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Compile Data Set for Download or QSAR

Found 226 hits Enz. Inhib. hit(s) with Target = 'Coagulation factor X' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Bos taurus)
BDBM50113792
PNG
(CHEMBL81521 | S-4-{2-[2-(1-Carbamimidoyl-piperidin...)
Show SMILES CN([C@@H](CC(O)=O)C(=O)N1CCCC[C@H]1CCOC1CCN(CC1)C(N)=N)C1CCCCC1
Show InChI InChI=1S/C24H43N5O4/c1-27(18-7-3-2-4-8-18)21(17-22(30)31)23(32)29-13-6-5-9-19(29)12-16-33-20-10-14-28(15-11-20)24(25)26/h18-21H,2-17H2,1H3,(H3,25,26)(H,30,31)/t19-,21-/m0/s1
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4.97n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory effect on Coagulation factor Xa (FXa) from bovine plasma


J Med Chem 45: 2432-53 (2002)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM13281
PNG
(4-Amino-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfonyl...)
Show SMILES COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cc(ccc2N)C(N)=N)C1=O
Show InChI InChI=1S/C23H25N5O4S/c1-32-18-5-2-14-3-6-19(12-16(14)11-18)33(30,31)27-21-8-9-28(23(21)29)13-17-10-15(22(25)26)4-7-20(17)24/h2-7,10-12,21,27H,8-9,13,24H2,1H3,(H3,25,26)/t21-/m0/s1
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6n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex


Bioorg Med Chem Lett 9: 2539-44 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50081009
PNG
(CHEMBL85938 | Thieno[3,2-b]pyridine-2-sulfonic aci...)
Show SMILES Nc1cc2ccnc(N)c2cc1CN1CC[C@H](NS(=O)(=O)c2cc3ncccc3s2)C1=O
Show InChI InChI=1S/C21H20N6O3S2/c22-15-9-12-3-6-25-20(23)14(12)8-13(15)11-27-7-4-16(21(27)28)26-32(29,30)19-10-17-18(31-19)2-1-5-24-17/h1-3,5-6,8-10,16,26H,4,7,11,22H2,(H2,23,25)/t16-/m0/s1
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6n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex


Bioorg Med Chem Lett 9: 2539-44 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM13279
PNG
(4-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfo...)
Show SMILES COc1ccc2ccc(cc2c1)S(=O)(=O)N(C)[C@H]1CCN(Cc2csc(c2)C(N)=N)C1=O
Show InChI InChI=1S/C22H24N4O4S2/c1-25(19-7-8-26(22(19)27)12-14-9-20(21(23)24)31-13-14)32(28,29)18-6-4-15-3-5-17(30-2)10-16(15)11-18/h3-6,9-11,13,19H,7-8,12H2,1-2H3,(H3,23,24)/t19-/m0/s1
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7n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex


Bioorg Med Chem Lett 9: 2539-44 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50072843
PNG
(2,7-Bis-(4-diaminomethyl-benzylidene)-cycloheptano...)
Show SMILES NC(N)c1ccc(\C=C2/CCCC\C(=C/c3ccc(cc3)C(N)N)C2=O)cc1
Show InChI InChI=1S/C23H28N4O/c24-22(25)17-9-5-15(6-10-17)13-19-3-1-2-4-20(21(19)28)14-16-7-11-18(12-8-16)23(26)27/h5-14,22-23H,1-4,24-27H2/b19-13+,20-14+
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13n/an/an/an/an/an/an/an/a



Institut für Biochemie

Curated by ChEMBL


Assay Description
Inhibitory activity against bovine coagulation factor X expressed as dissociation constant


J Med Chem 41: 5445-56 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM14058
PNG
(CHEMBL316053 | N-[(3S)-1-[(1-aminoisoquinolin-7-yl...)
Show SMILES Nc1nccc2ccc(CN3CC[C@H](NS(=O)(=O)c4cc5ncccc5s4)C3=O)cc12
Show InChI InChI=1S/C21H19N5O3S2/c22-20-15-10-13(3-4-14(15)5-8-24-20)12-26-9-6-16(21(26)27)25-31(28,29)19-11-17-18(30-19)2-1-7-23-17/h1-5,7-8,10-11,16,25H,6,9,12H2,(H2,22,24)/t16-/m0/s1
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22n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex


Bioorg Med Chem Lett 9: 2539-44 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50081011
PNG
(3-[(S)-2-Oxo-3-(thieno[3,2-b]pyridine-2-sulfonylam...)
Show SMILES NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3cc4ncccc4s3)C2=O)c1
Show InChI InChI=1S/C19H19N5O3S2/c20-18(21)13-4-1-3-12(9-13)11-24-8-6-14(19(24)25)23-29(26,27)17-10-15-16(28-17)5-2-7-22-15/h1-5,7,9-10,14,23H,6,8,11H2,(H3,20,21)/t14-/m0/s1
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26n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex


Bioorg Med Chem Lett 9: 2539-44 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50041224
PNG
((R)-3-(7-Carbamimidoyl-naphthalen-2-yl)-2-{4-[(S)-...)
Show SMILES CC(=N)N1CC[C@@H](C1)Oc1ccc(cc1)[C@@H](Cc1ccc2ccc(cc2c1)C(N)=N)C(O)=O
Show InChI InChI=1S/C26H28N4O3/c1-16(27)30-11-10-23(15-30)33-22-8-6-19(7-9-22)24(26(31)32)13-17-2-3-18-4-5-20(25(28)29)14-21(18)12-17/h2-9,12,14,23-24,27H,10-11,13,15H2,1H3,(H3,28,29)(H,31,32)/t23-,24+/m0/s1
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41n/an/an/an/an/an/an/an/a



Institut für Biochemie

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards Coagulation factor X


J Med Chem 41: 4240-50 (1998)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017916
PNG
(CHEMBL3289038)
Show SMILES N[C@H]1CC[C@@H](CC1)OC(=O)c1cc(Oc2ccc(cc2)C(N)=N)cc(Oc2ccc(cc2)C(N)=N)c1
Show InChI InChI=1S/C27H29N5O4/c28-19-5-11-22(12-6-19)36-27(33)18-13-23(34-20-7-1-16(2-8-20)25(29)30)15-24(14-18)35-21-9-3-17(4-10-21)26(31)32/h1-4,7-10,13-15,19,22H,5-6,11-12,28H2,(H3,29,30)(H3,31,32)/t19-,22-
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44n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM13280
PNG
(3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-...)
Show SMILES COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O
Show InChI InChI=1S/C23H24N4O4S/c1-31-19-7-5-16-6-8-20(13-18(16)12-19)32(29,30)26-21-9-10-27(23(21)28)14-15-3-2-4-17(11-15)22(24)25/h2-8,11-13,21,26H,9-10,14H2,1H3,(H3,24,25)/t21-/m0/s1
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47n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex


Bioorg Med Chem Lett 9: 2539-44 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017911
PNG
(CHEMBL3289033)
Show SMILES NCCN1CCC(CC1)C(=O)Nc1cc(Oc2ccc(cc2)C(N)=N)cc(Oc2ccc(cc2)C(N)=N)c1
Show InChI InChI=1S/C28H33N7O3/c29-11-14-35-12-9-20(10-13-35)28(36)34-21-15-24(37-22-5-1-18(2-6-22)26(30)31)17-25(16-21)38-23-7-3-19(4-8-23)27(32)33/h1-8,15-17,20H,9-14,29H2,(H3,30,31)(H3,32,33)(H,34,36)
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62n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017900
PNG
(CHEMBL3289018)
Show SMILES NC(=N)c1ccc(Oc2cc(Oc3ccc(cc3)C(N)=N)cc(c2)C(=O)NCC2CCCCC2)cc1
Show InChI InChI=1S/C28H31N5O3/c29-26(30)19-6-10-22(11-7-19)35-24-14-21(28(34)33-17-18-4-2-1-3-5-18)15-25(16-24)36-23-12-8-20(9-13-23)27(31)32/h6-16,18H,1-5,17H2,(H3,29,30)(H3,31,32)(H,33,34)
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73n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50081008
PNG
(7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(1,6-...)
Show SMILES COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cc3c(N)nccc3cc2N)C1=O
Show InChI InChI=1S/C25H25N5O4S/c1-34-19-4-2-15-3-5-20(11-17(15)10-19)35(32,33)29-23-7-9-30(25(23)31)14-18-12-21-16(13-22(18)26)6-8-28-24(21)27/h2-6,8,10-13,23,29H,7,9,14,26H2,1H3,(H2,27,28)/t23-/m0/s1
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80n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex


Bioorg Med Chem Lett 9: 2539-44 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017917
PNG
(CHEMBL3289032)
Show SMILES NCCC(=O)N1CCC(CC1)C(=O)Nc1cc(Oc2ccc(cc2)C(N)=N)cc(Oc2ccc(cc2)C(N)=N)c1
Show InChI InChI=1S/C29H33N7O4/c30-12-9-26(37)36-13-10-20(11-14-36)29(38)35-21-15-24(39-22-5-1-18(2-6-22)27(31)32)17-25(16-21)40-23-7-3-19(4-8-23)28(33)34/h1-8,15-17,20H,9-14,30H2,(H3,31,32)(H3,33,34)(H,35,38)
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95n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017934
PNG
(CHEMBL3289301)
Show SMILES N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(OCc2cccc(c2)C(N)=N)cc(OCc2cccc(c2)C(N)=N)c1
Show InChI InChI=1S/C29H34N6O3/c30-23-7-9-24(10-8-23)35-29(36)22-13-25(37-16-18-3-1-5-20(11-18)27(31)32)15-26(14-22)38-17-19-4-2-6-21(12-19)28(33)34/h1-6,11-15,23-24H,7-10,16-17,30H2,(H3,31,32)(H3,33,34)(H,35,36)/t23-,24-
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157n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50081001
PNG
(7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(1-am...)
Show SMILES COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2ccc3ccnc(N)c3c2)C1=O
Show InChI InChI=1S/C25H24N4O4S/c1-33-20-6-4-17-5-7-21(14-19(17)13-20)34(31,32)28-23-9-11-29(25(23)30)15-16-2-3-18-8-10-27-24(26)22(18)12-16/h2-8,10,12-14,23,28H,9,11,15H2,1H3,(H2,26,27)/t23-/m0/s1
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180n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex


Bioorg Med Chem Lett 9: 2539-44 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017906
PNG
(CHEMBL3289017)
Show SMILES NC(=N)c1ccc(Oc2cc(Oc3ccc(cc3)C(N)=N)cc(c2)C(=O)NC2CCCCC2)cc1
Show InChI InChI=1S/C27H29N5O3/c28-25(29)17-6-10-21(11-7-17)34-23-14-19(27(33)32-20-4-2-1-3-5-20)15-24(16-23)35-22-12-8-18(9-13-22)26(30)31/h6-16,20H,1-5H2,(H3,28,29)(H3,30,31)(H,32,33)
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190n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50072841
PNG
(3-(3-Diaminomethyl-phenyl)-2-[2-(naphthalene-2-sul...)
Show SMILES CC(C)OC(=O)C(Cc1cccc(c1)C(N)N)NC(=O)CNS(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H30N4O5S/c1-16(2)34-25(31)22(13-17-6-5-9-20(12-17)24(26)27)29-23(30)15-28-35(32,33)21-11-10-18-7-3-4-8-19(18)14-21/h3-12,14,16,22,24,28H,13,15,26-27H2,1-2H3,(H,29,30)
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240n/an/an/an/an/an/an/an/a



Institut für Biochemie

Curated by ChEMBL


Assay Description
Inhibitory activity against bovine coagulation factor X expressed as dissociation constant


J Med Chem 41: 5445-56 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50081004
PNG
(7-Methoxy-naphthalene-2-sulfonic acid [1-(4-amino-...)
Show SMILES COc1ccc2ccc(cc2c1)S(=O)(=O)NC1CCN(Cc2cc3c(N)nccc3s2)C1=O
Show InChI InChI=1S/C23H22N4O4S2/c1-31-16-4-2-14-3-5-18(11-15(14)10-16)33(29,30)26-20-7-9-27(23(20)28)13-17-12-19-21(32-17)6-8-25-22(19)24/h2-6,8,10-12,20,26H,7,9,13H2,1H3,(H2,24,25)
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250n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex


Bioorg Med Chem Lett 9: 2539-44 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017928
PNG
(CHEMBL3289029)
Show SMILES NC(=N)c1ccc(Oc2cc(Oc3ccc(cc3)C(N)=N)cc(c2)C(=O)N2CCc3ccccc3C2)cc1
Show InChI InChI=1S/C30H27N5O3/c31-28(32)20-5-9-24(10-6-20)37-26-15-23(30(36)35-14-13-19-3-1-2-4-22(19)18-35)16-27(17-26)38-25-11-7-21(8-12-25)29(33)34/h1-12,15-17H,13-14,18H2,(H3,31,32)(H3,33,34)
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273n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017926
PNG
(CHEMBL3289019)
Show SMILES CC1CCC(CC1)NC(=O)c1cc(Oc2ccc(cc2)C(N)=N)cc(Oc2ccc(cc2)C(N)=N)c1
Show InChI InChI=1S/C28H31N5O3/c1-17-2-8-21(9-3-17)33-28(34)20-14-24(35-22-10-4-18(5-11-22)26(29)30)16-25(15-20)36-23-12-6-19(7-13-23)27(31)32/h4-7,10-17,21H,2-3,8-9H2,1H3,(H3,29,30)(H3,31,32)(H,33,34)
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282n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50189310
PNG
(4,4''-(1,4-Phenylenebis(Methylene))Bis(Oxy)Dibenzi...)
Show SMILES NC(=N)c1ccc(OCc2ccc(COc3ccc(cc3)C(N)=N)cc2)cc1
Show InChI InChI=1S/C22H22N4O2/c23-21(24)17-5-9-19(10-6-17)27-13-15-1-2-16(4-3-15)14-28-20-11-7-18(8-12-20)22(25)26/h1-12H,13-14H2,(H3,23,24)(H3,25,26)
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327n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of bovine factor 10a using Boc-Ile-Glu-Gly-Arg-AMC as substrate after 20 mins by fluorimetric analysis


Bioorg Med Chem Lett 26: 3741-5 (2016)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017939
PNG
(CHEMBL3289028)
Show SMILES NC(=N)c1ccc(Oc2cc(Oc3ccc(cc3)C(N)=N)cc(c2)C(=O)N2CCC3CCCCC3C2)cc1
Show InChI InChI=1S/C30H33N5O3/c31-28(32)20-5-9-24(10-6-20)37-26-15-23(30(36)35-14-13-19-3-1-2-4-22(19)18-35)16-27(17-26)38-25-11-7-21(8-12-25)29(33)34/h5-12,15-17,19,22H,1-4,13-14,18H2,(H3,31,32)(H3,33,34)
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336n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50081007
PNG
(7-Methoxy-naphthalene-2-sulfonic acid [1-(2-amino-...)
Show SMILES COc1ccc2ccc(cc2c1)S(=O)(=O)NC1CCN(Cc2ccc3ccc(N)nc3c2)C1=O
Show InChI InChI=1S/C25H24N4O4S/c1-33-20-7-4-17-5-8-21(14-19(17)13-20)34(31,32)28-22-10-11-29(25(22)30)15-16-2-3-18-6-9-24(26)27-23(18)12-16/h2-9,12-14,22,28H,10-11,15H2,1H3,(H2,26,27)
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370n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex


Bioorg Med Chem Lett 9: 2539-44 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50189307
PNG
(CHEMBL3594082)
Show SMILES NC(=N)c1ccc(NCCCCCCCNc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C21H30N6/c22-20(23)16-6-10-18(11-7-16)26-14-4-2-1-3-5-15-27-19-12-8-17(9-13-19)21(24)25/h6-13,26-27H,1-5,14-15H2,(H3,22,23)(H3,24,25)
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391n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of bovine factor 10a using Boc-Ile-Glu-Gly-Arg-AMC as substrate after 20 mins by fluorimetric analysis


Bioorg Med Chem Lett 26: 3741-5 (2016)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017936
PNG
(CHEMBL3289022)
Show SMILES NCCCN1CCC(CC1)NC(=O)c1cc(Oc2ccc(cc2)C(N)=N)cc(Oc2ccc(cc2)C(N)=N)c1
Show InChI InChI=1S/C29H35N7O3/c30-12-1-13-36-14-10-22(11-15-36)35-29(37)21-16-25(38-23-6-2-19(3-7-23)27(31)32)18-26(17-21)39-24-8-4-20(5-9-24)28(33)34/h2-9,16-18,22H,1,10-15,30H2,(H3,31,32)(H3,33,34)(H,35,37)
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415n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50067525
PNG
(3-(3-Carbamimidoyl-phenyl)-2-[2-(toluene-4-sulfony...)
Show SMILES CCOC(=O)C(Cc1cccc(c1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C21H26N4O5S/c1-3-30-21(27)18(12-15-5-4-6-16(11-15)20(22)23)25-19(26)13-24-31(28,29)17-9-7-14(2)8-10-17/h4-11,18,24H,3,12-13H2,1-2H3,(H3,22,23)(H,25,26)
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460n/an/an/an/an/an/an/an/a



Institut für Biochemie

Curated by ChEMBL


Assay Description
Inhibitory activity against Coagulation factor X


J Med Chem 41: 4240-50 (1998)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017902
PNG
(CHEMBL3289034)
Show SMILES N[C@H]1CC[C@@H](CC1)C(=O)Nc1cc(Oc2ccc(cc2)C(N)=N)cc(Oc2ccc(cc2)C(N)=N)c1
Show InChI InChI=1S/C27H30N6O3/c28-19-7-1-18(2-8-19)27(34)33-20-13-23(35-21-9-3-16(4-10-21)25(29)30)15-24(14-20)36-22-11-5-17(6-12-22)26(31)32/h3-6,9-15,18-19H,1-2,7-8,28H2,(H3,29,30)(H3,31,32)(H,33,34)/t18-,19-
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503n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017897
PNG
(CHEMBL3289023)
Show SMILES N[C@H]1CC[C@@H](CC1)NC(=O)c1cc(Oc2ccc(cc2)C(N)=N)cc(Oc2ccc(cc2)C(N)=N)c1
Show InChI InChI=1S/C27H30N6O3/c28-19-5-7-20(8-6-19)33-27(34)18-13-23(35-21-9-1-16(2-10-21)25(29)30)15-24(14-18)36-22-11-3-17(4-12-22)26(31)32/h1-4,9-15,19-20H,5-8,28H2,(H3,29,30)(H3,31,32)(H,33,34)/t19-,20-
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516n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50067522
PNG
(2-[2-(4-Carbamimidoyl-benzenesulfonylamino)-acetyl...)
Show SMILES CCOC(=O)C(Cc1ccc(cc1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(cc1)C(N)=N
Show InChI InChI=1S/C21H26N6O5S/c1-2-32-21(29)17(11-13-3-5-14(6-4-13)19(22)23)27-18(28)12-26-33(30,31)16-9-7-15(8-10-16)20(24)25/h3-10,17,26H,2,11-12H2,1H3,(H3,22,23)(H3,24,25)(H,27,28)
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530n/an/an/an/an/an/an/an/a



Institut für Biochemie

Curated by ChEMBL


Assay Description
Inhibitory activity against Coagulation factor X


J Med Chem 41: 4240-50 (1998)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017941
PNG
(CHEMBL3289020)
Show SMILES NC(=N)c1ccc(Oc2cc(Oc3ccc(cc3)C(N)=N)cc(c2)C(=O)NC2CCC(O)CC2)cc1
Show InChI InChI=1S/C27H29N5O4/c28-25(29)16-1-9-21(10-2-16)35-23-13-18(27(34)32-19-5-7-20(33)8-6-19)14-24(15-23)36-22-11-3-17(4-12-22)26(30)31/h1-4,9-15,19-20,33H,5-8H2,(H3,28,29)(H3,30,31)(H,32,34)
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538n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50041220
PNG
(1,2-bis(5-amidinobenzofuran-2-yl)ethane | 2-(2-{5-...)
Show SMILES NC(=N)c1ccc2oc(CCc3cc4cc(ccc4o3)C(N)=N)cc2c1
Show InChI InChI=1S/C20H18N4O2/c21-19(22)11-1-5-17-13(7-11)9-15(25-17)3-4-16-10-14-8-12(20(23)24)2-6-18(14)26-16/h1-2,5-10H,3-4H2,(H3,21,22)(H3,23,24)
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570n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of bovine factor 10a


J Med Chem 53: 6243-74 (2010)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50067528
PNG
(3-(3-Carbamimidoyl-phenyl)-2-[2-(4-thiocarbamoyl-b...)
Show SMILES CCOC(=O)C(Cc1cccc(c1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(cc1)C(N)=S
Show InChI InChI=1S/C21H25N5O5S2/c1-2-31-21(28)17(11-13-4-3-5-15(10-13)19(22)23)26-18(27)12-25-33(29,30)16-8-6-14(7-9-16)20(24)32/h3-10,17,25H,2,11-12H2,1H3,(H3,22,23)(H2,24,32)(H,26,27)
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580n/an/an/an/an/an/an/an/a



Institut für Biochemie

Curated by ChEMBL


Assay Description
Inhibitory activity against Coagulation factor X


J Med Chem 41: 4240-50 (1998)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50066614
PNG
((E,E)-2,7-Bis(4-amidinobenzylidine)cycloheptan-1-o...)
Show SMILES NC(=N)c1ccc(\C=C2/CCCC\C(=C/c3ccc(cc3)C(N)=N)C2=O)cc1
Show InChI InChI=1S/C23H24N4O/c24-22(25)17-9-5-15(6-10-17)13-19-3-1-2-4-20(21(19)28)14-16-7-11-18(12-8-16)23(26)27/h5-14H,1-4H2,(H3,24,25)(H3,26,27)/b19-13+,20-14+
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610n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of bovine factor 10a


J Med Chem 53: 6243-74 (2010)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017935
PNG
(CHEMBL3289021)
Show SMILES NC(=N)c1ccc(Oc2cc(Oc3ccc(cc3)C(N)=N)cc(c2)C(=O)NC2CCN(CCO)CC2)cc1
Show InChI InChI=1S/C28H32N6O4/c29-26(30)18-1-5-22(6-2-18)37-24-15-20(28(36)33-21-9-11-34(12-10-21)13-14-35)16-25(17-24)38-23-7-3-19(4-8-23)27(31)32/h1-8,15-17,21,35H,9-14H2,(H3,29,30)(H3,31,32)(H,33,36)
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640n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50130871
PNG
(CHEMBL3632760)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cccc(n1)C1(F)CCCCC1
Show InChI InChI=1S/C20H21FN4/c21-20(9-2-1-3-10-20)18-6-4-5-16(25-18)17-12-14-11-13(19(22)23)7-8-15(14)24-17/h4-8,11-12,24H,1-3,9-10H2,(H3,22,23)
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700n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine factor 10a by fluorescence based assay using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH as substrate


Bioorg Med Chem Lett 25: 5309-14 (2015)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017904
PNG
(CHEMBL3289031)
Show SMILES CC1CCC(CC1)C(=O)Nc1cc(Oc2ccc(cc2)C(N)=N)cc(Oc2ccc(cc2)C(N)=N)c1
Show InChI InChI=1S/C28H31N5O3/c1-17-2-4-20(5-3-17)28(34)33-21-14-24(35-22-10-6-18(7-11-22)26(29)30)16-25(15-21)36-23-12-8-19(9-13-23)27(31)32/h6-17,20H,2-5H2,1H3,(H3,29,30)(H3,31,32)(H,33,34)
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743n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017938
PNG
(CHEMBL3289015)
Show SMILES NC(=N)c1ccc(Oc2cc(Oc3ccc(cc3)C(N)=N)cc(c2)C(N)=O)cc1
Show InChI InChI=1S/C21H19N5O3/c22-19(23)12-1-5-15(6-2-12)28-17-9-14(21(26)27)10-18(11-17)29-16-7-3-13(4-8-16)20(24)25/h1-11H,(H3,22,23)(H3,24,25)(H2,26,27)
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785n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50072845
PNG
(3-(3-Diaminomethyl-phenyl)-2-[2-(toluene-4-sulfony...)
Show SMILES COC(=O)C(Cc1cccc(c1)C(N)N)NC(=O)CNS(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C20H26N4O5S/c1-13-6-8-16(9-7-13)30(27,28)23-12-18(25)24-17(20(26)29-2)11-14-4-3-5-15(10-14)19(21)22/h3-10,17,19,23H,11-12,21-22H2,1-2H3,(H,24,25)
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840n/an/an/an/an/an/an/an/a



Institut für Biochemie

Curated by ChEMBL


Assay Description
Inhibitory activity against bovine coagulation factor X expressed as dissociation constant


J Med Chem 41: 5445-56 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50067532
PNG
(3-(3-Carbamimidoyl-phenyl)-2-[2-(toluene-4-sulfony...)
Show SMILES COC(=O)C(Cc1cccc(c1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C20H24N4O5S/c1-13-6-8-16(9-7-13)30(27,28)23-12-18(25)24-17(20(26)29-2)11-14-4-3-5-15(10-14)19(21)22/h3-10,17,23H,11-12H2,1-2H3,(H3,21,22)(H,24,25)
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840n/an/an/an/an/an/an/an/a



Institut für Biochemie

Curated by ChEMBL


Assay Description
Inhibitory activity against Coagulation factor X


J Med Chem 41: 4240-50 (1998)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017921
PNG
(CHEMBL3289016)
Show SMILES NC(=N)c1ccc(Oc2cc(N)cc(Oc3ccc(cc3)C(N)=N)c2)cc1
Show InChI InChI=1S/C20H19N5O2/c21-14-9-17(26-15-5-1-12(2-6-15)19(22)23)11-18(10-14)27-16-7-3-13(4-8-16)20(24)25/h1-11H,21H2,(H3,22,23)(H3,24,25)
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851n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017940
PNG
(CHEMBL3289037)
Show SMILES NC(=N)c1ccc(Oc2cc(NS(=O)(=O)c3ccc4ccccc4c3)cc(Oc3ccc(cc3)C(N)=N)c2)cc1
Show InChI InChI=1S/C30H25N5O4S/c31-29(32)20-5-10-24(11-6-20)38-26-16-23(17-27(18-26)39-25-12-7-21(8-13-25)30(33)34)35-40(36,37)28-14-9-19-3-1-2-4-22(19)15-28/h1-18,35H,(H3,31,32)(H3,33,34)
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876n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50081003
PNG
(7-Methoxy-naphthalene-2-sulfonic acid [(S)-1-(1-am...)
Show SMILES COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cc3c(N)nccc3cc2OC)C1=O
Show InChI InChI=1S/C26H26N4O5S/c1-34-20-5-3-16-4-6-21(12-18(16)11-20)36(32,33)29-23-8-10-30(26(23)31)15-19-13-22-17(14-24(19)35-2)7-9-28-25(22)27/h3-7,9,11-14,23,29H,8,10,15H2,1-2H3,(H2,27,28)/t23-/m0/s1
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890n/an/an/an/an/an/an/an/a



Rh£ne-Poulenc Rorer

Curated by ChEMBL


Assay Description
In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex


Bioorg Med Chem Lett 9: 2539-44 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017922
PNG
(CHEMBL3289025)
Show SMILES NC(=N)c1ccc(Oc2cc(Oc3ccc(cc3)C(N)=N)cc(c2)C(=O)NCC2CCC(O)CC2)cc1
Show InChI InChI=1S/C28H31N5O4/c29-26(30)18-3-9-22(10-4-18)36-24-13-20(28(35)33-16-17-1-7-21(34)8-2-17)14-25(15-24)37-23-11-5-19(6-12-23)27(31)32/h3-6,9-15,17,21,34H,1-2,7-8,16H2,(H3,29,30)(H3,31,32)(H,33,35)
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920n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Factor Xa (fXa)


(Bos taurus)
BDBM23910
PNG
(3-[(2S)-3-[4-(2-carbamimidamidoethyl)piperidin-1-y...)
Show SMILES NC(N)=NCCC1CCN(CC1)C(=O)[C@H](Cc1cccc(c1)C(N)=N)NS(=O)(=O)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C30H37N7O4S/c31-28(32)23-6-4-5-22(19-23)20-27(29(38)37-17-14-21(15-18-37)13-16-35-30(33)34)36-42(39,40)26-11-9-25(10-12-26)41-24-7-2-1-3-8-24/h1-12,19,21,27,36H,13-18,20H2,(H3,31,32)(H4,33,34,35)/t27-/m0/s1
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1.00E+3 -34.2n/an/an/an/an/a8.025



Curacyte Chemistry GmbH



Assay Description
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...


J Med Chem 49: 4116-26 (2006)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50130866
PNG
(CHEMBL3632755)
Show SMILES CC(C)c1cccc(-c2cc3cc(ccc3[nH]2)C(N)=N)c1O
Show InChI InChI=1S/C18H19N3O/c1-10(2)13-4-3-5-14(17(13)22)16-9-12-8-11(18(19)20)6-7-15(12)21-16/h3-10,21-22H,1-2H3,(H3,19,20)
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1.00E+3n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine factor 10a by fluorescence based assay using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH as substrate


Bioorg Med Chem Lett 25: 5309-14 (2015)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50017918
PNG
(CHEMBL3289026)
Show SMILES CCOC(=O)N1CCC(CC1)NC(=O)c1cc(Oc2ccc(cc2)C(N)=N)cc(Oc2ccc(cc2)C(N)=N)c1
Show InChI InChI=1S/C29H32N6O5/c1-2-38-29(37)35-13-11-21(12-14-35)34-28(36)20-15-24(39-22-7-3-18(4-8-22)26(30)31)17-25(16-20)40-23-9-5-19(6-10-23)27(32)33/h3-10,15-17,21H,2,11-14H2,1H3,(H3,30,31)(H3,32,33)(H,34,36)
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1.03E+3n/an/an/an/an/an/an/an/a



Aurigene Discovery Technologies Limited

Curated by ChEMBL


Assay Description
Inhibition of bovine plasma factor 10a using CH3OCO-D-CHA-Gly-Arg-pNA.AcoH substrate


Bioorg Med Chem 22: 3187-203 (2014)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50060054
PNG
(3-[2-[2-(7,7-Dimethyl-2-oxo-bicyclo[2.2.1]hept-1-y...)
Show SMILES CC1(C)C2CCC1(CCS(=O)(=O)NC(Cc1cccc(c1)C(N)=N)C(=O)N1CCN(CC1)S(C)(=O)=O)C(=O)C2
Show InChI InChI=1S/C26H39N5O6S2/c1-25(2)20-7-8-26(25,22(32)17-20)9-14-39(36,37)29-21(16-18-5-4-6-19(15-18)23(27)28)24(33)30-10-12-31(13-11-30)38(3,34)35/h4-6,15,20-21,29H,7-14,16-17H2,1-3H3,(H3,27,28)
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1.10E+3n/an/an/an/an/an/an/an/a



Klinikum der Friedrich-Schiller-Universit£t Jena

Curated by ChEMBL


Assay Description
Inhibitory activity against coagulation factor X.


J Med Chem 40: 3091-9 (1997)

More data for this
Ligand-Target Pair
Coagulation factor X


(Bos taurus)
BDBM50060046
PNG
(3-[(R)-2-[2-(7,7-Dimethyl-2-oxo-bicyclo[2.2.1]hept...)
Show SMILES CC1(C)C2CCC1(CCS(=O)(=O)N[C@H](Cc1cccc(c1)C(N)=N)C(=O)N1CCN(CC1)S(C)(=O)=O)C(=O)C2
Show InChI InChI=1S/C26H39N5O6S2/c1-25(2)20-7-8-26(25,22(32)17-20)9-14-39(36,37)29-21(16-18-5-4-6-19(15-18)23(27)28)24(33)30-10-12-31(13-11-30)38(3,34)35/h4-6,15,20-21,29H,7-14,16-17H2,1-3H3,(H3,27,28)/t20?,21-,26?/m1/s1
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1.10E+3n/an/an/an/an/an/an/an/a



Klinikum der Friedrich-Schiller-Universit£t Jena

Curated by ChEMBL


Assay Description
Inhibitory activity against coagulation factor X.


J Med Chem 40: 3091-9 (1997)

More data for this
Ligand-Target Pair
Factor Xa (fXa)


(Bos taurus)
BDBM23899
PNG
(3-[(2S)-2-[(4-cyclohexylbenzene)sulfonamido]-3-oxo...)
Show SMILES NC(=N)c1cccc(C[C@H](NS(=O)(=O)c2ccc(cc2)C2CCCCC2)C(=O)N2CCC(CC2)C(=O)N2CCNCC2)c1
Show InChI InChI=1S/C32H44N6O4S/c33-30(34)27-8-4-5-23(21-27)22-29(32(40)37-17-13-26(14-18-37)31(39)38-19-15-35-16-20-38)36-43(41,42)28-11-9-25(10-12-28)24-6-2-1-3-7-24/h4-5,8-12,21,24,26,29,35-36H,1-3,6-7,13-20,22H2,(H3,33,34)/t29-/m0/s1
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1.10E+3 -34.0n/an/an/an/an/a8.025



Curacyte Chemistry GmbH



Assay Description
The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used. Af...


J Med Chem 49: 4116-26 (2006)

More data for this
Ligand-Target Pair
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