,10-13,16-17,29H,3-4,6-9H2,1H3,(H,30,37)(H,31,33)(H2,32,34,38,39)/b20-11-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219886
PNG
(US9303033, O41, Table 44A, Compound 6)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)C(=O)c1ccc(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c(F)c1
Show InChI InChI=1/C26H27FN8O4/c1-13-11-34(12-14(2)39-13)25(37)15-3-6-19(18(27)7-15)30-21-9-22(29-17-4-5-17)35-23(32-21)16(10-28-35)8-20-24(36)33-26(38)31-20/h3,6-10,13-14,17,29H,4-5,11-12H2,1-2H3,(H,30,32)(H2,31,33,36,38)/b20-8-/t13-,14+
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219888
PNG
(US9303033, Q41, Table 44A, Compound 8)
Show SMILES CNC(=O)c1ccc(Nc2cc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c(F)c1
Show InChI InChI=1S/C21H19FN8O3/c1-23-19(31)10-2-5-14(13(22)6-10)26-16-8-17(25-12-3-4-12)30-18(28-16)11(9-24-30)7-15-20(32)29-21(33)27-15/h2,5-9,12,25H,3-4H2,1H3,(H,23,31)(H,26,28)(H2,27,29,32,33)/b15-7-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)

More data for this
Ligand-Target Pair
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