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Found 41 hits Enz. Inhib. hit(s) with Target = 'Cytochrome P450 11B1' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50444550
PNG
(CHEMBL3099704)
Show SMILES Fc1ccc(cc1)-c1cc(ccc1[C@H]1CCCCc2cncn12)C#N
Show InChI InChI=1S/C21H18FN3/c22-17-8-6-16(7-9-17)20-11-15(12-23)5-10-19(20)21-4-2-1-3-18-13-24-14-25(18)21/h5-11,13-14,21H,1-4H2/t21-/m1/s1
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n/an/a 0.300n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of rat recombinant CYP11B1 using 11-deoxycortisol as substrate by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50082277
PNG
(CHEMBL3421769)
Show SMILES [O-][N+](=O)c1ccc(c(OCCc2ccccc2)c1)-c1ccncc1
Show InChI InChI=1S/C19H16N2O3/c22-21(23)17-6-7-18(16-8-11-20-12-9-16)19(14-17)24-13-10-15-4-2-1-3-5-15/h1-9,11-12,14H,10,13H2
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n/an/a 163n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50082276
PNG
(CHEMBL3421770)
Show SMILES [O-][N+](=O)c1ccc(c(OCCCc2ccccc2)c1)-c1ccncc1
Show InChI InChI=1S/C20H18N2O3/c23-22(24)18-8-9-19(17-10-12-21-13-11-17)20(15-18)25-14-4-7-16-5-2-1-3-6-16/h1-3,5-6,8-13,15H,4,7,14H2
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n/an/a 370n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50444548
PNG
(CHEMBL3099696)
Show SMILES Cc1cc(ccc1[C@H]1CCc2cncn12)C#N
Show InChI InChI=1S/C14H13N3/c1-10-6-11(7-15)2-4-13(10)14-5-3-12-8-16-9-17(12)14/h2,4,6,8-9,14H,3,5H2,1H3/t14-/m1/s1
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n/an/a 386n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of rat recombinant CYP11B1 using 11-deoxycortisol as substrate by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50082288
PNG
(CHEMBL3421780)
Show SMILES N#Cc1ccc(c(OCCc2ccccc2)c1)-c1ccncc1
Show InChI InChI=1S/C20H16N2O/c21-15-17-6-7-19(18-8-11-22-12-9-18)20(14-17)23-13-10-16-4-2-1-3-5-16/h1-9,11-12,14H,10,13H2
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n/an/a 441n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50444549
PNG
(CHEMBL3099695)
Show SMILES Fc1cc(ccc1[C@H]1CCc2cncn12)C#N
Show InChI InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1
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n/an/a 495n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of rat recombinant CYP11B1 using 11-deoxycortisol as substrate by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50082287
PNG
(CHEMBL3421779)
Show SMILES N#Cc1ccc(c(OCCc2ccccc2)c1)-c1cccnc1
Show InChI InChI=1S/C20H16N2O/c21-14-17-8-9-19(18-7-4-11-22-15-18)20(13-17)23-12-10-16-5-2-1-3-6-16/h1-9,11,13,15H,10,12H2
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n/an/a 543n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50082278
PNG
(CHEMBL3421768)
Show SMILES [O-][N+](=O)c1ccc(c(OCc2ccccc2)c1)-c1ccncc1
Show InChI InChI=1S/C18H14N2O3/c21-20(22)16-6-7-17(15-8-10-19-11-9-15)18(12-16)23-13-14-4-2-1-3-5-14/h1-12H,13H2
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n/an/a 648n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50047262
PNG
((R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-y...)
Show SMILES N#Cc1ccc(cc1)[C@H]1CCCc2cncn12
Show InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2/t14-/m1/s1
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n/an/a 686n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of rat recombinant CYP11B1 using 11-deoxycortisol as substrate by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50082293
PNG
(CHEMBL3421785)
Show SMILES [O-][N+](=O)c1ccc(Cc2cccnc2)c(OCCc2ccccc2)c1
Show InChI InChI=1S/C20H18N2O3/c23-22(24)19-9-8-18(13-17-7-4-11-21-15-17)20(14-19)25-12-10-16-5-2-1-3-6-16/h1-9,11,14-15H,10,12-13H2
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n/an/a 706n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM8611
PNG
(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)
Show SMILES N#Cc1ccc(cc1)C1CCCc2cncn12
Show InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of ACTH-stimulated aldosterone production in rat adrenal tissue


J Med Chem 34: 725-36 (1991)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50082280
PNG
(CHEMBL3421766)
Show SMILES [O-][N+](=O)c1ccc(c(OCCc2ccccc2)c1)-c1cccnc1
Show InChI InChI=1S/C19H16N2O3/c22-21(23)17-8-9-18(16-7-4-11-20-14-16)19(13-17)24-12-10-15-5-2-1-3-6-15/h1-9,11,13-14H,10,12H2
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n/an/a 1.31E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50082281
PNG
(CHEMBL3421765)
Show SMILES [O-][N+](=O)c1ccc(c(OCc2ccccc2)c1)-c1cccnc1
Show InChI InChI=1S/C18H14N2O3/c21-20(22)16-8-9-17(15-7-4-10-19-12-15)18(11-16)23-13-14-5-2-1-3-6-14/h1-12H,13H2
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n/an/a 1.49E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50395609
PNG
(CHEMBL2165320)
Show SMILES O=C1CCc2cc(c(OCc3ccccc3)cc2N1)-c1cccnc1
Show InChI InChI=1S/C21H18N2O2/c24-21-9-8-16-11-18(17-7-4-10-22-13-17)20(12-19(16)23-21)25-14-15-5-2-1-3-6-15/h1-7,10-13H,8-9,14H2,(H,23,24)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50022121
PNG
(3-Imidazol-1-ylmethyl-2-isopropyl-1H-indole | 3-Im...)
Show SMILES CC(C)c1[nH]c2ccccc2c1Cn1ccnc1
Show InChI InChI=1S/C15H17N3/c1-11(2)15-13(9-18-8-7-16-10-18)12-5-3-4-6-14(12)17-15/h3-8,10-11,17H,9H2,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 11 beta-hydroxylase from rat adrenal gland


J Med Chem 29: 342-6 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50022121
PNG
(3-Imidazol-1-ylmethyl-2-isopropyl-1H-indole | 3-Im...)
Show SMILES CC(C)c1[nH]c2ccccc2c1Cn1ccnc1
Show InChI InChI=1S/C15H17N3/c1-11(2)15-13(9-18-8-7-16-10-18)12-5-3-4-6-14(12)17-15/h3-8,10-11,17H,9H2,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 28: 1427-32 (1985)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50082279
PNG
(CHEMBL3421767)
Show SMILES [O-][N+](=O)c1ccc(c(OCCCc2ccccc2)c1)-c1cccnc1
Show InChI InChI=1S/C20H18N2O3/c23-22(24)18-10-11-19(17-9-4-12-21-15-17)20(14-18)25-13-5-8-16-6-2-1-3-7-16/h1-4,6-7,9-12,14-15H,5,8,13H2
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n/an/a 2.08E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50439057
PNG
(CHEMBL2417553)
Show SMILES Cc1cncc(Cc2ccc(nc2)-c2ccccc2)c1
Show InChI InChI=1S/C18H16N2/c1-14-9-16(12-19-11-14)10-15-7-8-18(20-13-15)17-5-3-2-4-6-17/h2-9,11-13H,10H2,1H3
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n/an/a 2.44E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrate


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50439057
PNG
(CHEMBL2417553)
Show SMILES Cc1cncc(Cc2ccc(nc2)-c2ccccc2)c1
Show InChI InChI=1S/C18H16N2/c1-14-9-16(12-19-11-14)10-15-7-8-18(20-13-15)17-5-3-2-4-6-17/h2-9,11-13H,10H2,1H3
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n/an/a 2.44E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50082294
PNG
(CHEMBL3421786)
Show SMILES [O-][N+](=O)c1ccc(Cc2ccncc2)c(OCCc2ccccc2)c1
Show InChI InChI=1S/C20H18N2O3/c23-22(24)19-7-6-18(14-17-8-11-21-12-9-17)20(15-19)25-13-10-16-4-2-1-3-5-16/h1-9,11-12,15H,10,13-14H2
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n/an/a 2.85E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50028166
PNG
(CHEMBL934 | METYRAPONE | US9138393, Metyrapone | U...)
Show SMILES CC(C)(C(=O)c1cccnc1)c1cccnc1
Show InChI InChI=1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3
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n/an/a 4.61E+3n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50022118
PNG
(3-(3-Imidazol-1-ylmethyl-2-isopropyl-indol-1-yl)-p...)
Show SMILES CC(C)c1c(Cn2ccnc2)c2ccccc2n1CCC(O)=O
Show InChI InChI=1S/C18H21N3O2/c1-13(2)18-15(11-20-10-8-19-12-20)14-5-3-4-6-16(14)21(18)9-7-17(22)23/h3-6,8,10,12-13H,7,9,11H2,1-2H3,(H,22,23)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of 11 beta-hydroxylase from rat adrenal gland


J Med Chem 29: 342-6 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50022117
PNG
(1-Ethyl-3-imidazol-1-ylmethyl-1H-indole | CHEMBL11...)
Show SMILES CCn1cc(Cn2ccnc2)c2ccccc12
Show InChI InChI=1S/C14H15N3/c1-2-17-10-12(9-16-8-7-15-11-16)13-5-3-4-6-14(13)17/h3-8,10-11H,2,9H2,1H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 11 beta-hydroxylase from rat adrenal gland


J Med Chem 29: 342-6 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50025995
PNG
(4-(2-Imidazol-1-yl-ethoxy)-benzamide | CHEMBL30395)
Show SMILES NC(=O)c1ccc(OCCn2ccnc2)cc1
Show InChI InChI=1S/C12H13N3O2/c13-12(16)10-1-3-11(4-2-10)17-8-7-15-6-5-14-9-15/h1-6,9H,7-8H2,(H2,13,16)
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 28: 1427-32 (1985)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50022120
PNG
(3-Imidazol-1-ylmethyl-1H-indole | CHEMBL116794)
Show SMILES C(c1c[nH]c2ccccc12)n1ccnc1
Show InChI InChI=1S/C12H11N3/c1-2-4-12-11(3-1)10(7-14-12)8-15-6-5-13-9-15/h1-7,9,14H,8H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 11 beta-hydroxylase from rat adrenal gland


J Med Chem 29: 342-6 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50335360
PNG
(5-((1H-imidazol-1-yl)methyl)-2-phenylpyridine | CH...)
Show SMILES C(c1ccc(nc1)-c1ccccc1)n1ccnc1
Show InChI InChI=1S/C15H13N3/c1-2-4-14(5-3-1)15-7-6-13(10-17-15)11-18-9-8-16-12-18/h1-10,12H,11H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Saarland University

Curated by ChEMBL


Assay Description
Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysis


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM8611
PNG
(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)
Show SMILES N#Cc1ccc(cc1)C1CCCc2cncn12
Show InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2
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n/an/a 1.00E+5n/an/an/an/an/an/a



CIBA-GEIGY Corporation

Curated by ChEMBL


Assay Description
Inhibition of ACTH-stimulated corticosterone production in rat adrenal tissue


J Med Chem 34: 725-36 (1991)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM7962
PNG
(4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...)
Show SMILES OC(=O)c1ccc(OCCn2ccnc2)cc1
Show InChI InChI=1S/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of 11 beta-hydroxylase from rat adrenal gland


J Med Chem 29: 342-6 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50026004
PNG
(2-[4-(2-Imidazol-1-yl-ethoxy)-phenoxy]-acetamide |...)
Show SMILES NC(=O)COc1ccc(OCCn2ccnc2)cc1
Show InChI InChI=1S/C13H15N3O3/c14-13(17)9-19-12-3-1-11(2-4-12)18-8-7-16-6-5-15-10-16/h1-6,10H,7-9H2,(H2,14,17)
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 28: 1427-32 (1985)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM7962
PNG
(4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...)
Show SMILES OC(=O)c1ccc(OCCn2ccnc2)cc1
Show InChI InChI=1S/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 28: 1427-32 (1985)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50026000
PNG
(3-(2-Imidazol-1-yl-ethoxy)-benzoic acid | CHEMBL33...)
Show SMILES OC(=O)c1cccc(OCCn2ccnc2)c1
Show InChI InChI=1S/C12H12N2O3/c15-12(16)10-2-1-3-11(8-10)17-7-6-14-5-4-13-9-14/h1-5,8-9H,6-7H2,(H,15,16)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 28: 1427-32 (1985)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50025983
PNG
(CHEMBL34041 | [4-(2-Imidazol-1-yl-ethoxy)-phenoxy]...)
Show SMILES OC(=O)COc1ccc(OCCn2ccnc2)cc1
Show InChI InChI=1S/C13H14N2O4/c16-13(17)9-19-12-3-1-11(2-4-12)18-8-7-15-6-5-14-10-15/h1-6,10H,7-9H2,(H,16,17)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 28: 1427-32 (1985)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM7962
PNG
(4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...)
Show SMILES OC(=O)c1ccc(OCCn2ccnc2)cc1
Show InChI InChI=1S/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 29: 1643-50 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50022222
PNG
(2-Imidazol-1-ylmethyl-3-methyl-benzofuran-5-carbox...)
Show SMILES Cc1c(Cn2ccnc2)oc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C14H12N2O3/c1-9-11-6-10(14(17)18)2-3-12(11)19-13(9)7-16-5-4-15-8-16/h2-6,8H,7H2,1H3,(H,17,18)
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n/an/a 1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 29: 1643-50 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50022230
PNG
(3-Bromo-2-imidazol-1-ylmethyl-benzo[b]thiophene-5-...)
Show SMILES OC(=O)c1ccc2sc(Cn3ccnc3)c(Br)c2c1
Show InChI InChI=1S/C13H9BrN2O2S/c14-12-9-5-8(13(17)18)1-2-10(9)19-11(12)6-16-4-3-15-7-16/h1-5,7H,6H2,(H,17,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 29: 1643-50 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50000317
PNG
(3-(3-Imidazol-1-ylmethyl-2-methyl-indol-1-yl)-prop...)
Show SMILES Cc1c(Cn2ccnc2)c2ccccc2n1CCC(O)=O
Show InChI InChI=1S/C16H17N3O2/c1-12-14(10-18-9-7-17-11-18)13-4-2-3-5-15(13)19(12)8-6-16(20)21/h2-5,7,9,11H,6,8,10H2,1H3,(H,20,21)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of 11 beta-hydroxylase from rat adrenal gland


J Med Chem 29: 342-6 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50022223
PNG
(3-Chloro-2-imidazol-1-ylmethyl-benzofuran-5-carbox...)
Show SMILES OC(=O)c1ccc2oc(Cn3ccnc3)c(Cl)c2c1
Show InChI InChI=1S/C13H9ClN2O3/c14-12-9-5-8(13(17)18)1-2-10(9)19-11(12)6-16-4-3-15-7-16/h1-5,7H,6H2,(H,17,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 29: 1643-50 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50022217
PNG
(2-Imidazol-1-ylmethyl-benzo[b]thiophene-5-carboxyl...)
Show SMILES OC(=O)c1ccc2sc(Cn3ccnc3)cc2c1
Show InChI InChI=1S/C13H10N2O2S/c16-13(17)9-1-2-12-10(5-9)6-11(18-12)7-15-4-3-14-8-15/h1-6,8H,7H2,(H,16,17)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 29: 1643-50 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50022216
PNG
(2-Imidazol-1-ylmethyl-3-methyl-benzo[b]thiophene-5...)
Show SMILES Cc1c(Cn2ccnc2)sc2ccc(cc12)C(O)=O
Show InChI InChI=1S/C14H12N2O2S/c1-9-11-6-10(14(17)18)2-3-12(11)19-13(9)7-16-5-4-15-8-16/h2-6,8H,7H2,1H3,(H,17,18)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 29: 1643-50 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50022226
PNG
(6-Imidazol-1-ylmethyl-5-methyl-naphthalene-1-carbo...)
Show SMILES Cc1c(Cn2ccnc2)ccc2c(cccc12)C(O)=O
Show InChI InChI=1S/C16H14N2O2/c1-11-12(9-18-8-7-17-10-18)5-6-14-13(11)3-2-4-15(14)16(19)20/h2-8,10H,9H2,1H3,(H,19,20)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of rat adrenal 11-beta-hydroxylase


J Med Chem 29: 1643-50 (1986)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Rattus norvegicus)
BDBM50022124
PNG
(3-(3-Imidazol-1-ylmethyl-indol-1-yl)-propionic aci...)
Show SMILES OC(=O)CCn1cc(Cn2ccnc2)c2ccccc12
Show InChI InChI=1S/C15H15N3O2/c19-15(20)5-7-18-10-12(9-17-8-6-16-11-17)13-3-1-2-4-14(13)18/h1-4,6,8,10-11H,5,7,9H2,(H,19,20)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of 11 beta-hydroxylase from rat adrenal gland


J Med Chem 29: 342-6 (1986)

More data for this
Ligand-Target Pair