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Found 90 hits Enz. Inhib. hit(s) with Target = 'Coagulation factor X' AND taxid = 9986   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50079240
PNG
(3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4...)
Show SMILES NC(=N)c1cccc(c1)C1=NOC(Cn2cnnn2)(C1)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C24H22N10O4S/c25-22(26)16-5-3-4-15(10-16)19-11-24(38-31-19,13-34-14-29-32-33-34)23(35)30-21-9-8-17(12-28-21)18-6-1-2-7-20(18)39(27,36)37/h1-10,12,14H,11,13H2,(H3,25,26)(H2,27,36,37)(H,28,30,35)
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0.110n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibitory activity against Rabbit factor Xa was determined


Bioorg Med Chem Lett 13: 1023-8 (2003)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50087533
PNG
(3-(3-Carbamimidoyl-phenyl)-isoxazole-4-carboxylic ...)
Show SMILES NC(=N)c1cccc(c1)-c1nocc1C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C23H19N5O4S/c24-22(25)16-5-3-4-15(12-16)21-19(13-32-28-21)23(29)27-17-10-8-14(9-11-17)18-6-1-2-7-20(18)33(26,30)31/h1-13H,(H3,24,25)(H,27,29)(H2,26,30,31)
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0.400n/an/an/an/an/an/an/an/a



The DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was tested against rabbit Coagulation factor X


Bioorg Med Chem Lett 10: 685-9 (2000)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072442
PNG
(CHEMBL320269 | {(3-Carbamimidoyl-phenyl)-[2-(2'-su...)
Show SMILES COC(=O)CN(CCOc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C24H26N4O5S/c1-32-23(29)16-28(19-6-4-5-18(15-19)24(25)26)13-14-33-20-11-9-17(10-12-20)21-7-2-3-8-22(21)34(27,30)31/h2-12,15H,13-14,16H2,1H3,(H3,25,26)(H2,27,30,31)
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0.530n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50087538
PNG
((4S,5S)-3-(3-Carbamimidoyl-phenyl)-5-methoxymethyl...)
Show SMILES COC[C@H]1ON=C([C@@H]1C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C25H25N5O5S/c1-34-14-20-22(23(30-35-20)16-5-4-6-17(13-16)24(26)27)25(31)29-18-11-9-15(10-12-18)19-7-2-3-8-21(19)36(28,32)33/h2-13,20,22H,14H2,1H3,(H3,26,27)(H,29,31)(H2,28,32,33)/t20-,22-/m1/s1
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0.640n/an/an/an/an/an/an/an/a



The DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was tested against rabbit Coagulation factor X


Bioorg Med Chem Lett 10: 685-9 (2000)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50079252
PNG
(3-(3-Carbamimidoyl-phenyl)-5-methoxymethyl-4,5-dih...)
Show SMILES COCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C25H25N5O5S/c1-34-15-25(14-21(30-35-25)17-5-4-6-18(13-17)23(26)27)24(31)29-19-11-9-16(10-12-19)20-7-2-3-8-22(20)36(28,32)33/h2-13H,14-15H2,1H3,(H3,26,27)(H,29,31)(H2,28,32,33)
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0.800n/an/an/an/an/an/an/an/a



The DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was tested against rabbit Coagulation factor X


Bioorg Med Chem Lett 10: 685-9 (2000)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072448
PNG
(CHEMBL18767 | {(3-Carbamimidoyl-phenyl)-[3-(2'-sul...)
Show SMILES COC(=O)CN(CCCc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C25H28N4O4S/c1-33-24(30)17-29(21-8-4-7-20(16-21)25(26)27)15-5-6-18-11-13-19(14-12-18)22-9-2-3-10-23(22)34(28,31)32/h2-4,7-14,16H,5-6,15,17H2,1H3,(H3,26,27)(H2,28,31,32)
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1.30n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM35743
PNG
(CHEMBL479863 | cis-1,2-diaminocyclohexane derivati...)
Show SMILES CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1
Show InChI InChI=1S/C26H31ClN6O3S/c1-32(2)26(36)14-4-6-18(29-23(34)21-12-15-10-16(27)5-7-17(15)28-21)20(11-14)30-24(35)25-31-19-8-9-33(3)13-22(19)37-25/h5,7,10,12,14,18,20,28H,4,6,8-9,11,13H2,1-3H3,(H,29,34)(H,30,35)/t14-,18-,20+/m0/s1
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1.74n/an/an/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of rabbit factor 10a by Lineweaver-Burk plot


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072444
PNG
(CHEMBL320934 | {(3-Carbamimidoyl-phenyl)-[2-(2'-su...)
Show SMILES CC(C)OC(=O)CN(CCOc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C26H30N4O5S/c1-18(2)35-25(31)17-30(21-7-5-6-20(16-21)26(27)28)14-15-34-22-12-10-19(11-13-22)23-8-3-4-9-24(23)36(29,32)33/h3-13,16,18H,14-15,17H2,1-2H3,(H3,27,28)(H2,29,32,33)
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2.10n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50125242
PNG
(3-(3-Amino-4-chloro-phenyl)-5-(methanesulfonylamin...)
Show SMILES CS(=O)(=O)NCC1(CC(=NO1)c1ccc(Cl)c(N)c1)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C23H23ClN6O6S2/c1-37(32,33)28-13-23(11-19(30-36-23)14-6-8-17(24)18(25)10-14)22(31)29-21-9-7-15(12-27-21)16-4-2-3-5-20(16)38(26,34)35/h2-10,12,28H,11,13,25H2,1H3,(H2,26,34,35)(H,27,29,31)
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2.30n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibitory activity against Rabbit factor Xa was determined


Bioorg Med Chem Lett 13: 1023-8 (2003)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50324743
PNG
((3R,4R)-1-(2,2-DIFLUORO-ETHYL)-PYRROLIDINE-3,4-DIC...)
Show SMILES FC(F)CN1C[C@@H]([C@H](C1)C(=O)Nc1ccc(cc1F)-n1ccccc1=O)C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C24H21ClF3N5O3/c25-14-4-7-21(29-10-14)31-24(36)17-12-32(13-20(27)28)11-16(17)23(35)30-19-6-5-15(9-18(19)26)33-8-2-1-3-22(33)34/h1-10,16-17,20H,11-13H2,(H,30,35)(H,29,31,36)/t16-,17-/m0/s1
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3.30n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Binding affinity to rabbit factor 10a


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50125243
PNG
(3-(3-Amino-4-chloro-phenyl)-5-ureidomethyl-4,5-dih...)
Show SMILES NC(=O)NCC1(CC(=NO1)c1ccc(Cl)c(N)c1)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C23H22ClN7O5S/c24-16-7-5-13(9-17(16)25)18-10-23(36-31-18,12-29-22(26)33)21(32)30-20-8-6-14(11-28-20)15-3-1-2-4-19(15)37(27,34)35/h1-9,11H,10,12,25H2,(H3,26,29,33)(H2,27,34,35)(H,28,30,32)
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4.70n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibitory activity against Rabbit factor Xa was determined


Bioorg Med Chem Lett 13: 1023-8 (2003)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072445
PNG
(CHEMBL139063 | CHEMBL279628 | [3-(3-Carbamimidoyl-...)
Show SMILES COC(=O)CC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C26H25N5O6S/c1-36-23(32)15-26(14-21(31-37-26)17-5-4-6-18(13-17)24(27)28)25(33)30-19-11-9-16(10-12-19)20-7-2-3-8-22(20)38(29,34)35/h2-13H,14-15H2,1H3,(H3,27,28)(H,30,33)(H2,29,34,35)
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6.30n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072435
PNG
(CHEMBL106743 | {(3-Carbamimidoyl-phenyl)-[3-(2'-su...)
Show SMILES COC(=O)CN(CCCOc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C25H28N4O5S/c1-33-24(30)17-29(20-7-4-6-19(16-20)25(26)27)14-5-15-34-21-12-10-18(11-13-21)22-8-2-3-9-23(22)35(28,31)32/h2-4,6-13,16H,5,14-15,17H2,1H3,(H3,26,27)(H2,28,31,32)
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6.70n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072434
PNG
(CHEMBL317471 | {(3-Carbamimidoyl-phenyl)-[3-(2'-su...)
Show SMILES CC(C)OC(=O)CN(CCCc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C27H32N4O4S/c1-19(2)35-26(32)18-31(23-9-5-8-22(17-23)27(28)29)16-6-7-20-12-14-21(15-13-20)24-10-3-4-11-25(24)36(30,33)34/h3-5,8-15,17,19H,6-7,16,18H2,1-2H3,(H3,28,29)(H2,30,33,34)
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7.5n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072437
PNG
(CHEMBL105121 | {(3-Carbamimidoyl-phenyl)-[2-(2'-su...)
Show SMILES COC(=O)CN(CCc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C24H26N4O4S/c1-32-23(29)16-28(20-6-4-5-19(15-20)24(25)26)14-13-17-9-11-18(12-10-17)21-7-2-3-8-22(21)33(27,30)31/h2-12,15H,13-14,16H2,1H3,(H3,25,26)(H2,27,30,31)
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10n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072440
PNG
(3-{(2-Methoxy-ethyl)-[3-(2'-sulfamoyl-biphenyl-4-y...)
Show SMILES COCCN(CCCc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C25H30N4O3S/c1-32-17-16-29(22-8-4-7-21(18-22)25(26)27)15-5-6-19-11-13-20(14-12-19)23-9-2-3-10-24(23)33(28,30)31/h2-4,7-14,18H,5-6,15-17H2,1H3,(H3,26,27)(H2,28,30,31)
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11n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072449
PNG
(CHEMBL107097 | {(3-Carbamimidoyl-phenyl)-[3-(2'-su...)
Show SMILES NC(=N)c1cccc(c1)N(CCCc1ccc(cc1)-c1ccccc1S(N)(=O)=O)CC(O)=O
Show InChI InChI=1S/C24H26N4O4S/c25-24(26)19-6-3-7-20(15-19)28(16-23(29)30)14-4-5-17-10-12-18(13-11-17)21-8-1-2-9-22(21)33(27,31)32/h1-3,6-13,15H,4-5,14,16H2,(H3,25,26)(H,29,30)(H2,27,31,32)
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12n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072450
PNG
(3-{(2-Oxo-propyl)-[3-(2'-sulfamoyl-biphenyl-4-yl)-...)
Show SMILES CC(=O)CN(CCCc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C25H28N4O3S/c1-18(30)17-29(22-8-4-7-21(16-22)25(26)27)15-5-6-19-11-13-20(14-12-19)23-9-2-3-10-24(23)33(28,31)32/h2-4,7-14,16H,5-6,15,17H2,1H3,(H3,26,27)(H2,28,31,32)
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16n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072436
PNG
(3-{(2-Phenoxy-ethyl)-[3-(2'-sulfamoyl-biphenyl-4-y...)
Show SMILES NC(=N)c1cccc(c1)N(CCCc1ccc(cc1)-c1ccccc1S(N)(=O)=O)CCOc1ccccc1
Show InChI InChI=1S/C30H32N4O3S/c31-30(32)25-9-6-10-26(22-25)34(20-21-37-27-11-2-1-3-12-27)19-7-8-23-15-17-24(18-16-23)28-13-4-5-14-29(28)38(33,35)36/h1-6,9-18,22H,7-8,19-21H2,(H3,31,32)(H2,33,35,36)
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16n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50324745
PNG
((3R,4R)-methyl 3-(5-chloropyridin-2-ylcarbamoyl)-4...)
Show SMILES COC(=O)N1C[C@@H]([C@H](C1)C(=O)Nc1ccc(cc1F)-n1ccccc1=O)C(=O)Nc1ccc(Cl)cn1
Show InChI InChI=1S/C24H21ClFN5O5/c1-36-24(35)30-12-16(17(13-30)23(34)29-20-8-5-14(25)11-27-20)22(33)28-19-7-6-15(10-18(19)26)31-9-3-2-4-21(31)32/h2-11,16-17H,12-13H2,1H3,(H,28,33)(H,27,29,34)/t16-,17-/m0/s1
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17n/an/an/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Binding affinity to rabbit factor 10a


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072438
PNG
(3-{(2-Hydroxy-ethyl)-[3-(2'-sulfamoyl-biphenyl-4-y...)
Show SMILES NC(=N)c1cccc(c1)N(CCO)CCCc1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C24H28N4O3S/c25-24(26)20-6-3-7-21(17-20)28(15-16-29)14-4-5-18-10-12-19(13-11-18)22-8-1-2-9-23(22)32(27,30)31/h1-3,6-13,17,29H,4-5,14-16H2,(H3,25,26)(H2,27,30,31)
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17n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072446
PNG
(2-{(3-Carbamimidoyl-phenyl)-[3-(2'-sulfamoyl-biphe...)
Show SMILES NC(=O)CN(CCCc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C24H27N5O3S/c25-23(30)16-29(20-7-3-6-19(15-20)24(26)27)14-4-5-17-10-12-18(13-11-17)21-8-1-2-9-22(21)33(28,31)32/h1-3,6-13,15H,4-5,14,16H2,(H2,25,30)(H3,26,27)(H2,28,31,32)
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19n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072439
PNG
(CHEMBL325101 | {(3-Carbamimidoyl-phenyl)-[2-(2'-su...)
Show SMILES COC(=O)CN(c1cccc(c1)C(N)=N)S(=O)(=O)CCc1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C24H26N4O6S2/c1-34-23(29)16-28(20-6-4-5-19(15-20)24(25)26)35(30,31)14-13-17-9-11-18(12-10-17)21-7-2-3-8-22(21)36(27,32)33/h2-12,15H,13-14,16H2,1H3,(H3,25,26)(H2,27,32,33)
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21n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50062035
PNG
(5-(4-Carbamimidoyl-phenyl)-3-(3-carbamimidoyl-phen...)
Show SMILES COC(=O)CC(CCc1ccc(cc1)C(N)=N)c1cccc(c1)C(N)=N
Show InChI InChI=1S/C20H24N4O2/c1-26-18(25)12-16(15-3-2-4-17(11-15)20(23)24)10-7-13-5-8-14(9-6-13)19(21)22/h2-6,8-9,11,16H,7,10,12H2,1H3,(H3,21,22)(H3,23,24)
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34n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072433
PNG
(CHEMBL323381 | {(3-Carbamimidoyl-phenyl)-[2-(2'-su...)
Show SMILES CC(C)OC(=O)CN(c1cccc(c1)C(N)=N)S(=O)(=O)CCc1ccc(cc1)-c1ccccc1S(N)(=O)=O
Show InChI InChI=1S/C26H30N4O6S2/c1-18(2)36-25(31)17-30(22-7-5-6-21(16-22)26(27)28)37(32,33)15-14-19-10-12-20(13-11-19)23-8-3-4-9-24(23)38(29,34)35/h3-13,16,18H,14-15,17H2,1-2H3,(H3,27,28)(H2,29,34,35)
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37n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072447
PNG
(3-[2-(2'-Sulfamoyl-biphenyl-4-yl)-ethanesulfonylam...)
Show SMILES NC(=N)c1cccc(NS(=O)(=O)CCc2ccc(cc2)-c2ccccc2S(N)(=O)=O)c1
Show InChI InChI=1S/C21H22N4O4S2/c22-21(23)17-4-3-5-18(14-17)25-30(26,27)13-12-15-8-10-16(11-9-15)19-6-1-2-7-20(19)31(24,28)29/h1-11,14,25H,12-13H2,(H3,22,23)(H2,24,28,29)
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51n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072443
PNG
(3-[3-(2'-Sulfamoyl-biphenyl-4-yl)-propylamino]-ben...)
Show SMILES NC(=N)c1cccc(NCCCc2ccc(cc2)-c2ccccc2S(N)(=O)=O)c1
Show InChI InChI=1S/C22H24N4O2S/c23-22(24)18-6-3-7-19(15-18)26-14-4-5-16-10-12-17(13-11-16)20-8-1-2-9-21(20)29(25,27)28/h1-3,6-13,15,26H,4-5,14H2,(H3,23,24)(H2,25,27,28)
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83n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50072441
PNG
(CHEMBL323060 | CHEMBL92988 | [3-(3-Carbamimidoyl-p...)
Show SMILES COC(=O)CC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C21H22N6O4/c1-30-17(28)11-21(20(29)26-15-7-5-12(6-8-15)18(22)23)10-16(27-31-21)13-3-2-4-14(9-13)19(24)25/h2-9H,10-11H2,1H3,(H3,22,23)(H3,24,25)(H,26,29)
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94n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50448581
PNG
(CHEMBL3127463)
Show SMILES CC(C)CC(=O)Nc1cc(cc(c1)-c1ccc(cc1C(O)=O)C(N)=O)C1CC(C)(c2ccccc2)c2cc(ccc2N1)C(N)=N
Show InChI InChI=1S/C36H37N5O4/c1-20(2)13-32(42)40-26-15-23(27-11-9-22(34(39)43)17-28(27)35(44)45)14-24(16-26)31-19-36(3,25-7-5-4-6-8-25)29-18-21(33(37)38)10-12-30(29)41-31/h4-12,14-18,20,31,41H,13,19H2,1-3H3,(H3,37,38)(H2,39,43)(H,40,42)(H,44,45)
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3.20E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Binding affinity to New Zealand White rabbit factor 10a assessed as release of p-nitroaniline after 10 to 120 mins by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50032874
PNG
(CHEMBL3355683)
Show SMILES OC(=O)C(F)(F)F.NC[C@H]1CC[C@@H](CC1)C(=O)N[C@@H](Cc1ccccc1)c1nc(c(Cl)[nH]1)-c1ccc2c(N)n[nH]c2c1
Show InChI InChI=1/C26H30ClN7O.C2HF3O2/c27-23-22(18-10-11-19-20(13-18)33-34-24(19)29)31-25(32-23)21(12-15-4-2-1-3-5-15)30-26(35)17-8-6-16(14-28)7-9-17;3-2(4,5)1(6)7/h1-5,10-11,13,16-17,21H,6-9,12,14,28H2,(H,30,35)(H,31,32)(H3,29,33,34);(H,6,7)/t16-,17-,21-;/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of rabbit coagulation factor 10a using N-benzoyl-Ile-Glu-(OH, OMe)-Gly-Arg-pNA as substrate by spectrophotometric analysis


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50266924
PNG
((2R,4S)-N1-(4-Chlorophenyl)-4-(2,4-difluorophenyl)...)
Show SMILES O[C@@]1(C[C@@H](N(C1)C(=O)Nc1ccc(Cl)cc1)C(=O)Nc1ccc(cn1)-n1ccccc1=O)c1ccc(F)cc1F
Show InChI InChI=1S/C28H22ClF2N5O4/c29-17-4-7-19(8-5-17)33-27(39)36-16-28(40,21-10-6-18(30)13-22(21)31)14-23(36)26(38)34-24-11-9-20(15-32-24)35-12-2-1-3-25(35)37/h1-13,15,23,40H,14,16H2,(H,33,39)(H,32,34,38)/t23-,28-/m1/s1
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n/an/a 0.108n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rabbit F10a


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Coagulation factor X


(Oryctolagus cuniculus)
BDBM17283
PNG
((2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S...)
Show SMILES CC(=N)N1CC[C@@H](C1)Oc1ccc(cc1)[C@H](Cc1ccc2ccc(cc2c1)C(N)=N)C(O)=O
Show InChI InChI=1S/C26H28N4O3/c1-16(27)30-11-10-23(15-30)33-22-8-6-19(7-9-22)24(26(31)32)13-17-2-3-18-4-5-20(25(28)29)14-21(18)12-17/h2-9,12,14,23-24,27H,10-11,13,15H2,1H3,(H3,28,29)(H,31,32)/t23-,24-/m0/s1
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n/an/a 41n/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of serine protease factor Xa enzyme.


Bioorg Med Chem Lett 8: 3143-8 (1999)

More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080132
PNG
(CHEMBL3415976)
Show SMILES CCN(CC)Cc1cccn1-c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1/C24H27ClN4O3S/c1-3-27(4-2)15-19-6-5-13-28(19)17-7-9-18(10-8-17)29-16-20(32-24(29)31)14-26-23(30)21-11-12-22(25)33-21/h5-13,20H,3-4,14-16H2,1-2H3,(H,26,30)/t20-/s2
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n/an/a 460n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of prothombin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM7840
PNG
(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O
Show InChI InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
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n/an/a 510n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of prothombin time


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080107
PNG
(CHEMBL3415998)
Show SMILES CCN(CC)Cc1csc(n1)-c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1/C23H25ClN4O3S2/c1-3-27(4-2)12-16-14-32-22(26-16)15-5-7-17(8-6-15)28-13-18(31-23(28)30)11-25-21(29)19-9-10-20(24)33-19/h5-10,14,18H,3-4,11-13H2,1-2H3,(H,25,29)/t18-/s2
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n/an/a 720n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of prothombin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080132
PNG
(CHEMBL3415976)
Show SMILES CCN(CC)Cc1cccn1-c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1/C24H27ClN4O3S/c1-3-27(4-2)15-19-6-5-13-28(19)17-7-9-18(10-8-17)29-16-20(32-24(29)31)14-26-23(30)21-11-12-22(25)33-21/h5-13,20H,3-4,14-16H2,1-2H3,(H,26,30)/t20-/s2
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n/an/a 750n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of activated partial thromboplastin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080131
PNG
(CHEMBL3415975)
Show SMILES CN(C)Cc1cccn1-c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1/C22H23ClN4O3S/c1-25(2)13-17-4-3-11-26(17)15-5-7-16(8-6-15)27-14-18(30-22(27)29)12-24-21(28)19-9-10-20(23)31-19/h3-11,18H,12-14H2,1-2H3,(H,24,28)/t18-/s2
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n/an/a 780n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of prothombin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080133
PNG
(CHEMBL3415977)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)-n1cccc1CN1CCC1
Show InChI InChI=1/C23H23ClN4O3S/c24-21-9-8-20(32-21)22(29)25-13-19-15-28(23(30)31-19)17-6-4-16(5-7-17)27-12-1-3-18(27)14-26-10-2-11-26/h1,3-9,12,19H,2,10-11,13-15H2,(H,25,29)/t19-/s2
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n/an/a 810n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of prothombin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080143
PNG
(CHEMBL3415984)
Show SMILES CCN(CC)Cc1cccn1-c1ccc(N2C[C@H](CNC(=O)c3ccc(Cl)s3)OC2=O)c(F)c1
Show InChI InChI=1/C24H26ClFN4O3S/c1-3-28(4-2)14-17-6-5-11-29(17)16-7-8-20(19(26)12-16)30-15-18(33-24(30)32)13-27-23(31)21-9-10-22(25)34-21/h5-12,18H,3-4,13-15H2,1-2H3,(H,27,31)/t18-/s2
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n/an/a 820n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of prothombin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM7840
PNG
(RIVAROXABAN | US8822458, 44 | US8822458, 97)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O
Show InChI InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
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n/an/a 860n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of activated partial thromboplastin time


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080101
PNG
(CHEMBL3415997)
Show SMILES CCNCc1csc(n1)-c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1/C21H21ClN4O3S2/c1-2-23-9-14-12-30-20(25-14)13-3-5-15(6-4-13)26-11-16(29-21(26)28)10-24-19(27)17-7-8-18(22)31-17/h3-8,12,16,23H,2,9-11H2,1H3,(H,24,27)/t16-/s2
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n/an/a 890n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of prothombin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080142
PNG
(CHEMBL3415983)
Show SMILES CN(C)Cc1cccn1-c1ccc(N2C[C@H](CNC(=O)c3ccc(Cl)s3)OC2=O)c(F)c1
Show InChI InChI=1/C22H22ClFN4O3S/c1-26(2)12-15-4-3-9-27(15)14-5-6-18(17(24)10-14)28-13-16(31-22(28)30)11-25-21(29)19-7-8-20(23)32-19/h3-10,16H,11-13H2,1-2H3,(H,25,29)/t16-/s2
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n/an/a 910n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of prothombin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080100
PNG
(CHEMBL3415996)
Show SMILES CN(C)Cc1csc(n1)-c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1/C21H21ClN4O3S2/c1-25(2)10-14-12-30-20(24-14)13-3-5-15(6-4-13)26-11-16(29-21(26)28)9-23-19(27)17-7-8-18(22)31-17/h3-8,12,16H,9-11H2,1-2H3,(H,23,27)/t16-/s2
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n/an/a 920n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of prothombin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080107
PNG
(CHEMBL3415998)
Show SMILES CCN(CC)Cc1csc(n1)-c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1/C23H25ClN4O3S2/c1-3-27(4-2)12-16-14-32-22(26-16)15-5-7-17(8-6-15)28-13-18(31-23(28)30)11-25-21(29)19-9-10-20(24)33-19/h5-10,14,18H,3-4,11-13H2,1-2H3,(H,25,29)/t18-/s2
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n/an/a 1.03E+3n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of activated partial thromboplastin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080143
PNG
(CHEMBL3415984)
Show SMILES CCN(CC)Cc1cccn1-c1ccc(N2C[C@H](CNC(=O)c3ccc(Cl)s3)OC2=O)c(F)c1
Show InChI InChI=1/C24H26ClFN4O3S/c1-3-28(4-2)14-17-6-5-11-29(17)16-7-8-20(19(26)12-16)30-15-18(33-24(30)32)13-27-23(31)21-9-10-22(25)34-21/h5-12,18H,3-4,13-15H2,1-2H3,(H,27,31)/t18-/s2
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n/an/a 1.13E+3n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of activated partial thromboplastin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080101
PNG
(CHEMBL3415997)
Show SMILES CCNCc1csc(n1)-c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1/C21H21ClN4O3S2/c1-2-23-9-14-12-30-20(25-14)13-3-5-15(6-4-13)26-11-16(29-21(26)28)10-24-19(27)17-7-8-18(22)31-17/h3-8,12,16,23H,2,9-11H2,1H3,(H,24,27)/t16-/s2
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n/an/a 1.16E+3n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of activated partial thromboplastin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080100
PNG
(CHEMBL3415996)
Show SMILES CN(C)Cc1csc(n1)-c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1/C21H21ClN4O3S2/c1-25(2)10-14-12-30-20(24-14)13-3-5-15(6-4-13)26-11-16(29-21(26)28)9-23-19(27)17-7-8-18(22)31-17/h3-8,12,16H,9-11H2,1-2H3,(H,23,27)/t16-/s2
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n/an/a 1.24E+3n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of activated partial thromboplastin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080131
PNG
(CHEMBL3415975)
Show SMILES CN(C)Cc1cccn1-c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O
Show InChI InChI=1/C22H23ClN4O3S/c1-25(2)13-17-4-3-11-26(17)15-5-7-16(8-6-15)27-14-18(30-22(27)29)12-24-21(28)19-9-10-20(23)31-19/h3-11,18H,12-14H2,1-2H3,(H,24,28)/t18-/s2
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n/an/a 1.39E+3n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of activated partial thromboplastin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080133
PNG
(CHEMBL3415977)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)-n1cccc1CN1CCC1
Show InChI InChI=1/C23H23ClN4O3S/c24-21-9-8-20(32-21)22(29)25-13-19-15-28(23(30)31-19)17-6-4-16(5-7-17)27-12-1-3-18(27)14-26-10-2-11-26/h1,3-9,12,19H,2,10-11,13-15H2,(H,25,29)/t19-/s2
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n/an/a 1.52E+3n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of activated partial thromboplastin time


Citation and Details
More data for this
Ligand-Target Pair
Coagulation factor X


(Oryctolagus cuniculus)
BDBM50080134
PNG
(CHEMBL3415978)
Show SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)-n1cccc1CN1CCCC1
Show InChI InChI=1/C24H25ClN4O3S/c25-22-10-9-21(33-22)23(30)26-14-20-16-29(24(31)32-20)18-7-5-17(6-8-18)28-13-3-4-19(28)15-27-11-1-2-12-27/h3-10,13,20H,1-2,11-12,14-16H2,(H,26,30)/t20-/s2
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n/an/a 1.58E+3n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of F10a in rabbit plasma assessed as doubling of prothombin time


Citation and Details
More data for this
Ligand-Target Pair
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