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Found 107 hits Enz. Inhib. hit(s) with Target = 'Cyclooxygenase-1' AND taxid = 9615   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclooxygenase-1


(Canis familiaris)
BDBM50137420
PNG
(2-[5-(4-Ethoxy-phenyl)-3-trifluoromethyl-pyrazol-1...)
Show SMILES CCOc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C18H16F3N3O3S/c1-3-27-13-6-4-12(5-7-13)15-10-16(18(19,20)21)23-24(15)17-9-8-14(11-22-17)28(2,25)26/h4-11H,3H2,1-2H3
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n/an/a 50n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179624
PNG
(5-(2,3-dimethylphenoxy)-1-(5-(methylsulfonyl)pyrid...)
Show SMILES Cc1cccc(Oc2c(C#N)c(nn2-c2ccc(cn2)S(C)(=O)=O)C(F)(F)F)c1C
Show InChI InChI=1S/C19H15F3N4O3S/c1-11-5-4-6-15(12(11)2)29-18-14(9-23)17(19(20,21)22)25-26(18)16-8-7-13(10-24-16)30(3,27)28/h4-8,10H,1-3H3
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n/an/a 100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179602
PNG
(1-(5-(methylsulfonyl)pyridin-2-yl)-5-(5,6,7,8-tetr...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(c(C#N)c1Oc1cccc2CCCCc12)C(F)(F)F
Show InChI InChI=1S/C21H17F3N4O3S/c1-32(29,30)14-9-10-18(26-12-14)28-20(16(11-25)19(27-28)21(22,23)24)31-17-8-4-6-13-5-2-3-7-15(13)17/h4,6,8-10,12H,2-3,5,7H2,1H3
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179609
PNG
(1-(5-(methylsulfonyl)pyridin-2-yl)-5-(phenylthio)-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(c(C#N)c1Sc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C17H11F3N4O2S2/c1-28(25,26)12-7-8-14(22-10-12)24-16(27-11-5-3-2-4-6-11)13(9-21)15(23-24)17(18,19)20/h2-8,10H,1H3
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n/an/a 200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179598
PNG
(1-(5-(methylsulfonyl)pyridin-2-yl)-5-(propylthio)-...)
Show SMILES CCCSc1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C14H13F3N4O2S2/c1-3-6-24-13-10(7-18)12(14(15,16)17)20-21(13)11-5-4-9(8-19-11)25(2,22)23/h4-5,8H,3,6H2,1-2H3
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n/an/a 200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137411
PNG
(2-[3-Difluoromethyl-5-(4-methoxy-phenyl)-pyrazol-1...)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C17H15F2N3O3S/c1-25-12-5-3-11(4-6-12)15-9-14(17(18)19)21-22(15)16-8-7-13(10-20-16)26(2,23)24/h3-10,17H,1-2H3
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n/an/a 200n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137423
PNG
(2-(4-Chloro-3-difluoromethyl-5-phenyl-pyrazol-1-yl...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(C(F)F)c(Cl)c1-c1ccccc1
Show InChI InChI=1S/C16H12ClF2N3O2S/c1-25(23,24)11-7-8-12(20-9-11)22-15(10-5-3-2-4-6-10)13(17)14(21-22)16(18)19/h2-9,16H,1H3
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n/an/a 330n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179596
PNG
(5-(cyclopentylmethoxy)-1-(5-(methylsulfonyl)pyridi...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(c(C#N)c1OCC1CCCC1)C(F)(F)F
Show InChI InChI=1S/C17H17F3N4O3S/c1-28(25,26)12-6-7-14(22-9-12)24-16(27-10-11-4-2-3-5-11)13(8-21)15(23-24)17(18,19)20/h6-7,9,11H,2-5,10H2,1H3
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n/an/a 400n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179600
PNG
(5-(2-fluorobenzylthio)-1-(5-(methylsulfonyl)pyridi...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(c(C#N)c1SCc1ccccc1F)C(F)(F)F
Show InChI InChI=1S/C18H12F4N4O2S2/c1-30(27,28)12-6-7-15(24-9-12)26-17(13(8-23)16(25-26)18(20,21)22)29-10-11-4-2-3-5-14(11)19/h2-7,9H,10H2,1H3
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137438
PNG
(5-Methanesulfonyl-2-[5-(4-methoxy-phenyl)-3-triflu...)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O3S/c1-26-12-5-3-11(4-6-12)14-9-15(17(18,19)20)22-23(14)16-8-7-13(10-21-16)27(2,24)25/h3-10H,1-2H3
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n/an/a 830n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179616
PNG
(5-(benzylthio)-1-(5-(methylsulfonyl)pyridin-2-yl)-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(c(C#N)c1SCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C18H13F3N4O2S2/c1-29(26,27)13-7-8-15(23-10-13)25-17(28-11-12-5-3-2-4-6-12)14(9-22)16(24-25)18(19,20)21/h2-8,10H,11H2,1H3
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n/an/a 900n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137428
PNG
(2-[3-Difluoromethyl-5-(4-methylsulfanyl-phenyl)-py...)
Show SMILES CSc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C17H15F2N3O2S2/c1-25-12-5-3-11(4-6-12)15-9-14(17(18)19)21-22(15)16-8-7-13(10-20-16)26(2,23)24/h3-10,17H,1-2H3
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n/an/a 900n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137410
PNG
(2-[5-(4-Bromo-phenyl)-3-difluoromethyl-pyrazol-1-y...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Br)cc1)C(F)F
Show InChI InChI=1S/C16H12BrF2N3O2S/c1-25(23,24)12-6-7-15(20-9-12)22-14(8-13(21-22)16(18)19)10-2-4-11(17)5-3-10/h2-9,16H,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137424
PNG
(2-[4-Chloro-5-(3-chloro-4-methoxy-phenyl)-3-difluo...)
Show SMILES COc1ccc(cc1Cl)-c1c(Cl)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C17H13Cl2F2N3O3S/c1-27-12-5-3-9(7-11(12)18)16-14(19)15(17(20)21)23-24(16)13-6-4-10(8-22-13)28(2,25)26/h3-8,17H,1-2H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179631
PNG
(5-(sec-butylthio)-1-(5-(methylsulfonyl)pyridin-2-y...)
Show SMILES CCC(C)Sc1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C15H15F3N4O2S2/c1-4-9(2)25-14-11(7-19)13(15(16,17)18)21-22(14)12-6-5-10(8-20-12)26(3,23)24/h5-6,8-9H,4H2,1-3H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137437
PNG
(5-Methanesulfonyl-2-[5-(4-methylsulfanyl-phenyl)-3...)
Show SMILES CSc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S2/c1-26-12-5-3-11(4-6-12)14-9-15(17(18,19)20)22-23(14)16-8-7-13(10-21-16)27(2,24)25/h3-10H,1-2H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50176555
PNG
(3-(difluoromethyl)-5-(3-methylpiperidin-1-yl)-1-(5...)
Show SMILES CC1CCCN(C1)c1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C17H19F2N5O2S/c1-11-4-3-7-23(10-11)17-13(8-20)15(16(18)19)22-24(17)14-6-5-12(9-21-14)27(2,25)26/h5-6,9,11,16H,3-4,7,10H2,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179608
PNG
(5-(2-ethoxyethylthio)-1-(5-(methylsulfonyl)pyridin...)
Show SMILES CCOCCSc1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C15H15F3N4O3S2/c1-3-25-6-7-26-14-11(8-19)13(15(16,17)18)21-22(14)12-5-4-10(9-20-12)27(2,23)24/h4-5,9H,3,6-7H2,1-2H3
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50182339
PNG
(2-(furan-2-yl)-5-(1-(5-(methylsulfonyl)pyridin-2-y...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(c1)C#N)C(F)(F)F
Show InChI InChI=1S/C21H13F3N4O3S/c1-32(29,30)15-5-7-20(26-12-15)28-17(10-19(27-28)21(22,23)24)13-4-6-16(14(9-13)11-25)18-3-2-8-31-18/h2-10,12H,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137427
PNG
(2-(4-Bromo-3-difluoromethyl-5-phenyl-pyrazol-1-yl)...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(C(F)F)c(Br)c1-c1ccccc1
Show InChI InChI=1S/C16H12BrF2N3O2S/c1-25(23,24)11-7-8-12(20-9-11)22-15(10-5-3-2-4-6-10)13(17)14(21-22)16(18)19/h2-9,16H,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50182350
PNG
(2-(furan-2-yl)-5-(1-(5-(methylsulfonyl)pyridin-2-y...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(c1)C(N)=O)C(F)(F)F
Show InChI InChI=1S/C21H15F3N4O4S/c1-33(30,31)13-5-7-19(26-11-13)28-16(10-18(27-28)21(22,23)24)12-4-6-14(15(9-12)20(25)29)17-3-2-8-32-17/h2-11H,1H3,(H2,25,29)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50182349
PNG
(5-(methylsulfonyl)-2-(5-(4-(thiazol-5-yl)phenyl)-3...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(cc1)-c1cncs1)C(F)(F)F
Show InChI InChI=1S/C19H13F3N4O2S2/c1-30(27,28)14-6-7-18(24-9-14)26-15(8-17(25-26)19(20,21)22)12-2-4-13(5-3-12)16-10-23-11-29-16/h2-11H,1H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137439
PNG
(2-[5-(2-Fluoro-4-methoxy-phenyl)-3-trifluoromethyl...)
Show SMILES COc1ccc(-c2cc(nn2-c2ccc(cn2)S(C)(=O)=O)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C17H13F4N3O3S/c1-27-10-3-5-12(13(18)7-10)14-8-15(17(19,20)21)23-24(14)16-6-4-11(9-22-16)28(2,25)26/h3-9H,1-2H3
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n/an/a 2.80E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179621
PNG
(5-(cyclohexylthio)-1-(5-(methylsulfonyl)pyridin-2-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(c(C#N)c1SC1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C17H17F3N4O2S2/c1-28(25,26)12-7-8-14(22-10-12)24-16(27-11-5-3-2-4-6-11)13(9-21)15(23-24)17(18,19)20/h7-8,10-11H,2-6H2,1H3
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n/an/a 3.20E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179613
PNG
(5-(4-methylpentylthio)-1-(5-(methylsulfonyl)pyridi...)
Show SMILES CC(C)CCCSc1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H19F3N4O2S2/c1-11(2)5-4-8-27-16-13(9-21)15(17(18,19)20)23-24(16)14-7-6-12(10-22-14)28(3,25)26/h6-7,10-11H,4-5,8H2,1-3H3
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n/an/a 3.30E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50182338
PNG
(2-(5-(4-(furan-2-yl)-3-methylphenyl)-3-(trifluorom...)
Show SMILES Cc1cc(ccc1-c1ccco1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C21H16F3N3O3S/c1-13-10-14(5-7-16(13)18-4-3-9-30-18)17-11-19(21(22,23)24)26-27(17)20-8-6-15(12-25-20)31(2,28)29/h3-12H,1-2H3
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n/an/a 3.40E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50176547
PNG
(5-(3-methylbutan-2-ylamino)-1-(5-(methylsulfonyl)p...)
Show SMILES CC(C)C(C)Nc1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C16H18F3N5O2S/c1-9(2)10(3)22-15-12(7-20)14(16(17,18)19)23-24(15)13-6-5-11(8-21-13)27(4,25)26/h5-6,8-10,22H,1-4H3
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n/an/a 3.40E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179628
PNG
(1-(5-(methylsulfonyl)pyridin-2-yl)-5-(pentylthio)-...)
Show SMILES CCCCCSc1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C16H17F3N4O2S2/c1-3-4-5-8-26-15-12(9-20)14(16(17,18)19)22-23(15)13-7-6-11(10-21-13)27(2,24)25/h6-7,10H,3-5,8H2,1-2H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50182353
PNG
(2-(3-(difluoromethyl)-5-(3-methyl-4-(thiazol-4-yl)...)
Show SMILES Cc1cc(ccc1-c1cscn1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C20H16F2N4O2S2/c1-12-7-13(3-5-15(12)17-10-29-11-24-17)18-8-16(20(21)22)25-26(18)19-6-4-14(9-23-19)30(2,27)28/h3-11,20H,1-2H3
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n/an/a 3.80E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50176532
PNG
(6-(4-cyano-3-(difluoromethyl)-5-(2-methylbutylamin...)
Show SMILES CCC(C)CNc1c(C#N)c(nn1-c1ccc(cn1)S(N)(=O)=O)C(F)F
Show InChI InChI=1S/C15H18F2N6O2S/c1-3-9(2)7-21-15-11(6-18)13(14(16)17)22-23(15)12-5-4-10(8-20-12)26(19,24)25/h4-5,8-9,14,21H,3,7H2,1-2H3,(H2,19,24,25)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50176541
PNG
(6-(4-cyano-5-(2-methylbutylamino)-3-(trifluorometh...)
Show SMILES CCC(C)CNc1c(C#N)c(nn1-c1ccc(cn1)S(N)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C15H17F3N6O2S/c1-3-9(2)7-22-14-11(6-19)13(15(16,17)18)23-24(14)12-5-4-10(8-21-12)27(20,25)26/h4-5,8-9,22H,3,7H2,1-2H3,(H2,20,25,26)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50182334
PNG
(2-(3-(difluoromethyl)-5-(3-fluoro-4-(furan-2-yl)ph...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(F)c1)C(F)F
Show InChI InChI=1S/C20H14F3N3O3S/c1-30(27,28)13-5-7-19(24-11-13)26-17(10-16(25-26)20(22)23)12-4-6-14(15(21)9-12)18-3-2-8-29-18/h2-11,20H,1H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50182352
PNG
(2-(5-(3-chloro-4-(furan-2-yl)phenyl)-3-(difluorome...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(Cl)c1)C(F)F
Show InChI InChI=1S/C20H14ClF2N3O3S/c1-30(27,28)13-5-7-19(24-11-13)26-17(10-16(25-26)20(22)23)12-4-6-14(15(21)9-12)18-3-2-8-29-18/h2-11,20H,1H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM11639
PNG
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
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n/an/a 5.57E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclooxygenase-1


(Canis familiaris)
BDBM50176533
PNG
(1-(5-(methylsulfonyl)pyridin-2-yl)-5-(thiophen-2-y...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(c(C#N)c1NCc1cccs1)C(F)(F)F
Show InChI InChI=1S/C16H12F3N5O2S2/c1-28(25,26)11-4-5-13(21-9-11)24-15(22-8-10-3-2-6-27-10)12(7-20)14(23-24)16(17,18)19/h2-6,9,22H,8H2,1H3
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n/an/a 5.60E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50176539
PNG
(1-(5-(methylsulfonyl)pyridin-2-yl)-5-(pentan-3-yla...)
Show SMILES CCC(CC)Nc1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C16H18F3N5O2S/c1-4-10(5-2)22-15-12(8-20)14(16(17,18)19)23-24(15)13-7-6-11(9-21-13)27(3,25)26/h6-7,9-10,22H,4-5H2,1-3H3
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n/an/a 6.70E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50176546
PNG
(6-(4-cyano-3-(difluoromethyl)-5-((cis)-3,5-dimethy...)
Show SMILES C[C@H]1C[C@@H](C)CN(C1)c1c(C#N)c(nn1-c1ccc(cn1)S(N)(=O)=O)C(F)F
Show InChI InChI=1S/C17H20F2N6O2S/c1-10-5-11(2)9-24(8-10)17-13(6-20)15(16(18)19)23-25(17)14-4-3-12(7-22-14)28(21,26)27/h3-4,7,10-11,16H,5,8-9H2,1-2H3,(H2,21,26,27)/t10-,11+
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n/an/a 7.00E+3n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179593
PNG
(5-(2-methylcyclohexyloxy)-1-(5-(methylsulfonyl)pyr...)
Show SMILES CC1CCCCC1Oc1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C18H19F3N4O3S/c1-11-5-3-4-6-14(11)28-17-13(9-22)16(18(19,20)21)24-25(17)15-8-7-12(10-23-15)29(2,26)27/h7-8,10-11,14H,3-6H2,1-2H3
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n/an/a 7.10E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179595
PNG
(5-(3-methylcyclopentyloxy)-1-(5-(methylsulfonyl)py...)
Show SMILES CC1CCC(C1)Oc1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H17F3N4O3S/c1-10-3-4-11(7-10)27-16-13(8-21)15(17(18,19)20)23-24(16)14-6-5-12(9-22-14)28(2,25)26/h5-6,9-11H,3-4,7H2,1-2H3
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n/an/a 7.60E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137435
PNG
(2-(4-Chloro-5-phenyl-3-trifluoromethyl-pyrazol-1-y...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(c(Cl)c1-c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C16H11ClF3N3O2S/c1-26(24,25)11-7-8-12(21-9-11)23-14(10-5-3-2-4-6-10)13(17)15(22-23)16(18,19)20/h2-9H,1H3
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n/an/a 7.90E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179611
PNG
(5-(cycloheptyloxy)-1-(5-(methylsulfonyl)pyridin-2-...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(c(C#N)c1OC1CCCCCC1)C(F)(F)F
Show InChI InChI=1S/C18H19F3N4O3S/c1-29(26,27)13-8-9-15(23-11-13)25-17(28-12-6-4-2-3-5-7-12)14(10-22)16(24-25)18(19,20)21/h8-9,11-12H,2-7H2,1H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137432
PNG
(2-(3-Difluoromethyl-4-methyl-5-phenyl-pyrazol-1-yl...)
Show SMILES Cc1c(nn(c1-c1ccccc1)-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C17H15F2N3O2S/c1-11-15(17(18)19)21-22(16(11)12-6-4-3-5-7-12)14-9-8-13(10-20-14)25(2,23)24/h3-10,17H,1-2H3
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n/an/a 9.10E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137442
PNG
(2-[3-Difluoromethyl-5-(3-fluoro-4-methoxy-phenyl)-...)
Show SMILES COc1ccc(cc1F)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C17H14F3N3O3S/c1-26-15-5-3-10(7-12(15)18)14-8-13(17(19)20)22-23(14)16-6-4-11(9-21-16)27(2,24)25/h3-9,17H,1-2H3
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n/an/a 9.90E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179592
PNG
(5-isobutoxy-1-(5-(methylsulfonyl)pyridin-2-yl)-3-(...)
Show SMILES CC(C)COc1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C15H15F3N4O3S/c1-9(2)8-25-14-11(6-19)13(15(16,17)18)21-22(14)12-5-4-10(7-20-12)26(3,23)24/h4-5,7,9H,8H2,1-3H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137418
PNG
(2-(3-Difluoromethyl-5-p-tolyl-pyrazol-1-yl)-5-meth...)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C17H15F2N3O2S/c1-11-3-5-12(6-4-11)15-9-14(17(18)19)21-22(15)16-8-7-13(10-20-16)25(2,23)24/h3-10,17H,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179601
PNG
(5-(cyclohex-3-enylmethoxy)-1-(5-(methylsulfonyl)py...)
Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(c(C#N)c1OCC1CCC=CC1)C(F)(F)F
Show InChI InChI=1S/C18H17F3N4O3S/c1-29(26,27)13-7-8-15(23-10-13)25-17(28-11-12-5-3-2-4-6-12)14(9-22)16(24-25)18(19,20)21/h2-3,7-8,10,12H,4-6,11H2,1H3
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n/an/a 1.06E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50176556
PNG
(5-(2-methylcyclohexylamino)-1-(5-(methylsulfonyl)p...)
Show SMILES CC1CCCCC1Nc1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C18H20F3N5O2S/c1-11-5-3-4-6-14(11)24-17-13(9-22)16(18(19,20)21)25-26(17)15-8-7-12(10-23-15)29(2,27)28/h7-8,10-11,14,24H,3-6H2,1-2H3
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n/an/a 1.08E+4n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50182346
PNG
(2-(5-(3-methyl-4-(oxazol-2-yl)phenyl)-3-(trifluoro...)
Show SMILES Cc1cc(ccc1-c1ncco1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C20H15F3N4O3S/c1-12-9-13(3-5-15(12)19-24-7-8-30-19)16-10-17(20(21,22)23)26-27(16)18-6-4-14(11-25-18)31(2,28)29/h3-11H,1-2H3
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n/an/a 1.11E+4n/an/an/an/an/an/a



Veterinary Medicine Research and Development Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 in canine whole blood


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50179591
PNG
(5-(3-methylbutan-2-yloxy)-1-(5-(methylsulfonyl)pyr...)
Show SMILES CC(C)C(C)Oc1c(C#N)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C16H17F3N4O3S/c1-9(2)10(3)26-15-12(7-20)14(16(17,18)19)22-23(15)13-6-5-11(8-21-13)27(4,24)25/h5-6,8-10H,1-4H3
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n/an/a 1.18E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX1 by canine whole blood assay


Citation and Details
More data for this
Ligand-Target Pair
Cyclooxygenase-1


(Canis familiaris)
BDBM50137417
PNG
(2-[3-Difluoromethyl-5-(4-ethyl-phenyl)-pyrazol-1-y...)
Show SMILES CCc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F
Show InChI InChI=1S/C18H17F2N3O2S/c1-3-12-4-6-13(7-5-12)16-10-15(18(19)20)22-23(16)17-9-8-14(11-21-17)26(2,24)25/h4-11,18H,3H2,1-2H3
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n/an/a 1.20E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1.


Bioorg Med Chem Lett 14: 95-8 (2003)

More data for this
Ligand-Target Pair
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