BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 22 hits Enz. Inhib. hit(s) with Target = 'Cystic fibrosis transmembrane conductance regulator' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130980
PNG
(CHEMBL310408 | {3-[5-Bromo-2-(4-methoxy-benzyloxy)...)
Show SMILES COc1ccc(COc2ccc(Br)cc2-c2cc(CO)on2)cc1
Show InChI InChI=1S/C18H16BrNO4/c1-22-14-5-2-12(3-6-14)11-23-18-7-4-13(19)8-16(18)17-9-15(10-21)24-20-17/h2-9,21H,10-11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 1.04E+5n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM19459
PNG
(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/an/a 4.00E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130982
PNG
(CHEMBL85504 | {3-[2-(4-Bromo-benzyloxy)-phenyl]-is...)
Show SMILES OCc1cc(no1)-c1ccccc1OCc1ccc(Br)cc1
Show InChI InChI=1S/C17H14BrNO3/c18-13-7-5-12(6-8-13)11-21-17-4-2-1-3-15(17)16-9-14(10-20)22-19-16/h1-9,20H,10-11H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 1.47E+5n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130983
PNG
(3-[5-Bromo-2-(4-methoxy-benzyloxy)-phenyl]-5-chlor...)
Show SMILES COc1ccc(COc2ccc(Br)cc2-c2cc(CCl)on2)cc1
Show InChI InChI=1S/C18H15BrClNO3/c1-22-14-5-2-12(3-6-14)11-23-18-7-4-13(19)8-16(18)17-9-15(10-20)24-21-17/h2-9H,10-11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a>3.00E+5n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130984
PNG
(3-[2-(4-Bromo-benzyloxy)-phenyl]-5-methoxymethyl-i...)
Show SMILES COCc1cc(no1)-c1ccccc1OCc1ccc(Br)cc1
Show InChI InChI=1S/C18H16BrNO3/c1-21-12-15-10-17(20-23-15)16-4-2-3-5-18(16)22-11-13-6-8-14(19)9-7-13/h2-10H,11-12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a>3.00E+5n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130985
PNG
(3-[2-(3-Methoxy-benzyloxy)-phenyl]-4,5-dihydro-iso...)
Show SMILES COC(=O)C1CC(=NO1)c1ccccc1OCc1cccc(OC)c1
Show InChI InChI=1S/C19H19NO5/c1-22-14-7-5-6-13(10-14)12-24-17-9-4-3-8-15(17)16-11-18(25-20-16)19(21)23-2/h3-10,18H,11-12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 1.10E+5n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130986
PNG
(2-{3-[2-(3-Methoxy-benzyloxy)-phenyl]-isoxazol-5-y...)
Show SMILES COc1cccc(COc2ccccc2-c2cc(CCO)on2)c1
Show InChI InChI=1S/C19H19NO4/c1-22-15-6-4-5-14(11-15)13-23-19-8-3-2-7-17(19)18-12-16(9-10-21)24-20-18/h2-8,11-12,21H,9-10,13H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 1.77E+5n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130989
PNG
(5-Chloromethyl-3-[2-(3-methoxy-benzyloxy)-phenyl]-...)
Show SMILES COc1cccc(COc2ccccc2C2=NOC(CCl)C2)c1
Show InChI InChI=1S/C18H18ClNO3/c1-21-14-6-4-5-13(9-14)12-22-18-8-3-2-7-16(18)17-10-15(11-19)23-20-17/h2-9,15H,10-12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 6.60E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130988
PNG
(2-{3-[2-(4-Methoxy-benzyloxy)-phenyl]-isoxazol-5-y...)
Show SMILES COc1ccc(COc2ccccc2-c2cc(CCO)on2)cc1
Show InChI InChI=1S/C19H19NO4/c1-22-15-8-6-14(7-9-15)13-23-19-5-3-2-4-17(19)18-12-16(10-11-21)24-20-18/h2-9,12,21H,10-11,13H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 6.10E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130987
PNG
(5-Chloromethyl-3-[2-(4-methoxy-benzyloxy)-phenyl]-...)
Show SMILES COc1ccc(COc2ccccc2C2=NOC(CCl)C2)cc1
Show InChI InChI=1S/C18H18ClNO3/c1-21-14-8-6-13(7-9-14)12-22-18-5-3-2-4-16(18)17-10-15(11-19)23-20-17/h2-9,15H,10-12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 5.90E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130991
PNG
(3-[2-(4-Bromo-benzyloxy)-phenyl]-isoxazole-4,5-dic...)
Show SMILES COC(=O)c1onc(c1C(=O)OC)-c1ccccc1OCc1ccc(Br)cc1
Show InChI InChI=1S/C20H16BrNO6/c1-25-19(23)16-17(22-28-18(16)20(24)26-2)14-5-3-4-6-15(14)27-11-12-7-9-13(21)10-8-12/h3-10H,11H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
n/an/an/a 3.57E+5n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130990
PNG
(5-Butyl-3-[2-(4-methoxy-benzyloxy)-phenyl]-isoxazo...)
Show SMILES CCCCc1cc(no1)-c1ccccc1OCc1ccc(OC)cc1
Show InChI InChI=1S/C21H23NO3/c1-3-4-7-18-14-20(22-25-18)19-8-5-6-9-21(19)24-15-16-10-12-17(23-2)13-11-16/h5-6,8-14H,3-4,7,15H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a>3.00E+5n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130992
PNG
(CHEMBL83374 | {3-[2-(3-Methoxy-benzyloxy)-phenyl]-...)
Show SMILES COc1cccc(COc2ccccc2C2=NOC(CO)C2)c1
Show InChI InChI=1S/C18H19NO4/c1-21-14-6-4-5-13(9-14)12-22-18-8-3-2-7-16(18)17-10-15(11-20)23-19-17/h2-9,15,20H,10-12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 1.15E+5n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130993
PNG
(CHEMBL84391 | {3-[2-(3-Methoxy-benzyloxy)-phenyl]-...)
Show SMILES COc1cccc(COc2ccccc2-c2cc(CO)on2)c1
Show InChI InChI=1S/C18H17NO4/c1-21-14-6-4-5-13(9-14)12-22-18-8-3-2-7-16(18)17-10-15(11-20)23-19-17/h2-10,20H,11-12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 7.20E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130996
PNG
(2-{3-[2-(4-Bromo-benzyloxy)-phenyl]-isoxazol-5-yl}...)
Show SMILES OCCc1cc(no1)-c1ccccc1OCc1ccc(Br)cc1
Show InChI InChI=1S/C18H16BrNO3/c19-14-7-5-13(6-8-14)12-22-18-4-2-1-3-16(18)17-11-15(9-10-21)23-20-17/h1-8,11,21H,9-10,12H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 2.30E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130994
PNG
(3-[2-(4-Bromo-benzyloxy)-phenyl]-isoxazole-5-carbo...)
Show SMILES COC(=O)c1cc(no1)-c1ccccc1OCc1ccc(Br)cc1
Show InChI InChI=1S/C18H14BrNO4/c1-22-18(21)17-10-15(20-24-17)14-4-2-3-5-16(14)23-11-12-6-8-13(19)9-7-12/h2-10H,11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 1.00E+5n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130995
PNG
(CHEMBL81937 | {3-[2-(4-Methoxy-benzyloxy)-phenyl]-...)
Show SMILES COc1ccc(COc2ccccc2C2=NOC(CO)C2)cc1
Show InChI InChI=1S/C18H19NO4/c1-21-14-8-6-13(7-9-14)12-22-18-5-3-2-4-16(18)17-10-15(11-20)23-19-17/h2-9,15,20H,10-12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 4.90E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130998
PNG
(3-[2-(4-Methoxy-benzyloxy)-phenyl]-4,5-dihydro-iso...)
Show SMILES COC(=O)C1CC(=NO1)c1ccccc1OCc1ccc(OC)cc1
Show InChI InChI=1S/C19H19NO5/c1-22-14-9-7-13(8-10-14)12-24-17-6-4-3-5-15(17)16-11-18(25-20-16)19(21)23-2/h3-10,18H,11-12H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 5.00E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130997
PNG
(3-[2-(4-Bromo-benzyloxy)-phenyl]-4,5-dihydro-isoxa...)
Show SMILES COC(=O)C1CC(=NO1)c1ccccc1OCc1ccc(Br)cc1
Show InChI InChI=1S/C18H16BrNO4/c1-22-18(21)17-10-15(20-24-17)14-4-2-3-5-16(14)23-11-12-6-8-13(19)9-7-12/h2-9,17H,10-11H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 7.30E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50131000
PNG
(CHEMBL312783 | {3-[2-(4-Methoxy-benzyloxy)-phenyl]...)
Show SMILES COc1ccc(COc2ccccc2-c2cc(CO)on2)cc1
Show InChI InChI=1S/C18H17NO4/c1-21-14-8-6-13(7-9-14)12-22-18-5-3-2-4-16(18)17-10-15(11-20)23-19-17/h2-10,20H,11-12H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 6.40E+4n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130999
PNG
(3-[5-Bromo-2-(4-methoxy-benzyloxy)-phenyl]-4,5-dih...)
Show SMILES COC(=O)C1CC(=NO1)c1cc(Br)ccc1OCc1ccc(OC)cc1
Show InChI InChI=1S/C19H18BrNO5/c1-23-14-6-3-12(4-7-14)11-25-17-8-5-13(20)9-15(17)16-10-18(26-21-16)19(22)24-2/h3-9,18H,10-11H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 1.18E+5n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator


(Rattus norvegicus)
BDBM50130981
PNG
(3-[2-(4-Bromo-benzyloxy)-phenyl]-5-chloromethyl-is...)
Show SMILES ClCc1cc(no1)-c1ccccc1OCc1ccc(Br)cc1
Show InChI InChI=1S/C17H13BrClNO2/c18-13-7-5-12(6-8-13)11-21-17-4-2-1-3-15(17)16-9-14(10-19)22-20-16/h1-9H,10-11H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/an/a 2.20E+5n/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Kd (half effective concentration) of compound against CFTR (cystic fibrosis transmembrane conductance regulator) in rat was determined


Bioorg Med Chem Lett 13: 2509-12 (2003)

More data for this
Ligand-Target Pair