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Compile Data Set for Download or QSAR

Found 102 hits Enz. Inhib. hit(s) with Target = 'Cathepsin B' AND taxid = 9925   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin B


(Capra hircus (Goat))
BDBM120828
PNG
(N-formyl-5-(-3'-nitrophenyl)-3-phenylpyrazolin...)
Show SMILES [O-][N+](=O)c1cccc(c1)C1CC(=NN1C=O)c1ccccc1
Show InChI InChI=1S/C16H13N3O3/c20-11-18-16(13-7-4-8-14(9-13)19(21)22)10-15(17-18)12-5-2-1-3-6-12/h1-9,11,16H,10H2
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0.0110n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM50286441
PNG
((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C20H38N6O5/c1-11(2)9-15(24-13(5)27)17(28)26-16(10-12(3)4)18(29)25-14(19(30)31)7-6-8-23-20(21)22/h11-12,14-16H,6-10H2,1-5H3,(H,24,27)(H,25,29)(H,26,28)(H,30,31)(H4,21,22,23)/t14-,15-,16-/m0/s1
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0.0200n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Competitive inhibition of goat brain cathepsin B


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120829
PNG
(N-formyl-5-(-4'-nitrophenyl)-3-phenylpyrazolin...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C1CC(=NN1C=O)c1ccccc1
Show InChI InChI=1S/C16H13N3O3/c20-11-18-16(13-6-8-14(9-7-13)19(21)22)10-15(17-18)12-4-2-1-3-5-12/h1-9,11,16H,10H2
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0.113n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120827
PNG
(N-formyl-5-(-2'-nitrophenyl)-3-phenylpyrazolin...)
Show SMILES [O-][N+](=O)c1ccccc1C1CC(=NN1C=O)c1ccccc1
Show InChI InChI=1S/C16H13N3O3/c20-11-18-16(13-8-4-5-9-15(13)19(21)22)10-14(17-18)12-6-2-1-3-7-12/h1-9,11,16H,10H2
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0.141n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120822
PNG
(N-formyl-5-(-3'-chlorophenyl)-3-phenylpyrazoli...)
Show SMILES Clc1cccc(c1)C1CC(=NN1C=O)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c17-14-8-4-7-13(9-14)16-10-15(18-19(16)11-20)12-5-2-1-3-6-12/h1-9,11,16H,10H2
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0.146n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120821
PNG
(N-formyl-5-(-2'-chlorophenyl)-3-phenylpyrazoli...)
Show SMILES Clc1ccccc1C1CC(=NN1C=O)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c17-14-9-5-4-8-13(14)16-10-15(18-19(16)11-20)12-6-2-1-3-7-12/h1-9,11,16H,10H2
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0.180n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120823
PNG
(N-formyl-5-(-4'-chlorophenyl)-3-phenylpyrazoli...)
Show SMILES Clc1ccc(cc1)C1CC(=NN1C=O)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c17-14-8-6-13(7-9-14)16-10-15(18-19(16)11-20)12-4-2-1-3-5-12/h1-9,11,16H,10H2
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0.211n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120820
PNG
(N-formyl-3,5-diphenylpyrazoline (1a))
Show SMILES O=CN1N=C(CC1c1ccccc1)c1ccccc1
Show InChI InChI=1S/C16H14N2O/c19-12-18-16(14-9-5-2-6-10-14)11-15(17-18)13-7-3-1-4-8-13/h1-10,12,16H,11H2
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0.227n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120826
PNG
(N-formyl-5-(-4'-methoxyphenyl)-3-phenylpyrazol...)
Show SMILES COc1ccc(cc1)C1CC(=NN1C=O)c1ccccc1
Show InChI InChI=1S/C17H16N2O2/c1-21-15-9-7-14(8-10-15)17-11-16(18-19(17)12-20)13-5-3-2-4-6-13/h2-10,12,17H,11H2,1H3
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0.448n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120825
PNG
(N-formyl-5-(-3'-methoxyphenyl)-3-phenylpyrazol...)
Show SMILES COc1cccc(c1)C1CC(=NN1C=O)c1ccccc1
Show InChI InChI=1S/C17H16N2O2/c1-21-15-9-5-8-14(10-15)17-11-16(18-19(17)12-20)13-6-3-2-4-7-13/h2-10,12,17H,11H2,1H3
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0.455n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120824
PNG
(N-formyl-5-(-2'-methoxyphenyl)-3-phenylpyrazol...)
Show SMILES COc1ccccc1C1CC(=NN1C=O)c1ccccc1
Show InChI InChI=1S/C17H16N2O2/c1-21-17-10-6-5-9-14(17)16-11-15(18-19(16)12-20)13-7-3-2-4-8-13/h2-10,12,16H,11H2,1H3
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0.668n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120838
PNG
(N-benzoyl-5-(-3'-nitrophenyl)-3-phenylpyrazoli...)
Show SMILES [O-][N+](=O)c1cccc(c1)C1CC(=NN1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H17N3O3/c26-22(17-10-5-2-6-11-17)24-21(18-12-7-13-19(14-18)25(27)28)15-20(23-24)16-8-3-1-4-9-16/h1-14,21H,15H2
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1.95n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120839
PNG
(N-benzoyl-5-(-4'-nitrophenyl)-3-phenylpyrazoli...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C1CC(=NN1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H17N3O3/c26-22(18-9-5-2-6-10-18)24-21(17-11-13-19(14-12-17)25(27)28)15-20(23-24)16-7-3-1-4-8-16/h1-14,21H,15H2
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2.87n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120837
PNG
(N-benzoyl-5-(-2'-nitrophenyl)-3-phenylpyrazoli...)
Show SMILES [O-][N+](=O)c1ccccc1C1CC(=NN1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H17N3O3/c26-22(17-11-5-2-6-12-17)24-21(18-13-7-8-14-20(18)25(27)28)15-19(23-24)16-9-3-1-4-10-16/h1-14,21H,15H2
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5.72n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM150783
PNG
(2-(4-Fluorophenyl)-2,3-dihydroquinazolin-4(1H)-one...)
Show SMILES Fc1ccc(cc1)C1NC(=O)c2ccccc2N1
Show InChI InChI=1/C14H11FN2O/c15-10-7-5-9(6-8-10)13-16-12-4-2-1-3-11(12)14(18)17-13/h1-8,13,16H,(H,17,18)
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6.40n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 L of the enzyme solution was...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120832
PNG
(N-benzoyl-5-(-3'-chloro phenyl)-3-phenylpyrazo...)
Show SMILES Clc1cccc(c1)C1CC(=NN1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H17ClN2O/c23-19-13-7-12-18(14-19)21-15-20(16-8-3-1-4-9-16)24-25(21)22(26)17-10-5-2-6-11-17/h1-14,21H,15H2
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6.77n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120831
PNG
(N-benzoyl-5-(-2'-chloro phenyl)-3-phenylpyrazo...)
Show SMILES Clc1ccccc1C1CC(=NN1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H17ClN2O/c23-19-14-8-7-13-18(19)21-15-20(16-9-3-1-4-10-16)24-25(21)22(26)17-11-5-2-6-12-17/h1-14,21H,15H2
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7.75n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120833
PNG
(N-benzoyl-5-(-4'-chloro phenyl)-3-phenylpyrazo...)
Show SMILES Clc1ccc(cc1)C1CC(=NN1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H17ClN2O/c23-19-13-11-17(12-14-19)21-15-20(16-7-3-1-4-8-16)24-25(21)22(26)18-9-5-2-6-10-18/h1-14,21H,15H2
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9.25n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120830
PNG
(N-benzoyl-3,5-diphenylpyrazoline (2a))
Show SMILES O=C(N1N=C(CC1c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H18N2O/c25-22(19-14-8-3-9-15-19)24-21(18-12-6-2-7-13-18)16-20(23-24)17-10-4-1-5-11-17/h1-15,21H,16H2
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11.5n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120836
PNG
(N-benzoyl-5-(-4'-methoxy phenyl)-3-phenylpyraz...)
Show SMILES COc1ccc(cc1)C1CC(=NN1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H20N2O2/c1-27-20-14-12-18(13-15-20)22-16-21(17-8-4-2-5-9-17)24-25(22)23(26)19-10-6-3-7-11-19/h2-15,22H,16H2,1H3
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12.8n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM50286441
PNG
((S)-2-((S)-2-Acetylamino-4-(S)-methyl-pentanoylami...)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C20H38N6O5/c1-11(2)9-15(24-13(5)27)17(28)26-16(10-12(3)4)18(29)25-14(19(30)31)7-6-8-23-20(21)22/h11-12,14-16H,6-10H2,1-5H3,(H,24,27)(H,25,29)(H,26,28)(H,30,31)(H4,21,22,23)/t14-,15-,16-/m0/s1
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13n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Competitive inhibition of goat brain cathepsin B


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120835
PNG
(N-benzoyl-5-(-3'-methoxy phenyl)-3-phenylpyraz...)
Show SMILES COc1cccc(c1)C1CC(=NN1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H20N2O2/c1-27-20-14-8-13-19(15-20)22-16-21(17-9-4-2-5-10-17)24-25(22)23(26)18-11-6-3-7-12-18/h2-15,22H,16H2,1H3
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15.9n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM150782
PNG
(2-(4-Chlorophenyl)-2,3-dihydroquinazolin-4(1H)-one...)
Show SMILES Clc1ccc(cc1)C1NC(=O)c2ccccc2N1
Show InChI InChI=1/C14H11ClN2O/c15-10-7-5-9(6-8-10)13-16-12-4-2-1-3-11(12)14(18)17-13/h1-8,13,16H,(H,17,18)
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41n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 L of the enzyme solution was...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM50045436
PNG
(CHEMBL3309619)
Show SMILES [O-][N+](=O)c1ccc(\C=C\C(=N/Nc2ccccc2)\c2ccccc2)cc1
Show InChI InChI=1S/C21H17N3O2/c25-24(26)20-14-11-17(12-15-20)13-16-21(18-7-3-1-4-8-18)23-22-19-9-5-2-6-10-19/h1-16,22H/b16-13+,23-21+
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42n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Competitive inhibition of goat liver cathepsin B using BANA substrate by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM120834
PNG
(N-benzoyl-5-(-2'-methoxyphenyl)-3-phenylpyrazo...)
Show SMILES COc1ccccc1C1CC(=NN1C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H20N2O2/c1-27-22-15-9-8-14-19(22)21-16-20(17-10-4-2-5-11-17)24-25(21)23(26)18-12-6-3-7-13-18/h2-15,21H,16H2,1H3
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49.0n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Enzyme was equilibrated in 0.1 M phosphate buffer, pH 6.0 at 37 °C. All compounds were prepared in DMSO. Various concentrations of compounds we...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM50045437
PNG
(CHEMBL3309796)
Show SMILES [O-][N+](=O)c1ccc(cc1)C1CC(=NN1c1ccccc1)c1ccccc1
Show InChI InChI=1/C21H17N3O2/c25-24(26)19-13-11-17(12-14-19)21-15-20(16-7-3-1-4-8-16)22-23(21)18-9-5-2-6-10-18/h1-14,21H,15H2
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53n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Competitive inhibition of goat liver cathepsin B using BANA substrate by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM192658
PNG
(N’-(2-nitrophenylmethylene)benzohydrazide (1i...)
Show SMILES [O-][N+](=O)c1ccccc1\C=N\NC(=O)c1ccccc1
Show InChI InChI=1S/C14H11N3O3/c18-14(11-6-2-1-3-7-11)16-15-10-12-8-4-5-9-13(12)17(19)20/h1-10H,(H,16,18)/b15-10+
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113 -41.2n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM192660
PNG
(N’-(4-nitrophenylmethylene)benzohydrazide (1k...)
Show SMILES [O-][N+](=O)c1ccc(\C=N\NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H11N3O3/c18-14(12-4-2-1-3-5-12)16-15-10-11-6-8-13(9-7-11)17(19)20/h1-10H,(H,16,18)/b15-10+
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120 -41.1n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM50045439
PNG
(CHEMBL3309801)
Show SMILES [O-][N+](=O)c1ccc(cc1)C1CC(=NN1)c1ccccc1
Show InChI InChI=1/C15H13N3O2/c19-18(20)13-8-6-12(7-9-13)15-10-14(16-17-15)11-4-2-1-3-5-11/h1-9,15,17H,10H2
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131n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Competitive inhibition of goat liver cathepsin B using BANA substrate by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM192659
PNG
(N’-(3-nitrophenylmethylene)benzohydrazide (1j...)
Show SMILES [O-][N+](=O)c1cccc(\C=N\NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C14H11N3O3/c18-14(12-6-2-1-3-7-12)16-15-10-11-5-4-8-13(9-11)17(19)20/h1-10H,(H,16,18)/b15-10+
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140 -40.7n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM192656
PNG
(N’-(3-methoxyphenylmethylene)benzohydrazide (...)
Show SMILES COc1cccc(\C=N\NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C15H14N2O2/c1-19-14-9-5-6-12(10-14)11-16-17-15(18)13-7-3-2-4-8-13/h2-11H,1H3,(H,17,18)/b16-11+
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180 -40.0n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM192654
PNG
(N’-(4-chlorophenylmethylene)benzohydrazide (1...)
Show SMILES Clc1ccc(\C=N\NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H11ClN2O/c15-13-8-6-11(7-9-13)10-16-17-14(18)12-4-2-1-3-5-12/h1-10H,(H,17,18)/b16-10+
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190 -39.9n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM192652
PNG
(N’-(2-chlorophenylmethylene)benzohydrazide (1...)
Show SMILES Clc1ccccc1\C=N\NC(=O)c1ccccc1
Show InChI InChI=1S/C14H11ClN2O/c15-13-9-5-4-8-12(13)10-16-17-14(18)11-6-2-1-3-7-11/h1-10H,(H,17,18)/b16-10+
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210 -39.6n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM192653
PNG
(N’-(3-chlorophenylmethylene)benzohydrazide (1...)
Show SMILES Clc1cccc(\C=N\NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C14H11ClN2O/c15-13-8-4-5-11(9-13)10-16-17-14(18)12-6-2-1-3-7-12/h1-10H,(H,17,18)/b16-10+
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260 -39.1n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM192650
PNG
(N’-(phenylmethylene)benzohydrazide (1a))
Show SMILES O=C(N\N=C\c1ccccc1)c1ccccc1
Show InChI InChI=1S/C14H12N2O/c17-14(13-9-5-2-6-10-13)16-15-11-12-7-3-1-4-8-12/h1-11H,(H,16,17)/b15-11+
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290 -38.8n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM192657
PNG
(N’-(4-methoxyphenylmethylene)benzohydrazide (...)
Show SMILES COc1ccc(\C=N\NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C15H14N2O2/c1-19-14-9-7-12(8-10-14)11-16-17-15(18)13-5-3-2-4-6-13/h2-11H,1H3,(H,17,18)/b16-11+
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440 -37.7n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM50340089
PNG
(4-methoxybenzohydrazide | CHEMBL1588015)
Show SMILES COc1ccc(cc1)C(=O)NN
Show InChI InChI=1S/C8H10N2O2/c1-12-7-4-2-6(3-5-7)8(11)10-9/h2-5H,9H2,1H3,(H,10,11)
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640n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Competitive inhibition of cathepsin B in goat liver using alpha-N-benzoyl-D,L-arginine-2-naphthylamide as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM192668
PNG
(2-phenyl-5-(4-nitrophenyl)-1,3,4-oxadiazole (2k))
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C14H9N3O3/c18-17(19)12-8-6-11(7-9-12)14-16-15-13(20-14)10-4-2-1-3-5-10/h1-9H
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664 -36.7n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM192667
PNG
(2-phenyl-5-(2-nitrophenyl)-1,3,4-oxadiazole (2i))
Show SMILES [O-][N+](=O)c1ccccc1-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C14H9N3O3/c18-17(19)12-9-5-4-8-11(12)14-16-15-13(20-14)10-6-2-1-3-7-10/h1-9H
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790 -36.2n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM192655
PNG
(N’-(2-methoxyphenylmethylene)benzohydrazide (...)
Show SMILES COc1ccccc1\C=N\NC(=O)c1ccccc1
Show InChI InChI=1S/C15H14N2O2/c1-19-14-10-6-5-9-13(14)11-16-17-15(18)12-7-3-2-4-8-12/h2-11H,1H3,(H,17,18)/b16-11+
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830 -36.1n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM50001681
PNG
(CHEMBL339003 | Phenyl-Acetic Acid Hydrazide)
Show SMILES NNC(=O)Cc1ccccc1
Show InChI InChI=1S/C8H10N2O/c9-10-8(11)6-7-4-2-1-3-5-7/h1-5H,6,9H2,(H,10,11)
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869n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Competitive inhibition of cathepsin B in goat liver using alpha-N-benzoyl-D,L-arginine-2-naphthylamide as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM50001694
PNG
(CHEMBL3238003)
Show SMILES Nc1cccc(c1)-c1nnc(-c2cccc(N)c2)n1N
Show InChI InChI=1S/C14H14N6/c15-11-5-1-3-9(7-11)13-18-19-14(20(13)17)10-4-2-6-12(16)8-10/h1-8H,15-17H2
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950n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Non-competitive inhibition of cathepsin B in goat liver using alpha-N-benzoyl-D,L-arginine-2-naphthylamide as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM63525
PNG
(2-(3-nitrophenyl)-5-phenyl-1,3,4-oxadiazole | 2-ph...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C14H9N3O3/c18-17(19)12-8-4-7-11(9-12)14-16-15-13(20-14)10-5-2-1-3-6-10/h1-9H
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1.00E+3 -35.6n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM48184
PNG
(2-(3-chlorophenyl)-5-phenyl-1,3,4-oxadiazole | 2-p...)
Show SMILES Clc1cccc(c1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C14H9ClN2O/c15-12-8-4-7-11(9-12)14-17-16-13(18-14)10-5-2-1-3-6-10/h1-9H
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1.28E+3 -35.0n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM50045440
PNG
(CHEMBL3309806)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cc(nn1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H15N3O2/c25-24(26)19-13-11-17(12-14-19)21-15-20(16-7-3-1-4-8-16)22-23(21)18-9-5-2-6-10-18/h1-15H
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1.31E+3n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Competitive inhibition of goat liver cathepsin B using BANA substrate by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM91562
PNG
(3-(4-methoxyphenyl)-2,5-diphenyl-3,4-dihydropyrazo...)
Show SMILES COc1ccc(cc1)C1CC(=NN1c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H20N2O/c1-25-20-14-12-18(13-15-20)22-16-21(17-8-4-2-5-9-17)23-24(22)19-10-6-3-7-11-19/h2-15,22H,16H2,1H3
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1.31E+3n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Competitive inhibition of goat liver cathepsin B using BANA substrate by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM91550
PNG
(1,3-diphenyl-5-(p-tolyl)-2-pyrazoline | 3-(4-methy...)
Show SMILES Cc1ccc(cc1)C1CC(=NN1c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H20N2/c1-17-12-14-19(15-13-17)22-16-21(18-8-4-2-5-9-18)23-24(22)20-10-6-3-7-11-20/h2-15,22H,16H2,1H3
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1.37E+3n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Competitive inhibition of goat liver cathepsin B using BANA substrate by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM50001682
PNG
(CHEMBL3237995)
Show SMILES NNC(=O)c1ccccc1Cl
Show InChI InChI=1S/C7H7ClN2O/c8-6-4-2-1-3-5(6)7(11)10-9/h1-4H,9H2,(H,10,11)
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1.40E+3n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Competitive inhibition of cathepsin B in goat liver using alpha-N-benzoyl-D,L-arginine-2-naphthylamide as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM50001687
PNG
(CHEMBL3237997)
Show SMILES Nn1c(nnc1-c1cccc(c1)[N+]([O-])=O)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C14H10N6O4/c15-18-13(9-3-1-5-11(7-9)19(21)22)16-17-14(18)10-4-2-6-12(8-10)20(23)24/h1-8H,15H2
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1.40E+3n/an/an/an/an/an/an/an/a



Kurukshetra University

Curated by ChEMBL


Assay Description
Non-competitive inhibition of cathepsin B in goat liver using alpha-N-benzoyl-D,L-arginine-2-naphthylamide as substrate by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
Cathepsin B


(Capra hircus (Goat))
BDBM150779
PNG
(2-(4-Nitrophenyl)-2,3-dihydroquinazolin-4(1H)-one ...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C1NC(=O)c2ccccc2N1
Show InChI InChI=1/C14H11N3O3/c18-14-11-3-1-2-4-12(11)15-13(16-14)9-5-7-10(8-6-9)17(19)20/h1-8,13,15H,(H,16,18)
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1.57E+3n/an/an/an/an/an/an/an/a



Kurukshetra University



Assay Description
Cathepsin B and H were first activated in the presence of thiol activators at pH 6.0 and pH 7.0, respectively. Then, 15 L of the enzyme solution was...


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