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Compile Data Set for Download or QSAR

Found 130 hits Enz. Inhib. hit(s) with Target = 'Cytochrome P450 19A1' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014320
PNG
(8-Chloro-5-(4-chloro-phenyl)-5H-indeno[1,2-d]pyrim...)
Show SMILES Clc1ccc(cc1)C1c2ccc(Cl)cc2-c2ncncc12
Show InChI InChI=1S/C17H10Cl2N2/c18-11-3-1-10(2-4-11)16-13-6-5-12(19)7-14(13)17-15(16)8-20-9-21-17/h1-9,16H
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24n/an/an/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for Cytochrome P450 19A1


J Med Chem 33: 2933-42 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014324
PNG
(5-[Bis-(4-chloro-phenyl)-methyl]-pyrimidine | 5-[B...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C17H12Cl2N2/c18-15-5-1-12(2-6-15)17(14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,17H
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29n/an/an/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for Cytochrome P450 19A1


J Med Chem 33: 2933-42 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014315
PNG
((rac)-6-((4-chlorophenyl)(1H-1,2,4-triazol-1-yl)me...)
Show SMILES Cn1nnc2ccc(cc12)C(c1ccc(Cl)cc1)n1cncn1
Show InChI InChI=1S/C16H13ClN6/c1-22-15-8-12(4-7-14(15)20-21-22)16(23-10-18-9-19-23)11-2-5-13(17)6-3-11/h2-10,16H,1H3
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n/an/a 3n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity for Cytochrome P450 19A1


J Med Chem 33: 2933-42 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50049763
PNG
(2-[1-(3H-Imidazol-4-yl)-meth-(E)-ylidene]-3,4-dihy...)
Show SMILES O=C1C(CCc2ccccc12)=Cc1cnc[nH]1
Show InChI InChI=1S/C14H12N2O/c17-14-11(7-12-8-15-9-16-12)6-5-10-3-1-2-4-13(10)14/h1-4,7-9H,5-6H2,(H,15,16)
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n/an/a 170n/an/an/an/an/an/a



American University of Ras Al Khaimah

Curated by ChEMBL


Assay Description
Inhibition of rat ovarian aromatase


Eur J Med Chem 102: 375-86 (2015)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50123022
PNG
(CHEMBL169251)
Show SMILES O=C1\C(CCc2ccccc12)=C/c1c[nH]cn1
Show InChI InChI=1S/C14H12N2O/c17-14-11(7-12-8-15-9-16-12)6-5-10-3-1-2-4-13(10)14/h1-4,7-9H,5-6H2,(H,15,16)/b11-7-
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n/an/a 260n/an/an/an/an/an/a



American University of Ras Al Khaimah

Curated by ChEMBL


Assay Description
Inhibition of rat ovarian aromatase


Eur J Med Chem 102: 375-86 (2015)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50035204
PNG
(4-(6-Methoxy-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]...)
Show SMILES COc1ccc2CCC3C(C3c2c1)c1ccncc1
Show InChI InChI=1S/C17H17NO/c1-19-13-4-2-11-3-5-14-16(17(14)15(11)10-13)12-6-8-18-9-7-12/h2,4,6-10,14,16-17H,3,5H2,1H3
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n/an/a 265n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
In vitro inhibition of rat ovarian microsomal Cytochrome P450 19A1


J Med Chem 38: 2103-11 (1995)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50009606
PNG
(5-Hydroxy-2-pyridin-4-ylmethyl-3,4-dihydro-2H-naph...)
Show SMILES Oc1cccc2C(=O)C(Cc3ccncc3)CCc12
Show InChI InChI=1S/C16H15NO2/c18-15-3-1-2-14-13(15)5-4-12(16(14)19)10-11-6-8-17-9-7-11/h1-3,6-9,12,18H,4-5,10H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
In vitro inhibition of rat ovarian aromatase cytochrome P450 19A1


J Med Chem 34: 2685-91 (1991)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50009605
PNG
(2-(pyridin-4-ylmethylene)-3,4-dihydronaphthalen-1(...)
Show SMILES O=C1\C(CCc2ccccc12)=C\c1ccncc1
Show InChI InChI=1S/C16H13NO/c18-16-14(11-12-7-9-17-10-8-12)6-5-13-3-1-2-4-15(13)16/h1-4,7-11H,5-6H2/b14-11+
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n/an/a 4.60E+3n/an/an/an/an/an/a



American University of Ras Al Khaimah

Curated by ChEMBL


Assay Description
Inhibition of rat ovarian aromatase


Eur J Med Chem 102: 375-86 (2015)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM9460
PNG
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)
Show SMILES CCC1(CCC(=O)NC1=O)c1ccc(N)cc1
Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
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n/an/a 6.20E+3n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
In vitro inhibition of rat ovarian microsomal Cytochrome P450 19A1


J Med Chem 38: 2103-11 (1995)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50009618
PNG
(5-Methoxy-2-pyridin-4-ylmethyl-3,4-dihydro-2H-naph...)
Show SMILES COc1cccc2C(=O)C(Cc3ccncc3)CCc12
Show InChI InChI=1S/C17H17NO2/c1-20-16-4-2-3-15-14(16)6-5-13(17(15)19)11-12-7-9-18-10-8-12/h2-4,7-10,13H,5-6,11H2,1H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
In vitro inhibition of rat ovarian aromatase cytochrome P450 19A1


J Med Chem 34: 2685-91 (1991)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM9460
PNG
(3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione | 3...)
Show SMILES CCC1(CCC(=O)NC1=O)c1ccc(N)cc1
Show InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
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n/an/a 3.40E+4n/an/an/an/an/an/a



Universität des Saarlandes

Curated by ChEMBL


Assay Description
Inhibition of rat ovarian Cytochrome P450 19A


J Med Chem 34: 2685-91 (1991)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014749
PNG
(3-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-1H-...)
Show SMILES Clc1ccc(cc1)C(c1ccn[nH]1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C19H14Cl2N4/c20-16-5-1-14(2-6-16)19(18-9-10-23-24-18,25-12-11-22-13-25)15-3-7-17(21)8-4-15/h1-13H,(H,23,24)
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n/an/an/an/a 61n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014750
PNG
(3-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-pyr...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)(c1cccnc1)n1ccnc1
Show InChI InChI=1S/C21H15Cl2N3/c22-19-7-3-16(4-8-19)21(26-13-12-25-15-26,18-2-1-11-24-14-18)17-5-9-20(23)10-6-17/h1-15H
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n/an/an/an/a 50n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014752
PNG
(1-[Bis-(2-chloro-phenyl)-methyl]-1H-imidazole | CH...)
Show SMILES Clc1ccccc1C(c1ccccc1Cl)n1ccnc1
Show InChI InChI=1S/C16H12Cl2N2/c17-14-7-3-1-5-12(14)16(20-10-9-19-11-20)13-6-2-4-8-15(13)18/h1-11,16H
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n/an/an/an/a 76n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014751
PNG
(3-[1,1-Bis-(4-chloro-phenyl)-ethyl]-pyridine | CHE...)
Show SMILES CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1S/C19H15Cl2N/c1-19(16-3-2-12-22-13-16,14-4-8-17(20)9-5-14)15-6-10-18(21)11-7-15/h2-13H,1H3
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n/an/an/an/a 145n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014753
PNG
(3-[Chloro-bis-(4-chloro-phenyl)-methyl]-pyridine :...)
Show SMILES Clc1ccc(cc1)C(Cl)(c1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1S/C18H12Cl3N/c19-16-7-3-13(4-8-16)18(21,15-2-1-11-22-12-15)14-5-9-17(20)10-6-14/h1-12H
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n/an/an/an/a 200n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014754
PNG
(1-[(4-Chloro-phenyl)-(4-methoxy-phenyl)-methyl]-1H...)
Show SMILES COc1ccc(cc1)C(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C17H15ClN2O/c1-21-16-8-4-14(5-9-16)17(20-11-10-19-12-20)13-2-6-15(18)7-3-13/h2-12,17H,1H3
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n/an/an/an/a 8.40n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014755
PNG
(1-[Bis-(4-methoxy-phenyl)-methyl]-1H-imidazole | C...)
Show SMILES COc1ccc(cc1)C(c1ccc(OC)cc1)n1ccnc1
Show InChI InChI=1S/C18H18N2O2/c1-21-16-7-3-14(4-8-16)18(20-12-11-19-13-20)15-5-9-17(22-2)10-6-15/h3-13,18H,1-2H3
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n/an/an/an/a 13n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014756
PNG
(1-[Bis-(4-chloro-phenyl)-methyl]-1H-imidazole | CH...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C16H12Cl2N2/c17-14-5-1-12(2-6-14)16(20-10-9-19-11-20)13-3-7-15(18)8-4-13/h1-11,16H
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n/an/an/an/a 42n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014760
PNG
(Bis-(4-chloro-phenyl)-(1H-tetrazol-5-yl)-methanol ...)
Show SMILES OC(c1nnn[nH]1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C14H10Cl2N4O/c15-11-5-1-9(2-6-11)14(21,13-17-19-20-18-13)10-3-7-12(16)8-4-10/h1-8,21H,(H,17,18,19,20)
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n/an/an/an/a>5.00E+3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014758
PNG
(Bis-(4-chloro-phenyl)-pyridin-3-yl-methanol | CHEM...)
Show SMILES OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1S/C18H13Cl2NO/c19-16-7-3-13(4-8-16)18(22,15-2-1-11-21-12-15)14-5-9-17(20)10-6-14/h1-12,22H
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n/an/an/an/a 150n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014757
PNG
((4-Chloro-phenyl)-(2-chloro-phenyl)-pyridin-3-yl-m...)
Show SMILES OC(c1ccc(Cl)cc1)(c1cccnc1)c1ccccc1Cl
Show InChI InChI=1S/C18H13Cl2NO/c19-15-9-7-13(8-10-15)18(22,14-4-3-11-21-12-14)16-5-1-2-6-17(16)20/h1-12,22H
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n/an/an/an/a>2.00E+3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014759
PNG
(5-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-thi...)
Show SMILES Clc1ccc(cc1)C(c1cncs1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C19H13Cl2N3S/c20-16-5-1-14(2-6-16)19(18-11-23-13-25-18,24-10-9-22-12-24)15-3-7-17(21)8-4-15/h1-13H
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n/an/an/an/a 17n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014761
PNG
(Bis-(4-chloro-phenyl)-(2H-[1,2,3]triazol-4-yl)-met...)
Show SMILES OC(c1cnn[nH]1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H11Cl2N3O/c16-12-5-1-10(2-6-12)15(21,14-9-18-20-19-14)11-3-7-13(17)8-4-11/h1-9,21H,(H,18,19,20)
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n/an/an/an/a 2.00E+3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014762
PNG
(Bis-(4-chloro-phenyl)-piperidin-3-yl-methanol | CH...)
Show SMILES OC(C1CCCNC1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H19Cl2NO/c19-16-7-3-13(4-8-16)18(22,15-2-1-11-21-12-15)14-5-9-17(20)10-6-14/h3-10,15,21-22H,1-2,11-12H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014766
PNG
(Bis-(4-chloro-phenyl)-pyrimidin-4-yl-methanol | CH...)
Show SMILES OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccncn1
Show InChI InChI=1S/C17H12Cl2N2O/c18-14-5-1-12(2-6-14)17(22,16-9-10-20-11-21-16)13-3-7-15(19)8-4-13/h1-11,22H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014764
PNG
(5-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-1H-...)
Show SMILES Clc1ccc(cc1)C(c1nnc[nH]1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C18H13Cl2N5/c19-15-5-1-13(2-6-15)18(17-22-11-23-24-17,25-10-9-21-12-25)14-3-7-16(20)8-4-14/h1-12H,(H,22,23,24)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014765
PNG
(1-[Bis-(4-chloro-phenyl)-methyl]-piperidine | CHEM...)
Show SMILES Clc1ccc(cc1)C(N1CCCCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H19Cl2N/c19-16-8-4-14(5-9-16)18(21-12-2-1-3-13-21)15-6-10-17(20)11-7-15/h4-11,18H,1-3,12-13H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014767
PNG
(2-[Bis-(4-chloro-phenyl)-methyl]-1H-pyrrole | CHEM...)
Show SMILES Clc1ccc(cc1)C(c1ccc[nH]1)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H13Cl2N/c18-14-7-3-12(4-8-14)17(16-2-1-11-20-16)13-5-9-15(19)10-6-13/h1-11,17,20H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014763
PNG
(4-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-1H-...)
Show SMILES Clc1ccc(cc1)C(c1cn[nH]c1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C19H14Cl2N4/c20-17-5-1-14(2-6-17)19(16-11-23-24-12-16,25-10-9-22-13-25)15-3-7-18(21)8-4-15/h1-13H,(H,23,24)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014768
PNG
((4-Chloro-2-methoxy-phenyl)-phenyl-pyridin-3-yl-me...)
Show SMILES COc1cc(Cl)ccc1C(O)(c1ccccc1)c1cccnc1
Show InChI InChI=1S/C19H16ClNO2/c1-23-18-12-16(20)9-10-17(18)19(22,14-6-3-2-4-7-14)15-8-5-11-21-13-15/h2-13,22H,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014769
PNG
(1-[Bis-(4-chloro-phenyl)-methyl]-1H-pyrazole | CHE...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)n1cccn1
Show InChI InChI=1S/C16H12Cl2N2/c17-14-6-2-12(3-7-14)16(20-11-1-10-19-20)13-4-8-15(18)9-5-13/h1-11,16H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014771
PNG
(Bis-(4-chloro-phenyl)-thiazol-5-yl-methanol | CHEM...)
Show SMILES OC(c1cncs1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H11Cl2NOS/c17-13-5-1-11(2-6-13)16(20,15-9-19-10-21-15)12-3-7-14(18)8-4-12/h1-10,20H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014770
PNG
(Bis-(4-chloro-phenyl)-(1H-imidazol-2-yl)-methanol ...)
Show SMILES OC(c1ncc[nH]1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H12Cl2N2O/c17-13-5-1-11(2-6-13)16(21,15-19-9-10-20-15)12-3-7-14(18)8-4-12/h1-10,21H,(H,19,20)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014773
PNG
(1-[Bis-(4-bromo-phenyl)-methyl]-1H-imidazole | CHE...)
Show SMILES Brc1ccc(cc1)C(c1ccc(Br)cc1)n1ccnc1
Show InChI InChI=1S/C16H12Br2N2/c17-14-5-1-12(2-6-14)16(20-10-9-19-11-20)13-3-7-15(18)8-4-13/h1-11,16H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014772
PNG
(3-[Bis-(4-chloro-phenyl)-fluoro-methyl]-pyridine |...)
Show SMILES FC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cccnc1
Show InChI InChI=1S/C18H12Cl2FN/c19-16-7-3-13(4-8-16)18(21,15-2-1-11-22-12-15)14-5-9-17(20)10-6-14/h1-12H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014775
PNG
(5-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-pyr...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)(c1cncnc1)n1ccnc1
Show InChI InChI=1S/C20H14Cl2N4/c21-18-5-1-15(2-6-18)20(26-10-9-23-14-26,17-11-24-13-25-12-17)16-3-7-19(22)8-4-16/h1-14H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014776
PNG
(1-[bis(4-chlorophenyl)(1H-imidazol-2-yl)methyl]-1H...)
Show SMILES Clc1ccc(cc1)C(c1ncc[nH]1)(c1ccc(Cl)cc1)n1ccnc1
Show InChI InChI=1S/C19H14Cl2N4/c20-16-5-1-14(2-6-16)19(18-23-9-10-24-18,25-12-11-22-13-25)15-3-7-17(21)8-4-15/h1-13H,(H,23,24)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014777
PNG
(1-Di-p-tolylmethyl-1H-imidazole | CHEMBL135381)
Show SMILES Cc1ccc(cc1)C(c1ccc(C)cc1)n1ccnc1
Show InChI InChI=1S/C18H18N2/c1-14-3-7-16(8-4-14)18(20-12-11-19-13-20)17-9-5-15(2)6-10-17/h3-13,18H,1-2H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014774
PNG
(Bis-(4-chloro-phenyl)-pyrazin-2-yl-methanol | CHEM...)
Show SMILES OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1cnccn1
Show InChI InChI=1S/C17H12Cl2N2O/c18-14-5-1-12(2-6-14)17(22,16-11-20-9-10-21-16)13-3-7-15(19)8-4-13/h1-11,22H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014779
PNG
(1-[Bis-(4-chloro-phenyl)-methyl]-piperazine | CHEM...)
Show SMILES Clc1ccc(cc1)C(N1CCNCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H18Cl2N2/c18-15-5-1-13(2-6-15)17(21-11-9-20-10-12-21)14-3-7-16(19)8-4-14/h1-8,17,20H,9-12H2
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n/an/an/an/a 1.93E+3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014324
PNG
(5-[Bis-(4-chloro-phenyl)-methyl]-pyrimidine | 5-[B...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)c1cncnc1
Show InChI InChI=1S/C17H12Cl2N2/c18-15-5-1-12(2-6-15)17(14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,17H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014778
PNG
(Bis-(4-chloro-phenyl)-(1H-pyrazol-4-yl)-methanol |...)
Show SMILES OC(c1cn[nH]c1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H12Cl2N2O/c17-14-5-1-11(2-6-14)16(21,13-9-19-20-10-13)12-3-7-15(18)8-4-12/h1-10,21H,(H,19,20)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014782
PNG
(1-[Bis-(4-chloro-phenyl)-methyl]-1H-[1,2,3]triazol...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)n1ccnn1
Show InChI InChI=1S/C15H11Cl2N3/c16-13-5-1-11(2-6-13)15(20-10-9-18-19-20)12-3-7-14(17)8-4-12/h1-10,15H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014780
PNG
(1-[Bis-(4-chloro-phenyl)-methyl]-1H-[1,2,4]triazol...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)n1cncn1
Show InChI InChI=1S/C15H11Cl2N3/c16-13-5-1-11(2-6-13)15(20-10-18-9-19-20)12-3-7-14(17)8-4-12/h1-10,15H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014781
PNG
(1-[(2-Methoxy-phenyl)-phenyl-methyl]-1H-imidazole ...)
Show SMILES COc1ccccc1C(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C17H16N2O/c1-20-16-10-6-5-9-15(16)17(19-12-11-18-13-19)14-7-3-2-4-8-14/h2-13,17H,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014785
PNG
(Bis-(4-chloro-phenyl)-(1H-imidazol-4-yl)-methanol ...)
Show SMILES OC(c1cnc[nH]1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H12Cl2N2O/c17-13-5-1-11(2-6-13)16(21,15-9-19-10-20-15)12-3-7-14(18)8-4-12/h1-10,21H,(H,19,20)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014786
PNG
(2-[Bis-(4-chloro-phenyl)-methyl]-2H-tetrazole | CH...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)n1ncnn1
Show InChI InChI=1S/C14H10Cl2N4/c15-12-5-1-10(2-6-12)14(20-18-9-17-19-20)11-3-7-13(16)8-4-11/h1-9,14H
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014784
PNG
((4-Chloro-phenyl)-pyridin-3-yl-(3-trifluoromethyl-...)
Show SMILES OC(c1ccc(Cl)cc1)(c1cccnc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C19H13ClF3NO/c20-17-8-6-13(7-9-17)18(25,16-5-2-10-24-12-16)14-3-1-4-15(11-14)19(21,22)23/h1-12,25H
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PC sid
UniChem
AffyNet 
PubMed
n/an/an/an/a 650n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
Cytochrome P450 19A1


(Rattus norvegicus)
BDBM50014783
PNG
(2-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-pyr...)
Show SMILES Clc1ccc(cc1)C(c1ccc(Cl)cc1)(c1ccccn1)n1ccnc1
Show InChI InChI=1S/C21H15Cl2N3/c22-18-8-4-16(5-9-18)21(26-14-13-24-15-26,20-3-1-2-12-25-20)17-6-10-19(23)11-7-17/h1-15H
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KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
n/an/an/an/a 29n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome


J Med Chem 33: 416-29 (1990)

More data for this
Ligand-Target Pair
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