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Found 1289 hits Enz. Inhib. hit(s) with Target = 'Casein kinase II' AND taxid = 9913   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Casein Kinase II


(Bos taurus (bovine))
BDBM21447
PNG
(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Show SMILES CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t35-/m1/s1
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>1n/an/an/an/an/an/an/an/a



Institut de Chimie des Substances Naturelles

Curated by ChEMBL


Assay Description
Binding affinity to bovine beta-casein A1


Bioorg Med Chem 22: 4474-89 (2014)


Article DOI: 10.1016/j.bmc.2014.04.019
BindingDB Entry DOI: 10.7270/Q29K4CW0
More data for this
Ligand-Target Pair
Casein kinase II alpha (prime)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM15211
PNG
(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Show SMILES Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1
Show InChI InChI=1S/C20H20BrN3O2S/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20/h1-10,12,15,22,24H,11,13-14H2/b3-2+
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1.37E+5n/an/an/an/an/an/an/an/a



Institute for Biochemistry

Curated by ChEMBL


Assay Description
Inhibitory constant against bovine CK2


J Biol Chem 271: 26157-64 (1996)


Article DOI: 10.1074/jbc.271.42.26157
BindingDB Entry DOI: 10.7270/Q2BR8T3M
More data for this
Ligand-Target Pair
Casein kinase II alpha (prime)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50366348
PNG
(CHEMBL1233654)
Show SMILES C[C@H]1CNCCN1S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3/t11-/m0/s1
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7.80E+5n/an/an/an/an/an/an/an/a



Institute for Biochemistry

Curated by ChEMBL


Assay Description
Inhibitory constant against CK2


J Biol Chem 271: 26157-64 (1996)


Article DOI: 10.1074/jbc.271.42.26157
BindingDB Entry DOI: 10.7270/Q2BR8T3M
More data for this
Ligand-Target Pair
Casein kinase II alpha (prime)


(Homo sapiens (human)-Homo sapiens (Human))
BDBM15210
PNG
(CHEMBL148333 | H-8 | Lopac-M-9656 | N-(2-methylami...)
Show SMILES CNCCNS(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C12H15N3O2S/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12/h2-6,9,13,15H,7-8H2,1H3
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9.50E+5n/an/an/an/an/an/an/an/a



Institute for Biochemistry

Curated by ChEMBL


Assay Description
Inhibitory constant against CK2


J Biol Chem 271: 26157-64 (1996)


Article DOI: 10.1074/jbc.271.42.26157
BindingDB Entry DOI: 10.7270/Q2BR8T3M
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM218843
PNG
(US9303033, A1, Example 5)
Show SMILES Nc1cc(Nc2cccc(Cl)c2)nc2c(\C=C3/NC(=O)NC3=O)cnn12
Show InChI InChI=1S/C16H12ClN7O2/c17-9-2-1-3-10(5-9)20-13-6-12(18)24-14(22-13)8(7-19-24)4-11-15(25)23-16(26)21-11/h1-7H,18H2,(H,20,22)(H2,21,23,25,26)/b11-4-
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n/an/a<0.100n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219548
PNG
(US9303033, O28, Table 37A, Compound 222)
Show SMILES C[C@@H](Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1ccc(C)cc1
Show InChI InChI=1S/C21H22N8O2/c1-11-3-5-13(6-4-11)12(2)23-19-26-17-14(9-16-18(30)27-21(31)25-16)10-22-29(17)20(28-19)24-15-7-8-15/h3-6,9-10,12,15H,7-8H2,1-2H3,(H2,23,24,26,28)(H2,25,27,30,31)/b16-9-/t12-/m1/s1
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219561
PNG
(US9303033, B29, Table 37A, Compound 235)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(NCc3ccccc3-n3ccnc3)nc12
Show InChI InChI=1S/C22H20N10O2/c33-19-16(27-22(34)29-19)9-14-11-25-32-18(14)28-20(30-21(32)26-15-5-6-15)24-10-13-3-1-2-4-17(13)31-8-7-23-12-31/h1-4,7-9,11-12,15H,5-6,10H2,(H2,24,26,28,30)(H2,27,29,33,34)/b16-9-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219563
PNG
(US9303033, D29, Table 37A, Compound 237)
Show SMILES CC(Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1ccc(Br)cc1
Show InChI InChI=1S/C20H19BrN8O2/c1-10(11-2-4-13(21)5-3-11)23-18-26-16-12(8-15-17(30)27-20(31)25-15)9-22-29(16)19(28-18)24-14-6-7-14/h2-5,8-10,14H,6-7H2,1H3,(H2,23,24,26,28)(H2,25,27,30,31)/b15-8-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219564
PNG
(US9303033, E29, Table 37A, Compound 238)
Show SMILES C[C@H](Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1ccc(Br)cc1
Show InChI InChI=1S/C20H19BrN8O2/c1-10(11-2-4-13(21)5-3-11)23-18-26-16-12(8-15-17(30)27-20(31)25-15)9-22-29(16)19(28-18)24-14-6-7-14/h2-5,8-10,14H,6-7H2,1H3,(H2,23,24,26,28)(H2,25,27,30,31)/b15-8-/t10-/m0/s1
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219568
PNG
(US9303033, I29, Table 37A, Compound 242)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(nc12)N1CCC(CC1)c1cccc(c1)C#N
Show InChI InChI=1S/C24H23N9O2/c25-12-14-2-1-3-16(10-14)15-6-8-32(9-7-15)22-29-20-17(11-19-21(34)30-24(35)28-19)13-26-33(20)23(31-22)27-18-4-5-18/h1-3,10-11,13,15,18H,4-9H2,(H,27,29,31)(H2,28,30,34,35)/b19-11-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219569
PNG
(US9303033, J29, Table 37A, Compound 243)
Show SMILES FC1(F)CCC(CC1)Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C18H20F2N8O2/c19-18(20)5-3-11(4-6-18)22-15-25-13-9(7-12-14(29)26-17(30)24-12)8-21-28(13)16(27-15)23-10-1-2-10/h7-8,10-11H,1-6H2,(H2,22,23,25,27)(H2,24,26,29,30)/b12-7-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219572
PNG
(US9303033, M29, Table 37A, Compound 246)
Show SMILES CN(C)S(=O)(=O)N1CCN(CC1)c1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C18H24N10O4S/c1-25(2)33(31,32)27-7-5-26(6-8-27)16-22-14-11(9-13-15(29)23-18(30)21-13)10-19-28(14)17(24-16)20-12-3-4-12/h9-10,12H,3-8H2,1-2H3,(H,20,22,24)(H2,21,23,29,30)/b13-9-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219575
PNG
(US9303033, P29, Table 37A, Compound 249)
Show SMILES CN(Cc1ccccc1Br)c1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C20H19BrN8O2/c1-28(10-11-4-2-3-5-14(11)21)18-25-16-12(8-15-17(30)26-20(31)24-15)9-22-29(16)19(27-18)23-13-6-7-13/h2-5,8-9,13H,6-7,10H2,1H3,(H,23,25,27)(H2,24,26,30,31)/b15-8-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219577
PNG
(US9303033, R29, Table 37A, Compound 251)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(nc12)N1CCC(CC1)C#N
Show InChI InChI=1S/C18H19N9O2/c19-8-10-3-5-26(6-4-10)16-23-14-11(7-13-15(28)24-18(29)22-13)9-20-27(14)17(25-16)21-12-1-2-12/h7,9-10,12H,1-6H2,(H,21,23,25)(H2,22,24,28,29)/b13-7-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219582
PNG
(US9303033, W29, Table 37A, Compound 256)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(nc12)N1CCC(CC1)c1ccc(cc1)C#N
Show InChI InChI=1S/C24H23N9O2/c25-12-14-1-3-15(4-2-14)16-7-9-32(10-8-16)22-29-20-17(11-19-21(34)30-24(35)28-19)13-26-33(20)23(31-22)27-18-5-6-18/h1-4,11,13,16,18H,5-10H2,(H,27,29,31)(H2,28,30,34,35)/b19-11-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219584
PNG
(US9303033, Y29, Table 37A, Compound 258)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(nc12)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C21H27N9O3/c31-18-16(24-21(32)26-18)11-13-12-22-30-17(13)25-19(27-20(30)23-14-1-2-14)29-5-3-15(4-6-29)28-7-9-33-10-8-28/h11-12,14-15H,1-10H2,(H,23,25,27)(H2,24,26,31,32)/b16-11-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219587
PNG
(US9303033, B30, Table 37A, Compound 261)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(nc12)N1CCN(CC1)c1ncccc1C#N
Show InChI InChI=1S/C22H21N11O2/c23-11-13-2-1-5-24-17(13)31-6-8-32(9-7-31)20-28-18-14(10-16-19(34)29-22(35)27-16)12-25-33(18)21(30-20)26-15-3-4-15/h1-2,5,10,12,15H,3-4,6-9H2,(H,26,28,30)(H2,27,29,34,35)/b16-10-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219590
PNG
(US9303033, E30, Table 37A, Compound 264)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(nc12)N1CCN(CC1)c1ccc(cn1)C#N
Show InChI InChI=1S/C22H21N11O2/c23-10-13-1-4-17(24-11-13)31-5-7-32(8-6-31)20-28-18-14(9-16-19(34)29-22(35)27-16)12-25-33(18)21(30-20)26-15-2-3-15/h1,4,9,11-12,15H,2-3,5-8H2,(H,26,28,30)(H2,27,29,34,35)/b16-9-
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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219592
PNG
(US9303033, G30, Table 37A, Compound 266)
Show SMILES CN(Cc1c(F)cccc1Cl)c1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C20H18ClFN8O2/c1-29(9-12-13(21)3-2-4-14(12)22)18-26-16-10(7-15-17(31)27-20(32)25-15)8-23-30(16)19(28-18)24-11-5-6-11/h2-4,7-8,11H,5-6,9H2,1H3,(H,24,26,28)(H2,25,27,31,32)/b15-7-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219594
PNG
(US9303033, I30, Table 37A, Compound 268)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(nc12)N1CCN(Cc2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C24H24N10O2/c25-12-15-1-3-16(4-2-15)14-32-7-9-33(10-8-32)22-29-20-17(11-19-21(35)30-24(36)28-19)13-26-34(20)23(31-22)27-18-5-6-18/h1-4,11,13,18H,5-10,14H2,(H,27,29,31)(H2,28,30,35,36)/b19-11-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219595
PNG
(US9303033, J30, Table 37A, Compound 269)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(nc12)N1Cc2ccccc2C1
Show InChI InChI=1S/C20H18N8O2/c29-17-15(23-20(30)25-17)7-13-8-21-28-16(13)24-18(26-19(28)22-14-5-6-14)27-9-11-3-1-2-4-12(11)10-27/h1-4,7-8,14H,5-6,9-10H2,(H,22,24,26)(H2,23,25,29,30)/b15-7-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219598
PNG
(US9303033, M30, Table 37A, Compound 272)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(nc12)N(CCC#N)C1CC1
Show InChI InChI=1S/C18H19N9O2/c19-6-1-7-26(12-4-5-12)16-23-14-10(8-13-15(28)24-18(29)22-13)9-20-27(14)17(25-16)21-11-2-3-11/h8-9,11-12H,1-5,7H2,(H,21,23,25)(H2,22,24,28,29)/b13-8-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219600
PNG
(US9303033, O30, Table 37A, Compound 274)
Show SMILES Cc1cc2ccccc2n1CCNc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C23H23N9O2/c1-13-10-14-4-2-3-5-18(14)31(13)9-8-24-21-28-19-15(11-17-20(33)29-23(34)27-17)12-25-32(19)22(30-21)26-16-6-7-16/h2-5,10-12,16H,6-9H2,1H3,(H2,24,26,28,30)(H2,27,29,33,34)/b17-11-
PDB

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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219604
PNG
(US9303033, S30, Table 37A, Compound 278)
Show SMILES C[C@H](Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)C1CCCCC1
Show InChI InChI=1S/C20H26N8O2/c1-11(12-5-3-2-4-6-12)22-18-25-16-13(9-15-17(29)26-20(30)24-15)10-21-28(16)19(27-18)23-14-7-8-14/h9-12,14H,2-8H2,1H3,(H2,22,23,25,27)(H2,24,26,29,30)/b15-9-/t11-/m0/s1
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219608
PNG
(US9303033, W30, Table 37A, Compound 282)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(nc12)N1CCc2ccc(cc2C1)C#N
Show InChI InChI=1S/C22H19N9O2/c23-9-12-1-2-13-5-6-30(11-15(13)7-12)20-27-18-14(8-17-19(32)28-22(33)26-17)10-24-31(18)21(29-20)25-16-3-4-16/h1-2,7-8,10,16H,3-6,11H2,(H,25,27,29)(H2,26,28,32,33)/b17-8-
PDB

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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219610
PNG
(US9303033, Y30, Table 37A, Compound 284)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(NCC3CCCOC3)nc12
Show InChI InChI=1S/C18H22N8O3/c27-15-13(22-18(28)24-15)6-11-8-20-26-14(11)23-16(25-17(26)21-12-3-4-12)19-7-10-2-1-5-29-9-10/h6,8,10,12H,1-5,7,9H2,(H2,19,21,23,25)(H2,22,24,27,28)/b13-6-
PDB

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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219615
PNG
(US9303033, D31, Table 37A, Compound 289)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C18H23N9O4S/c1-2-32(30,31)26-7-5-25(6-8-26)16-22-14-11(9-13-15(28)23-18(29)21-13)10-19-27(14)17(24-16)20-12-3-4-12/h9-10,12H,2-8H2,1H3,(H,20,22,24)(H2,21,23,28,29)/b13-9-
PDB

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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219630
PNG
(US9303033, S31, Table 37A, Compound 304)
Show SMILES CC(Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1cc(C)ccn1
Show InChI InChI=1S/C20H21N9O2/c1-10-5-6-21-14(7-10)11(2)23-18-26-16-12(8-15-17(30)27-20(31)25-15)9-22-29(16)19(28-18)24-13-3-4-13/h5-9,11,13H,3-4H2,1-2H3,(H2,23,24,26,28)(H2,25,27,30,31)/b15-8-
PDB

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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219632
PNG
(US9303033, U31, Table 37A, Compound 306)
Show SMILES CC(Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1ccc(C)cn1
Show InChI InChI=1S/C20H21N9O2/c1-10-3-6-14(21-8-10)11(2)23-18-26-16-12(7-15-17(30)27-20(31)25-15)9-22-29(16)19(28-18)24-13-4-5-13/h3,6-9,11,13H,4-5H2,1-2H3,(H2,23,24,26,28)(H2,25,27,30,31)/b15-7-
PDB

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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219633
PNG
(US9303033, V31, Table 37A, Compound 307)
Show SMILES CCC(Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1ccccn1
Show InChI InChI=1S/C20H21N9O2/c1-2-13(14-5-3-4-8-21-14)24-18-26-16-11(9-15-17(30)27-20(31)25-15)10-22-29(16)19(28-18)23-12-6-7-12/h3-5,8-10,12-13H,2,6-7H2,1H3,(H2,23,24,26,28)(H2,25,27,30,31)/b15-9-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219635
PNG
(US9303033, X31, Table 37A, Compound 309)
Show SMILES C[C@H](Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1ccccn1
Show InChI InChI=1S/C19H19N9O2/c1-10(13-4-2-3-7-20-13)22-17-25-15-11(8-14-16(29)26-19(30)24-14)9-21-28(15)18(27-17)23-12-5-6-12/h2-4,7-10,12H,5-6H2,1H3,(H2,22,23,25,27)(H2,24,26,29,30)/b14-8-/t10-/m0/s1
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219638
PNG
(US9303033, A32, Table 37A, Compound 312)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)c1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C22H21F3N10O2/c23-22(24,25)14-2-1-5-26-17(14)33-6-8-34(9-7-33)19-30-16-12(10-15-18(36)31-21(37)29-15)11-27-35(16)20(32-19)28-13-3-4-13/h1-2,5,10-11,13H,3-4,6-9H2,(H,28,30,32)(H2,29,31,36,37)/b15-10-
PDB

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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219645
PNG
(US9303033, H32, Table 37A, Compound 319)
Show SMILES Clc1cc(ccc1CNc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)C#N
Show InChI InChI=1S/C20H16ClN9O2/c21-14-5-10(7-22)1-2-11(14)8-23-18-27-16-12(6-15-17(31)28-20(32)26-15)9-24-30(16)19(29-18)25-13-3-4-13/h1-2,5-6,9,13H,3-4,8H2,(H2,23,25,27,29)(H2,26,28,31,32)/b15-6-
PDB

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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219646
PNG
(US9303033, I32, Table 37A, Compound 320)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(Nc3ccc(cc3)-n3cccn3)nc12
Show InChI InChI=1S/C21H18N10O2/c32-18-16(26-21(33)28-18)10-12-11-23-31-17(12)27-19(29-20(31)25-14-2-3-14)24-13-4-6-15(7-5-13)30-9-1-8-22-30/h1,4-11,14H,2-3H2,(H2,24,25,27,29)(H2,26,28,32,33)/b16-10-
PDB

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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219655
PNG
(US9303033, R32, Table 37A, Compound 329)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(Nc3ccc(cc3)C#N)nc12
Show InChI InChI=1S/C19H15N9O2/c20-8-10-1-3-12(4-2-10)22-17-25-15-11(7-14-16(29)26-19(30)24-14)9-21-28(15)18(27-17)23-13-5-6-13/h1-4,7,9,13H,5-6H2,(H2,22,23,25,27)(H2,24,26,29,30)/b14-7-
PDB

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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219656
PNG
(US9303033, S32, Table 37A, Compound 330)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(Nc3cccc(c3)C#N)nc12
Show InChI InChI=1S/C19H15N9O2/c20-8-10-2-1-3-13(6-10)22-17-25-15-11(7-14-16(29)26-19(30)24-14)9-21-28(15)18(27-17)23-12-4-5-12/h1-3,6-7,9,12H,4-5H2,(H2,22,23,25,27)(H2,24,26,29,30)/b14-7-
PDB

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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219657
PNG
(US9303033, T32, Table 37A, Compound 331)
Show SMILES Fc1cc(ccc1Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)C#N
Show InChI InChI=1S/C19H14FN9O2/c20-12-5-9(7-21)1-4-13(12)24-17-26-15-10(6-14-16(30)27-19(31)25-14)8-22-29(15)18(28-17)23-11-2-3-11/h1,4-6,8,11H,2-3H2,(H2,23,24,26,28)(H2,25,27,30,31)/b14-6-
PDB

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n/an/a<10n/an/an/an/an/an/a



SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219658
PNG
(US9303033, U32, Table 37A, Compound 332)
Show SMILES CCC(Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C22H24N8O4S/c1-3-16(12-4-8-15(9-5-12)35(2,33)34)25-20-27-18-13(10-17-19(31)28-22(32)26-17)11-23-30(18)21(29-20)24-14-6-7-14/h4-5,8-11,14,16H,3,6-7H2,1-2H3,(H2,24,25,27,29)(H2,26,28,31,32)/b17-10-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219660
PNG
(US9303033, W32, Table 37A, Compound 334)
Show SMILES CCC(Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1cccc(C)n1
Show InChI InChI=1S/C21H23N9O2/c1-3-14(15-6-4-5-11(2)23-15)25-19-27-17-12(9-16-18(31)28-21(32)26-16)10-22-30(17)20(29-19)24-13-7-8-13/h4-6,9-10,13-14H,3,7-8H2,1-2H3,(H2,24,25,27,29)(H2,26,28,31,32)/b16-9-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219663
PNG
(US9303033, Z32, Table 37A, Compound 337)
Show SMILES FC(F)(F)C(Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1ccccn1
Show InChI InChI=1S/C19H16F3N9O2/c20-19(21,22)13(11-3-1-2-6-23-11)27-16-28-14-9(7-12-15(32)29-18(33)26-12)8-24-31(14)17(30-16)25-10-4-5-10/h1-3,6-8,10,13H,4-5H2,(H2,25,27,28,30)(H2,26,29,32,33)/b12-7-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219665
PNG
(US9303033, B33, Table 37A, Compound 339)
Show SMILES Clc1ccc(Nc2nc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)nc1
Show InChI InChI=1S/C17H14ClN9O2/c18-9-1-4-12(19-7-9)23-15-24-13-8(5-11-14(28)25-17(29)22-11)6-20-27(13)16(26-15)21-10-2-3-10/h1,4-7,10H,2-3H2,(H2,22,25,28,29)(H2,19,21,23,24,26)/b11-5-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219668
PNG
(US9303033, E33, Table 37A, Compound 342)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(nc12)N1CCc2ccccc12
Show InChI InChI=1S/C20H18N8O2/c29-17-14(23-20(30)25-17)9-12-10-21-28-16(12)24-18(26-19(28)22-13-5-6-13)27-8-7-11-3-1-2-4-15(11)27/h1-4,9-10,13H,5-8H2,(H,22,24,26)(H2,23,25,29,30)/b14-9-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219669
PNG
(US9303033, F33, Table 37A, Compound 343)
Show SMILES C[C@@H](Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1ccc(cc1F)C#N
Show InChI InChI=1S/C21H18FN9O2/c1-10(14-5-2-11(8-23)6-15(14)22)25-19-28-17-12(7-16-18(32)29-21(33)27-16)9-24-31(17)20(30-19)26-13-3-4-13/h2,5-7,9-10,13H,3-4H2,1H3,(H2,25,26,28,30)(H2,27,29,32,33)/b16-7-/t10-/m1/s1
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219670
PNG
(US9303033, G33, Table 37A, Compound 344)
Show SMILES C[C@@H](Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1cc(C)ccc1F
Show InChI InChI=1S/C21H21FN8O2/c1-10-3-6-15(22)14(7-10)11(2)24-19-27-17-12(8-16-18(31)28-21(32)26-16)9-23-30(17)20(29-19)25-13-4-5-13/h3,6-9,11,13H,4-5H2,1-2H3,(H2,24,25,27,29)(H2,26,28,31,32)/b16-8-/t11-/m1/s1
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219671
PNG
(US9303033, H33, Table 37A, Compound 345 | US930303...)
Show SMILES C[C@H](Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1cc(Cl)ccc1F
Show InChI InChI=1S/C20H18ClFN8O2/c1-9(13-7-11(21)2-5-14(13)22)24-18-27-16-10(6-15-17(31)28-20(32)26-15)8-23-30(16)19(29-18)25-12-3-4-12/h2,5-9,12H,3-4H2,1H3,(H2,24,25,27,29)(H2,26,28,31,32)/b15-6-/t9-/m0/s1
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219672
PNG
(US9303033, I33, Table 37A, Compound 346)
Show SMILES Cc1nccn1-c1ccccc1CNc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1
Show InChI InChI=1S/C23H22N10O2/c1-13-24-8-9-32(13)18-5-3-2-4-14(18)11-25-21-29-19-15(10-17-20(34)30-23(35)28-17)12-26-33(19)22(31-21)27-16-6-7-16/h2-5,8-10,12,16H,6-7,11H2,1H3,(H2,25,27,29,31)(H2,28,30,34,35)/b17-10-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219673
PNG
(US9303033, J33, Table 37A, Compound 347)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(NCc3ccccc3-n3cccn3)nc12
Show InChI InChI=1S/C22H20N10O2/c33-19-16(27-22(34)29-19)10-14-12-25-32-18(14)28-20(30-21(32)26-15-6-7-15)23-11-13-4-1-2-5-17(13)31-9-3-8-24-31/h1-5,8-10,12,15H,6-7,11H2,(H2,23,26,28,30)(H2,27,29,33,34)/b16-10-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219674
PNG
(US9303033, K33, Table 37A, Compound 348)
Show SMILES O=C1NC(=O)\C(N1)=C\c1cnn2c(NC3CC3)nc(NCc3ccccc3-n3cncn3)nc12
Show InChI InChI=1S/C21H19N11O2/c33-18-15(27-21(34)29-18)7-13-9-24-32-17(13)28-19(30-20(32)26-14-5-6-14)23-8-12-3-1-2-4-16(12)31-11-22-10-25-31/h1-4,7,9-11,14H,5-6,8H2,(H2,23,26,28,30)(H2,27,29,33,34)/b15-7-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219675
PNG
(US9303033, L33, Table 37A, Compound 349)
Show SMILES CC(Nc1nc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1)c1ccccc1-n1cccn1
Show InChI InChI=1S/C23H22N10O2/c1-13(16-5-2-3-6-18(16)32-10-4-9-24-32)26-21-29-19-14(11-17-20(34)30-23(35)28-17)12-25-33(19)22(31-21)27-15-7-8-15/h2-6,9-13,15H,7-8H2,1H3,(H2,26,27,29,31)(H2,28,30,34,35)/b17-11-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
Casein kinase II alpha/beta


(Homo sapiens (human)-Rattus norvegicus)
BDBM219676
PNG
(US9303033, M33, Table 37A, Compound 350)
Show SMILES Fc1ccc(Cl)c(Nc2nc(NC3CC3)n3ncc(\C=C4/NC(=O)NC4=O)c3n2)c1
Show InChI InChI=1S/C18H14ClFN8O2/c19-11-4-1-9(20)6-12(11)23-16-25-14-8(5-13-15(29)26-18(30)24-13)7-21-28(14)17(27-16)22-10-2-3-10/h1,4-7,10H,2-3H2,(H2,22,23,25,27)(H2,24,26,29,30)/b13-5-
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SENHWA BIOSCIENCES, INC.

US Patent


Assay Description
In a final reaction volume of 50 μl, CK2 ααββ (4 ng, 8.5 mU) was incubated with various concentrations of test compounds in ...


US Patent US9303033 (2016)


BindingDB Entry DOI: 10.7270/Q2CN72RX
More data for this
Ligand-Target Pair
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