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Found 187 hits Enz. Inhib. hit(s) with Target = 'Collagenase (ChC)' AND taxid = 1498   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11354
PNG
(Hydroxamate 35 | N-Pentafluorophenylsulfonyl-N-4-n...)
Show SMILES ONC(=O)CN(Cc1ccc(cc1)N(=O)=O)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C15H10F5N3O6S/c16-10-11(17)13(19)15(14(20)12(10)18)30(28,29)22(6-9(24)21-25)5-7-1-3-8(4-2-7)23(26)27/h1-4,25H,5-6H2,(H,21,24)
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5 -47.4n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11357
PNG
(Hydroxamate 38 | N-hydroxy-2-{[(2-nitrophenyl)meth...)
Show SMILES CC(N(Cc1ccccc1N(=O)=O)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)C(=O)NO
Show InChI InChI=1S/C16H12F5N3O6S/c1-7(16(25)22-26)23(6-8-4-2-3-5-9(8)24(27)28)31(29,30)15-13(20)11(18)10(17)12(19)14(15)21/h2-5,7,26H,6H2,1H3,(H,22,25)
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5 -47.4n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11363
PNG
(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)C(=O)NO
Show InChI InChI=1S/C16H12ClF5N2O4S/c1-7(16(25)23-26)24(6-8-4-2-3-5-9(8)17)29(27,28)15-13(21)11(19)10(18)12(20)14(15)22/h2-5,7,26H,6H2,1H3,(H,23,25)
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5 -47.4n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11363
PNG
(2-{[(2-chlorophenyl)methyl](2,3,4,5,6-pentafluorob...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)C(=O)NO
Show InChI InChI=1S/C16H12ClF5N2O4S/c1-7(16(25)23-26)24(6-8-4-2-3-5-9(8)17)29(27,28)15-13(21)11(19)10(18)12(20)14(15)22/h2-5,7,26H,6H2,1H3,(H,23,25)
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5 -47.4n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11341
PNG
(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)
Show SMILES CC(C)C(N(Cc1ccccc1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)C(=O)NO
Show InChI InChI=1S/C18H17F5N2O4S/c1-9(2)16(18(26)24-27)25(8-10-6-4-3-5-7-10)30(28,29)17-14(22)12(20)11(19)13(21)15(17)23/h3-7,9,16,27H,8H2,1-2H3,(H,24,26)
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5 -47.4n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11348
PNG
(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)
Show SMILES CC(C)CC(N(Cc1ccccc1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)C(=O)NO
Show InChI InChI=1S/C19H19F5N2O4S/c1-10(2)8-12(19(27)25-28)26(9-11-6-4-3-5-7-11)31(29,30)18-16(23)14(21)13(20)15(22)17(18)24/h3-7,10,12,28H,8-9H2,1-2H3,(H,25,27)
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5 -47.4n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11360
PNG
(Hydroxamate 41 | N-hydroxy-2-{[(4-nitrophenyl)meth...)
Show SMILES CC(N(Cc1ccc(cc1)N(=O)=O)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)C(=O)NO
Show InChI InChI=1S/C16H12F5N3O6S/c1-7(16(25)22-26)23(6-8-2-4-9(5-3-8)24(27)28)31(29,30)15-13(20)11(18)10(17)12(19)14(15)21/h2-5,7,26H,6H2,1H3,(H,22,25)
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5 -47.4n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11816
PNG
(2-{[(2-chlorophenyl)methyl][(phenylformamido)metha...)
Show SMILES CC(N(Cc1ccccc1Cl)C(=S)NC(=O)c1ccccc1)C(=O)NO
Show InChI InChI=1S/C18H18ClN3O3S/c1-12(16(23)21-25)22(11-14-9-5-6-10-15(14)19)18(26)20-17(24)13-7-3-2-4-8-13/h2-10,12,25H,11H2,1H3,(H,21,23)(H,20,24,26)
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6 -46.9n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11351
PNG
(Hydroxamate 32 | N-hydroxy-2-{[(2-nitrophenyl)meth...)
Show SMILES ONC(=O)CN(Cc1ccccc1N(=O)=O)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C15H10F5N3O6S/c16-10-11(17)13(19)15(14(20)12(10)18)30(28,29)22(6-9(24)21-25)5-7-3-1-2-4-8(7)23(26)27/h1-4,25H,5-6H2,(H,21,24)
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6 -46.9n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11336
PNG
(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)
Show SMILES CC(N(Cc1ccccc1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F)C(=O)NO
Show InChI InChI=1S/C16H13F5N2O4S/c1-8(16(24)22-25)23(7-9-5-3-2-4-6-9)28(26,27)15-13(20)11(18)10(17)12(19)14(15)21/h2-6,8,25H,7H2,1H3,(H,22,24)
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6 -46.9n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11330
PNG
(2-[benzyl(2,3,4,5,6-pentafluorobenzene)sulfonamido...)
Show SMILES ONC(=O)CN(Cc1ccccc1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C15H11F5N2O4S/c16-10-11(17)13(19)15(14(20)12(10)18)27(25,26)22(7-9(23)21-24)6-8-4-2-1-3-5-8/h1-5,24H,6-7H2,(H,21,23)
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6 -46.9n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11776
PNG
(2-{[(2-chlorophenyl)methyl][3-(trifluoromethyl)ben...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1cccc(c1)C(F)(F)F)C(=O)NO
Show InChI InChI=1S/C17H16ClF3N2O4S/c1-11(16(24)22-25)23(10-12-5-2-3-8-15(12)18)28(26,27)14-7-4-6-13(9-14)17(19,20)21/h2-9,11,25H,10H2,1H3,(H,22,24)
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6 -46.9n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11783
PNG
(4-{[(2-chlorophenyl)methyl][1-(hydroxycarbamoyl)et...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc(cc1)C(=O)NO)C(=O)NO
Show InChI InChI=1S/C17H18ClN3O6S/c1-11(16(22)19-24)21(10-13-4-2-3-5-15(13)18)28(26,27)14-8-6-12(7-9-14)17(23)20-25/h2-9,11,24-25H,10H2,1H3,(H,19,22)(H,20,23)
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7 -46.5n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11788
PNG
(2-{[(2-chlorophenyl)methyl](quinoline-8-)sulfonami...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1cccc2cccnc12)C(=O)NO
Show InChI InChI=1S/C19H18ClN3O4S/c1-13(19(24)22-25)23(12-15-6-2-3-9-16(15)20)28(26,27)17-10-4-7-14-8-5-11-21-18(14)17/h2-11,13,25H,12H2,1H3,(H,22,24)
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7 -46.5n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11784
PNG
(2-{[(2-chlorophenyl)methyl](naphthalene-1-)sulfona...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1cccc2ccccc12)C(=O)NO
Show InChI InChI=1S/C20H19ClN2O4S/c1-14(20(24)22-25)23(13-16-8-3-5-11-18(16)21)28(26,27)19-12-6-9-15-7-2-4-10-17(15)19/h2-12,14,25H,13H2,1H3,(H,22,24)
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8 -46.2n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11347
PNG
(2-[benzyl(1,1,2,2,3,3,4,4,4-nonafluorobutane)sulfo...)
Show SMILES CC(C)CC(N(Cc1ccccc1)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)NO
Show InChI InChI=1S/C17H19F9N2O4S/c1-10(2)8-12(13(29)27-30)28(9-11-6-4-3-5-7-11)33(31,32)17(25,26)15(20,21)14(18,19)16(22,23)24/h3-7,10,12,30H,8-9H2,1-2H3,(H,27,29)
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8 -46.2n/an/an/an/an/a7.525



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Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11780
PNG
(hydroxamate deriv. B26 | tert-butyl N-(5-{[(2-chlo...)
Show SMILES COc1ccc(cc1NC(=O)OC(C)(C)C)S(=O)(=O)N(Cc1ccccc1Cl)C(C)C(=O)NO
Show InChI InChI=1S/C22H28ClN3O7S/c1-14(20(27)25-29)26(13-15-8-6-7-9-17(15)23)34(30,31)16-10-11-19(32-5)18(12-16)24-21(28)33-22(2,3)4/h6-12,14,29H,13H2,1-5H3,(H,24,28)(H,25,27)
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8 -46.2n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11804
PNG
(2-({[(4-chlorobenzene)sulfonyl]carbamoyl}[(2-chlor...)
Show SMILES CC(N(Cc1ccccc1Cl)C(=O)NS(=O)(=O)c1ccc(Cl)cc1)C(=O)NO
Show InChI InChI=1S/C17H17Cl2N3O5S/c1-11(16(23)20-25)22(10-12-4-2-3-5-15(12)19)17(24)21-28(26,27)14-8-6-13(18)7-9-14/h2-9,11,25H,10H2,1H3,(H,20,23)(H,21,24)
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8 -46.2n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11759
PNG
(2-{[(2-chlorophenyl)methyl](1,1,2,2,3,3,4,4,5,5,6,...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)NO
Show InChI InChI=1S/C18H12ClF17N2O4S/c1-7(10(39)37-40)38(6-8-4-2-3-5-9(8)19)43(41,42)18(35,36)16(30,31)14(26,27)12(22,23)11(20,21)13(24,25)15(28,29)17(32,33)34/h2-5,7,40H,6H2,1H3,(H,37,39)
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8 -46.2n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)

More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11774
PNG
(hydroxamate deriv. B20 | tert-butyl N-(3-{[(2-chlo...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1cccc(NC(=O)OC(C)(C)C)c1)C(=O)NO
Show InChI InChI=1S/C21H26ClN3O6S/c1-14(19(26)24-28)25(13-15-8-5-6-11-18(15)22)32(29,30)17-10-7-9-16(12-17)23-20(27)31-21(2,3)4/h5-12,14,28H,13H2,1-4H3,(H,23,27)(H,24,26)
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8 -46.2n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11782
PNG
(3-{[(2-chlorophenyl)methyl][1-(hydroxycarbamoyl)et...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1cccc(c1)C(=O)NO)C(=O)NO
Show InChI InChI=1S/C17H18ClN3O6S/c1-11(16(22)19-24)21(10-13-5-2-3-8-15(13)18)28(26,27)14-7-4-6-12(9-14)17(23)20-25/h2-9,11,24-25H,10H2,1H3,(H,19,22)(H,20,23)
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8 -46.2n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


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More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11781
PNG
(2-{[(2-chlorophenyl)methyl](3,5-dichloro-2-hydroxy...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1cc(Cl)cc(Cl)c1O)C(=O)NO
Show InChI InChI=1S/C16H15Cl3N2O5S/c1-9(16(23)20-24)21(8-10-4-2-3-5-12(10)18)27(25,26)14-7-11(17)6-13(19)15(14)22/h2-7,9,22,24H,8H2,1H3,(H,20,23)
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9 -45.9n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11773
PNG
(hydroxamate deriv. B19 | tert-butyl N-(4-{[(2-chlo...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(=O)NO
Show InChI InChI=1S/C21H26ClN3O6S/c1-14(19(26)24-28)25(13-15-7-5-6-8-18(15)22)32(29,30)17-11-9-16(10-12-17)23-20(27)31-21(2,3)4/h5-12,14,28H,13H2,1-4H3,(H,23,27)(H,24,26)
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9 -45.9n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11785
PNG
(2-{[(2-chlorophenyl)methyl](naphthalene-2-)sulfona...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc2ccccc2c1)C(=O)NO
Show InChI InChI=1S/C20H19ClN2O4S/c1-14(20(24)22-25)23(13-17-8-4-5-9-19(17)21)28(26,27)18-11-10-15-6-2-3-7-16(15)12-18/h2-12,14,25H,13H2,1H3,(H,22,24)
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9 -45.9n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11803
PNG
(2-{[(2-chlorophenyl)methyl]({[(4-fluorobenzene)sul...)
Show SMILES CC(N(Cc1ccccc1Cl)C(=O)NS(=O)(=O)c1ccc(F)cc1)C(=O)NO
Show InChI InChI=1S/C17H17ClFN3O5S/c1-11(16(23)20-25)22(10-12-4-2-3-5-15(12)18)17(24)21-28(26,27)14-8-6-13(19)7-9-14/h2-9,11,25H,10H2,1H3,(H,20,23)(H,21,24)
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9 -45.9n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11786
PNG
(2-{[(2-chlorophenyl)methyl][5-(dimethylamino)napht...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1cccc2c(cccc12)N(C)C)C(=O)NO
Show InChI InChI=1S/C22H24ClN3O4S/c1-15(22(27)24-28)26(14-16-8-4-5-11-19(16)23)31(29,30)21-13-7-9-17-18(21)10-6-12-20(17)25(2)3/h4-13,15,28H,14H2,1-3H3,(H,24,27)
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10 -45.7n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11771
PNG
(2-[(3-chloro-4-nitrobenzene)[(2-chlorophenyl)methy...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc(c(Cl)c1)[N+]([O-])=O)C(=O)NO
Show InChI InChI=1S/C16H15Cl2N3O6S/c1-10(16(22)19-23)20(9-11-4-2-3-5-13(11)17)28(26,27)12-6-7-15(21(24)25)14(18)8-12/h2-8,10,23H,9H2,1H3,(H,19,22)
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10 -45.7n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11342
PNG
(2-[benzyl(1,1,2,2,3,3,4,4,4-nonafluorobutane)sulfo...)
Show SMILES CC(C)C(N(Cc1ccccc1)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)NO
Show InChI InChI=1S/C16H17F9N2O4S/c1-9(2)11(12(28)26-29)27(8-10-6-4-3-5-7-10)32(30,31)16(24,25)14(19,20)13(17,18)15(21,22)23/h3-7,9,11,29H,8H2,1-2H3,(H,26,28)
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10 -45.7n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11356
PNG
(Hydroxamate 37 | N-hydroxy-2-{[(2-nitrophenyl)meth...)
Show SMILES CC(N(Cc1ccccc1N(=O)=O)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)NO
Show InChI InChI=1S/C14H12F9N3O6S/c1-7(10(27)24-28)25(6-8-4-2-3-5-9(8)26(29)30)33(31,32)14(22,23)12(17,18)11(15,16)13(19,20)21/h2-5,7,28H,6H2,1H3,(H,24,27)
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10 -45.7n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11806
PNG
(2-{[(2-chlorophenyl)methyl]({[(2-methylbenzene)sul...)
Show SMILES CC(N(Cc1ccccc1Cl)C(=O)NS(=O)(=O)c1ccccc1C)C(=O)NO
Show InChI InChI=1S/C18H20ClN3O5S/c1-12-7-3-6-10-16(12)28(26,27)21-18(24)22(13(2)17(23)20-25)11-14-8-4-5-9-15(14)19/h3-10,13,25H,11H2,1-2H3,(H,20,23)(H,21,24)
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10 -45.7n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11815
PNG
(2-{[(2-chlorophenyl)methyl][(2,4-dinitrophenyl)sul...)
Show SMILES CC(N(Cc1ccccc1Cl)Sc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O)C(=O)NO
Show InChI InChI=1S/C16H15ClN4O6S/c1-10(16(22)18-23)19(9-11-4-2-3-5-13(11)17)28-15-7-6-12(20(24)25)8-14(15)21(26)27/h2-8,10,23H,9H2,1H3,(H,18,22)
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11 -45.4n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11362
PNG
(2-{[(2-chlorophenyl)methyl](1,1,2,2,3,3,4,4,4-nona...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)NO
Show InChI InChI=1S/C14H12ClF9N2O4S/c1-7(10(27)25-28)26(6-8-4-2-3-5-9(8)15)31(29,30)14(23,24)12(18,19)11(16,17)13(20,21)22/h2-5,7,28H,6H2,1H3,(H,25,27)
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11 -45.4n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)

More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11769
PNG
(2-{[(2-chlorophenyl)methyl](3-nitrobenzene)sulfona...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1cccc(c1)[N+]([O-])=O)C(=O)NO
Show InChI InChI=1S/C16H16ClN3O6S/c1-11(16(21)18-22)19(10-12-5-2-3-8-15(12)17)27(25,26)14-7-4-6-13(9-14)20(23)24/h2-9,11,22H,10H2,1H3,(H,18,21)
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11 -45.4n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11805
PNG
((2S)-2-{[(2-chlorophenyl)methyl]({[(4-methylbenzen...)
Show SMILES C[C@H](N(Cc1ccccc1Cl)C(=O)NS(=O)(=O)c1ccc(C)cc1)C(=O)NO
Show InChI InChI=1S/C18H20ClN3O5S/c1-12-7-9-15(10-8-12)28(26,27)21-18(24)22(13(2)17(23)20-25)11-14-5-3-4-6-16(14)19/h3-10,13,25H,11H2,1-2H3,(H,20,23)(H,21,24)/t13-/m0/s1
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11 -45.4n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11359
PNG
(Hydroxamate 40 | N-hydroxy-2-{[(4-nitrophenyl)meth...)
Show SMILES CC(N(Cc1ccc(cc1)N(=O)=O)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)NO
Show InChI InChI=1S/C14H12F9N3O6S/c1-7(10(27)24-28)25(6-8-2-4-9(5-3-8)26(29)30)33(31,32)14(22,23)12(17,18)11(15,16)13(19,20)21/h2-5,7,28H,6H2,1H3,(H,24,27)
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11 -45.4n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11772
PNG
(2-{[(2-chlorophenyl)methyl](4-acetamidobenzene)sul...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc(NC(C)=O)cc1)C(=O)NO
Show InChI InChI=1S/C18H20ClN3O5S/c1-12(18(24)21-25)22(11-14-5-3-4-6-17(14)19)28(26,27)16-9-7-15(8-10-16)20-13(2)23/h3-10,12,25H,11H2,1-2H3,(H,20,23)(H,21,24)
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11 -45.4n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11362
PNG
(2-{[(2-chlorophenyl)methyl](1,1,2,2,3,3,4,4,4-nona...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)NO
Show InChI InChI=1S/C14H12ClF9N2O4S/c1-7(10(27)25-28)26(6-8-4-2-3-5-9(8)15)31(29,30)14(23,24)12(18,19)11(16,17)13(20,21)22/h2-5,7,28H,6H2,1H3,(H,25,27)
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11 -45.4n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11787
PNG
(2-{[(2-chlorophenyl)methyl](thiophene-2-)sulfonami...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1cccs1)C(=O)NO
Show InChI InChI=1S/C14H15ClN2O4S2/c1-10(14(18)16-19)17(9-11-5-2-3-6-12(11)15)23(20,21)13-7-4-8-22-13/h2-8,10,19H,9H2,1H3,(H,16,18)
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11 -45.4n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11812
PNG
(2-{[(2-chlorophenyl)methyl](naphthalen-1-ylcarbamo...)
Show SMILES CC(N(Cc1ccccc1Cl)C(=O)Nc1cccc2ccccc12)C(=O)NO
Show InChI InChI=1S/C21H20ClN3O3/c1-14(20(26)24-28)25(13-16-8-3-5-11-18(16)22)21(27)23-19-12-6-9-15-7-2-4-10-17(15)19/h2-12,14,28H,13H2,1H3,(H,23,27)(H,24,26)
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11 -45.4n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11814
PNG
(2-{[(2-chlorophenyl)methyl][(2-nitrophenyl)sulfany...)
Show SMILES CC(N(Cc1ccccc1Cl)Sc1ccccc1[N+]([O-])=O)C(=O)NO
Show InChI InChI=1S/C16H16ClN3O4S/c1-11(16(21)18-22)19(10-12-6-2-3-7-13(12)17)25-15-9-5-4-8-14(15)20(23)24/h2-9,11,22H,10H2,1H3,(H,18,21)
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12 -45.2n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11335
PNG
(2-[benzyl(1,1,2,2,3,3,4,4,4-nonafluorobutane)sulfo...)
Show SMILES CC(N(Cc1ccccc1)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)NO
Show InChI InChI=1S/C14H13F9N2O4S/c1-8(10(26)24-27)25(7-9-5-3-2-4-6-9)30(28,29)14(22,23)12(17,18)11(15,16)13(19,20)21/h2-6,8,27H,7H2,1H3,(H,24,26)
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12 -45.2n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11353
PNG
(Hydroxamate 34 | N-hydroxy-2-{[(4-nitrophenyl)meth...)
Show SMILES ONC(=O)CN(Cc1ccc(cc1)N(=O)=O)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C13H10F9N3O6S/c14-10(15,12(18,19)20)11(16,17)13(21,22)32(30,31)24(6-9(26)23-27)5-7-1-3-8(4-2-7)25(28)29/h1-4,27H,5-6H2,(H,23,26)
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12 -45.2n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11813
PNG
((2S)-2-{[(2-chlorophenyl)methyl][(4-nitrophenyl)su...)
Show SMILES C[C@H](N(Cc1ccccc1Cl)Sc1ccc(cc1)[N+]([O-])=O)C(=O)NO
Show InChI InChI=1S/C16H16ClN3O4S/c1-11(16(21)18-22)19(10-12-4-2-3-5-15(12)17)25-14-8-6-13(7-9-14)20(23)24/h2-9,11,22H,10H2,1H3,(H,18,21)/t11-/m0/s1
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13 -45.0n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


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More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11350
PNG
(Hydroxamate 31 | N-hydroxy-2-{[(2-nitrophenyl)meth...)
Show SMILES ONC(=O)CN(Cc1ccccc1N(=O)=O)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C13H10F9N3O6S/c14-10(15,12(18,19)20)11(16,17)13(21,22)32(30,31)24(6-9(26)23-27)5-7-3-1-2-4-8(7)25(28)29/h1-4,27H,5-6H2,(H,23,26)
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13 -45.0n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11349
PNG
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C(CC(C)C)C(=O)NO
Show InChI InChI=1S/C20H26N2O5S/c1-15(2)13-19(20(23)21-24)22(14-16-7-5-4-6-8-16)28(25,26)18-11-9-17(27-3)10-12-18/h4-12,15,19,24H,13-14H2,1-3H3,(H,21,23)
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13 -45.0n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11329
PNG
(2-[benzyl(1,1,2,2,3,3,4,4,4-nonafluorobutane)sulfo...)
Show SMILES ONC(=O)CN(Cc1ccccc1)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C13H11F9N2O4S/c14-10(15,12(18,19)20)11(16,17)13(21,22)29(27,28)24(7-9(25)23-26)6-8-4-2-1-3-5-8/h1-5,26H,6-7H2,(H,23,25)
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13 -45.0n/an/an/an/an/a7.525



Universita degli Studi



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11810
PNG
(2-{[(2-chlorophenyl)methyl][(2,4-difluorophenyl)ca...)
Show SMILES CC(N(Cc1ccccc1Cl)C(=O)Nc1ccc(F)cc1F)C(=O)NO
Show InChI InChI=1S/C17H16ClF2N3O3/c1-10(16(24)22-26)23(9-11-4-2-3-5-13(11)18)17(25)21-15-7-6-12(19)8-14(15)20/h2-8,10,26H,9H2,1H3,(H,21,25)(H,22,24)
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14 -44.8n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11768
PNG
(2-{[(2-chlorophenyl)methyl](4-nitrobenzene)sulfona...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O)C(=O)NO
Show InChI InChI=1S/C16H16ClN3O6S/c1-11(16(21)18-22)19(10-12-4-2-3-5-15(12)17)27(25,26)14-8-6-13(7-9-14)20(23)24/h2-9,11,22H,10H2,1H3,(H,18,21)
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15 -44.7n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)

More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11809
PNG
(2-{[(4-chlorophenyl)carbamoyl][(2-chlorophenyl)met...)
Show SMILES CC(N(Cc1ccccc1Cl)C(=O)Nc1ccc(Cl)cc1)C(=O)NO
Show InChI InChI=1S/C17H17Cl2N3O3/c1-11(16(23)21-25)22(10-12-4-2-3-5-15(12)19)17(24)20-14-8-6-13(18)7-9-14/h2-9,11,25H,10H2,1H3,(H,20,24)(H,21,23)
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15 -44.7n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11811
PNG
(2-{[(2-chlorophenyl)methyl][(3,4-dichlorophenyl)ca...)
Show SMILES CC(N(Cc1ccccc1Cl)C(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)NO
Show InChI InChI=1S/C17H16Cl3N3O3/c1-10(16(24)22-26)23(9-11-4-2-3-5-13(11)18)17(25)21-12-6-7-14(19)15(20)8-12/h2-8,10,26H,9H2,1H3,(H,21,25)(H,22,24)
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15 -44.7n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Citation and Details
More data for this
Ligand-Target Pair
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