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Found 36 hits Enz. Inhib. hit(s) with Target = 'Core-binding factor subunit beta (CBFB)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123672
PNG
(US8748618, AI-4-49)
Show SMILES Clc1cc(Cl)c2[nH]c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C12H7Cl2N3/c13-7-5-8(14)11-10(6-7)16-12(17-11)9-3-1-2-4-15-9/h1-6H,(H,16,17)
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US Patent
n/an/a 700n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123674
PNG
(US8748618, AI-4-48)
Show SMILES FC(F)(F)c1cc(Cl)c2[nH]c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C13H7ClF3N3/c14-8-5-7(13(15,16)17)6-10-11(8)20-12(19-10)9-3-1-2-4-18-9/h1-6H,(H,19,20)
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n/an/a 760n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123675
PNG
(US8748618, AI-10-3)
Show SMILES C1CN(CCO1)c1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C16H16N4O/c1-2-6-17-14(3-1)16-18-13-5-4-12(11-15(13)19-16)20-7-9-21-10-8-20/h1-6,11H,7-10H2,(H,18,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123665
PNG
(US8748618, AI-10-47)
Show SMILES FC(F)(F)Oc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H8F3N3O/c14-13(15,16)20-8-4-5-9-11(7-8)19-12(18-9)10-3-1-2-6-17-10/h1-7H,(H,18,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123684
PNG
(US8748618, LD-2-101)
Show SMILES COc1ccnc(c1)-c1nc2ccc(CO)cc2[nH]1
Show InChI InChI=1S/C14H13N3O2/c1-19-10-4-5-15-13(7-10)14-16-11-3-2-9(8-18)6-12(11)17-14/h2-7,18H,8H2,1H3,(H,16,17)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123673
PNG
(US8748618, LD-2-23)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H8F3N3/c14-13(15,16)8-4-5-9-11(7-8)19-12(18-9)10-3-1-2-6-17-10/h1-7H,(H,18,19)
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123671
PNG
(US8748618, AI-10-51)
Show SMILES OCc1cc2nc([nH]c2cc1Cl)-c1ccccn1
Show InChI InChI=1S/C13H10ClN3O/c14-9-6-12-11(5-8(9)7-18)16-13(17-12)10-3-1-2-4-15-10/h1-6,18H,7H2,(H,16,17)
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123670
PNG
(US8748618, LD-1-39)
Show SMILES OCc1c(F)cc2[nH]c(nc2c1F)-c1ccccn1
Show InChI InChI=1S/C13H9F2N3O/c14-8-5-10-12(11(15)7(8)6-19)18-13(17-10)9-3-1-2-4-16-9/h1-5,19H,6H2,(H,17,18)
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123659
PNG
(US8748618, AI-4-70 (or) LD-2-21)
Show SMILES CC(C)Oc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C15H15N3O/c1-10(2)19-11-6-7-12-14(9-11)18-15(17-12)13-5-3-4-8-16-13/h3-10H,1-2H3,(H,17,18)
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123669
PNG
(US8748618, AI-4-43)
Show SMILES Fc1cc2[nH]c(nc2c(F)c1F)-c1ccccn1
Show InChI InChI=1S/C12H6F3N3/c13-6-5-8-11(10(15)9(6)14)18-12(17-8)7-3-1-2-4-16-7/h1-5H,(H,17,18)
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University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123657
PNG
(US8748618, LD-1-29 (or) AI-10-54)
Show SMILES CCOc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C14H13N3O/c1-2-18-10-6-7-11-13(9-10)17-14(16-11)12-5-3-4-8-15-12/h3-9H,2H2,1H3,(H,16,17)
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123663
PNG
(US8748618, AI-10-35)
Show SMILES SCc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H11N3S/c17-8-9-4-5-10-12(7-9)16-13(15-10)11-3-1-2-6-14-11/h1-7,17H,8H2,(H,15,16)
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n/an/a 1.80E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123678
PNG
(US8748618, AI-10-96)
Show SMILES FC(F)(F)Oc1cc(-c2cccnc2)c2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C18H11F3N4O/c19-18(20,21)26-12-8-13(11-4-3-6-22-10-11)16-15(9-12)24-17(25-16)14-5-1-2-7-23-14/h1-10H,(H,24,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM50180737
PNG
(5,6-dimethyl-2-(pyridin-2-yl)-1H-benzo[d]imidazole...)
Show SMILES Cc1cc2nc([nH]c2cc1C)-c1ccccn1
Show InChI InChI=1S/C14H13N3/c1-9-7-12-13(8-10(9)2)17-14(16-12)11-5-3-4-6-15-11/h3-8H,1-2H3,(H,16,17)
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123685
PNG
(US8748618, AI-10-77)
Show SMILES COc1ccnc(c1)-c1nc2ccc(OC=O)cc2[nH]1
Show InChI InChI=1S/C14H11N3O3/c1-19-9-4-5-15-13(6-9)14-16-11-3-2-10(20-8-18)7-12(11)17-14/h2-8H,1H3,(H,16,17)
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123654
PNG
(US8748618, AI-4-57 (or) LD-1-11C | US8748618, LD-1...)
Show SMILES OCc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H11N3O/c17-8-9-4-5-10-12(7-9)16-13(15-10)11-3-1-2-6-14-11/h1-7,17H,8H2,(H,15,16)
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University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123680
PNG
(US8748618, AI-10-11)
Show SMILES COCCOc1ccc(nc1)-c1nc2ccc(CO)cc2[nH]1
Show InChI InChI=1S/C16H17N3O3/c1-21-6-7-22-12-3-5-14(17-9-12)16-18-13-4-2-11(10-20)8-15(13)19-16/h2-5,8-9,20H,6-7,10H2,1H3,(H,18,19)
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM50180732
PNG
(5-Chloro-2-pyridin-2-yl-1H-benzoimidazole | 5-chlo...)
Show SMILES Clc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C12H8ClN3/c13-8-4-5-9-11(7-8)16-12(15-9)10-3-1-2-6-14-10/h1-7H,(H,15,16)
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University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123681
PNG
(US8748618, AI-10-87)
Show SMILES COCCOc1ccc(nc1)-c1nc2ccc(OC(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C16H14F3N3O3/c1-23-6-7-24-11-3-5-13(20-9-11)15-21-12-4-2-10(8-14(12)22-15)25-16(17,18)19/h2-5,8-9H,6-7H2,1H3,(H,21,22)
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University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM50180735
PNG
(5-fluoro-2-(pyridin-2-yl)-1H-benzo[d]imidazole | 5...)
Show SMILES Fc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C12H8FN3/c13-8-4-5-9-11(7-8)16-12(15-9)10-3-1-2-6-14-10/h1-7H,(H,15,16)
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University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123661
PNG
(US8748618, AI-10-61)
Show SMILES Oc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C12H9N3O/c16-8-4-5-9-11(7-8)15-12(14-9)10-3-1-2-6-13-10/h1-7,16H,(H,14,15)
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University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123668
PNG
(US8748618, LD-1-33)
Show SMILES Fc1cc2nc([nH]c2cc1F)-c1ccccn1
Show InChI InChI=1S/C12H7F2N3/c13-7-5-10-11(6-8(7)14)17-12(16-10)9-3-1-2-4-15-9/h1-6H,(H,16,17)
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University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123679
PNG
(US8748618, AI-4-61 (or) AI-10-52)
Show SMILES COc1ccc(nc1)-c1nc2ccc(CO)cc2[nH]1
Show InChI InChI=1S/C14H13N3O2/c1-19-10-3-5-12(15-7-10)14-16-11-4-2-9(8-18)6-13(11)17-14/h2-7,18H,8H2,1H3,(H,16,17)
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University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123654
PNG
(US8748618, AI-4-57 (or) LD-1-11C | US8748618, LD-1...)
Show SMILES OCc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H11N3O/c17-8-9-4-5-10-12(7-9)16-13(15-10)11-3-1-2-6-14-11/h1-7,17H,8H2,(H,15,16)
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n/an/a 2.60E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM50180733
PNG
(5-Methyl-2-pyridin-2-yl-1H-benzoimidazole | 5-meth...)
Show SMILES Cc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H11N3/c1-9-5-6-10-12(8-9)16-13(15-10)11-4-2-3-7-14-11/h2-8H,1H3,(H,15,16)
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n/an/a 2.90E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123682
PNG
(US8748618, AI-10-53)
Show SMILES COc1cccnc1-c1nc2ccc(CO)cc2[nH]1
Show InChI InChI=1S/C14H13N3O2/c1-19-12-3-2-6-15-13(12)14-16-10-5-4-9(8-18)7-11(10)17-14/h2-7,18H,8H2,1H3,(H,16,17)
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123664
PNG
(US8748618, AI-10-37)
Show SMILES CS(=O)(=O)c1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H11N3O2S/c1-19(17,18)9-5-6-10-12(8-9)16-13(15-10)11-4-2-3-7-14-11/h2-8H,1H3,(H,15,16)
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n/an/a 3.30E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123676
PNG
(US8748618, AI-10-88)
Show SMILES c1cn(cn1)-c1ccc2[nH]c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C15H11N5/c1-2-6-17-13(3-1)15-18-12-5-4-11(9-14(12)19-15)20-8-7-16-10-20/h1-10H,(H,18,19)
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n/an/a 3.40E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123658
PNG
(US8748618, AI-4-42)
Show SMILES CCOc1cccc2[nH]c(nc12)-c1ccccn1
Show InChI InChI=1S/C14H13N3O/c1-2-18-12-8-5-7-10-13(12)17-14(16-10)11-6-3-4-9-15-11/h3-9H,2H2,1H3,(H,16,17)
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n/an/a 4.20E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123667
PNG
(US8748618, LD-1-23)
Show SMILES Cc1ccc2nc([nH]c2c1C)-c1ccccn1
Show InChI InChI=1S/C14H13N3/c1-9-6-7-11-13(10(9)2)17-14(16-11)12-5-3-4-8-15-12/h3-8H,1-2H3,(H,16,17)
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n/an/a 4.30E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123662
PNG
(US8748618, LD-1-138)
Show SMILES OCc1cc2nc([nH]c2cc1CO)-c1ccccn1
Show InChI InChI=1S/C14H13N3O2/c18-7-9-5-12-13(6-10(9)8-19)17-14(16-12)11-3-1-2-4-15-11/h1-6,18-19H,7-8H2,(H,16,17)
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n/an/a 4.60E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123666
PNG
(US8748618, AI-4-46)
Show SMILES Cc1cccc2[nH]c(nc12)-c1ccccn1
Show InChI InChI=1S/C13H11N3/c1-9-5-4-7-10-12(9)16-13(15-10)11-6-2-3-8-14-11/h2-8H,1H3,(H,15,16)
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n/an/a 5.30E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123656
PNG
(US8748618, AI-4-52)
Show SMILES COc1cccc2[nH]c(nc12)-c1ccccn1
Show InChI InChI=1S/C13H11N3O/c1-17-11-7-4-6-9-12(11)16-13(15-9)10-5-2-3-8-14-10/h2-8H,1H3,(H,15,16)
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n/an/a 5.50E+3n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123654
PNG
(US8748618, AI-4-57 (or) LD-1-11C | US8748618, LD-1...)
Show SMILES OCc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H11N3O/c17-8-9-4-5-10-12(7-9)16-13(15-10)11-3-1-2-6-14-11/h1-7,17H,8H2,(H,15,16)
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123683
PNG
(US8748618, AI-10-65)
Show SMILES Fc1cccnc1-c1nc2ccc(OC(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C13H7F4N3O/c14-8-2-1-5-18-11(8)12-19-9-4-3-7(6-10(9)20-12)21-13(15,16)17/h1-6H,(H,19,20)
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n/an/a 2.20E+4n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair
Core-binding factor subunit beta (CBFB)


(Homo sapiens (Human))
BDBM123677
PNG
(US8748618, AI-10-57)
Show SMILES O=COc1ccc2nc([nH]c2c1)-c1ccccn1
Show InChI InChI=1S/C13H9N3O2/c17-8-18-9-4-5-10-12(7-9)16-13(15-10)11-3-1-2-6-14-11/h1-8H,(H,15,16)
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n/an/a 4.00E+4n/an/an/an/an/an/a



University of Virginia Patent Foundation

US Patent


Assay Description
We have developed effective assays to monitor the inhibition of CBFβ-SMMHC binding to the Runt domain (as well as for CBFβ binding to the R...


US Patent US8748618 (2014)

More data for this
Ligand-Target Pair