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Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'DNA polymerase catalytic subunit' AND taxid = 10306   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA polymerase catalytic subunit


(Human herpesvirus 1 (strain KOS) (HHV-1) (Human he...)
BDBM50251807
PNG
((R)-N-(4-chlorobenzyl)-2-(((2-(furan-2-yl)-2-hydro...)
Show SMILES CN(C[C@@H](O)c1ccco1)Cc1cc2c(o1)n(C)cc(C(=O)NCc1ccc(Cl)cc1)c2=O
Show InChI InChI=1S/C24H24ClN3O5/c1-27(14-20(29)21-4-3-9-32-21)12-17-10-18-22(30)19(13-28(2)24(18)33-17)23(31)26-11-15-5-7-16(25)8-6-15/h3-10,13,20,29H,11-12,14H2,1-2H3,(H,26,31)/t20-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of HSV1 DNA polymerase by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase catalytic subunit


(Human herpesvirus 1 (strain KOS) (HHV-1) (Human he...)
BDBM50251459
PNG
((R)-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyridin-2...)
Show SMILES CN(C[C@@H](O)c1ccccn1)Cc1cc2c(o1)n(C)cc(C(=O)NCc1ccc(Cl)cc1)c2=O
Show InChI InChI=1S/C25H25ClN4O4/c1-29(15-22(31)21-5-3-4-10-27-21)13-18-11-19-23(32)20(14-30(2)25(19)34-18)24(33)28-12-16-6-8-17(26)9-7-16/h3-11,14,22,31H,12-13,15H2,1-2H3,(H,28,33)/t22-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 350n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of HSV1 DNA polymerase by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase catalytic subunit


(Human herpesvirus 1 (strain KOS) (HHV-1) (Human he...)
BDBM50090910
PNG
(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Show SMILES C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1C[C@@H]3C[C@]21CC[C@]3(O)CO
Show InChI InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 438n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of HSV1 DNA polymerase by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase catalytic subunit


(Human herpesvirus 1 (strain KOS) (HHV-1) (Human he...)
BDBM50370476
PNG
(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Show SMILES Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO[P@@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H16N5O13P3/c1-5-3-15(10(17)12-9(5)16)8-2-6(13-14-11)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h3,6-8H,2,4H2,1H3,(H,21,22)(H,23,24)(H,12,16,17)(H2,18,19,20)/t6-,7+,8+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3.30E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of HSV1 DNA polymerase by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair