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Compile Data Set for Download or QSAR

Found 577 hits Enz. Inhib. hit(s) with Target = 'Corticotropin releasing factor receptor' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50087556
PNG
((4-Fluoro-butyl)-propyl-[2,5,6-trimethyl-7-(2,4,6-...)
Show SMILES CCCN(CCCCF)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C25H35FN4/c1-8-12-29(13-10-9-11-26)24-22-19(5)20(6)30(25(22)28-21(7)27-24)23-17(3)14-16(2)15-18(23)4/h14-15H,8-13H2,1-7H3
PDB
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0.910n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum


Bioorg Med Chem Lett 10: 707-10 (2000)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074501
PNG
(Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-ph...)
Show SMILES CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3
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1n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Affinity for the Corticotropin releasing factor receptor 1 (CRHR1) was determined in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074439
PNG
(1-(2-Bromo-4,6-dimethoxy-phenyl)-4,6-dimethyl-1H-p...)
Show SMILES COc1cc(Br)c(c(OC)c1)-n1ccc2c(C)cc(C)nc12
Show InChI InChI=1S/C17H17BrN2O2/c1-10-7-11(2)19-17-13(10)5-6-20(17)16-14(18)8-12(21-3)9-15(16)22-4/h5-9H,1-4H3
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1n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM35723
PNG
(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc23)c(C)c1
Show InChI InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
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1n/an/an/an/an/an/an/an/a



Sanofi-Synthelabo

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM35723
PNG
(CHEMBL344159 | N-[4-(7-Chloro-5-hydroxy-2,3,4,5-te...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc23)c(C)c1
Show InChI InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
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1.70n/an/an/an/an/an/an/an/a



Sanofi-Synthelabo

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50058163
PNG
(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)
Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3
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1.80n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 926-35 (1999)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50131716
PNG
(CHEMBL430892 | [3-(4-Bromo-2-chloro-phenyl)-2,5-di...)
Show SMILES COCCN(CCOC)c1nc(C)nc2c(c(C)nn12)-c1ccc(Br)cc1Cl
Show InChI InChI=1S/C19H23BrClN5O2/c1-12-17(15-6-5-14(20)11-16(15)21)18-22-13(2)23-19(26(18)24-12)25(7-9-27-3)8-10-28-4/h5-6,11H,7-10H2,1-4H3
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1.90n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by ChEMBL


Assay Description
Affinity for the Corticotropin releasing factor receptor 1 (CRHR1) was determined in rat brain


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50087559
PNG
(CHEMBL164206 | Cyclopropylmethyl-propyl-[2,5,6-tri...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C25H34N4/c1-8-11-28(14-21-9-10-21)24-22-18(5)19(6)29(25(22)27-20(7)26-24)23-16(3)12-15(2)13-17(23)4/h12-13,21H,8-11,14H2,1-7H3
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2.30n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum


Bioorg Med Chem Lett 10: 707-10 (2000)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074501
PNG
(Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-ph...)
Show SMILES CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3
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2.5n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum


Bioorg Med Chem Lett 10: 707-10 (2000)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50096721
PNG
(5-Chloro-N-cyclopropylmethyl-N'-(2,6-dichloro-4-tr...)
Show SMILES CCCC[Sn](CCCC)(CCCC)c1cc(Cl)c(Nc2nc(C)nc(N(CCC)CC3CC3)c2Cl)c(Cl)c1
Show InChI InChI=1S/C18H20Cl3N4.3C4H9.Sn/c1-3-9-25(10-12-7-8-12)18-15(21)17(22-11(2)23-18)24-16-13(19)5-4-6-14(16)20;3*1-3-4-2;/h5-6,12H,3,7-10H2,1-2H3,(H,22,23,24);3*1,3-4H2,2H3;
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3n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Binding affinity towards Corticotropin releasing hormone receptor type 1 of rat cerebellum using [125I]-Tyr-sauvagine as radioligand.


Bioorg Med Chem Lett 11: 331-3 (2001)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50087560
PNG
(CHEMBL348967 | Ethyl-(4-fluoro-butyl)-[2,5,6-trime...)
Show SMILES CCN(CCCCF)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H33FN4/c1-8-28(12-10-9-11-25)23-21-18(5)19(6)29(24(21)27-20(7)26-23)22-16(3)13-15(2)14-17(22)4/h13-14H,8-12H2,1-7H3
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3.5n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum


Bioorg Med Chem Lett 10: 707-10 (2000)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50116105
PNG
(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C
Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3
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3.80n/an/an/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Displacement of [125I]-sauvagine from rat CRF-1 receptor expressed in rat cortical membrane after 2 hrs by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074411
PNG
((2-Bromo-4,6-dimethoxy-phenyl)-(4,6-dimethyl-pyrim...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1c(Br)cc(OC)cc1OC
Show InChI InChI=1S/C16H20BrN3O2/c1-6-20(16-18-10(2)7-11(3)19-16)15-13(17)8-12(21-4)9-14(15)22-5/h7-9H,6H2,1-5H3
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5n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50348782
PNG
(CHEMBL1807053)
Show SMILES CCC(CC)Nc1nc(C)c(nc1OC)-c1ccc(OC(F)(F)F)cc1OC
Show InChI InChI=1S/C19H24F3N3O3/c1-6-12(7-2)24-17-18(27-5)25-16(11(3)23-17)14-9-8-13(10-15(14)26-4)28-19(20,21)22/h8-10,12H,6-7H2,1-5H3,(H,23,24)
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9.80n/an/an/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Displacement of [125I]-sauvagine from rat CRF-1 receptor expressed in rat cortical membrane after 2 hrs by scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50087561
PNG
(Butyl-(4-fluoro-butyl)-[2,5,6-trimethyl-7-(2,4,6-t...)
Show SMILES CCCCN(CCCCF)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C26H37FN4/c1-8-9-13-30(14-11-10-12-27)25-23-20(5)21(6)31(26(23)29-22(7)28-25)24-18(3)15-17(2)16-19(24)4/h15-16H,8-14H2,1-7H3
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10n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum


Bioorg Med Chem Lett 10: 707-10 (2000)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50096722
PNG
(5-Chloro-N-cyclopropylmethyl-N'-(2,6-dichloro-4-io...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(I)cc2Cl)c1Cl
Show InChI InChI=1S/C18H20Cl3IN4/c1-3-6-26(9-11-4-5-11)18-15(21)17(23-10(2)24-18)25-16-13(19)7-12(22)8-14(16)20/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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14n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Binding affinity towards Corticotropin releasing hormone receptor type 1 of rat cerebellum using [125I]-Tyr-sauvagine as radioligand.


Bioorg Med Chem Lett 11: 331-3 (2001)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074456
PNG
(CHEMBL10504 | SC241 | [3-(2-Bromo-4-isopropyl-phen...)
Show SMILES COCCN(CCOC)c1nc(C)nc2n(nnc12)-c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C20H27BrN6O2/c1-13(2)15-6-7-17(16(21)12-15)27-20-18(24-25-27)19(22-14(3)23-20)26(8-10-28-4)9-11-29-5/h6-7,12-13H,8-11H2,1-5H3
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14.8n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 926-35 (1999)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM85397
PNG
(CRA1000)
Show SMILES CCN(c1nc(C)cc(n1)N1CCC=C(C1)c1cccc(F)c1)c1ccc(CC(C)C)cc1SC
Show InChI InChI=1S/C29H35FN4S/c1-6-34(26-13-12-22(15-20(2)3)17-27(26)35-5)29-31-21(4)16-28(32-29)33-14-8-10-24(19-33)23-9-7-11-25(30)18-23/h7,9-13,16-18,20H,6,8,14-15,19H2,1-5H3
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15.7n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 926-35 (1999)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50177574
PNG
(3-(4-(2-methoxybenzyloxy)phenylsulfonyl)-N-mesityl...)
Show SMILES COc1ccccc1COc1ccc(cc1)S(=O)(=O)c1ccc(C)nc1Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C29H30N2O4S/c1-19-16-20(2)28(21(3)17-19)31-29-27(15-10-22(4)30-29)36(32,33)25-13-11-24(12-14-25)35-18-23-8-6-7-9-26(23)34-5/h6-17H,18H2,1-5H3,(H,30,31)
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17n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM85398
PNG
(CRA1001)
Show SMILES CCN(c1nc(C)cc(n1)N1CCC=C(C1)c1cccc(F)c1)c1ccc(CC(C)C)cc1Br
Show InChI InChI=1S/C28H32BrFN4/c1-5-34(26-12-11-21(14-19(2)3)16-25(26)29)28-31-20(4)15-27(32-28)33-13-7-9-23(18-33)22-8-6-10-24(30)17-22/h6,8-12,15-17,19H,5,7,13-14,18H2,1-4H3
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18.6n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 926-35 (1999)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM85397
PNG
(CRA1000)
Show SMILES CCN(c1nc(C)cc(n1)N1CCC=C(C1)c1cccc(F)c1)c1ccc(CC(C)C)cc1SC
Show InChI InChI=1S/C29H35FN4S/c1-6-34(26-13-12-22(15-20(2)3)17-27(26)35-5)29-31-21(4)16-28(32-29)33-14-8-10-24(19-33)23-9-7-11-25(30)18-23/h7,9-13,16-18,20H,6,8,14-15,19H2,1-5H3
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PubMed
20.6n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 926-35 (1999)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074456
PNG
(CHEMBL10504 | SC241 | [3-(2-Bromo-4-isopropyl-phen...)
Show SMILES COCCN(CCOC)c1nc(C)nc2n(nnc12)-c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C20H27BrN6O2/c1-13(2)15-6-7-17(16(21)12-15)27-20-18(24-25-27)19(22-14(3)23-20)26(8-10-28-4)9-11-29-5/h6-7,12-13H,8-11H2,1-5H3
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20.7n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 926-35 (1999)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50096723
PNG
(CHEMBL113333 | N-(4-Bromo-2,6-dichloro-phenyl)-5-c...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Br)cc2Cl)c1Cl
Show InChI InChI=1S/C18H20BrCl3N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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21n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Binding affinity towards Corticotropin releasing hormone receptor type 1 of rat cerebellum using [125I]-Tyr-sauvagine as radioligand.


Bioorg Med Chem Lett 11: 331-3 (2001)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074372
PNG
((2-Bromo-4-isopropyl-phenyl)-ethyl-(4-methyl-6-mor...)
Show SMILES CCN(c1nc(C)cc(n1)N1CCOCC1)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C20H27BrN4O/c1-5-25(18-7-6-16(14(2)3)13-17(18)21)20-22-15(4)12-19(23-20)24-8-10-26-11-9-24/h6-7,12-14H,5,8-11H2,1-4H3
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22n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM85398
PNG
(CRA1001)
Show SMILES CCN(c1nc(C)cc(n1)N1CCC=C(C1)c1cccc(F)c1)c1ccc(CC(C)C)cc1Br
Show InChI InChI=1S/C28H32BrFN4/c1-5-34(26-12-11-21(14-19(2)3)16-25(26)29)28-31-20(4)15-27(32-28)33-13-7-9-23(18-33)22-8-6-10-24(30)17-22/h6,8-12,15-17,19H,5,7,13-14,18H2,1-4H3
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22.3n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 289: 926-35 (1999)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074435
PNG
(1-(2-Bromo-4-isopropyl-phenyl)-6-methyl-4-morpholi...)
Show SMILES CC(C)c1ccc(c(Br)c1)-n1ccc2c(cc(C)nc12)N1CCOCC1
Show InChI InChI=1S/C21H24BrN3O/c1-14(2)16-4-5-19(18(22)13-16)25-7-6-17-20(12-15(3)23-21(17)25)24-8-10-26-11-9-24/h4-7,12-14H,8-11H2,1-3H3
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28n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074420
PNG
(1-(2-Bromo-4,6-dimethoxy-phenyl)-4,6-dimethyl-1H-p...)
Show SMILES COc1cc(Br)c(c(OC)c1)-n1cc(C#N)c2c(C)cc(C)nc12
Show InChI InChI=1S/C18H16BrN3O2/c1-10-5-11(2)21-18-16(10)12(8-20)9-22(18)17-14(19)6-13(23-3)7-15(17)24-4/h5-7,9H,1-4H3
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29n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50087557
PNG
(CHEMBL164042 | Cyclopropylmethyl-(3-fluoro-propyl)...)
Show SMILES Cc1c(C)c2c(nc(C)nc2n1-c1c(C)cc(C)cc1C)N(CCCF)CC1CC1
Show InChI InChI=1S/C25H33FN4/c1-15-12-16(2)23(17(3)13-15)30-19(5)18(4)22-24(27-20(6)28-25(22)30)29(11-7-10-26)14-21-8-9-21/h12-13,21H,7-11,14H2,1-6H3
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30n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Compound was tested in vitro for its ability to displace [125 I]Tyr-sauvagine from corticotropin-releasing hormone type 1 receptor in rat cerebellum


Bioorg Med Chem Lett 10: 707-10 (2000)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50054245
PNG
(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl
Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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PubMed
31n/an/an/an/an/an/an/an/a



NIDDK

Curated by ChEMBL


Assay Description
Binding affinity towards Corticotropin releasing hormone receptor type 1 of rat cerebellum using [125I]-Tyr-sauvagine as radioligand.


Bioorg Med Chem Lett 11: 331-3 (2001)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50177568
PNG
(3-(4-(benzyloxy)phenylsulfonyl)-N-mesityl-6-methyl...)
Show SMILES Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCc3ccccc3)cc2)c(C)c1
Show InChI InChI=1S/C28H28N2O3S/c1-19-16-20(2)27(21(3)17-19)30-28-26(15-10-22(4)29-28)34(31,32)25-13-11-24(12-14-25)33-18-23-8-6-5-7-9-23/h5-17H,18H2,1-4H3,(H,29,30)
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32n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50177576
PNG
(3-(4-(3,5-dimethoxybenzyloxy)phenylsulfonyl)-N-mes...)
Show SMILES COc1cc(COc2ccc(cc2)S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)cc(OC)c1
Show InChI InChI=1S/C30H32N2O5S/c1-19-13-20(2)29(21(3)14-19)32-30-28(12-7-22(4)31-30)38(33,34)27-10-8-24(9-11-27)37-18-23-15-25(35-5)17-26(16-23)36-6/h7-17H,18H2,1-6H3,(H,31,32)
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34n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074425
PNG
(1-(2-Bromo-4-isopropyl-phenyl)-6-methyl-4-phenyl-1...)
Show SMILES CC(C)c1ccc(c(Br)c1)-n1cc(C#N)c2c(cc(C)nc12)-c1ccccc1
Show InChI InChI=1S/C24H20BrN3/c1-15(2)18-9-10-22(21(25)12-18)28-14-19(13-26)23-20(11-16(3)27-24(23)28)17-7-5-4-6-8-17/h4-12,14-15H,1-3H3
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34n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074429
PNG
(1-(2-Bromo-4-isopropyl-phenyl)-6-methyl-4-phenyl-1...)
Show SMILES CC(C)c1ccc(c(Br)c1)-n1ccc2c(cc(C)nc12)-c1ccccc1
Show InChI InChI=1S/C23H21BrN2/c1-15(2)18-9-10-22(21(24)14-18)26-12-11-19-20(13-16(3)25-23(19)26)17-7-5-4-6-8-17/h4-15H,1-3H3
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36n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074351
PNG
((4,6-Dimethyl-pyrimidin-2-yl)-ethyl-(2-iodo-4-isop...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(cc1I)C(C)C
Show InChI InChI=1S/C17H22IN3/c1-6-21(17-19-12(4)9-13(5)20-17)16-8-7-14(11(2)3)10-15(16)18/h7-11H,6H2,1-5H3
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38n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074351
PNG
((4,6-Dimethyl-pyrimidin-2-yl)-ethyl-(2-iodo-4-isop...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(cc1I)C(C)C
Show InChI InChI=1S/C17H22IN3/c1-6-21(17-19-12(4)9-13(5)20-17)16-8-7-14(11(2)3)10-15(16)18/h7-11H,6H2,1-5H3
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38n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074353
PNG
((2-Bromo-4,6-dimethoxy-phenyl)-ethyl-(4-methyl-6-m...)
Show SMILES CCN(c1nc(C)nc(n1)N1CCOCC1)c1c(Br)cc(OC)cc1OC
Show InChI InChI=1S/C18H24BrN5O3/c1-5-24(16-14(19)10-13(25-3)11-15(16)26-4)18-21-12(2)20-17(22-18)23-6-8-27-9-7-23/h10-11H,5-9H2,1-4H3
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43n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074350
PNG
((2-Bromo-4-isopropyl-phenyl)-(4,6-dimethyl-pyrimid...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C17H22BrN3/c1-6-21(17-19-12(4)9-13(5)20-17)16-8-7-14(11(2)3)10-15(16)18/h7-11H,6H2,1-5H3
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46n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074350
PNG
((2-Bromo-4-isopropyl-phenyl)-(4,6-dimethyl-pyrimid...)
Show SMILES CCN(c1nc(C)cc(C)n1)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C17H22BrN3/c1-6-21(17-19-12(4)9-13(5)20-17)16-8-7-14(11(2)3)10-15(16)18/h7-11H,6H2,1-5H3
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46n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074437
PNG
(1-(2-Bromo-4-isopropyl-phenyl)-4,6-dimethyl-1H-pyr...)
Show SMILES CC(C)c1ccc(c(Br)c1)-n1ccc2c(C)cc(C)nc12
Show InChI InChI=1S/C18H19BrN2/c1-11(2)14-5-6-17(16(19)10-14)21-8-7-15-12(3)9-13(4)20-18(15)21/h5-11H,1-4H3
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47n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074432
PNG
((4,6-Dimethyl-pyrimidin-2-yl)-(2-iodo-4-isopropyl-...)
Show SMILES CC(C)c1ccc(N(C)c2nc(C)cc(C)n2)c(I)c1
Show InChI InChI=1S/C16H20IN3/c1-10(2)13-6-7-15(14(17)9-13)20(5)16-18-11(3)8-12(4)19-16/h6-10H,1-5H3
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48n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50177581
PNG
(CHEMBL437893 | methyl 3-((4-(2-(mesitylamino)-6-me...)
Show SMILES COC(=O)c1cccc(COc2ccc(cc2)S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)c1
Show InChI InChI=1S/C30H30N2O5S/c1-19-15-20(2)28(21(3)16-19)32-29-27(14-9-22(4)31-29)38(34,35)26-12-10-25(11-13-26)37-18-23-7-6-8-24(17-23)30(33)36-5/h6-17H,18H2,1-5H3,(H,31,32)
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49n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50177584
PNG
(3-(4-ethylphenylsulfonyl)-N-mesityl-6-methylpyridi...)
Show SMILES CCc1ccc(cc1)S(=O)(=O)c1ccc(C)nc1Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H26N2O2S/c1-6-19-8-10-20(11-9-19)28(26,27)21-12-7-18(5)24-23(21)25-22-16(3)13-15(2)14-17(22)4/h7-14H,6H2,1-5H3,(H,24,25)
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52n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50177572
PNG
(3-(4-(3-methoxybenzyloxy)phenylsulfonyl)-N-mesityl...)
Show SMILES COc1cccc(COc2ccc(cc2)S(=O)(=O)c2ccc(C)nc2Nc2c(C)cc(C)cc2C)c1
Show InChI InChI=1S/C29H30N2O4S/c1-19-15-20(2)28(21(3)16-19)31-29-27(14-9-22(4)30-29)36(32,33)26-12-10-24(11-13-26)35-18-23-7-6-8-25(17-23)34-5/h6-17H,18H2,1-5H3,(H,30,31)
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58n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074430
PNG
(1-(2-Bromo-4-isopropyl-phenyl)-4-chloro-6-methyl-1...)
Show SMILES CC(C)c1ccc(c(Br)c1)-n1ccc2c(Cl)cc(C)nc12
Show InChI InChI=1S/C17H16BrClN2/c1-10(2)12-4-5-16(14(18)9-12)21-7-6-13-15(19)8-11(3)20-17(13)21/h4-10H,1-3H3
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67n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50177582
PNG
(3-((4-(2-(mesitylamino)-6-methylpyridin-3-ylsulfon...)
Show SMILES Cc1cc(C)c(Nc2nc(C)ccc2S(=O)(=O)c2ccc(OCc3cccc(c3)C#N)cc2)c(C)c1
Show InChI InChI=1S/C29H27N3O3S/c1-19-14-20(2)28(21(3)15-19)32-29-27(13-8-22(4)31-29)36(33,34)26-11-9-25(10-12-26)35-18-24-7-5-6-23(16-24)17-30/h5-16H,18H2,1-4H3,(H,31,32)
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75n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor in rat frontal cortex homogenates


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074419
PNG
(1-(2-Bromo-4-isopropyl-phenyl)-6-chloro-4-methyl-1...)
Show SMILES CC(C)c1ccc(c(Br)c1)-n1ccc2c(C)cc(Cl)nc12
Show InChI InChI=1S/C17H16BrClN2/c1-10(2)12-4-5-15(14(18)9-12)21-7-6-13-11(3)8-16(19)20-17(13)21/h4-10H,1-3H3
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79n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074408
PNG
((2-Bromo-4-isopropyl-phenyl)-(4,6-dimethyl-pyrimid...)
Show SMILES CC(C)c1ccc(N(C)c2nc(C)cc(C)n2)c(Br)c1
Show InChI InChI=1S/C16H20BrN3/c1-10(2)13-6-7-15(14(17)9-13)20(5)16-18-11(3)8-12(4)19-16/h6-10H,1-5H3
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96n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074408
PNG
((2-Bromo-4-isopropyl-phenyl)-(4,6-dimethyl-pyrimid...)
Show SMILES CC(C)c1ccc(N(C)c2nc(C)cc(C)n2)c(Br)c1
Show InChI InChI=1S/C16H20BrN3/c1-10(2)13-6-7-15(14(17)9-13)20(5)16-18-11(3)8-12(4)19-16/h6-10H,1-5H3
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96n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity of the compound was measured on rat Corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50403726
PNG
(CHEMBL2112936)
Show SMILES N[C@H]1CCCC[C@@H]1NC(=O)c1c2N[C@@H]3CCCC[C@H]3Nc2c2C(=O)c3ccccc3-c3ncnc1c23
Show InChI InChI=1S/C28H30N6O2/c29-16-9-3-4-10-17(16)34-28(36)22-24-20-21(25-26(22)33-19-12-6-5-11-18(19)32-25)27(35)15-8-2-1-7-14(15)23(20)30-13-31-24/h1-2,7-8,13,16-19,32-33H,3-6,9-12,29H2,(H,34,36)/t16-,17-,18+,19+/m0/s1
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110n/an/an/an/an/an/an/an/a



A Subsidiary of Agouron Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 9: 765-70 (1999)

More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))
BDBM50074423
PNG
(1-(2-Bromo-4-isopropyl-phenyl)-6-methyl-4-morpholi...)
Show SMILES CC(C)c1ccc(c(Br)c1)-n1cc(C#N)c2c(cc(C)nc12)N1CCOCC1
Show InChI InChI=1S/C22H23BrN4O/c1-14(2)16-4-5-19(18(23)11-16)27-13-17(12-24)21-20(10-15(3)25-22(21)27)26-6-8-28-9-7-26/h4-5,10-11,13-14H,6-9H2,1-3H3
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112n/an/an/an/an/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Binding affinity was determined against corticotropin releasing factor receptor 1


Citation and Details
More data for this
Ligand-Target Pair
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