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Found 44 hits Enz. Inhib. hit(s) with Target = 'Cell division protein FtsZ' AND taxid = 83333   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cell division protein FtsZ


(Escherichia coli)
BDBM50439495
PNG
(CHEMBL2418095)
Show SMILES Oc1cc(O)c2Oc3cc(C\C=C(Cl)/Cc4cc(O)c(Oc5cc(C\C=C(Cl)/Cc2c1)c(O)cc5Cl)c(O)c4)c(O)cc3Cl
Show InChI InChI=1S/C32H24Cl4O8/c33-19-3-1-16-10-29(22(35)13-24(16)38)43-31-18(9-21(37)12-28(31)42)8-20(34)4-2-17-11-30(23(36)14-25(17)39)44-32-26(40)6-15(5-19)7-27(32)41/h3-4,6-7,9-14,37-42H,1-2,5,8H2/b19-3+,20-4+
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n/an/a 6.70n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079359
PNG
(VIRIDITOXIN | Viriditoxin)
Show SMILES COC(=O)CC1Cc2cc3cc(OC)c(c(O)c3c(O)c2C(=O)O1)-c1c(OC)cc2cc3CC(CC(=O)OC)OC(=O)c3c(O)c2c1O
Show InChI InChI=1/C34H30O14/c1-43-19-9-15-5-13-7-17(11-21(35)45-3)47-33(41)25(13)29(37)23(15)31(39)27(19)28-20(44-2)10-16-6-14-8-18(12-22(36)46-4)48-34(42)26(14)30(38)24(16)32(28)40/h5-6,9-10,17-18,37-40H,7-8,11-12H2,1-4H3
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n/an/a 7n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079359
PNG
(VIRIDITOXIN | Viriditoxin)
Show SMILES COC(=O)CC1Cc2cc3cc(OC)c(c(O)c3c(O)c2C(=O)O1)-c1c(OC)cc2cc3CC(CC(=O)OC)OC(=O)c3c(O)c2c1O
Show InChI InChI=1/C34H30O14/c1-43-19-9-15-5-13-7-17(11-21(35)45-3)47-33(41)25(13)29(37)23(15)31(39)27(19)28-20(44-2)10-16-6-14-8-18(12-22(36)46-4)48-34(42)26(14)30(38)24(16)32(28)40/h5-6,9-10,17-18,37-40H,7-8,11-12H2,1-4H3
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n/an/a 8.20n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ polymerization


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50083355
PNG
(CHEMBL3423282)
Show SMILES Cc1nc2ccccc2n1C(=O)\C=C\c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H12Cl2N2O/c1-11-20-15-4-2-3-5-16(15)21(11)17(22)9-7-12-6-8-13(18)10-14(12)19/h2-10H,1H3/b9-7+
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n/an/a 30n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli ATCC 25922 recombinant N-His6-tagged FtsZ polymerization expressed in Escherichia coli BL21(DE3) incubated for 15 mins...


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50203065
PNG
(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Show SMILES O=C\C=C\c1ccccc1
Show InChI InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+
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n/an/a 5.81E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50203065
PNG
(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Show SMILES O=C\C=C\c1ccccc1
Show InChI InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+
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n/an/a 6.86E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ polymerization


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079361
PNG
(CHEMBL3416824)
Show SMILES Oc1ccccc1Cc1ccc(O)c(Cc2c(O)c(Cc3cc(Cc4ccccc4O)ccc3O)c3O[C@@H](CC(=O)c3c2O)c2ccccc2)c1
Show InChI InChI=1/C43H36O8/c44-34-12-6-4-10-28(34)18-25-14-16-36(46)30(20-25)22-32-41(49)33(23-31-21-26(15-17-37(31)47)19-29-11-5-7-13-35(29)45)43-40(42(32)50)38(48)24-39(51-43)27-8-2-1-3-9-27/h1-17,20-21,39,44-47,49-50H,18-19,22-24H2/t39-/s2
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n/an/a 8.30E+3n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086108
PNG
(CHEMBL3425702)
Show SMILES [NH3+]CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C22H19ClN4/c23-18-8-5-15(6-9-18)7-10-21-26-20-14-17-4-2-1-3-16(17)13-19(20)22(27-21)25-12-11-24/h1-10,13-14H,11-12,24H2,(H,25,26,27)/p+1/b10-7+
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n/an/a 9.00E+3n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079358
PNG
(CHEMBL3416948)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H23ClN4/c1-29(2)14-13-26-24-21-15-18-5-3-4-6-19(18)16-22(21)27-23(28-24)12-9-17-7-10-20(25)11-8-17/h3-12,15-16H,13-14H2,1-2H3,(H,26,27,28)/b12-9+
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n/an/a 1.20E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50079360
PNG
(CHEBI:69681 | DICHAMANETIN | Dichamanetin)
Show SMILES Oc1ccccc1Cc1c(O)c(Cc2ccccc2O)c2O[C@@H](CC(=O)c2c1O)c1ccccc1
Show InChI InChI=1/C29H24O6/c30-22-12-6-4-10-18(22)14-20-27(33)21(15-19-11-5-7-13-23(19)31)29-26(28(20)34)24(32)16-25(35-29)17-8-2-1-3-9-17/h1-13,25,30-31,33-34H,14-16H2/t25-/s2
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n/an/a 1.25E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086088
PNG
(CHEMBL3425706)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(cc2)N=[N+]=[N-])nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H23N7/c1-31(2)14-13-26-24-21-15-18-5-3-4-6-19(18)16-22(21)27-23(28-24)12-9-17-7-10-20(11-8-17)29-30-25/h3-12,15-16H,13-14H2,1-2H3,(H,26,27,28)/b12-9+
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086098
PNG
(CHEMBL3425705)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(I)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H23IN4/c1-29(2)14-13-26-24-21-15-18-5-3-4-6-19(18)16-22(21)27-23(28-24)12-9-17-7-10-20(25)11-8-17/h3-12,15-16H,13-14H2,1-2H3,(H,26,27,28)/b12-9+
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n/an/a 2.40E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086206
PNG
(CHEMBL3425606)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(C)cc12
Show InChI InChI=1S/C21H23ClN4/c1-15-4-10-19-18(14-15)21(23-12-13-26(2)3)25-20(24-19)11-7-16-5-8-17(22)9-6-16/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)/b11-7+
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n/an/a 2.40E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086123
PNG
(CHEMBL3425694)
Show SMILES CN(C)CCOc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H22ClN3O/c1-28(2)13-14-29-24-21-15-18-5-3-4-6-19(18)16-22(21)26-23(27-24)12-9-17-7-10-20(25)11-8-17/h3-12,15-16H,13-14H2,1-2H3/b12-9+
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n/an/a 2.60E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086124
PNG
(CHEMBL3425693)
Show SMILES Cc1ccc2nc(\C=C\c3ccc(Cl)cc3)nc(NCC[NH3+])c2c1
Show InChI InChI=1S/C19H19ClN4/c1-13-2-8-17-16(12-13)19(22-11-10-21)24-18(23-17)9-5-14-3-6-15(20)7-4-14/h2-9,12H,10-11,21H2,1H3,(H,22,23,24)/p+1/b9-5+
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n/an/a 2.70E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086201
PNG
(CHEMBL3425611)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C26H25ClN4/c1-31(2)17-16-28-26-23-18-21(20-6-4-3-5-7-20)11-14-24(23)29-25(30-26)15-10-19-8-12-22(27)13-9-19/h3-15,18H,16-17H2,1-2H3,(H,28,29,30)/b15-10+
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n/an/a 2.80E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086203
PNG
(CHEMBL3425609)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(Br)cc12
Show InChI InChI=1S/C20H20BrClN4/c1-26(2)12-11-23-20-17-13-15(21)6-9-18(17)24-19(25-20)10-5-14-3-7-16(22)8-4-14/h3-10,13H,11-12H2,1-2H3,(H,23,24,25)/b10-5+
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086200
PNG
(CHEMBL3425612)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)-c1ccncc1
Show InChI InChI=1S/C25H24ClN5/c1-31(2)16-15-28-25-22-17-20(19-11-13-27-14-12-19)6-9-23(22)29-24(30-25)10-5-18-3-7-21(26)8-4-18/h3-14,17H,15-16H2,1-2H3,(H,28,29,30)/b10-5+
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50439496
PNG
(CHEMBL2418096 | US9169182, J23)
Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl
Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+
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n/an/a 3.60E+4n/an/an/an/an/an/a



THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
The bacterial cytoskeletal protein FtsZ is a GTPase and has structural homology to the eukaryotic cytoskeletal protein tubulin, but lacks significant...


US Patent US9169182 (2015)

More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50439496
PNG
(CHEMBL2418096 | US9169182, J23)
Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl
Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+
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n/an/a 3.70E+4n/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086197
PNG
(CHEMBL3425615)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)C1=CCCCC1
Show InChI InChI=1S/C26H29ClN4/c1-31(2)17-16-28-26-23-18-21(20-6-4-3-5-7-20)11-14-24(23)29-25(30-26)15-10-19-8-12-22(27)13-9-19/h6,8-15,18H,3-5,7,16-17H2,1-2H3,(H,28,29,30)/b15-10+
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n/an/a 4.90E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086109
PNG
(CHEMBL3425701)
Show SMILES C[N+](C)(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C25H26ClN4/c1-30(2,3)15-14-27-25-22-16-19-6-4-5-7-20(19)17-23(22)28-24(29-25)13-10-18-8-11-21(26)12-9-18/h4-13,16-17H,14-15H2,1-3H3,(H,27,28,29)/q+1/b13-10+
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n/an/a 5.20E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086199
PNG
(CHEMBL3425613)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)-c1ccc2ccccc2c1
Show InChI InChI=1S/C30H27ClN4/c1-35(2)18-17-32-30-27-20-25(24-11-10-22-5-3-4-6-23(22)19-24)12-15-28(27)33-29(34-30)16-9-21-7-13-26(31)14-8-21/h3-16,19-20H,17-18H2,1-2H3,(H,32,33,34)/b16-9+
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n/an/a 5.80E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086120
PNG
(CHEMBL3425697)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C25H25ClN4/c1-30(2)15-5-14-27-25-22-16-19-6-3-4-7-20(19)17-23(22)28-24(29-25)13-10-18-8-11-21(26)12-9-18/h3-4,6-13,16-17H,5,14-15H2,1-2H3,(H,27,28,29)/b13-10+
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n/an/a 6.50E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086105
PNG
(CHEMBL3425704)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)C(=O)c1ccccc1
Show InChI InChI=1S/C27H25ClN4O/c1-32(2)17-16-29-27-23-18-21(26(33)20-6-4-3-5-7-20)11-14-24(23)30-25(31-27)15-10-19-8-12-22(28)13-9-19/h3-15,18H,16-17H2,1-2H3,(H,29,30,31)/b15-10+
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n/an/a 8.50E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086202
PNG
(CHEMBL3425610)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(I)cc12
Show InChI InChI=1S/C20H20ClIN4/c1-26(2)12-11-23-20-17-13-16(22)8-9-18(17)24-19(25-20)10-5-14-3-6-15(21)7-4-14/h3-10,13H,11-12H2,1-2H3,(H,23,24,25)/b10-5+
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n/an/a 9.50E+4n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086204
PNG
(CHEMBL3425608)
Show SMILES COc1cc2nc(\C=C\c3ccc(Cl)cc3)nc(NCCN(C)C)c2cc1OC
Show InChI InChI=1S/C22H25ClN4O2/c1-27(2)12-11-24-22-17-13-19(28-3)20(29-4)14-18(17)25-21(26-22)10-7-15-5-8-16(23)9-6-15/h5-10,13-14H,11-12H2,1-4H3,(H,24,25,26)/b10-7+
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n/an/a 1.00E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086118
PNG
(CHEMBL3425699)
Show SMILES CC(C)(C)OC(=O)NCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C27H27ClN4O2/c1-27(2,3)34-26(33)30-15-14-29-25-22-16-19-6-4-5-7-20(19)17-23(22)31-24(32-25)13-10-18-8-11-21(28)12-9-18/h4-13,16-17H,14-15H2,1-3H3,(H,30,33)(H,29,31,32)/b13-10+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086116
PNG
(CHEMBL3425700)
Show SMILES CC(C)(C)OC(=O)CNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C26H24ClN3O2/c1-26(2,3)32-24(31)16-28-25-21-14-18-6-4-5-7-19(18)15-22(21)29-23(30-25)13-10-17-8-11-20(27)12-9-17/h4-15H,16H2,1-3H3,(H,28,29,30)/b13-10+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086198
PNG
(CHEMBL3425614)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(cc12)-c1cccs1
Show InChI InChI=1S/C24H23ClN4S/c1-29(2)14-13-26-24-20-16-18(22-4-3-15-30-22)8-11-21(20)27-23(28-24)12-7-17-5-9-19(25)10-6-17/h3-12,15-16H,13-14H2,1-2H3,(H,26,27,28)/b12-7+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086121
PNG
(CHEMBL3425696)
Show SMILES COCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C23H20ClN3O/c1-28-13-12-25-23-20-14-17-4-2-3-5-18(17)15-21(20)26-22(27-23)11-8-16-6-9-19(24)10-7-16/h2-11,14-15H,12-13H2,1H3,(H,25,26,27)/b11-8+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086122
PNG
(CHEMBL3425695)
Show SMILES CSCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C23H20ClN3S/c1-28-13-12-25-23-20-14-17-4-2-3-5-18(17)15-21(20)26-22(27-23)11-8-16-6-9-19(24)10-7-16/h2-11,14-15H,12-13H2,1H3,(H,25,26,27)/b11-8+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086107
PNG
(CHEMBL3425703)
Show SMILES CC(=O)NCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H21ClN4O/c1-16(30)26-12-13-27-24-21-14-18-4-2-3-5-19(18)15-22(21)28-23(29-24)11-8-17-6-9-20(25)10-7-17/h2-11,14-15H,12-13H2,1H3,(H,26,30)(H,27,28,29)/b11-8+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086208
PNG
(CHEMBL3425604)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccccc12
Show InChI InChI=1S/C20H21ClN4/c1-25(2)14-13-22-20-17-5-3-4-6-18(17)23-19(24-20)12-9-15-7-10-16(21)11-8-15/h3-12H,13-14H2,1-2H3,(H,22,23,24)/b12-9+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086119
PNG
(CHEMBL3425698)
Show SMILES COCCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C24H22ClN3O/c1-29-14-4-13-26-24-21-15-18-5-2-3-6-19(18)16-22(21)27-23(28-24)12-9-17-7-10-20(25)11-8-17/h2-3,5-12,15-16H,4,13-14H2,1H3,(H,26,27,28)/b12-9+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086205
PNG
(CHEMBL3425607)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cc(ccc12)C(F)(F)F
Show InChI InChI=1S/C21H20ClF3N4/c1-29(2)12-11-26-20-17-9-6-15(21(23,24)25)13-18(17)27-19(28-20)10-5-14-3-7-16(22)8-4-14/h3-10,13H,11-12H2,1-2H3,(H,26,27,28)/b10-5+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086125
PNG
(CHEMBL3425692)
Show SMILES Cc1ccc2nc(\C=C\c3ccc(Cl)cc3)nc(NCCNC(=O)OC(C)(C)C)c2c1
Show InChI InChI=1S/C24H27ClN4O2/c1-16-5-11-20-19(15-16)22(26-13-14-27-23(30)31-24(2,3)4)29-21(28-20)12-8-17-6-9-18(25)10-7-17/h5-12,15H,13-14H2,1-4H3,(H,27,30)(H,26,28,29)/b12-8+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086207
PNG
(CHEMBL3425605)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(Cl)cc2)nc2cccc(C)c12
Show InChI InChI=1S/C21H23ClN4/c1-15-5-4-6-18-20(15)21(23-13-14-26(2)3)25-19(24-18)12-9-16-7-10-17(22)11-8-16/h4-12H,13-14H2,1-3H3,(H,23,24,25)/b12-9+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086196
PNG
(CHEMBL3425689)
Show SMILES Cc1ccc2nc(nc(NCC[NH3+])c2c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C18H18ClN5O/c1-11-2-7-15-14(10-11)16(21-9-8-20)24-17(23-15)18(25)22-13-5-3-12(19)4-6-13/h2-7,10H,8-9,20H2,1H3,(H,22,25)(H,21,23,24)/p+1
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086191
PNG
(CHEMBL3425690)
Show SMILES CN(C)CCNc1nc(nc2ccc(C)cc12)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H24ClN5O/c1-14-4-9-18-17(12-14)19(23-10-11-27(2)3)26-20(25-18)21(28)24-13-15-5-7-16(22)8-6-15/h4-9,12H,10-11,13H2,1-3H3,(H,24,28)(H,23,25,26)
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50086180
PNG
(CHEMBL3425691)
Show SMILES COCCNc1nc(\C=C\c2ccc(Cl)cc2)nc2ccc(C)cc12
Show InChI InChI=1S/C20H20ClN3O/c1-14-3-9-18-17(13-14)20(22-11-12-25-2)24-19(23-18)10-6-15-4-7-16(21)8-5-15/h3-10,13H,11-12H2,1-2H3,(H,22,23,24)/b10-6+
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n/an/a>1.28E+5n/an/an/an/an/an/a



University of California at Davis

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli FtsZ GTPase activity after 5 mins by enzyme-coupled inhibition assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM186046
PNG
(US9169182, J24)
Show SMILES Oc1cc(O)cc(C\C(Cl)=C/Cc2cc(O)c(Cl)cc2O)c1
Show InChI InChI=1S/C16H14Cl2O4/c17-11(3-9-4-12(19)7-13(20)5-9)2-1-10-6-16(22)14(18)8-15(10)21/h2,4-8,19-22H,1,3H2/b11-2+
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US Patent
n/an/a 1.60E+5n/an/an/an/an/an/a



THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

US Patent


Assay Description
The bacterial cytoskeletal protein FtsZ is a GTPase and has structural homology to the eukaryotic cytoskeletal protein tubulin, but lacks significant...


US Patent US9169182 (2015)

More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50399003
PNG
(CHEMBL2180486)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cccc(CN=C(N)N)c1
Show InChI InChI=1S/C18H23N3/c1-18(2,3)16-9-7-14(8-10-16)15-6-4-5-13(11-15)12-21-17(19)20/h4-11H,12H2,1-3H3,(H4,19,20,21)
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n/an/an/a 3.80E+3n/an/an/an/an/a



University of Medicine and Dentistry of New Jersey

Curated by ChEMBL


Assay Description
Binding affinity to Escherichia coli FtsZ at 25 degC by fluorescence anisotropy assay


Citation and Details
More data for this
Ligand-Target Pair
Cell division protein FtsZ


(Escherichia coli)
BDBM50010058
PNG
(CHEBI:51231 | DAPI)
Show SMILES NC(=N)c1ccc(cc1)-c1cc2ccc(cc2[nH]1)C(N)=N
Show InChI InChI=1S/C16H15N5/c17-15(18)10-3-1-9(2-4-10)13-7-11-5-6-12(16(19)20)8-14(11)21-13/h1-8,21H,(H3,17,18)(H3,19,20)
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n/an/an/a 1.66E+4n/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Binding affinity to Escherichia coli FtsZ by fluorescence anisotrophy


Citation and Details
More data for this
Ligand-Target Pair