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Found 12 hits Enz. Inhib. hit(s) with Target = 'DNA helicase/primase complex protein' AND taxid = 10299   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA helicase/primase complex protein


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50034949
PNG
(2-Amino-6-(3,5-dichloro-phenylamino)-3H-pyrimidin-...)
Show SMILES Nc1nc(Nc2cc(Cl)cc(Cl)c2)cc(=O)[nH]1
Show InChI InChI=1S/C10H8Cl2N4O/c11-5-1-6(12)3-7(2-5)14-8-4-9(17)16-10(13)15-8/h1-4H,(H4,13,14,15,16,17)
KEGG

UniProtKB/SwissProt

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n/an/a 770n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells


J Med Chem 38: 1820-5 (1995)

More data for this
Ligand-Target Pair
DNA helicase/primase complex protein


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50034950
PNG
(2-Amino-6-(3,4-dichloro-phenylamino)-3H-pyrimidin-...)
Show SMILES Nc1nc(Nc2ccc(Cl)c(Cl)c2)cc(=O)[nH]1
Show InChI InChI=1S/C10H8Cl2N4O/c11-6-2-1-5(3-7(6)12)14-8-4-9(17)16-10(13)15-8/h1-4H,(H4,13,14,15,16,17)
KEGG

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n/an/a 850n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells


J Med Chem 38: 1820-5 (1995)

More data for this
Ligand-Target Pair
DNA helicase/primase complex protein


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50034955
PNG
(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Show SMILES Nc1nc(Nc2ccc(Cl)c(Cl)c2)nc2nc[nH]c12
Show InChI InChI=1S/C11H8Cl2N6/c12-6-2-1-5(3-7(6)13)17-11-18-9(14)8-10(19-11)16-4-15-8/h1-4H,(H4,14,15,16,17,18,19)
KEGG

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n/an/a 850n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells


J Med Chem 38: 1820-5 (1995)

More data for this
Ligand-Target Pair
DNA helicase/primase complex protein


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50013091
PNG
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Show SMILES Clc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19)
KEGG

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PubMed
n/an/a 880n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells


J Med Chem 38: 1820-5 (1995)

More data for this
Ligand-Target Pair
DNA helicase/primase complex protein


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50034947
PNG
(2-(3,5-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Show SMILES Clc1cc(Cl)cc(Nc2nc3nc[nH]c3c(=O)[nH]2)c1
Show InChI InChI=1S/C11H7Cl2N5O/c12-5-1-6(13)3-7(2-5)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19)
KEGG

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n/an/a 910n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells


J Med Chem 38: 1820-5 (1995)

More data for this
Ligand-Target Pair
DNA helicase/primase complex protein


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50034963
PNG
(CHEMBL51501 | N*2*-(3,5-Dichloro-phenyl)-9H-purine...)
Show SMILES Nc1nc(Nc2cc(Cl)cc(Cl)c2)nc2nc[nH]c12
Show InChI InChI=1S/C11H8Cl2N6/c12-5-1-6(13)3-7(2-5)17-11-18-9(14)8-10(19-11)16-4-15-8/h1-4H,(H4,14,15,16,17,18,19)
KEGG

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n/an/a 920n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells


J Med Chem 38: 1820-5 (1995)

More data for this
Ligand-Target Pair
DNA helicase/primase complex protein


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50028342
PNG
(6-(3,4-Dichloro-phenylamino)-1H-pyrimidine-2,4-dio...)
Show SMILES Clc1ccc(Nc2cc(=O)[nH]c(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C10H7Cl2N3O2/c11-6-2-1-5(3-7(6)12)13-8-4-9(16)15-10(17)14-8/h1-4H,(H3,13,14,15,16,17)
KEGG

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PubMed
n/an/a>2.00E+3n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells


J Med Chem 38: 1820-5 (1995)

More data for this
Ligand-Target Pair
DNA helicase/primase complex protein


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50034952
PNG
(6-(3,5-Dichloro-phenylamino)-1H-pyrimidine-2,4-dio...)
Show SMILES Clc1cc(Cl)cc(Nc2cc(=O)[nH]c(=O)[nH]2)c1
Show InChI InChI=1S/C10H7Cl2N3O2/c11-5-1-6(12)3-7(2-5)13-8-4-9(16)15-10(17)14-8/h1-4H,(H3,13,14,15,16,17)
KEGG

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PubMed
n/an/a>2.00E+3n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells


J Med Chem 38: 1820-5 (1995)

More data for this
Ligand-Target Pair
DNA helicase/primase complex protein


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50034961
PNG
(6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...)
Show SMILES Nc1nc(Cl)cc(Nc2ccc(Cl)c(Cl)c2)n1
Show InChI InChI=1S/C10H7Cl3N4/c11-6-2-1-5(3-7(6)12)15-9-4-8(13)16-10(14)17-9/h1-4H,(H3,14,15,16,17)
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n/an/a 8.70E+3n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primase


J Med Chem 38: 1820-5 (1995)

More data for this
Ligand-Target Pair
DNA helicase/primase complex protein


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50034955
PNG
(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Show SMILES Nc1nc(Nc2ccc(Cl)c(Cl)c2)nc2nc[nH]c12
Show InChI InChI=1S/C11H8Cl2N6/c12-6-2-1-5(3-7(6)13)17-11-18-9(14)8-10(19-11)16-4-15-8/h1-4H,(H4,14,15,16,17,18,19)
KEGG

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PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primase


J Med Chem 38: 1820-5 (1995)

More data for this
Ligand-Target Pair
DNA helicase/primase complex protein


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50013091
PNG
(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Show SMILES Clc1ccc(Nc2nc3nc[nH]c3c(=O)[nH]2)cc1Cl
Show InChI InChI=1S/C11H7Cl2N5O/c12-6-2-1-5(3-7(6)13)16-11-17-9-8(10(19)18-11)14-4-15-9/h1-4H,(H3,14,15,16,17,18,19)
KEGG

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PubMed
n/an/a 5.90E+4n/an/an/an/an/an/a



Stanford University Medical School

Curated by ChEMBL


Assay Description
Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primase


J Med Chem 38: 1820-5 (1995)

More data for this
Ligand-Target Pair
DNA helicase/primase complex protein


(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
BDBM50137912
PNG
((Biphenyl-4-sulfinyl)-acetic acid | (Biphenyl-4-su...)
Show SMILES OC(=O)CS(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C14H12O4S/c15-14(16)10-19(17,18)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9H,10H2,(H,15,16)
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Article
PubMed
n/an/a>8.00E+4n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibitory concentration against herpes simplex virus helicase primase 8 (HSV)


Citation and Details
More data for this
Ligand-Target Pair