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Compile Data Set for Download or QSAR

Found 87 hits Enz. Inhib. hit(s) with Target = 'D-Amino Acid Oxidase (DAAO)' AND taxid = 9823   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50004955
PNG
(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)
Show SMILES OC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12)
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3.40E+3n/an/an/an/an/an/an/an/a



Sunovion Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Competitive inhibition of pig kidney DAAO in presence of D-alanine


J Med Chem 56: 3710-24 (2013)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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2.10E+4n/an/an/an/an/an/an/an/a



Johns Hopkins University

Curated by ChEMBL


Assay Description
Competitive inhibition of pig kidney DAAO using D-Alanine as substrate by Michaelis-Menten plot analysis


Bioorg Med Chem Lett 23: 3910-3 (2013)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM31148
PNG
(3-hydroxyquinolin-2(1H)-one, 2)
Show SMILES Oc1cc2ccccc2[nH]c1=O
Show InChI InChI=1S/C9H7NO2/c11-8-5-6-3-1-2-4-7(6)10-9(8)12/h1-5,11H,(H,10,12)
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n/an/a 100n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170227
PNG
(CHEMBL3805642)
Show SMILES Cc1c(F)cnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C8H6FN3O2/c1-3-4(9)2-10-6-5(3)11-7(13)8(14)12-6/h2H,1H3,(H,11,13)(H,10,12,14)
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n/an/a 150n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170229
PNG
(CHEMBL3804851)
Show SMILES Clc1ccnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C7H4ClN3O2/c8-3-1-2-9-5-4(3)10-6(12)7(13)11-5/h1-2H,(H,10,12)(H,9,11,13)
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n/an/a 180n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM23174
PNG
(6-chloro-1,2-benzoxazol-3-ol | 6-chlorobenzo[d]iso...)
Show SMILES Clc1ccc2c(c1)o[nH]c2=O
Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)
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n/an/a 188n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...


J Med Chem 51: 3357-9 (2008)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393043
PNG
(CHEMBL2152732)
Show SMILES On1c2ccc3CCOc3c2[nH]c1=O
Show InChI InChI=1S/C9H8N2O3/c12-9-10-7-6(11(9)13)2-1-5-3-4-14-8(5)7/h1-2,13H,3-4H2,(H,10,12)
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n/an/a 200n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170230
PNG
(CHEMBL445990)
Show SMILES Oc1noc2cc(Cl)ccc12
Show InChI InChI=1S/C7H4ClNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)
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n/an/a 210n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170228
PNG
(CHEMBL3804953)
Show SMILES Brc1ccnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C7H4BrN3O2/c8-3-1-2-9-5-4(3)10-6(12)7(13)11-5/h1-2H,(H,10,12)(H,9,11,13)
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n/an/a 220n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170225
PNG
(CHEMBL3805223)
Show SMILES Clc1cnc2[nH]c(=O)c(=O)[nH]c2c1Br
Show InChI InChI=1S/C7H3BrClN3O2/c8-3-2(9)1-10-5-4(3)11-6(13)7(14)12-5/h1H,(H,11,13)(H,10,12,14)
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n/an/a 240n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170226
PNG
(CHEMBL92084)
Show SMILES Cc1c(Cl)cnc2nc(O)c(O)nc12
Show InChI InChI=1S/C8H6ClN3O2/c1-3-4(9)2-10-6-5(3)11-7(13)8(14)12-6/h2H,1H3,(H,11,13)(H,10,12,14)
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n/an/a 260n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM23175
PNG
(6-methyl-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-...)
Show SMILES Cc1ccc2c(c1)o[nH]c2=O
Show InChI InChI=1S/C8H7NO2/c1-5-2-3-6-7(4-5)11-9-8(6)10/h2-4H,1H3,(H,9,10)
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n/an/a 269n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...


J Med Chem 51: 3357-9 (2008)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170234
PNG
(CHEMBL329680)
Show SMILES Cc1c(Br)cnc2nc(O)c(O)nc12
Show InChI InChI=1S/C8H6BrN3O2/c1-3-4(9)2-10-6-5(3)11-7(13)8(14)12-6/h2H,1H3,(H,11,13)(H,10,12,14)
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n/an/a 400n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393045
PNG
(CHEMBL2152734)
Show SMILES On1c2cc(F)cc(F)c2[nH]c1=O
Show InChI InChI=1S/C7H4F2N2O2/c8-3-1-4(9)6-5(2-3)11(13)7(12)10-6/h1-2,13H,(H,10,12)
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n/an/a 400n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393063
PNG
(CHEMBL2152724)
Show SMILES COc1cccc2n(O)c(=O)[nH]c12
Show InChI InChI=1S/C8H8N2O3/c1-13-6-4-2-3-5-7(6)9-8(11)10(5)12/h2-4,12H,1H3,(H,9,11)
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n/an/a 400n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393061
PNG
(CHEMBL2152722)
Show SMILES Cc1cccc2n(O)c(=O)[nH]c12
Show InChI InChI=1S/C8H8N2O2/c1-5-3-2-4-6-7(5)9-8(11)10(6)12/h2-4,12H,1H3,(H,9,11)
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TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM23173
PNG
(6-fluoro-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-...)
Show SMILES Fc1ccc2c(c1)o[nH]c2=O
Show InChI InChI=1S/C7H4FNO2/c8-4-1-2-5-6(3-4)11-9-7(5)10/h1-3H,(H,9,10)
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n/an/a 444n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...


J Med Chem 51: 3357-9 (2008)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170246
PNG
(CHEMBL3806244)
Show SMILES Fc1cnc2[nH]c(=O)c(=O)[nH]c2c1
Show InChI InChI=1S/C7H4FN3O2/c8-3-1-4-5(9-2-3)11-7(13)6(12)10-4/h1-2H,(H,10,12)(H,9,11,13)
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Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170232
PNG
(CHEMBL3805370)
Show SMILES Clc1c(Br)cnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C7H3BrClN3O2/c8-2-1-10-5-4(3(2)9)11-6(13)7(14)12-5/h1H,(H,11,13)(H,10,12,14)
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n/an/a 480n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393060
PNG
(CHEMBL2152721)
Show SMILES On1c2cccc(F)c2[nH]c1=O
Show InChI InChI=1S/C7H5FN2O2/c8-4-2-1-3-5-6(4)9-7(11)10(5)12/h1-3,12H,(H,9,11)
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TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170274
PNG
(CHEMBL3804949)
Show SMILES FC(F)(F)c1ccnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C8H4F3N3O2/c9-8(10,11)3-1-2-12-5-4(3)13-6(15)7(16)14-5/h1-2H,(H,13,15)(H,12,14,16)
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Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170231
PNG
(CHEMBL3806101)
Show SMILES Brc1cnc2[nH]c(=O)c(=O)[nH]c2c1Br
Show InChI InChI=1S/C7H3Br2N3O2/c8-2-1-10-5-4(3(2)9)11-6(13)7(14)12-5/h1H,(H,11,13)(H,10,12,14)
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n/an/a 530n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM23170
PNG
(5-bromo-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-o...)
Show SMILES Brc1ccc2o[nH]c(=O)c2c1
Show InChI InChI=1S/C7H4BrNO2/c8-4-1-2-6-5(3-4)7(10)9-11-6/h1-3H,(H,9,10)
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n/an/a 599n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...


J Med Chem 51: 3357-9 (2008)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393051
PNG
(CHEMBL2152740)
Show SMILES On1c2cc(F)ccc2[nH]c1=O
Show InChI InChI=1S/C7H5FN2O2/c8-4-1-2-5-6(3-4)10(12)7(11)9-5/h1-3,12H,(H,9,11)
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TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170277
PNG
(CHEMBL3805717)
Show SMILES Cc1ccnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C8H7N3O2/c1-4-2-3-9-6-5(4)10-7(12)8(13)11-6/h2-3H,1H3,(H,10,12)(H,9,11,13)
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n/an/a 630n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170233
PNG
(CHEMBL3805789)
Show SMILES Clc1cnc2[nH]c(=O)c(=O)[nH]c2c1Cl
Show InChI InChI=1S/C7H3Cl2N3O2/c8-2-1-10-5-4(3(2)9)11-6(13)7(14)12-5/h1H,(H,11,13)(H,10,12,14)
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n/an/a 650n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393070
PNG
(CHEMBL2152731)
Show SMILES Cc1c(F)ccc2n(O)c(=O)[nH]c12
Show InChI InChI=1S/C8H7FN2O2/c1-4-5(9)2-3-6-7(4)10-8(12)11(6)13/h2-3,13H,1H3,(H,10,12)
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n/an/a 700n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM23178
PNG
(6-nitro-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-o...)
Show SMILES [O-][N+](=O)c1ccc2c(c1)o[nH]c2=O
Show InChI InChI=1S/C7H4N2O4/c10-7-5-2-1-4(9(11)12)3-6(5)13-8-7/h1-3H,(H,8,10)
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n/an/a 722n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...


J Med Chem 51: 3357-9 (2008)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393069
PNG
(CHEMBL2152730)
Show SMILES Cc1ccc2n(O)c(=O)[nH]c2c1C
Show InChI InChI=1S/C9H10N2O2/c1-5-3-4-7-8(6(5)2)10-9(12)11(7)13/h3-4,13H,1-2H3,(H,10,12)
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n/an/a 1.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393046
PNG
(CHEMBL2152735)
Show SMILES On1c2ccc(F)cc2[nH]c1=O
Show InChI InChI=1S/C7H5FN2O2/c8-4-1-2-6-5(3-4)9-7(11)10(6)12/h1-3,12H,(H,9,11)
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n/an/a 1.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393049
PNG
(CHEMBL2152738)
Show SMILES Cc1cc2[nH]c(=O)n(O)c2cc1F
Show InChI InChI=1S/C8H7FN2O2/c1-4-2-6-7(3-5(4)9)11(13)8(12)10-6/h2-3,13H,1H3,(H,10,12)
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n/an/a 1.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393059
PNG
(CHEMBL2152720)
Show SMILES On1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C7H6N2O2/c10-7-8-5-3-1-2-4-6(5)9(7)11/h1-4,11H,(H,8,10)
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n/an/a 1.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM23171
PNG
(5-iodo-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-ol...)
Show SMILES Ic1ccc2o[nH]c(=O)c2c1
Show InChI InChI=1S/C7H4INO2/c8-4-1-2-6-5(3-4)7(10)9-11-6/h1-3H,(H,9,10)
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n/an/a 1.51E+3n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...


J Med Chem 51: 3357-9 (2008)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM23166
PNG
(1,2-benzoxazol-3-ol | BIO | benzo[d]isoxazol-3-ol)
Show SMILES O=c1[nH]oc2ccccc12
Show InChI InChI=1S/C7H5NO2/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9)
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n/an/a 1.88E+3n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...


J Med Chem 51: 3357-9 (2008)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393052
PNG
(CHEMBL2152741)
Show SMILES On1c2cc(Cl)ccc2[nH]c1=O
Show InChI InChI=1S/C7H5ClN2O2/c8-4-1-2-5-6(3-4)10(12)7(11)9-5/h1-3,12H,(H,9,11)
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n/an/a 2.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170276
PNG
(CHEMBL3805575)
Show SMILES CCc1ccnc2[nH]c(=O)c(=O)[nH]c12
Show InChI InChI=1S/C9H9N3O2/c1-2-5-3-4-10-7-6(5)11-8(13)9(14)12-7/h3-4H,2H2,1H3,(H,11,13)(H,10,12,14)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM23176
PNG
(6-methoxy-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3...)
Show SMILES COc1ccc2c(c1)o[nH]c2=O
Show InChI InChI=1S/C8H7NO3/c1-11-5-2-3-6-7(4-5)12-9-8(6)10/h2-4H,1H3,(H,9,10)
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n/an/a 2.57E+3n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...


J Med Chem 51: 3357-9 (2008)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM23172
PNG
(5-nitro-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-o...)
Show SMILES [O-][N+](=O)c1ccc2o[nH]c(=O)c2c1
Show InChI InChI=1S/C7H4N2O4/c10-7-5-3-4(9(11)12)1-2-6(5)13-8-7/h1-3H,(H,8,10)
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n/an/a 2.95E+3n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...


J Med Chem 51: 3357-9 (2008)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393047
PNG
(CHEMBL2152736)
Show SMILES Cc1ccc2n(O)c(=O)[nH]c2c1
Show InChI InChI=1S/C8H8N2O2/c1-5-2-3-7-6(4-5)9-8(11)10(7)12/h2-4,12H,1H3,(H,9,11)
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n/an/a 4.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393044
PNG
(CHEMBL2152733)
Show SMILES Cc1cc(C)c2[nH]c(=O)n(O)c2c1
Show InChI InChI=1S/C9H10N2O2/c1-5-3-6(2)8-7(4-5)11(13)9(12)10-8/h3-4,13H,1-2H3,(H,10,12)
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n/an/a 4.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM23179
PNG
(6-(trifluoromethyl)-1,2-benzoxazol-3-ol | Benzo[d]...)
Show SMILES FC(F)(F)c1ccc2c(c1)o[nH]c2=O
Show InChI InChI=1S/C8H4F3NO2/c9-8(10,11)4-1-2-5-6(3-4)14-12-7(5)13/h1-3H,(H,12,13)
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n/an/a 5.00E+3n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...


J Med Chem 51: 3357-9 (2008)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170280
PNG
(CHEMBL27808)
Show SMILES Oc1nc2cccnc2nc1O
Show InChI InChI=1S/C7H5N3O2/c11-6-7(12)10-5-4(9-6)2-1-3-8-5/h1-3H,(H,9,11)(H,8,10,12)
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n/an/a 5.70E+3n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170245
PNG
(CHEMBL123118)
Show SMILES Oc1nc2cc(Cl)cnc2nc1O
Show InChI InChI=1S/C7H4ClN3O2/c8-3-1-4-5(9-2-3)11-7(13)6(12)10-4/h1-2H,(H,10,12)(H,9,11,13)
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n/an/a 6.70E+3n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393053
PNG
(CHEMBL2152742)
Show SMILES Cc1ccc2[nH]c(=O)n(O)c2c1
Show InChI InChI=1S/C8H8N2O2/c1-5-2-3-6-7(4-5)10(12)8(11)9-6/h2-4,12H,1H3,(H,9,11)
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n/an/a 7.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM23169
PNG
(4-fluoro-1,2-benzoxazol-3-ol | Benzo[d]isoxazol-3-...)
Show SMILES Fc1cccc2o[nH]c(=O)c12
Show InChI InChI=1S/C7H4FNO2/c8-4-2-1-3-5-6(4)7(10)9-11-5/h1-3H,(H,9,10)
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n/an/a 7.82E+3n/an/an/an/a8.522



MGI Pharma



Assay Description
D-amino acid oxidase (DAAO) was assayed in a 96-well plate format. D-serine was oxidatively deaminated by porcine D-amino acid oxidase in the presenc...


J Med Chem 51: 3357-9 (2008)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393050
PNG
(CHEMBL2152739)
Show SMILES On1c2cc3CCCc3cc2[nH]c1=O
Show InChI InChI=1S/C10H10N2O2/c13-10-11-8-4-6-2-1-3-7(6)5-9(8)12(10)14/h4-5,14H,1-3H2,(H,11,13)
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n/an/a 1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393066
PNG
(CHEMBL2152727)
Show SMILES CC(C)c1cccc2n(O)c(=O)[nH]c12
Show InChI InChI=1S/C10H12N2O2/c1-6(2)7-4-3-5-8-9(7)11-10(13)12(8)14/h3-6,14H,1-2H3,(H,11,13)
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n/an/a 1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170244
PNG
(CHEMBL122339)
Show SMILES Oc1nc2cc(Br)cnc2nc1O
Show InChI InChI=1S/C7H4BrN3O2/c8-3-1-4-5(9-2-3)11-7(13)6(12)10-4/h1-2H,(H,10,12)(H,9,11,13)
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n/an/a 1.24E+4n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50170279
PNG
(CHEMBL281055)
Show SMILES Cc1ccc2nc(O)c(O)nc2n1
Show InChI InChI=1S/C8H7N3O2/c1-4-2-3-5-6(9-4)11-8(13)7(12)10-5/h2-3H,1H3,(H,10,12)(H,9,11,13)
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n/an/a 1.77E+4n/an/an/an/an/an/a



Shanghai Jiao Tong University

Curated by ChEMBL


Assay Description
Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reade...


Eur J Med Chem 117: 19-32 (2016)

More data for this
Ligand-Target Pair
D-Amino Acid Oxidase (DAAO)


(Sus scrofa (pig))
BDBM50393062
PNG
(CHEMBL2152723)
Show SMILES CCc1cccc2n(O)c(=O)[nH]c12
Show InChI InChI=1S/C9H10N2O2/c1-2-6-4-3-5-7-8(6)10-9(12)11(7)13/h3-5,13H,2H2,1H3,(H,10,12)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
n/an/a 2.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of pig DAAO using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay


Citation and Details
More data for this
Ligand-Target Pair
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