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Compile Data Set for Download or QSAR

Found 80 hits Enz. Inhib. hit(s) with Target = 'DNA gyrase subunit A' AND taxid = 83333   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139408
PNG
(US8889671, 38)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2C[C@H](CF)OC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H21F2N5O7/c1-8-6-28-14-10(4-22(16(28)9(2)34-8)18(30)25-20(32)26-19(22)31)3-12-15(13(14)24)36-27-17(12)29-7-11(5-23)35-21(29)33/h3,8-9,11,16H,4-7H2,1-2H3,(H2,25,26,30,31,32)/t8-,9+,11+,16-/s2
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US Patent
n/an/a 67n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139409
PNG
(US8889671, 39)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@H](COC2=O)C=C)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C23H22FN5O7/c1-4-12-8-34-22(33)29(12)18-13-5-11-6-23(19(30)25-21(32)26-20(23)31)17-10(3)35-9(2)7-28(17)15(11)14(24)16(13)36-27-18/h4-5,9-10,12,17H,1,6-8H2,2-3H3,(H2,25,26,30,31,32)/t9-,10+,12+,17-/s2
PDB
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n/an/a 97n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139407
PNG
(US8889671, 37)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2C[C@H](CO)OC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H22FN5O8/c1-8-5-27-14-10(4-22(16(27)9(2)34-8)18(30)24-20(32)25-19(22)31)3-12-15(13(14)23)36-26-17(12)28-6-11(7-29)35-21(28)33/h3,8-9,11,16,29H,4-7H2,1-2H3,(H2,24,25,30,31,32)/t8-,9+,11-,16-/s2
PDB
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KEGG

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n/an/a 120n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139428
PNG
(US8889671, 65)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@H](COC2=O)C#C)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C23H20FN5O7/c1-4-12-8-34-22(33)29(12)18-13-5-11-6-23(19(30)25-21(32)26-20(23)31)17-10(3)35-9(2)7-28(17)15(11)14(24)16(13)36-27-18/h1,5,9-10,12,17H,6-8H2,2-3H3,(H2,25,26,30,31,32)/t9-,10+,12+,17-/s2
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n/an/a 120n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139386
PNG
(US8889671, 15)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](CF)COC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H21F2N5O7/c1-8-6-28-14-10(4-22(16(28)9(2)35-8)18(30)25-20(32)26-19(22)31)3-12-15(13(14)24)36-27-17(12)29-11(5-23)7-34-21(29)33/h3,8-9,11,16H,4-7H2,1-2H3,(H2,25,26,30,31,32)/t8-,9+,11+,16-/s2
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n/an/a 130n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139388
PNG
(US8889671, 17 | US8889671, 67)
Show SMILES COC[C@H]1COC(=O)N1c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C23H24FN5O8/c1-9-6-28-15-11(5-23(17(28)10(2)36-9)19(30)25-21(32)26-20(23)31)4-13-16(14(15)24)37-27-18(13)29-12(7-34-3)8-35-22(29)33/h4,9-10,12,17H,5-8H2,1-3H3,(H2,25,26,30,31,32)/t9-,10+,12+,17-/s2
PDB
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n/an/a 140n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139443
PNG
(US8889671, 47)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@H](CN=[N+]=[N-])COC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H21FN8O7/c1-8-6-30-14-10(4-22(16(30)9(2)37-8)18(32)26-20(34)27-19(22)33)3-12-15(13(14)23)38-28-17(12)31-11(5-25-29-24)7-36-21(31)35/h3,8-9,11,16H,4-7H2,1-2H3,(H2,26,27,32,33,34)/t8-,9+,11-,16-/s2
PDB
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US Patent
n/an/a 150n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139445
PNG
(US8889671, 55)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](COC2=O)c2ccccn2)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C26H23FN6O7/c1-11-9-32-18-13(8-26(20(32)12(2)39-11)22(34)29-24(36)30-23(26)35)7-14-19(17(18)27)40-31-21(14)33-16(10-38-25(33)37)15-5-3-4-6-28-15/h3-7,11-12,16,20H,8-10H2,1-2H3,(H2,29,30,34,35,36)/t11-,12+,16+,20-/s2
PDB
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US Patent
n/an/a 150n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139390
PNG
(US8889671, 19)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2C[C@@H](CF)OC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H21F2N5O7/c1-8-6-28-14-10(4-22(16(28)9(2)34-8)18(30)25-20(32)26-19(22)31)3-12-15(13(14)24)36-27-17(12)29-7-11(5-23)35-21(29)33/h3,8-9,11,16H,4-7H2,1-2H3,(H2,25,26,30,31,32)/t8-,9+,11-,16-/s2
PDB
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US Patent
n/an/a 160n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139434
PNG
(US8889671, 71)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](CC#N)COC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C23H21FN6O7/c1-9-7-29-15-11(6-23(17(29)10(2)36-9)19(31)26-21(33)27-20(23)32)5-13-16(14(15)24)37-28-18(13)30-12(3-4-25)8-35-22(30)34/h5,9-10,12,17H,3,6-8H2,1-2H3,(H2,26,27,31,32,33)/t9-,10+,12+,17-/s2
PDB
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n/an/a 160n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139376
PNG
(US8889671, 5)
Show SMILES C[C@H]1COC(=O)N1c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/s2
PDB
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US Patent
n/an/a 169n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139397
PNG
(US8889671, 26)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2C[C@@H](CO)OC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H22FN5O8/c1-8-5-27-14-10(4-22(16(27)9(2)34-8)18(30)24-20(32)25-19(22)31)3-12-15(13(14)23)36-26-17(12)28-6-11(7-29)35-21(28)33/h3,8-9,11,16,29H,4-7H2,1-2H3,(H2,24,25,30,31,32)/t8-,9+,11+,16-/s2
PDB
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US Patent
n/an/a 170n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139429
PNG
(US8889671, 66)
Show SMILES C[C@H]1COC(=O)N1c1noc2c(Cl)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C22H22ClN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/s2
PDB
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US Patent
n/an/a 170n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139416
PNG
(US8889671, 46)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](CS(C)(=O)=O)COC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C23H24FN5O9S/c1-9-6-28-15-11(5-23(17(28)10(2)37-9)19(30)25-21(32)26-20(23)31)4-13-16(14(15)24)38-27-18(13)29-12(7-36-22(29)33)8-39(3,34)35/h4,9-10,12,17H,5-8H2,1-3H3,(H2,25,26,30,31,32)/t9-,10+,12-,17-/s2
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n/an/a 170n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139441
PNG
(US8889671, 80)
Show SMILES COC[C@@H]1[C@@H](C)OC(=O)N1c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C24H26FN5O8/c1-9-7-29-16-12(6-24(18(29)11(3)36-9)20(31)26-22(33)27-21(24)32)5-13-17(15(16)25)38-28-19(13)30-14(8-35-4)10(2)37-23(30)34/h5,9-11,14,18H,6-8H2,1-4H3,(H2,26,27,31,32,33)/t9-,10-,11+,14-,18-/s2
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n/an/a 170n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139387
PNG
(US8889671, 16)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@H](CF)COC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H21F2N5O7/c1-8-6-28-14-10(4-22(16(28)9(2)35-8)18(30)25-20(32)26-19(22)31)3-12-15(13(14)24)36-27-17(12)29-11(5-23)7-34-21(29)33/h3,8-9,11,16H,4-7H2,1-2H3,(H2,25,26,30,31,32)/t8-,9+,11-,16-/s2
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US Patent
n/an/a 190n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139419
PNG
(US8889671, 50)
Show SMILES COCCOC[C@H]1COC(=O)N1c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C25H28FN5O9/c1-11-8-30-17-13(7-25(19(30)12(2)39-11)21(32)27-23(34)28-22(25)33)6-15-18(16(17)26)40-29-20(15)31-14(10-38-24(31)35)9-37-5-4-36-3/h6,11-12,14,19H,4-5,7-10H2,1-3H3,(H2,27,28,32,33,34)/t11-,12+,14+,19-/s2
PDB
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US Patent
n/an/a 200n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139393
PNG
(US8889671, 22)
Show SMILES C[C@@H]1CN(C(=O)O1)c1noc2c(Cl)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C22H22ClN5O7/c1-8-6-27-14-11(5-22(16(27)10(3)33-8)18(29)24-20(31)25-19(22)30)4-12-15(13(14)23)35-26-17(12)28-7-9(2)34-21(28)32/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9-,10+,16-/s2
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n/an/a 210n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139431
PNG
(US8889671, 68)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@H](COC2=O)c2ncnn2C)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C24H23FN8O7/c1-9-6-32-15-11(5-24(17(32)10(2)39-9)20(34)28-22(36)29-21(24)35)4-12-16(14(15)25)40-30-18(12)33-13(7-38-23(33)37)19-26-8-27-31(19)3/h4,8-10,13,17H,5-7H2,1-3H3,(H2,28,29,34,35,36)/t9-,10+,13-,17-/s2
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n/an/a 220n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139404
PNG
(US8889671, 34)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(Cl)c23)N2[C@@H](CCCF)COC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C24H25ClFN5O7/c1-10-8-30-16-12(7-24(18(30)11(2)37-10)20(32)27-22(34)28-21(24)33)6-14-17(15(16)25)38-29-19(14)31-13(4-3-5-26)9-36-23(31)35/h6,10-11,13,18H,3-5,7-9H2,1-2H3,(H2,27,28,32,33,34)/t10-,11+,13+,18-/s2
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n/an/a 230n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139403
PNG
(US8889671, 33)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(Cl)c23)N2[C@@H](CCCO)COC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C24H26ClN5O8/c1-10-8-29-16-12(7-24(18(29)11(2)37-10)20(32)26-22(34)27-21(24)33)6-14-17(15(16)25)38-28-19(14)30-13(4-3-5-31)9-36-23(30)35/h6,10-11,13,18,31H,3-5,7-9H2,1-2H3,(H2,26,27,32,33,34)/t10-,11+,13+,18-/s2
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n/an/a 260n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139396
PNG
(US8889671, 25)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](CC=C)COC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C24H24FN5O7/c1-4-5-13-9-35-23(34)30(13)19-14-6-12-7-24(20(31)26-22(33)27-21(24)32)18-11(3)36-10(2)8-29(18)16(12)15(25)17(14)37-28-19/h4,6,10-11,13,18H,1,5,7-9H2,2-3H3,(H2,26,27,31,32,33)/t10-,11+,13+,18-/s2
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n/an/a 260n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139415
PNG
(US8889671, 45)
Show SMILES CSC[C@H]1COC(=O)N1c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C23H24FN5O7S/c1-9-6-28-15-11(5-23(17(28)10(2)35-9)19(30)25-21(32)26-20(23)31)4-13-16(14(15)24)36-27-18(13)29-12(8-37-3)7-34-22(29)33/h4,9-10,12,17H,5-8H2,1-3H3,(H2,25,26,30,31,32)/t9-,10+,12-,17-/s2
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n/an/a 260n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139399
PNG
(US8889671, 29)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](CCCO)COC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C24H26FN5O8/c1-10-8-29-16-12(7-24(18(29)11(2)37-10)20(32)26-22(34)27-21(24)33)6-14-17(15(16)25)38-28-19(14)30-13(4-3-5-31)9-36-23(30)35/h6,10-11,13,18,31H,3-5,7-9H2,1-2H3,(H2,26,27,32,33,34)/t10-,11+,13+,18-/s2
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n/an/a 270n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139412
PNG
(US8889671, 42)
Show SMILES CON=C[C@H]1COC(=O)N1c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C23H23FN6O8/c1-9-7-29-15-11(5-23(17(29)10(2)37-9)19(31)26-21(33)27-20(23)32)4-13-16(14(15)24)38-28-18(13)30-12(6-25-35-3)8-36-22(30)34/h4,6,9-10,12,17H,5,7-8H2,1-3H3,(H2,26,27,31,32,33)/b25-6+/t9-,10+,12+,17-/s2
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n/an/a 290n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139435
PNG
(US8889671, 72)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@H](COC2=O)[C@@H](O)CO)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C23H24FN5O9/c1-8-5-28-15-10(4-23(17(28)9(2)37-8)19(32)25-21(34)26-20(23)33)3-11-16(14(15)24)38-27-18(11)29-12(13(31)6-30)7-36-22(29)35/h3,8-9,12-13,17,30-31H,4-7H2,1-2H3,(H2,25,26,32,33,34)/t8-,9+,12-,13+,17-/s2
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n/an/a 290n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139405
PNG
(US8889671, 35)
Show SMILES COC[C@@H]1CN(C(=O)O1)c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C23H24FN5O8/c1-9-6-28-15-11(5-23(17(28)10(2)35-9)19(30)25-21(32)26-20(23)31)4-13-16(14(15)24)37-27-18(13)29-7-12(8-34-3)36-22(29)33/h4,9-10,12,17H,5-8H2,1-3H3,(H2,25,26,30,31,32)/t9-,10+,12+,17-/s2
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n/an/a 310n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139388
PNG
(US8889671, 17 | US8889671, 67)
Show SMILES COC[C@H]1COC(=O)N1c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C23H24FN5O8/c1-9-6-28-15-11(5-23(17(28)10(2)36-9)19(30)25-21(32)26-20(23)31)4-13-16(14(15)24)37-27-18(13)29-12(7-34-3)8-35-22(29)33/h4,9-10,12,17H,5-8H2,1-3H3,(H2,25,26,30,31,32)/t9-,10+,12+,17-/s2
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n/an/a 330n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139436
PNG
(US8889671, 73)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@H](COC2=O)[C@H](O)CO)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C23H24FN5O9/c1-8-5-28-15-10(4-23(17(28)9(2)37-8)19(32)25-21(34)26-20(23)33)3-11-16(14(15)24)38-27-18(11)29-12(13(31)6-30)7-36-22(29)35/h3,8-9,12-13,17,30-31H,4-7H2,1-2H3,(H2,25,26,32,33,34)/t8-,9+,12-,13-,17-/s2
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n/an/a 340n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139447
PNG
(US8889671, 61 | US8889671, 63)
Show SMILES C[C@@H]1CN2C([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](COC2=O)c2ncccn2)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C25H22FN7O7/c1-10-8-32-16-12(7-25(18(32)11(2)39-10)21(34)29-23(36)30-22(25)35)6-13-17(15(16)26)40-31-20(13)33-14(9-38-24(33)37)19-27-4-3-5-28-19/h3-6,10-11,14,18H,7-9H2,1-2H3,(H2,29,30,34,35,36)/t10-,11+,14+,18?/s2
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n/an/a 340n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139418
PNG
(US8889671, 49)
Show SMILES CCOC[C@H]1COC(=O)N1c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C24H26FN5O8/c1-4-35-8-13-9-36-23(34)30(13)19-14-5-12-6-24(20(31)26-22(33)27-21(24)32)18-11(3)37-10(2)7-29(18)16(12)15(25)17(14)38-28-19/h5,10-11,13,18H,4,6-9H2,1-3H3,(H2,26,27,31,32,33)/t10-,11+,13+,18-/s2
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n/an/a 380n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139410
PNG
(US8889671, 40)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2C[C@@H](OC2=O)C=NO)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H21FN6O8/c1-8-6-28-14-10(4-22(16(28)9(2)35-8)18(30)25-20(32)26-19(22)31)3-12-15(13(14)23)37-27-17(12)29-7-11(5-24-34)36-21(29)33/h3,5,8-9,11,16,34H,4,6-7H2,1-2H3,(H2,25,26,30,31,32)/b24-5+/t8-,9+,11+,16-/s2
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n/an/a 380n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139444
PNG
(US8889671, 53)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2C[C@@H](OC2=O)c2ccccn2)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C26H23FN6O7/c1-11-9-32-18-13(8-26(20(32)12(2)38-11)22(34)29-24(36)30-23(26)35)7-14-19(17(18)27)40-31-21(14)33-10-16(39-25(33)37)15-5-3-4-6-28-15/h3-7,11-12,16,20H,8-10H2,1-2H3,(H2,29,30,34,35,36)/t11-,12+,16-,20-/s2
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n/an/a 380n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139447
PNG
(US8889671, 61 | US8889671, 63)
Show SMILES C[C@@H]1CN2C([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](COC2=O)c2ncccn2)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C25H22FN7O7/c1-10-8-32-16-12(7-25(18(32)11(2)39-10)21(34)29-23(36)30-22(25)35)6-13-17(15(16)26)40-31-20(13)33-14(9-38-24(33)37)19-27-4-3-5-28-19/h3-6,10-11,14,18H,7-9H2,1-2H3,(H2,29,30,34,35,36)/t10-,11+,14+,18?/s2
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n/an/a 380n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139375
PNG
(US8889671, 4)
Show SMILES C[C@@H]1CN(C(=O)O1)c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C22H22FN5O7/c1-8-6-27-14-11(5-22(16(27)10(3)33-8)18(29)24-20(31)25-19(22)30)4-12-15(13(14)23)35-26-17(12)28-7-9(2)34-21(28)32/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9-,10+,16-/s2
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n/an/a 390n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139391
PNG
(US8889671, 20)
Show SMILES COC[C@@H]1CN(C(=O)O1)c1noc2c(Cl)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C23H24ClN5O8/c1-9-6-28-15-11(5-23(17(28)10(2)35-9)19(30)25-21(32)26-20(23)31)4-13-16(14(15)24)37-27-18(13)29-7-12(8-34-3)36-22(29)33/h4,9-10,12,17H,5-8H2,1-3H3,(H2,25,26,30,31,32)/t9-,10+,12+,17-/s2
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n/an/a 420n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139401
PNG
(US8889671, 31)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](CCO)COC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C23H24FN5O8/c1-9-7-28-15-11(6-23(17(28)10(2)36-9)19(31)25-21(33)26-20(23)32)5-13-16(14(15)24)37-27-18(13)29-12(3-4-30)8-35-22(29)34/h5,9-10,12,17,30H,3-4,6-8H2,1-2H3,(H2,25,26,31,32,33)/t9-,10+,12+,17-/s2
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n/an/a 420n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139420
PNG
(US8889671, 51)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@H](COC2=O)C(F)F)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H20F3N5O7/c1-7-5-29-13-9(4-22(15(29)8(2)36-7)18(31)26-20(33)27-19(22)32)3-10-14(12(13)23)37-28-17(10)30-11(16(24)25)6-35-21(30)34/h3,7-8,11,15-16H,4-6H2,1-2H3,(H2,26,27,31,32,33)/t7-,8+,11-,15-/s2
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n/an/a 430n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139413
PNG
(US8889671, 43)
Show SMILES CON=C[C@H]1CN(C(=O)O1)c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C23H23FN6O8/c1-9-7-29-15-11(5-23(17(29)10(2)36-9)19(31)26-21(33)27-20(23)32)4-13-16(14(15)24)38-28-18(13)30-8-12(6-25-35-3)37-22(30)34/h4,6,9-10,12,17H,5,7-8H2,1-3H3,(H2,26,27,31,32,33)/b25-6+/t9-,10+,12+,17-/s2
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n/an/a 440n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139440
PNG
(US8889671, 78)
Show SMILES C[C@H]1OC(=O)N([C@H]1CF)c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C23H23F2N5O7/c1-8-7-29-15-11(5-23(17(29)10(3)35-8)19(31)26-21(33)27-20(23)32)4-12-16(14(15)25)37-28-18(12)30-13(6-24)9(2)36-22(30)34/h4,8-10,13,17H,5-7H2,1-3H3,(H2,26,27,31,32,33)/t8-,9-,10+,13+,17-/s2
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n/an/a 440n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139411
PNG
(US8889671, 41)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@H](COC2=O)C#N)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H19FN6O7/c1-8-6-28-14-10(4-22(16(28)9(2)35-8)18(30)25-20(32)26-19(22)31)3-12-15(13(14)23)36-27-17(12)29-11(5-24)7-34-21(29)33/h3,8-9,11,16H,4,6-7H2,1-2H3,(H2,25,26,30,31,32)/t8-,9+,11+,16-/s2
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n/an/a 460n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139437
PNG
(US8889671, 74)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@H](COC2=O)C=NO)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H21FN6O8/c1-8-6-28-14-10(4-22(16(28)9(2)36-8)18(30)25-20(32)26-19(22)31)3-12-15(13(14)23)37-27-17(12)29-11(5-24-34)7-35-21(29)33/h3,5,8-9,11,16,34H,4,6-7H2,1-2H3,(H2,25,26,30,31,32)/b24-5+/t8-,9+,11+,16-/s2
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n/an/a 470n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139400
PNG
(US8889671, 30)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](CCCF)COC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C24H25F2N5O7/c1-10-8-30-16-12(7-24(18(30)11(2)37-10)20(32)27-22(34)28-21(24)33)6-14-17(15(16)26)38-29-19(14)31-13(4-3-5-25)9-36-23(31)35/h6,10-11,13,18H,3-5,7-9H2,1-2H3,(H2,27,28,32,33,34)/t10-,11+,13+,18-/s2
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n/an/a 500n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139384
PNG
(US8889671, 13)
Show SMILES CC[C@H]1CN(C(=O)O1)c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C23H24FN4O8/c1-4-12-8-28(22(32)34-12)18-13-5-11-6-23(19(29)25-21(31)26-20(23)30)17-10(3)33-9(2)7-27(17)15(11)14(24)16(13)35-36-18/h5,9-10,12,17H,4,6-8H2,1-3H3,(H2,25,26,29,30,31)/t9-,10+,12+,17-/s2
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n/an/a 510n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139394
PNG
(US8889671, 23)
Show SMILES C[C@H]1OC(=O)N([C@H]1C)c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C23H24FN5O7/c1-8-7-28-15-12(6-23(17(28)11(4)34-8)19(30)25-21(32)26-20(23)31)5-13-16(14(15)24)36-27-18(13)29-9(2)10(3)35-22(29)33/h5,8-11,17H,6-7H2,1-4H3,(H2,25,26,30,31,32)/t8-,9+,10-,11+,17-/s2
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n/an/a 520n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139414
PNG
(US8889671, 44)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2C[C@H](CN=[N+]=[N-])OC2=O)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H21FN8O7/c1-8-6-30-14-10(4-22(16(30)9(2)36-8)18(32)26-20(34)27-19(22)33)3-12-15(13(14)23)38-28-17(12)31-7-11(5-25-29-24)37-21(31)35/h3,8-9,11,16H,4-7H2,1-2H3,(H2,26,27,32,33,34)/t8-,9+,11+,16-/s2
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n/an/a 530n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139439
PNG
(US8889671, 77)
Show SMILES C[C@@H](O)[C@H]1COC(=O)N1c1noc2c(F)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C23H24FN5O8/c1-8-6-28-15-11(5-23(17(28)10(3)36-8)19(31)25-21(33)26-20(23)32)4-12-16(14(15)24)37-27-18(12)29-13(9(2)30)7-35-22(29)34/h4,8-10,13,17,30H,5-7H2,1-3H3,(H2,25,26,31,32,33)/t8-,9-,10+,13-,17-/s2
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n/an/a 530n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139442
PNG
(US8889671, 27)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@H](COC2=O)C2CCOCC2)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C26H28FN5O8/c1-11-9-31-18-14(8-26(20(31)12(2)39-11)22(33)28-24(35)29-23(26)34)7-15-19(17(18)27)40-30-21(15)32-16(10-38-25(32)36)13-3-5-37-6-4-13/h7,11-13,16,20H,3-6,8-10H2,1-2H3,(H2,28,29,33,34,35)/t11-,12+,16-,20-/s2
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n/an/a 530n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139392
PNG
(US8889671, 21)
Show SMILES COC[C@H]1CN(C(=O)O1)c1noc2c(Cl)c3N4C[C@@H](C)O[C@@H](C)[C@@H]4C4(Cc3cc12)C(=O)NC(=O)NC4=O
Show InChI InChI=1/C23H24ClN5O8/c1-9-6-28-15-11(5-23(17(28)10(2)35-9)19(30)25-21(32)26-20(23)31)4-13-16(14(15)24)37-27-18(13)29-7-12(8-34-3)36-22(29)33/h4,9-10,12,17H,5-8H2,1-3H3,(H2,25,26,30,31,32)/t9-,10+,12-,17-/s2
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n/an/a 540n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
DNA Gyrase Subunit A


(Escherichia coli (strain K12))
BDBM139438
PNG
(US8889671, 76)
Show SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2C[C@H](OC2=O)C#N)C(=O)NC(=O)NC1=O
Show InChI InChI=1/C22H19FN6O7/c1-8-6-28-14-10(4-22(16(28)9(2)34-8)18(30)25-20(32)26-19(22)31)3-12-15(13(14)23)36-27-17(12)29-7-11(5-24)35-21(29)33/h3,8-9,11,16H,4,6-7H2,1-2H3,(H2,25,26,30,31,32)/t8-,9+,11-,16-/s2
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n/an/a 550n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/mL of topologic...


US Patent US8889671 (2014)

More data for this
Ligand-Target Pair
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