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Compile Data Set for Download or QSAR

Found 43 hits Enz. Inhib. hit(s) with Target = 'DNA polymerase kappa' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA polymerase kappa


(Homo sapiens)
BDBM50379292
PNG
(CHEMBL2011646)
Show SMILES C\C=C\C1=CC2=CC(=O)[C@@](C)(OC(=O)c3c(C)cc(O)cc3O)[C@@H](O)[C@@H]2CO1
Show InChI InChI=1S/C21H22O7/c1-4-5-14-7-12-8-17(24)21(3,19(25)15(12)10-27-14)28-20(26)18-11(2)6-13(22)9-16(18)23/h4-9,15,19,22-23,25H,10H2,1-3H3/b5-4+/t15-,19+,21-/m1/s1
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9.85E+3n/an/an/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using dTTP as substrate by Dixon plot analy...


J Nat Prod 75: 135-41 (2012)

More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens)
BDBM50379292
PNG
(CHEMBL2011646)
Show SMILES C\C=C\C1=CC2=CC(=O)[C@@](C)(OC(=O)c3c(C)cc(O)cc3O)[C@@H](O)[C@@H]2CO1
Show InChI InChI=1S/C21H22O7/c1-4-5-14-7-12-8-17(24)21(3,19(25)15(12)10-27-14)28-20(26)18-11(2)6-13(22)9-16(18)23/h4-9,15,19,22-23,25H,10H2,1-3H3/b5-4+/t15-,19+,21-/m1/s1
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1.81E+4n/an/an/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Non-competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using ploy(dA)/oligo(dT)18 as substrate...


J Nat Prod 75: 135-41 (2012)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM21688
PNG
(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Show SMILES CCc1cc(Nc2cc(=O)n(CCCCN3CCN(CC3C)c3c(F)cc4c(c3F)n(cc(C(O)=O)c4=O)C3CC3)c(=O)[nH]2)ccc1C
Show InChI InChI=1S/C35H40F2N6O5/c1-4-22-15-23(8-7-20(22)2)38-28-17-29(44)42(35(48)39-28)12-6-5-11-40-13-14-41(18-21(40)3)32-27(36)16-25-31(30(32)37)43(24-9-10-24)19-26(33(25)45)34(46)47/h7-8,15-17,19,21,24,38H,4-6,9-14,18H2,1-3H3,(H,39,48)(H,46,47)
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6.84E+5 -18.8n/an/an/an/an/a7.537



Microbiotix



Assay Description
Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...


Antimicrob Agents Chemother 51: 119-27 (2007)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM21686
PNG
(3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)urac...)
Show SMILES CCc1cc(Nc2cc(=O)n(CCCCO)c(=O)[nH]2)ccc1C
Show InChI InChI=1S/C17H23N3O3/c1-3-13-10-14(7-6-12(13)2)18-15-11-16(22)20(17(23)19-15)8-4-5-9-21/h6-7,10-11,18,21H,3-5,8-9H2,1-2H3,(H,19,23)
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>1.01E+6>-17.8n/an/an/an/an/a7.537



Microbiotix



Assay Description
Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...


Antimicrob Agents Chemother 51: 119-27 (2007)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408427
PNG
(CHEMBL483492)
Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)nc1N
Show InChI InChI=1S/C10H17FN3O12P3/c1-5-3-14(10(15)13-9(5)12)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H2,12,13,15)(H2,16,17,18)/t6-,7+,8+/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


J Med Chem 41: 2040-6 (1998)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408426
PNG
(CHEMBL2092833)
Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


J Med Chem 41: 2040-6 (1998)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408426
PNG
(CHEMBL2092833)
Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


J Med Chem 41: 2040-6 (1998)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408425
PNG
(CHEMBL2092835)
Show SMILES Nc1ccn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)n1
Show InChI InChI=1S/C9H15FN3O12P3/c10-5-3-8(13-2-1-7(11)12-9(13)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8H,3-4H2,(H,18,19)(H,20,21)(H2,11,12,14)(H2,15,16,17)/t5-,6+,8+/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


J Med Chem 41: 2040-6 (1998)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50448482
PNG
(CHEMBL3126408)
Show SMILES C[C@H]1C\C(C)=C\C=C/C(=O)O[C@@H](Cc2nc(CCCCC(=O)O1)cs2)\C=C(/C)\C=C\C(\C)=C\CN(C)C
Show InChI InChI=1S/C30H42N2O4S/c1-22(16-17-32(5)6)14-15-24(3)19-27-20-28-31-26(21-37-28)11-7-8-12-29(33)35-25(4)18-23(2)10-9-13-30(34)36-27/h9-10,13-16,19,21,25,27H,7-8,11-12,17-18,20H2,1-6H3/b13-9-,15-14+,22-16+,23-10+,24-19+/t25-,27+/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of DNA polymerase-gamma (unknown origin) assessed as incorporation of Br(d)UTP by colorimetric analysis


Bioorg Med Chem 22: 116-25 (2013)

More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens)
BDBM50356642
PNG
(CHEMBL1917196)
Show SMILES CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C22H28O4/c1-2-3-4-5-6-7-8-9-10-14-21(25)26-20-13-11-12-17-18(23)15-16-19(24)22(17)20/h11-13,15-16H,2-10,14H2,1H3
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n/an/a 6.80E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA tem...


Bioorg Med Chem 19: 5803-12 (2011)

More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens)
BDBM50356643
PNG
(CHEMBL1917198)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C28H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-27(31)32-26-19-17-18-23-24(29)21-22-25(30)28(23)26/h9-10,17-19,21-22H,2-8,11-16,20H2,1H3/b10-9-
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n/an/a 8.10E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His6-tagged human DNA polymerase kappa (amino acids 1 to 560) using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA tem...


Bioorg Med Chem 19: 5803-12 (2011)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50191511
PNG
(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(ccc2-c2ccc(Cl)cc2)N2CCCC2=O)cc1F
Show InChI InChI=1S/C37H33ClFN3O4/c38-26-11-8-23(9-12-26)30-15-13-28(41-18-4-7-35(41)43)19-25(30)22-46-29-14-16-31(32(39)21-29)36-40-33-20-24(37(44)45)10-17-34(33)42(36)27-5-2-1-3-6-27/h8-17,19-21,27H,1-7,18,22H2,(H,44,45)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Central Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DNA polymerase gamma


J Med Chem 49: 4721-36 (2006)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50428818
PNG
(CHEMBL3142662)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C30H37N3O5/c1-6-19(2)26(28(36)31-24-13-9-11-21-10-7-8-12-23(21)24)33-27(35)25(32-29(37)38-30(3,4)5)18-20-14-16-22(34)17-15-20/h7-17,19,25-26,34H,6,18H2,1-5H3,(H,31,36)(H,32,37)(H,33,35)
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n/an/a 1.15E+4n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 mins


Bioorg Med Chem 21: 403-11 (2012)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50251277
PNG
(CHEMBL458178 | Kasanosin A)
Show SMILES COc1cc(C)c(C(=O)O[C@H]2CC3=C(COC(\C=C\CO)=C3)C(=O)[C@@]2(C)O)c(O)c1
Show InChI InChI=1S/C22H24O8/c1-12-7-15(28-3)10-17(24)19(12)21(26)30-18-9-13-8-14(5-4-6-23)29-11-16(13)20(25)22(18,2)27/h4-5,7-8,10,18,23-24,27H,6,9,11H2,1-3H3/b5-4+/t18-,22-/m0/s1
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n/an/a 3.50E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma


Bioorg Med Chem 16: 4594-9 (2008)

More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens)
BDBM50379292
PNG
(CHEMBL2011646)
Show SMILES C\C=C\C1=CC2=CC(=O)[C@@](C)(OC(=O)c3c(C)cc(O)cc3O)[C@@H](O)[C@@H]2CO1
Show InChI InChI=1S/C21H22O7/c1-4-5-14-7-12-8-17(24)21(3,19(25)15(12)10-27-14)28-20(26)18-11(2)6-13(22)9-16(18)23/h4-9,15,19,22-23,25H,10H2,1-3H3/b5-4+/t15-,19+,21-/m1/s1
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n/an/a 4.86E+4n/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into po...


J Nat Prod 75: 135-41 (2012)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408425
PNG
(CHEMBL2092835)
Show SMILES Nc1ccn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)n1
Show InChI InChI=1S/C9H15FN3O12P3/c10-5-3-8(13-2-1-7(11)12-9(13)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8H,3-4H2,(H,18,19)(H,20,21)(H2,11,12,14)(H2,15,16,17)/t5-,6+,8+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


J Med Chem 41: 2040-6 (1998)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408427
PNG
(CHEMBL483492)
Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)nc1N
Show InChI InChI=1S/C10H17FN3O12P3/c1-5-3-14(10(15)13-9(5)12)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H2,12,13,15)(H2,16,17,18)/t6-,7+,8+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


J Med Chem 41: 2040-6 (1998)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50335554
PNG
(({[({[2-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)e...)
Show SMILES Nc1nc2n(CCOCP(O)(=O)OP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C8H14N5O11P3/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-22-4-25(15,16)23-27(20,21)24-26(17,18)19/h3H,1-2,4H2,(H,15,16)(H,20,21)(H2,17,18,19)(H3,9,11,12,14)
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n/an/a 5.94E+4n/an/an/an/an/an/a



USA.

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma by microplate reader analysis


Antimicrob Agents Chemother 53: 2777-84 (2009)

More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens)
BDBM50375301
PNG
(CHEMBL260980)
Show SMILES COc1cc(O)c2c(c1)c1C(C)CC(=O)c1oc2=O
Show InChI InChI=1S/C14H12O5/c1-6-3-10(16)13-11(6)8-4-7(18-2)5-9(15)12(8)14(17)19-13/h4-6,15H,3H2,1-2H3
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n/an/a 5.98E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase kappa


Bioorg Med Chem 16: 2939-44 (2008)

More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens)
BDBM50379293
PNG
(CHEMBL2011648)
Show SMILES C\C=C\C1=CC2=CC(=O)[C@@](C)(O)[C@@H](OC(=O)c3c(C)cc(O)cc3O)[C@@H]2CO1
Show InChI InChI=1S/C21H22O7/c1-4-5-14-7-12-8-17(24)21(3,26)19(15(12)10-27-14)28-20(25)18-11(2)6-13(22)9-16(18)23/h4-9,15,19,22-23,26H,10H2,1-3H3/b5-4+/t15-,19+,21-/m1/s1
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n/an/a 5.98E+4n/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into po...


J Nat Prod 75: 135-41 (2012)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50251278
PNG
(CHEMBL457091 | Kasanosin B)
Show SMILES COc1cc(C)c(C(=O)O[C@@]2(C)[C@@H](O)CC3=C(COC(\C=C\CO)=C3)C2=O)c(O)c1
Show InChI InChI=1S/C22H24O8/c1-12-7-15(28-3)10-17(24)19(12)21(27)30-22(2)18(25)9-13-8-14(5-4-6-23)29-11-16(13)20(22)26/h4-5,7-8,10,18,23-25H,6,9,11H2,1-3H3/b5-4+/t18-,22-/m0/s1
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n/an/a 7.29E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma


Bioorg Med Chem 16: 4594-9 (2008)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50205415
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Show SMILES Cc1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H17N2O15P3/c1-4-2-12(10(16)11-8(4)15)9-7(14)6(13)5(25-9)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5-7,9,13-14H,3H2,1H3,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t5-,6-,7-,9-/m1/s1
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n/an/a 8.00E+4n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


J Med Chem 41: 2040-6 (1998)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50333127
PNG
((beta-D-2',3'-dideoxy-5'-F-cytidine-5'-triphosphat...)
Show SMILES Nc1ccn([C@H]2CC[C@H](O2)[C@@H](F)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C9H15FN3O12P3/c10-8(23-27(18,19)25-28(20,21)24-26(15,16)17)5-1-2-7(22-5)13-4-3-6(11)12-9(13)14/h3-5,7-8H,1-2H2,(H,18,19)(H,20,21)(H2,11,12,14)(H2,15,16,17)/t5-,7+,8-/m0/s1
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n/an/a 8.50E+4n/an/an/an/an/an/a



303A College Road East

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...


Antimicrob Agents Chemother 54: 3187-96 (2010)

More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens)
BDBM50375300
PNG
(TALAROFLAVONE)
Show SMILES COc1cc2c(C(=O)OC22C(C)CC(=O)C2=O)c(O)c1
Show InChI InChI=1S/C14H12O6/c1-6-3-10(16)12(17)14(6)8-4-7(19-2)5-9(15)11(8)13(18)20-14/h4-6,15H,3H2,1-2H3
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n/an/a 8.65E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase kappa


Bioorg Med Chem 16: 2939-44 (2008)

More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens)
BDBM50379294
PNG
(CHEMBL2011647)
Show SMILES Cc1cc(O)cc(O)c1C(=O)O[C@H]1[C@@H]2COC(\C=C\CO)=CC2=CC(=O)[C@@]1(C)O
Show InChI InChI=1S/C21H22O8/c1-11-6-13(23)9-16(24)18(11)20(26)29-19-15-10-28-14(4-3-5-22)7-12(15)8-17(25)21(19,2)27/h3-4,6-9,15,19,22-24,27H,5,10H2,1-2H3/b4-3+/t15-,19+,21-/m1/s1
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n/an/a 8.89E+4n/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into po...


J Nat Prod 75: 135-41 (2012)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50090910
PNG
(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Show SMILES C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1C[C@@H]3C[C@]21CC[C@]3(O)CO
Show InChI InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



303A College Road East

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...


Antimicrob Agents Chemother 54: 3187-96 (2010)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408428
PNG
(CHEMBL2092834)
Show SMILES OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]1O[C@@H](C[C@H]1F)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H14FN2O13P3/c10-5-3-8(12-2-1-7(13)11-9(12)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8H,3-4H2,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17)/t5-,6+,8+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


J Med Chem 41: 2040-6 (1998)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50021053
PNG
(CHEMBL3287609)
Show SMILES C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1c1ccc2c(N)ncnn12
Show InChI InChI=1S/C12H19N4O13P3/c1-12(18)9(17)8(4-26-31(22,23)29-32(24,25)28-30(19,20)21)27-10(12)6-2-3-7-11(13)14-5-15-16(6)7/h2-3,5,8-10,17-18H,4H2,1H3,(H,22,23)(H,24,25)(H2,13,14,15)(H2,19,20,21)/t8-,9-,10+,12-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Biota Scientific Management Pty. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma


ACS Med Chem Lett 5: 679-84 (2014)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50336503
PNG
(10-acetyl-11-(3-(benzyloxy)-4-methoxyphenyl)-3,3-d...)
Show SMILES COc1ccc(cc1OCc1ccccc1)C1C2C(=O)CC(C)(C)CC2=Nc2ccccc2N1C(C)=O
Show InChI InChI=1S/C31H32N2O4/c1-20(34)33-25-13-9-8-12-23(25)32-24-17-31(2,3)18-26(35)29(24)30(33)22-14-15-27(36-4)28(16-22)37-19-21-10-6-5-7-11-21/h5-16,29-30H,17-19H2,1-4H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tibotec BVBA

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma


Antimicrob Agents Chemother 52: 4420-31 (2008)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50336502
PNG
(10-acetyl-11-(2,4-dichlorophenyl)-3,3-dimethyl-2,3...)
Show SMILES CC(=O)N1C(C2C(=O)CC(C)(C)CC2=Nc2ccccc12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H22Cl2N2O2/c1-13(28)27-19-7-5-4-6-17(19)26-18-11-23(2,3)12-20(29)21(18)22(27)15-9-8-14(24)10-16(15)25/h4-10,21-22H,11-12H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tibotec BVBA

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma


Antimicrob Agents Chemother 52: 4420-31 (2008)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408428
PNG
(CHEMBL2092834)
Show SMILES OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]1O[C@@H](C[C@H]1F)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C9H14FN2O13P3/c10-5-3-8(12-2-1-7(13)11-9(12)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8H,3-4H2,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17)/t5-,6+,8+/m1/s1
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Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


J Med Chem 41: 2040-6 (1998)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50335556
PNG
(CHEMBL1652469 | [({[({2-[2-amino-6-(cyclopropylami...)
Show SMILES Nc1nc(NC2CC2)c2ncn(CCOCP(O)(=O)OP(O)(=O)OP(O)(O)=O)c2n1
Show InChI InChI=1S/C11H19N6O10P3/c12-11-15-9(14-7-1-2-7)8-10(16-11)17(5-13-8)3-4-25-6-28(18,19)26-30(23,24)27-29(20,21)22/h5,7H,1-4,6H2,(H,18,19)(H,23,24)(H2,20,21,22)(H3,12,14,15,16)
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n/an/a>1.50E+5n/an/an/an/an/an/a



USA.

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma by microplate reader analysis


Antimicrob Agents Chemother 53: 2777-84 (2009)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50428818
PNG
(CHEMBL3142662)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C30H37N3O5/c1-6-19(2)26(28(36)31-24-13-9-11-21-10-7-8-12-23(21)24)33-27(35)25(32-29(37)38-30(3,4)5)18-20-14-16-22(34)17-15-20/h7-17,19,25-26,34H,6,18H2,1-5H3,(H,31,36)(H,32,37)(H,33,35)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase mu using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 mins


Bioorg Med Chem 21: 403-11 (2012)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50428818
PNG
(CHEMBL3142662)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C30H37N3O5/c1-6-19(2)26(28(36)31-24-13-9-11-21-10-7-8-12-23(21)24)33-27(35)25(32-29(37)38-30(3,4)5)18-20-14-16-22(34)17-15-20/h7-17,19,25-26,34H,6,18H2,1-5H3,(H,31,36)(H,32,37)(H,33,35)
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Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 mins


Bioorg Med Chem 21: 403-11 (2012)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50428818
PNG
(CHEMBL3142662)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C30H37N3O5/c1-6-19(2)26(28(36)31-24-13-9-11-21-10-7-8-12-23(21)24)33-27(35)25(32-29(37)38-30(3,4)5)18-20-14-16-22(34)17-15-20/h7-17,19,25-26,34H,6,18H2,1-5H3,(H,31,36)(H,32,37)(H,33,35)
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Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of calf TdT polymerase measured at 37 degC for 60 mins


Bioorg Med Chem 21: 403-11 (2012)

More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens)
BDBM50448691
PNG
(CHEMBL3127729)
Show SMILES C\C(\C=C\CCC(=O)N1CCCC1=O)=C/C1CCCCO1
Show InChI InChI=1S/C17H25NO3/c1-14(13-15-8-4-5-12-21-15)7-2-3-9-16(19)18-11-6-10-17(18)20/h2,7,13,15H,3-6,8-12H2,1H3/b7-2+,14-13+
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n/an/a>2.00E+5n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-6-tagged human DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into p...


Bioorg Med Chem 22: 1070-6 (2014)

More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens)
BDBM50448690
PNG
(CHEMBL3127728)
Show SMILES CCCCC(=O)C=C(C)C=CCCC(=O)N1CCCC1=O
Show InChI InChI=1S/C17H25NO3/c1-3-4-9-15(19)13-14(2)8-5-6-10-16(20)18-12-7-11-17(18)21/h5,8,13H,3-4,6-7,9-12H2,1-2H3
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Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-6-tagged human DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into p...


Bioorg Med Chem 22: 1070-6 (2014)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50428818
PNG
(CHEMBL3142662)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C30H37N3O5/c1-6-19(2)26(28(36)31-24-13-9-11-21-10-7-8-12-23(21)24)33-27(35)25(32-29(37)38-30(3,4)5)18-20-14-16-22(34)17-15-20/h7-17,19,25-26,34H,6,18H2,1-5H3,(H,31,36)(H,32,37)(H,33,35)
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Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 mins


Bioorg Med Chem 21: 403-11 (2012)

More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens)
BDBM50448688
PNG
(PECILOCIN | Pecilocin | Variotin)
Show SMILES CCCC[C@@H](O)\C=C(/C)\C=C\C=C\C(=O)N1CCCC1=O
Show InChI InChI=1S/C17H25NO3/c1-3-4-9-15(19)13-14(2)8-5-6-10-16(20)18-12-7-11-17(18)21/h5-6,8,10,13,15,19H,3-4,7,9,11-12H2,1-2H3/b8-5+,10-6+,14-13+/t15-/m1/s1
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n/an/a>2.00E+5n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-6-tagged human DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into p...


Bioorg Med Chem 22: 1070-6 (2014)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50428818
PNG
(CHEMBL3142662)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C30H37N3O5/c1-6-19(2)26(28(36)31-24-13-9-11-21-10-7-8-12-23(21)24)33-27(35)25(32-29(37)38-30(3,4)5)18-20-14-16-22(34)17-15-20/h7-17,19,25-26,34H,6,18H2,1-5H3,(H,31,36)(H,32,37)(H,33,35)
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Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase eta using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 mins


Bioorg Med Chem 21: 403-11 (2012)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50428818
PNG
(CHEMBL3142662)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C30H37N3O5/c1-6-19(2)26(28(36)31-24-13-9-11-21-10-7-8-12-23(21)24)33-27(35)25(32-29(37)38-30(3,4)5)18-20-14-16-22(34)17-15-20/h7-17,19,25-26,34H,6,18H2,1-5H3,(H,31,36)(H,32,37)(H,33,35)
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Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase kappa using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 mins


Bioorg Med Chem 21: 403-11 (2012)

More data for this
Ligand-Target Pair
DNA polymerase kappa


(Homo sapiens)
BDBM50448689
PNG
(CHEMBL3127730)
Show SMILES CCCC[C@@H](O)\C=C(/C)\C=C\C=C/C(=O)N1CCCC1=O
Show InChI InChI=1S/C17H25NO3/c1-3-4-9-15(19)13-14(2)8-5-6-10-16(20)18-12-7-11-17(18)21/h5-6,8,10,13,15,19H,3-4,7,9,11-12H2,1-2H3/b8-5+,10-6-,14-13+/t15-/m1/s1
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Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-6-tagged human DNA polymerase kappa expressed in Escherichia coli assessed as inhibition of incorporation of dTTP into p...


Bioorg Med Chem 22: 1070-6 (2014)

More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50333129
PNG
(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)
Show SMILES C[C@@]1(F)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C10H16FN2O14P3/c1-10(11)7(15)5(25-8(10)13-3-2-6(14)12-9(13)16)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-8,15H,4H2,1H3,(H,20,21)(H,22,23)(H,12,14,16)(H2,17,18,19)/t5-,7-,8-,10-/m1/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



303A College Road East

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...


Antimicrob Agents Chemother 54: 3187-96 (2010)

More data for this
Ligand-Target Pair