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Found 15 hits Enz. Inhib. hit(s) with Target = 'Cell division protein FtsZ' AND taxid = 224308   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50392993
PNG
(TOTAROL)
Show SMILES CC(C)c1c(O)ccc2c1CC[C@H]1C(C)(C)CCC[C@]21C
Show InChI InChI=1S/C20H30O/c1-13(2)18-14-7-10-17-19(3,4)11-6-12-20(17,5)15(14)8-9-16(18)21/h8-9,13,17,21H,6-7,10-12H2,1-5H3/t17-,20+/m0/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity by enzyme-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50067040
PNG
(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)
Show SMILES COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O
Show InChI InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3
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n/an/a 3.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ polymerization


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085934
PNG
(CHEMBL3425686)
Show SMILES CN(C)CCNc1nc(nc2ccc(C)cc12)-c1ccc2ccccc2c1
Show InChI InChI=1S/C23H24N4/c1-16-8-11-21-20(14-16)23(24-12-13-27(2)3)26-22(25-21)19-10-9-17-6-4-5-7-18(17)15-19/h4-11,14-15H,12-13H2,1-3H3,(H,24,25,26)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085935
PNG
(CHEMBL3425685)
Show SMILES COc1ccc(cc1)-c1nc(NCCN(C)C)c2cc(C)ccc2n1
Show InChI InChI=1S/C20H24N4O/c1-14-5-10-18-17(13-14)20(21-11-12-24(2)3)23-19(22-18)15-6-8-16(25-4)9-7-15/h5-10,13H,11-12H2,1-4H3,(H,21,22,23)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085936
PNG
(CHEMBL3425684)
Show SMILES CN(C)CCNc1nc(nc2ccc(C)cc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN4/c1-13-4-9-17-16(12-13)19(21-10-11-24(2)3)23-18(22-17)14-5-7-15(20)8-6-14/h4-9,12H,10-11H2,1-3H3,(H,21,22,23)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085932
PNG
(CHEMBL3425687)
Show SMILES CN(C)CCNc1nc(nc2ccc(C)cc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C21H22N4O/c1-14-8-9-17-16(12-14)20(22-10-11-25(2)3)24-21(23-17)19-13-15-6-4-5-7-18(15)26-19/h4-9,12-13H,10-11H2,1-3H3,(H,22,23,24)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085931
PNG
(CHEMBL3425688)
Show SMILES CN(C)CCNc1nc(nc2ccc(C)cc12)-c1cccs1
Show InChI InChI=1S/C17H20N4S/c1-12-6-7-14-13(11-12)16(18-8-9-21(2)3)20-17(19-14)15-5-4-10-22-15/h4-7,10-11H,8-9H2,1-3H3,(H,18,19,20)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085937
PNG
(CHEMBL3425683)
Show SMILES CN(C)CCNc1nc(N)nc2ccc(C)cc12
Show InChI InChI=1S/C13H19N5/c1-9-4-5-11-10(8-9)12(17-13(14)16-11)15-6-7-18(2)3/h4-5,8H,6-7H2,1-3H3,(H3,14,15,16,17)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50085995
PNG
(CHEMBL3425682)
Show SMILES CN(C)CCNc1nc(NCc2ccc(Cl)cc2)nc2ccc(C)cc12
Show InChI InChI=1S/C20H24ClN5/c1-14-4-9-18-17(12-14)19(22-10-11-26(2)3)25-20(24-18)23-13-15-5-7-16(21)8-6-15/h4-9,12H,10-11,13H2,1-3H3,(H2,22,23,24,25)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50086040
PNG
(CHEMBL3425681)
Show SMILES CN(C)CCNc1nc(NCc2ccccc2)nc2ccc(C)cc12
Show InChI InChI=1S/C20H25N5/c1-15-9-10-18-17(13-15)19(21-11-12-25(2)3)24-20(23-18)22-14-16-7-5-4-6-8-16/h4-10,13H,11-12,14H2,1-3H3,(H2,21,22,23,24)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50086041
PNG
(CHEMBL3425680)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(I)cc2)nc2ccc(C)cc12
Show InChI InChI=1S/C21H23IN4/c1-15-4-10-19-18(14-15)21(23-12-13-26(2)3)25-20(24-19)11-7-16-5-8-17(22)9-6-16/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)/b11-7+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50086043
PNG
(CHEMBL3425679)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Br)cc2)nc2ccc(C)cc12
Show InChI InChI=1S/C21H23BrN4/c1-15-4-10-19-18(14-15)21(23-12-13-26(2)3)25-20(24-19)11-7-16-5-8-17(22)9-6-16/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)/b11-7+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50086044
PNG
(CHEMBL3425678)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(cc2)C(C)(C)C)nc2ccc(C)cc12
Show InChI InChI=1S/C25H32N4/c1-18-7-13-22-21(17-18)24(26-15-16-29(5)6)28-23(27-22)14-10-19-8-11-20(12-9-19)25(2,3)4/h7-14,17H,15-16H2,1-6H3,(H,26,27,28)/b14-10+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50086048
PNG
(CHEMBL3425616)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(cc2)C(F)(F)F)nc2ccc(C)cc12
Show InChI InChI=1S/C22H23F3N4/c1-15-4-10-19-18(14-15)21(26-12-13-29(2)3)28-20(27-19)11-7-16-5-8-17(9-6-16)22(23,24)25/h4-11,14H,12-13H2,1-3H3,(H,26,27,28)/b11-7+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Bacillus subtilis FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein ftsZ


(Bacillus subtilis)
BDBM50079357
PNG
(CHEMBL3416826)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc(\C=C2\SC(=S)NC2=O)o1
Show InChI InChI=1S/C15H8F3NO2S2/c16-15(17,18)9-3-1-2-8(6-9)11-5-4-10(21-11)7-12-13(20)19-14(22)23-12/h1-7H,(H,19,20,22)/b12-7+
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n/an/an/a 1.50E+3n/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Binding affinity to Bacillus subtilis FtsZ


Citation and Details
More data for this
Ligand-Target Pair