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Compile Data Set for Download or QSAR

Found 46 hits Enz. Inhib. hit(s) with Target = 'Cell division protein FtsZ' AND taxid = 83333   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cell division protein FtsZ


(Escherichia coli)
BDBM50439495
PNG
(CHEMBL2418095)
Show SMILES Oc1cc(O)c2Oc3cc(C\C=C(Cl)/Cc4cc(O)c(Oc5cc(C\C=C(Cl)/Cc2c1)c(O)cc5Cl)c(O)c4)c(O)cc3Cl
Show InChI InChI=1S/C32H24Cl4O8/c33-19-3-1-16-10-29(22(35)13-24(16)38)43-31-18(9-21(37)12-28(31)42)8-20(34)4-2-17-11-30(23(36)14-25(17)39)44-32-26(40)6-15(5-19)7-27(32)41/h3-4,6-7,9-14,37-42H,1-2,5,8H2/b19-3+,20-4+
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n/an/a 6.70n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079359
PNG
(VIRIDITOXIN | Viriditoxin)
Show SMILES COC(=O)CC1Cc2cc3cc(OC)c(c(O)c3c(O)c2C(=O)O1)-c1c(OC)cc2cc3CC(CC(=O)OC)OC(=O)c3c(O)c2c1O
Show InChI InChI=1S/C34H30O14/c1-43-19-9-15-5-13-7-17(11-21(35)45-3)47-33(41)25(13)29(37)23(15)31(39)27(19)28-20(44-2)10-16-6-14-8-18(12-22(36)46-4)48-34(42)26(14)30(38)24(16)32(28)40/h5-6,9-10,17-18,37-40H,7-8,11-12H2,1-4H3
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n/an/a 7n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079359
PNG
(VIRIDITOXIN | Viriditoxin)
Show SMILES COC(=O)CC1Cc2cc3cc(OC)c(c(O)c3c(O)c2C(=O)O1)-c1c(OC)cc2cc3CC(CC(=O)OC)OC(=O)c3c(O)c2c1O
Show InChI InChI=1S/C34H30O14/c1-43-19-9-15-5-13-7-17(11-21(35)45-3)47-33(41)25(13)29(37)23(15)31(39)27(19)28-20(44-2)10-16-6-14-8-18(12-22(36)46-4)48-34(42)26(14)30(38)24(16)32(28)40/h5-6,9-10,17-18,37-40H,7-8,11-12H2,1-4H3
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n/an/a 8.20n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ polymerization


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50083355
PNG
(CHEMBL3423282)
Show SMILES Cc1nc2ccccc2n1C(=O)\C=C\c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H12Cl2N2O/c1-11-20-15-4-2-3-5-16(15)21(11)17(22)9-7-12-6-8-13(18)10-14(12)19/h2-10H,1H3/b9-7+
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n/an/a 30n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli ATCC 25922 recombinant N-His6-tagged FtsZ polymerization expressed in Escherichia coli BL21(DE3) incubated for 15 mins...


Eur J Med Chem 97: 32-41 (2015)


Article DOI: 10.1016/j.ejmech.2015.04.048
BindingDB Entry DOI: 10.7270/Q2377BFK
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50203065
PNG
(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Show SMILES O=C\C=C\c1ccccc1
Show InChI InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+
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n/an/a 5.81E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50203065
PNG
(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Show SMILES O=C\C=C\c1ccccc1
Show InChI InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+
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n/an/a 6.86E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ polymerization


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079361
PNG
(CHEMBL3416824)
Show SMILES Oc1ccccc1Cc1ccc(O)c(Cc2c(O)c(Cc3cc(Cc4ccccc4O)ccc3O)c3O[C@@H](CC(=O)c3c2O)c2ccccc2)c1
Show InChI InChI=1S/C43H36O8/c44-34-12-6-4-10-28(34)18-25-14-16-36(46)30(20-25)22-32-41(49)33(23-31-21-26(15-17-37(31)47)19-29-11-5-7-13-35(29)45)43-40(42(32)50)38(48)24-39(51-43)27-8-2-1-3-9-27/h1-17,20-21,39,44-47,49-50H,18-19,22-24H2/t39-/m0/s1
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n/an/a 8.30E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086108
PNG
(CHEMBL3425702)
Show SMILES [NH3+]CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C22H19ClN4/c23-18-8-5-15(6-9-18)7-10-21-26-20-14-17-4-2-1-3-16(17)13-19(20)22(27-21)25-12-11-24/h1-10,13-14H,11-12,24H2,(H,25,26,27)/p+1/b10-7+
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n/an/a 9.00E+3n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50203126
PNG
(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Show SMILES COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC
Show InChI InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Stony Brook University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Escherichia coli K12 FtsZ assembly by light-scattering assay


Bioorg Med Chem 24: 6354-6369 (2016)


Article DOI: 10.1016/j.bmc.2016.05.003
BindingDB Entry DOI: 10.7270/Q2SN0BZ0
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079358
PNG
(CHEMBL3416948)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H23ClN4/c1-29(2)14-13-26-24-21-15-18-5-3-4-6-19(18)16-22(21)27-23(28-24)12-9-17-7-10-20(25)11-8-17/h3-12,15-16H,13-14H2,1-2H3,(H,26,27,28)/b12-9+
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n/an/a 1.20E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079360
PNG
(CHEBI:69681 | DICHAMANETIN | Dichamanetin)
Show SMILES Oc1ccccc1Cc1c(O)c(Cc2ccccc2O)c2O[C@@H](CC(=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C29H24O6/c30-22-12-6-4-10-18(22)14-20-27(33)21(15-19-11-5-7-13-23(19)31)29-26(28(20)34)24(32)16-25(35-29)17-8-2-1-3-9-17/h1-13,25,30-31,33-34H,14-16H2/t25-/m0/s1
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n/an/a 1.25E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086088
PNG
(CHEMBL3425706)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(cc2)N=[N+]=[N-])nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H23N7/c1-31(2)14-13-26-24-21-15-18-5-3-4-6-19(18)16-22(21)27-23(28-24)12-9-17-7-10-20(11-8-17)29-30-25/h3-12,15-16H,13-14H2,1-2H3,(H,26,27,28)/b12-9+
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50203126
PNG
(3,4-dimethoxy-6,7-dihydro-[1,3]dioxolo[4,5-g]pyrid...)
Show SMILES COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC
Show InChI InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Stony Brook University

Curated by ChEMBL


Assay Description
Inhibition of recombinant Escherichia coli K12 FtsZ GTPase activity by malachite green sodium molybdate assay


Bioorg Med Chem 24: 6354-6369 (2016)


Article DOI: 10.1016/j.bmc.2016.05.003
BindingDB Entry DOI: 10.7270/Q2SN0BZ0
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086206
PNG
(CHEMBL3425606)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(C)cc12
Show InChI InChI=1S/C21H23ClN4/c1-15-4-10-19-18(14-15)21(23-12-13-26(2)3)25-20(24-19)11-7-16-5-8-17(22)9-6-16/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)/b11-7+
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n/an/a 2.40E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086098
PNG
(CHEMBL3425705)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(I)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H23IN4/c1-29(2)14-13-26-24-21-15-18-5-3-4-6-19(18)16-22(21)27-23(28-24)12-9-17-7-10-20(25)11-8-17/h3-12,15-16H,13-14H2,1-2H3,(H,26,27,28)/b12-9+
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n/an/a 2.40E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086123
PNG
(CHEMBL3425694)
Show SMILES CN(C)CCOc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H22ClN3O/c1-28(2)13-14-29-24-21-15-18-5-3-4-6-19(18)16-22(21)26-23(27-24)12-9-17-7-10-20(25)11-8-17/h3-12,15-16H,13-14H2,1-2H3/b12-9+
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University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086124
PNG
(CHEMBL3425693)
Show SMILES Cc1ccc2nc(\C=C\c3ccc(Cl)cc3)nc(NCC[NH3+])c2c1
Show InChI InChI=1S/C19H19ClN4/c1-13-2-8-17-16(12-13)19(22-11-10-21)24-18(23-17)9-5-14-3-6-15(20)7-4-14/h2-9,12H,10-11,21H2,1H3,(H,22,23,24)/p+1/b9-5+
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n/an/a 2.70E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086201
PNG
(CHEMBL3425611)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C26H25ClN4/c1-31(2)17-16-28-26-23-18-21(20-6-4-3-5-7-20)11-14-24(23)29-25(30-26)15-10-19-8-12-22(27)13-9-19/h3-15,18H,16-17H2,1-2H3,(H,28,29,30)/b15-10+
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n/an/a 2.80E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086200
PNG
(CHEMBL3425612)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)-c1ccncc1
Show InChI InChI=1S/C25H24ClN5/c1-31(2)16-15-28-25-22-17-20(19-11-13-27-14-12-19)6-9-23(22)29-24(30-25)10-5-18-3-7-21(26)8-4-18/h3-14,17H,15-16H2,1-2H3,(H,28,29,30)/b10-5+
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086203
PNG
(CHEMBL3425609)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(Br)cc12
Show InChI InChI=1S/C20H20BrClN4/c1-26(2)12-11-23-20-17-13-15(21)6-9-18(17)24-19(25-20)10-5-14-3-7-16(22)8-4-14/h3-10,13H,11-12H2,1-2H3,(H,23,24,25)/b10-5+
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50439496
PNG
(CHEMBL2418096 | US9169182, J23)
Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl
Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+
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n/an/a 3.60E+4n/an/an/an/an/an/a



THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
The bacterial cytoskeletal protein FtsZ is a GTPase and has structural homology to the eukaryotic cytoskeletal protein tubulin, but lacks significant...


US Patent US9169182 (2015)


BindingDB Entry DOI: 10.7270/Q22Z149Z
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50439496
PNG
(CHEMBL2418096 | US9169182, J23)
Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl
Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+
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n/an/a 3.70E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086197
PNG
(CHEMBL3425615)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)C1=CCCCC1
Show InChI InChI=1S/C26H29ClN4/c1-31(2)17-16-28-26-23-18-21(20-6-4-3-5-7-20)11-14-24(23)29-25(30-26)15-10-19-8-12-22(27)13-9-19/h6,8-15,18H,3-5,7,16-17H2,1-2H3,(H,28,29,30)/b15-10+
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n/an/a 4.90E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086109
PNG
(CHEMBL3425701)
Show SMILES C[N+](C)(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C25H26ClN4/c1-30(2,3)15-14-27-25-22-16-19-6-4-5-7-20(19)17-23(22)28-24(29-25)13-10-18-8-11-21(26)12-9-18/h4-13,16-17H,14-15H2,1-3H3,(H,27,28,29)/q+1/b13-10+
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n/an/a 5.20E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086199
PNG
(CHEMBL3425613)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)-c1ccc2ccccc2c1
Show InChI InChI=1S/C30H27ClN4/c1-35(2)18-17-32-30-27-20-25(24-11-10-22-5-3-4-6-23(22)19-24)12-15-28(27)33-29(34-30)16-9-21-7-13-26(31)14-8-21/h3-16,19-20H,17-18H2,1-2H3,(H,32,33,34)/b16-9+
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n/an/a 5.80E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086120
PNG
(CHEMBL3425697)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C25H25ClN4/c1-30(2)15-5-14-27-25-22-16-19-6-3-4-7-20(19)17-23(22)28-24(29-25)13-10-18-8-11-21(26)12-9-18/h3-4,6-13,16-17H,5,14-15H2,1-2H3,(H,27,28,29)/b13-10+
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n/an/a 6.50E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086105
PNG
(CHEMBL3425704)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)C(=O)c1ccccc1
Show InChI InChI=1S/C27H25ClN4O/c1-32(2)17-16-29-27-23-18-21(26(33)20-6-4-3-5-7-20)11-14-24(23)30-25(31-27)15-10-19-8-12-22(28)13-9-19/h3-15,18H,16-17H2,1-2H3,(H,29,30,31)/b15-10+
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n/an/a 8.50E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086202
PNG
(CHEMBL3425610)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(I)cc12
Show InChI InChI=1S/C20H20ClIN4/c1-26(2)12-11-23-20-17-13-16(22)8-9-18(17)24-19(25-20)10-5-14-3-6-15(21)7-4-14/h3-10,13H,11-12H2,1-2H3,(H,23,24,25)/b10-5+
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n/an/a 9.50E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086204
PNG
(CHEMBL3425608)
Show SMILES COc1cc2nc(\C=C\c3ccc(Cl)cc3)nc(NCCN(C)C)c2cc1OC
Show InChI InChI=1S/C22H25ClN4O2/c1-27(2)12-11-24-22-17-13-19(28-3)20(29-4)14-18(17)25-21(26-22)10-7-15-5-8-16(23)9-6-15/h5-10,13-14H,11-12H2,1-4H3,(H,24,25,26)/b10-7+
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086208
PNG
(CHEMBL3425604)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccccc12
Show InChI InChI=1S/C20H21ClN4/c1-25(2)14-13-22-20-17-5-3-4-6-18(17)23-19(24-20)12-9-15-7-10-16(21)11-8-15/h3-12H,13-14H2,1-2H3,(H,22,23,24)/b12-9+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086207
PNG
(CHEMBL3425605)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cccc(C)c12
Show InChI InChI=1S/C21H23ClN4/c1-15-5-4-6-18-20(15)21(23-13-14-26(2)3)25-19(24-18)12-9-16-7-10-17(22)11-8-16/h4-12H,13-14H2,1-3H3,(H,23,24,25)/b12-9+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086205
PNG
(CHEMBL3425607)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C21H20ClF3N4/c1-29(2)12-11-26-20-17-9-6-15(21(23,24)25)13-18(17)27-19(28-20)10-5-14-3-7-16(22)8-4-14/h3-10,13H,11-12H2,1-2H3,(H,26,27,28)/b10-5+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086198
PNG
(CHEMBL3425614)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)-c1cccs1
Show InChI InChI=1S/C24H23ClN4S/c1-29(2)14-13-26-24-20-16-18(22-4-3-15-30-22)8-11-21(20)27-23(28-24)12-7-17-5-9-19(25)10-6-17/h3-12,15-16H,13-14H2,1-2H3,(H,26,27,28)/b12-7+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086196
PNG
(CHEMBL3425689)
Show SMILES Cc1ccc2nc(nc(NCC[NH3+])c2c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C18H18ClN5O/c1-11-2-7-15-14(10-11)16(21-9-8-20)24-17(23-15)18(25)22-13-5-3-12(19)4-6-13/h2-7,10H,8-9,20H2,1H3,(H,22,25)(H,21,23,24)/p+1
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086191
PNG
(CHEMBL3425690)
Show SMILES CN(C)CCNc1nc(nc2ccc(C)cc12)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H24ClN5O/c1-14-4-9-18-17(12-14)19(23-10-11-27(2)3)26-20(25-18)21(28)24-13-15-5-7-16(22)8-6-15/h4-9,12H,10-11,13H2,1-3H3,(H,24,28)(H,23,25,26)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086180
PNG
(CHEMBL3425691)
Show SMILES COCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(C)cc12
Show InChI InChI=1S/C20H20ClN3O/c1-14-3-9-18-17(13-14)20(22-11-12-25-2)24-19(23-18)10-6-15-4-7-16(21)8-5-15/h3-10,13H,11-12H2,1-2H3,(H,22,23,24)/b10-6+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086125
PNG
(CHEMBL3425692)
Show SMILES Cc1ccc2nc(\C=C\c3ccc(Cl)cc3)nc(NCCNC(=O)OC(C)(C)C)c2c1
Show InChI InChI=1S/C24H27ClN4O2/c1-16-5-11-20-19(15-16)22(26-13-14-27-23(30)31-24(2,3)4)29-21(28-20)12-8-17-6-9-18(25)10-7-17/h5-12,15H,13-14H2,1-4H3,(H,27,30)(H,26,28,29)/b12-8+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086121
PNG
(CHEMBL3425696)
Show SMILES COCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C23H20ClN3O/c1-28-13-12-25-23-20-14-17-4-2-3-5-18(17)15-21(20)26-22(27-23)11-8-16-6-9-19(24)10-7-16/h2-11,14-15H,12-13H2,1H3,(H,25,26,27)/b11-8+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086119
PNG
(CHEMBL3425698)
Show SMILES COCCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H22ClN3O/c1-29-14-4-13-26-24-21-15-18-5-2-3-6-19(18)16-22(21)27-23(28-24)12-9-17-7-10-20(25)11-8-17/h2-3,5-12,15-16H,4,13-14H2,1H3,(H,26,27,28)/b12-9+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086118
PNG
(CHEMBL3425699)
Show SMILES CC(C)(C)OC(=O)NCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C27H27ClN4O2/c1-27(2,3)34-26(33)30-15-14-29-25-22-16-19-6-4-5-7-20(19)17-23(22)31-24(32-25)13-10-18-8-11-21(28)12-9-18/h4-13,16-17H,14-15H2,1-3H3,(H,30,33)(H,29,31,32)/b13-10+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086116
PNG
(CHEMBL3425700)
Show SMILES CC(C)(C)OC(=O)CNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C26H24ClN3O2/c1-26(2,3)32-24(31)16-28-25-21-14-18-6-4-5-7-19(18)15-22(21)29-23(30-25)13-10-17-8-11-20(27)12-9-17/h4-15H,16H2,1-3H3,(H,28,29,30)/b13-10+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086107
PNG
(CHEMBL3425703)
Show SMILES CC(=O)NCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H21ClN4O/c1-16(30)26-12-13-27-24-21-14-18-4-2-3-5-19(18)15-22(21)28-23(29-24)11-8-17-6-9-20(25)10-7-17/h2-11,14-15H,12-13H2,1H3,(H,26,30)(H,27,28,29)/b11-8+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086122
PNG
(CHEMBL3425695)
Show SMILES CSCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C23H20ClN3S/c1-28-13-12-25-23-20-14-17-4-2-3-5-18(17)15-21(20)26-22(27-23)11-8-16-6-9-19(24)10-7-16/h2-11,14-15H,12-13H2,1H3,(H,25,26,27)/b11-8+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


ACS Med Chem Lett 6: 308-12 (2015)


Article DOI: 10.1021/ml500497s
BindingDB Entry DOI: 10.7270/Q2PV6N4C
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM186046
PNG
(US9169182, J24)
Show SMILES Oc1cc(O)cc(C\C(Cl)=C/Cc2cc(O)c(Cl)cc2O)c1
Show InChI InChI=1S/C16H14Cl2O4/c17-11(3-9-4-12(19)7-13(20)5-9)2-1-10-6-16(22)14(18)8-15(10)21/h2,4-8,19-22H,1,3H2/b11-2+
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n/an/a 1.60E+5n/an/an/an/an/an/a



THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
The bacterial cytoskeletal protein FtsZ is a GTPase and has structural homology to the eukaryotic cytoskeletal protein tubulin, but lacks significant...


US Patent US9169182 (2015)


BindingDB Entry DOI: 10.7270/Q22Z149Z
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50399003
PNG
(CHEMBL2180486)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cccc(CN=C(N)N)c1
Show InChI InChI=1S/C18H23N3/c1-18(2,3)16-9-7-14(8-10-16)15-6-4-5-13(11-15)12-21-17(19)20/h4-11H,12H2,1-3H3,(H4,19,20,21)
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n/an/an/a 3.80E+3n/an/an/an/an/a



University of Medicine and Dentistry of New Jersey

Curated by ChEMBL


Assay Description
Binding affinity to Escherichia coli FtsZ at 25 degC by fluorescence anisotropy assay


J Med Chem 55: 10160-76 (2012)


Article DOI: 10.1021/jm3012728
BindingDB Entry DOI: 10.7270/Q2ZG6TC8
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50010058
PNG
(CHEBI:51231 | DAPI)
Show SMILES NC(=N)c1ccc(cc1)-c1cc2ccc(cc2[nH]1)C(N)=N
Show InChI InChI=1S/C16H15N5/c17-15(18)10-3-1-9(2-4-10)13-7-11-5-6-12(16(19)20)8-14(11)21-13/h1-8,21H,(H3,17,18)(H3,19,20)
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n/an/an/a 1.66E+4n/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Binding affinity to Escherichia coli FtsZ by fluorescence anisotrophy


Eur J Med Chem 95: 1-15 (2015)


Article DOI: 10.1016/j.ejmech.2015.03.026
BindingDB Entry DOI: 10.7270/Q2S75J14
More data for this
Ligand-Target Pair