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Found 16 hits Enz. Inhib. hit(s) with Target = 'Cytochrome P450 11B2' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM50444550
PNG
(CHEMBL3099704)
Show SMILES Fc1ccc(cc1)-c1cc(ccc1[C@H]1CCCCc2cncn12)C#N
Show InChI InChI=1S/C21H18FN3/c22-17-8-6-16(7-9-17)20-11-15(12-23)5-10-19(20)21-4-2-1-3-18-13-24-14-25(18)21/h5-11,13-14,21H,1-4H2/t21-/m1/s1
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n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of rat recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM50444548
PNG
(CHEMBL3099696)
Show SMILES Cc1cc(ccc1[C@H]1CCc2cncn12)C#N
Show InChI InChI=1S/C14H13N3/c1-10-6-11(7-15)2-4-13(10)14-5-3-12-8-16-9-17(12)14/h2,4,6,8-9,14H,3,5H2,1H3/t14-/m1/s1
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n/an/a 24n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of rat recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM50444549
PNG
(CHEMBL3099695)
Show SMILES Fc1cc(ccc1[C@H]1CCc2cncn12)C#N
Show InChI InChI=1S/C13H10FN3/c14-12-5-9(6-15)1-3-11(12)13-4-2-10-7-16-8-17(10)13/h1,3,5,7-8,13H,2,4H2/t13-/m1/s1
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n/an/a 111n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of rat recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM50047262
PNG
((R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-y...)
Show SMILES N#Cc1ccc(cc1)[C@H]1CCCc2cncn12
Show InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2/t14-/m1/s1
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n/an/a 118n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of rat recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM8611
PNG
(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)
Show SMILES N#Cc1ccc(cc1)C1CCCc2cncn12
Show InChI InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2
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n/an/a 600n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices


J Med Chem 38: 2103-11 (1995)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM50035209
PNG
(4-(1a,2,3,7b-Tetrahydro-1H-cyclopropa[a]naphthalen...)
Show SMILES C1Cc2ccccc2C2C1C2c1ccncc1
Show InChI InChI=1S/C16H15N/c1-2-4-13-11(3-1)5-6-14-15(16(13)14)12-7-9-17-10-8-12/h1-4,7-10,14-16H,5-6H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices


J Med Chem 38: 2103-11 (1995)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM50035208
PNG
(1-Pyridin-4-yl-1a,2,3,7b-tetrahydro-1H-cyclopropa[...)
Show SMILES Oc1ccc2CCC3C(C3c2c1)c1ccncc1
Show InChI InChI=1S/C16H15NO/c18-12-3-1-10-2-4-13-15(16(13)14(10)9-12)11-5-7-17-8-6-11/h1,3,5-9,13,15-16,18H,2,4H2
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n/an/a 7.00E+3n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices


J Med Chem 38: 2103-11 (1995)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM50378780
PNG
((S)-VOROZOLE)
Show SMILES Cn1nnc2ccc(cc12)[C@H](c1ccc(Cl)cc1)n1cncn1
Show InChI InChI=1S/C16H13ClN6/c1-22-15-8-12(4-7-14(15)20-21-22)16(23-10-18-9-19-23)11-2-5-13(17)6-3-11/h2-10,16H,1H3/t16-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices


J Med Chem 38: 2103-11 (1995)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM50035204
PNG
(4-(6-Methoxy-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]...)
Show SMILES COc1ccc2CCC3C(C3c2c1)c1ccncc1
Show InChI InChI=1S/C17H17NO/c1-19-13-4-2-11-3-5-14-16(17(14)15(11)10-13)12-6-8-18-9-7-12/h2,4,6-10,14,16-17H,3,5H2,1H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices


J Med Chem 38: 2103-11 (1995)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM50035204
PNG
(4-(6-Methoxy-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]...)
Show SMILES COc1ccc2CCC3C(C3c2c1)c1ccncc1
Show InChI InChI=1S/C17H17NO/c1-19-13-4-2-11-3-5-14-16(17(14)15(11)10-13)12-6-8-18-9-7-12/h2,4,6-10,14,16-17H,3,5H2,1H3
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n/an/a 1.50E+4n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices


J Med Chem 38: 2103-11 (1995)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM50011762
PNG
((1R,5S)1-(4-Amino-phenyl)-3-cyclohexylmethyl-3-aza...)
Show SMILES Nc1ccc(cc1)C12CC1C(=O)N(CC1CCCCC1)C2=O
Show InChI InChI=1S/C18H22N2O2/c19-14-8-6-13(7-9-14)18-10-15(18)16(21)20(17(18)22)11-12-4-2-1-3-5-12/h6-9,12,15H,1-5,10-11,19H2
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n/an/a>3.40E+4n/an/an/an/an/an/a



CIBA-GEIGY AG.

Curated by ChEMBL


Assay Description
In vitro inhibition of aldosterone production in rat adrenal tissue


J Med Chem 34: 1329-34 (1991)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM9460
PNG
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)
Show SMILES CCC1(CCC(=O)NC1=O)c1ccc(N)cc1
Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices


J Med Chem 38: 2103-11 (1995)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM9460
PNG
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)
Show SMILES CCC1(CCC(=O)NC1=O)c1ccc(N)cc1
Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
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n/an/a 8.00E+4n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slices


J Med Chem 38: 2103-11 (1995)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM9460
PNG
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)
Show SMILES CCC1(CCC(=O)NC1=O)c1ccc(N)cc1
Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
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n/an/a 1.10E+5n/an/an/an/an/an/a



CIBA-GEIGY AG.

Curated by ChEMBL


Assay Description
In vitro inhibition of aldosterone production in rat adrenal tissue


J Med Chem 34: 1329-34 (1991)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM50011756
PNG
(1-(4-Amino-phenyl)-3-cyclohexyl-3-aza-bicyclo[3.1....)
Show SMILES Nc1ccc(cc1)C12CC(C1)C(=O)N(C1CCCCC1)C2=O
Show InChI InChI=1S/C18H22N2O2/c19-14-8-6-13(7-9-14)18-10-12(11-18)16(21)20(17(18)22)15-4-2-1-3-5-15/h6-9,12,15H,1-5,10-11,19H2
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n/an/a 1.40E+5n/an/an/an/an/an/a



CIBA-GEIGY AG.

Curated by ChEMBL


Assay Description
In vitro inhibition of aldosterone production in rat adrenal tissue


J Med Chem 34: 1329-34 (1991)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Rattus norvegicus)
BDBM50011762
PNG
((1R,5S)1-(4-Amino-phenyl)-3-cyclohexylmethyl-3-aza...)
Show SMILES Nc1ccc(cc1)C12CC1C(=O)N(CC1CCCCC1)C2=O
Show InChI InChI=1S/C18H22N2O2/c19-14-8-6-13(7-9-14)18-10-15(18)16(21)20(17(18)22)11-12-4-2-1-3-5-12/h6-9,12,15H,1-5,10-11,19H2
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n/an/a>3.30E+5n/an/an/an/an/an/a



CIBA-GEIGY AG.

Curated by ChEMBL


Assay Description
In vitro inhibition of aldosterone production in rat adrenal tissue


J Med Chem 34: 1329-34 (1991)

More data for this
Ligand-Target Pair