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Found 15 hits Enz. Inhib. hit(s) with Target = 'DNA (cytosine-5)-methyltransferase 1' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031315
PNG
(CHEMBL3358028)
Show SMILES CC(C)NCC(O)COC(Cn1c2ccccc2c2ccccc12)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C33H35N3O2/c1-23(2)34-19-24(37)22-38-25(20-35-30-15-7-3-11-26(30)27-12-4-8-16-31(27)35)21-36-32-17-9-5-13-28(32)29-14-6-10-18-33(29)36/h3-18,23-25,34,37H,19-22H2,1-2H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031320
PNG
(CHEMBL3358030)
Show SMILES CC(C)NC[C@H](O)COC(Cn1c2ccccc2c2ccccc12)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C33H35N3O2/c1-23(2)34-19-24(37)22-38-25(20-35-30-15-7-3-11-26(30)27-12-4-8-16-31(27)35)21-36-32-17-9-5-13-28(32)29-14-6-10-18-33(29)36/h3-18,23-25,34,37H,19-22H2,1-2H3/t24-/s2
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n/an/a 1.80E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM43255
PNG
(1-(3,6-dichloro-9-carbazolyl)-3-[2-(3H-indol-3-yl)...)
Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccc(Cl)cc2c2cc(Cl)ccc12
Show InChI InChI=1S/C25H23Cl2N3O/c26-17-5-7-24-21(11-17)22-12-18(27)6-8-25(22)30(24)15-19(31)14-28-10-9-16-13-29-23-4-2-1-3-20(16)23/h1-8,11-13,19,28-29,31H,9-10,14-15H2
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n/an/a 2.50E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031321
PNG
(CHEMBL3358029)
Show SMILES CC(C)NC[C@@H](O)COC(Cn1c2ccccc2c2ccccc12)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C33H35N3O2/c1-23(2)34-19-24(37)22-38-25(20-35-30-15-7-3-11-26(30)27-12-4-8-16-31(27)35)21-36-32-17-9-5-13-28(32)29-14-6-10-18-33(29)36/h3-18,23-25,34,37H,19-22H2,1-2H3/t24-/s2
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n/an/a 2.50E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031331
PNG
(CHEMBL3358016)
Show SMILES O[C@H](CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C25H25N3O/c29-19(16-26-14-13-18-15-27-23-10-4-1-7-20(18)23)17-28-24-11-5-2-8-21(24)22-9-3-6-12-25(22)28/h1-12,15,19,26-27,29H,13-14,16-17H2/t19-/s2
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n/an/a 7.30E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031317
PNG
(CHEMBL3358015)
Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C25H25N3O/c29-19(16-26-14-13-18-15-27-23-10-4-1-7-20(18)23)17-28-24-11-5-2-8-21(24)22-9-3-6-12-25(22)28/h1-12,15,19,26-27,29H,13-14,16-17H2
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n/an/a 1.03E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031325
PNG
(CHEMBL3358023)
Show SMILES OCCNCC(O)Cn1c2ccc(Br)cc2c2cc(Br)ccc12
Show InChI InChI=1/C17H18Br2N2O2/c18-11-1-3-16-14(7-11)15-8-12(19)2-4-17(15)21(16)10-13(23)9-20-5-6-22/h1-4,7-8,13,20,22-23H,5-6,9-10H2
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n/an/a 1.41E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031329
PNG
(CHEMBL3358017)
Show SMILES O[C@@H](CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C25H25N3O/c29-19(16-26-14-13-18-15-27-23-10-4-1-7-20(18)23)17-28-24-11-5-2-8-21(24)22-9-3-6-12-25(22)28/h1-12,15,19,26-27,29H,13-14,16-17H2/t19-/s2
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CHEMBL
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n/an/a 1.56E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031328
PNG
(CHEMBL3358020)
Show SMILES OC(CNCCc1ccccc1)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C23H24N2O/c26-19(16-24-15-14-18-8-2-1-3-9-18)17-25-22-12-6-4-10-20(22)21-11-5-7-13-23(21)25/h1-13,19,24,26H,14-17H2
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n/an/a 2.07E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031327
PNG
(CHEMBL3358021)
Show SMILES COCCNCC(O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C18H22N2O2/c1-22-11-10-19-12-14(21)13-20-17-8-4-2-6-15(17)16-7-3-5-9-18(16)20/h2-9,14,19,21H,10-13H2,1H3
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n/an/a 2.96E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031322
PNG
(CHEMBL3358027)
Show SMILES CC(C)(CO)CC(O)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C19H23NO2/c1-19(2,13-21)11-14(22)12-20-17-9-5-3-7-15(17)16-8-4-6-10-18(16)20/h3-10,14,21-22H,11-13H2,1-2H3
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n/an/a 7.09E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031318
PNG
(CHEMBL1911321)
Show SMILES OC(CNCc1ccccc1)Cn1c2CCCCc2c2ccccc12
Show InChI InChI=1/C22H26N2O/c25-18(15-23-14-17-8-2-1-3-9-17)16-24-21-12-6-4-10-19(21)20-11-5-7-13-22(20)24/h1-4,6,8-10,12,18,23,25H,5,7,11,13-16H2
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n/an/a 8.09E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031323
PNG
(CHEMBL1557883)
Show SMILES CC1CCN(CC(O)Cn2c3ccccc3c3ccccc23)CC1
Show InChI InChI=1/C21H26N2O/c1-16-10-12-22(13-11-16)14-17(24)15-23-20-8-4-2-6-18(20)19-7-3-5-9-21(19)23/h2-9,16-17,24H,10-15H2,1H3
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n/an/a 8.41E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins before additio...


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031315
PNG
(CHEMBL3358028)
Show SMILES CC(C)NCC(O)COC(Cn1c2ccccc2c2ccccc12)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C33H35N3O2/c1-23(2)34-19-24(37)22-38-25(20-35-30-15-7-3-11-26(30)27-12-4-8-16-31(27)35)21-36-32-17-9-5-13-28(32)29-14-6-10-18-33(29)36/h3-18,23-25,34,37H,19-22H2,1-2H3
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n/an/an/a 910n/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) by SPR assay


Citation and Details
More data for this
Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1


(Mus musculus)
BDBM50031317
PNG
(CHEMBL3358015)
Show SMILES OC(CNCCc1c[nH]c2ccccc12)Cn1c2ccccc2c2ccccc12
Show InChI InChI=1/C25H25N3O/c29-19(16-26-14-13-18-15-27-23-10-4-1-7-20(18)23)17-28-24-11-5-2-8-21(24)22-9-3-6-12-25(22)28/h1-12,15,19,26-27,29H,13-14,16-17H2
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n/an/an/a 1.09E+3n/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Binding affinity to N-terminal His6-tagged mouse DNMT1 (731 to 1602 residues) expressed in Escherichia coli BL21 (DE3) by SPR assay


Citation and Details
More data for this
Ligand-Target Pair