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Found 73 hits Enz. Inhib. hit(s) with Target = 'DNA polymerase lambda' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM21688
PNG
(1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...)
Show SMILES CCc1cc(Nc2cc(=O)n(CCCCN3CCN(CC3C)c3c(F)cc4c(c3F)n(cc(C(O)=O)c4=O)C3CC3)c(=O)[nH]2)ccc1C
Show InChI InChI=1S/C35H40F2N6O5/c1-4-22-15-23(8-7-20(22)2)38-28-17-29(44)42(35(48)39-28)12-6-5-11-40-13-14-41(18-21(40)3)32-27(36)16-25-31(30(32)37)43(24-9-10-24)19-26(33(25)45)34(46)47/h7-8,15-17,19,21,24,38H,4-6,9-14,18H2,1-3H3,(H,39,48)(H,46,47)
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PubMed
6.84E+5 -18.8n/an/an/an/an/a7.537



Microbiotix



Assay Description
Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM21686
PNG
(3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)urac...)
Show SMILES CCc1cc(Nc2cc(=O)n(CCCCO)c(=O)[nH]2)ccc1C
Show InChI InChI=1S/C17H23N3O3/c1-3-13-10-14(7-6-12(13)2)18-15-11-16(22)20(17(23)19-15)8-4-5-9-21/h6-7,10-11,18,21H,3-5,8-9H2,1-2H3,(H,19,23)
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>1.01E+6>-17.8n/an/an/an/an/a7.537



Microbiotix



Assay Description
Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408427
PNG
(CHEMBL483492)
Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)nc1N
Show InChI InChI=1S/C10H17FN3O12P3/c1-5-3-14(10(15)13-9(5)12)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H2,12,13,15)(H2,16,17,18)/t6-,7+,8+/m1/s1
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n/an/a 500n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408426
PNG
(CHEMBL2092833)
Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408426
PNG
(CHEMBL2092833)
Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408425
PNG
(CHEMBL2092835)
Show SMILES Nc1ccn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)n1
Show InChI InChI=1S/C9H15FN3O12P3/c10-5-3-8(13-2-1-7(11)12-9(13)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8H,3-4H2,(H,18,19)(H,20,21)(H2,11,12,14)(H2,15,16,17)/t5-,6+,8+/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50448482
PNG
(CHEMBL3126408)
Show SMILES C[C@H]1C\C(C)=C\C=C/C(=O)O[C@@H](Cc2nc(CCCCC(=O)O1)cs2)\C=C(/C)\C=C\C(\C)=C\CN(C)C
Show InChI InChI=1S/C30H42N2O4S/c1-22(16-17-32(5)6)14-15-24(3)19-27-20-28-31-26(21-37-28)11-7-8-12-29(33)35-25(4)18-23(2)10-9-13-30(34)36-27/h9-10,13-16,19,21,25,27H,7-8,11-12,17-18,20H2,1-6H3/b13-9-,15-14+,22-16+,23-10+,24-19+/t25-,27+/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of DNA polymerase-gamma (unknown origin) assessed as incorporation of Br(d)UTP by colorimetric analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104089
PNG
((Z)-5-(3-Nitro-4-(o-tolylthio)benzylidene)-2-thiox...)
Show SMILES Cc1ccccc1Sc1ccc(C=C2SC(S)=NC2=O)cc1[N+]([O-])=O
Show InChI InChI=1S/C17H12N2O3S3/c1-10-4-2-3-5-13(10)24-14-7-6-11(8-12(14)19(21)22)9-15-16(20)18-17(23)25-15/h2-9H,1H3,(H,18,20,23)
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n/an/a 3.90E+3n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104093
PNG
((Z)-5-(3-Bromo-4-((3-fluoro-4-methylphenyl)thio)be...)
Show SMILES Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2Br)cc1F
Show InChI InChI=1S/C17H11BrFNOS3/c1-9-2-4-11(8-13(9)19)23-14-5-3-10(6-12(14)18)7-15-16(21)20-17(22)24-15/h2-8H,1H3,(H,20,21,22)
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104097
PNG
((Z)-5-(2,4-Bis(p-tolylthio)benzylidene)-2-thioxoth...)
Show SMILES Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)c(Sc3ccc(C)cc3)c2)cc1
Show InChI InChI=1S/C24H19NOS4/c1-15-3-8-18(9-4-15)28-20-12-7-17(13-22-23(26)25-24(27)30-22)21(14-20)29-19-10-5-16(2)6-11-19/h3-14H,1-2H3,(H,25,26,27)
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n/an/a 4.00E+3n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104079
PNG
((Z)-5-(3-Chloro-4-(p-tolylthio)benzylidene)-2-thio...)
Show SMILES Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2Cl)cc1
Show InChI InChI=1S/C17H12ClNOS3/c1-10-2-5-12(6-3-10)22-14-7-4-11(8-13(14)18)9-15-16(20)19-17(21)23-15/h2-9H,1H3,(H,19,20,21)
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n/an/a 5.70E+3n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104067
PNG
(DNA polymerase inhibitor 1)
Show SMILES Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2[N+]([O-])=O)cc1
Show InChI InChI=1S/C17H12N2O3S3/c1-10-2-5-12(6-3-10)24-14-7-4-11(8-13(14)19(21)22)9-15-16(20)18-17(23)25-15/h2-9H,1H3,(H,18,20,23)
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n/an/a 5.90E+3n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104088
PNG
((Z)-5-(3-Nitro-4-(m-tolylthio)benzylidene)-2-thiox...)
Show SMILES Cc1cccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2[N+]([O-])=O)c1
Show InChI InChI=1S/C17H12N2O3S3/c1-10-3-2-4-12(7-10)24-14-6-5-11(8-13(14)19(21)22)9-15-16(20)18-17(23)25-15/h2-9H,1H3,(H,18,20,23)
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n/an/a 6.00E+3n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM50356642
PNG
(CHEMBL1917196)
Show SMILES CCCCCCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C22H28O4/c1-2-3-4-5-6-7-8-9-10-14-21(25)26-20-13-11-12-17-18(23)15-16-19(24)22(17)20/h11-13,15-16H,2-10,14H2,1H3
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n/an/a 7.00E+3n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substr...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104087
PNG
((Z)-5-(3-Nitro-4-((2,3,5,6-tetrafluoro-4-(trifluor...)
Show SMILES [O-][N+](=O)c1cc(C=C2SC(S)=NC2=O)ccc1Sc1c(F)c(F)c(c(F)c1F)C(F)(F)F
Show InChI InChI=1S/C17H5F7N2O3S3/c18-10-9(17(22,23)24)11(19)13(21)14(12(10)20)31-7-2-1-5(3-6(7)26(28)29)4-8-15(27)25-16(30)32-8/h1-4H,(H,25,27,30)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104090
PNG
((Z)-5-(4-((3,5-Dimethylphenyl)thio)-3-nitrobenzyli...)
Show SMILES Cc1cc(C)cc(Sc2ccc(C=C3SC(S)=NC3=O)cc2[N+]([O-])=O)c1
Show InChI InChI=1S/C18H14N2O3S3/c1-10-5-11(2)7-13(6-10)25-15-4-3-12(8-14(15)20(22)23)9-16-17(21)19-18(24)26-16/h3-9H,1-2H3,(H,19,21,24)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104091
PNG
((Z)-5-(4-(Naphthalen-2-ylthio)-3-nitrobenzylidene)...)
Show SMILES [O-][N+](=O)c1cc(C=C2SC(S)=NC2=O)ccc1Sc1ccc2ccccc2c1
Show InChI InChI=1S/C20H12N2O3S3/c23-19-18(28-20(26)21-19)10-12-5-8-17(16(9-12)22(24)25)27-15-7-6-13-3-1-2-4-14(13)11-15/h1-11H,(H,21,23,26)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104094
PNG
(23 (Z)-2-Thioxo-5-(4-(o-tolylthio)benzylidene)thia...)
Show SMILES Cc1ccccc1Sc1ccc(C=C2SC(S)=NC2=O)cc1
Show InChI InChI=1S/C17H13NOS3/c1-11-4-2-3-5-14(11)21-13-8-6-12(7-9-13)10-15-16(19)18-17(20)22-15/h2-10H,1H3,(H,18,19,20)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104095
PNG
((Z)-5-(3-Fluoro-4-(o-tolylthio)benzylidene)-2-thio...)
Show SMILES Cc1ccccc1Sc1ccc(C=C2SC(S)=NC2=O)cc1F
Show InChI InChI=1S/C17H12FNOS3/c1-10-4-2-3-5-13(10)22-14-7-6-11(8-12(14)18)9-15-16(20)19-17(21)23-15/h2-9H,1H3,(H,19,20,21)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104096
PNG
((Z)-2-Thioxo-5-(4-(o-tolylthio)-3- (trifluoromethy...)
Show SMILES Cc1ccccc1Sc1ccc(C=C2SC(S)=NC2=O)cc1C(F)(F)F
Show InChI InChI=1S/C18H12F3NOS3/c1-10-4-2-3-5-13(10)25-14-7-6-11(8-12(14)18(19,20)21)9-15-16(23)22-17(24)26-15/h2-9H,1H3,(H,22,23,24)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104086
PNG
((Z)-5-(4-((3-Fluoro-4-methylphenyl)thio)-3-nitrobe...)
Show SMILES Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2[N+]([O-])=O)cc1F
Show InChI InChI=1S/C17H11FN2O3S3/c1-9-2-4-11(8-12(9)18)25-14-5-3-10(6-13(14)20(22)23)7-15-16(21)19-17(24)26-15/h2-8H,1H3,(H,19,21,24)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


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More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104084
PNG
((Z)-5-(3-Nitro-4-((4-(trifluoromethyl)phenyl)thio)...)
Show SMILES [O-][N+](=O)c1cc(C=C2SC(S)=NC2=O)ccc1Sc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H9F3N2O3S3/c18-17(19,20)10-2-4-11(5-3-10)27-13-6-1-9(7-12(13)22(24)25)8-14-15(23)21-16(26)28-14/h1-8H,(H,21,23,26)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


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More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104083
PNG
((Z)-5-(4-((4-Ethylphenyl)thio)-3-nitrobenzylidene)...)
Show SMILES CCc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2[N+]([O-])=O)cc1
Show InChI InChI=1S/C18H14N2O3S3/c1-2-11-3-6-13(7-4-11)25-15-8-5-12(9-14(15)20(22)23)10-16-17(21)19-18(24)26-16/h3-10H,2H2,1H3,(H,19,21,24)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


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More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104082
PNG
((Z)-5-((4-Oxo-2-thioxothiazolidin-5-ylidene)methyl...)
Show SMILES Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2C#N)cc1
Show InChI InChI=1S/C18H12N2OS3/c1-11-2-5-14(6-3-11)23-15-7-4-12(8-13(15)10-19)9-16-17(21)20-18(22)24-16/h2-9H,1H3,(H,20,21,22)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


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More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104081
PNG
((Z)-2-Thioxo-5-(4-(p-tolylthio)-3- (trifluoromethy...)
Show SMILES Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2C(F)(F)F)cc1
Show InChI InChI=1S/C18H12F3NOS3/c1-10-2-5-12(6-3-10)25-14-7-4-11(8-13(14)18(19,20)21)9-15-16(23)22-17(24)26-15/h2-9H,1H3,(H,22,23,24)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104080
PNG
((Z)-5-(3-Bromo-4-(p-tolylthio)benzylidene)-2-thiox...)
Show SMILES Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2Br)cc1
Show InChI InChI=1S/C17H12BrNOS3/c1-10-2-5-12(6-3-10)22-14-7-4-11(8-13(14)18)9-15-16(20)19-17(21)23-15/h2-9H,1H3,(H,19,20,21)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


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More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104077
PNG
((Z)-2-Thioxo-5-(4-(p-tolylthio)benzylidene)thiazol...)
Show SMILES Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2)cc1
Show InChI InChI=1S/C17H13NOS3/c1-11-2-6-13(7-3-11)21-14-8-4-12(5-9-14)10-15-16(19)18-17(20)22-15/h2-10H,1H3,(H,18,19,20)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104078
PNG
((Z)-5-(3-Fluoro-4-(p-tolylthio)benzylidene)-2-thio...)
Show SMILES Cc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2F)cc1
Show InChI InChI=1S/C17H12FNOS3/c1-10-2-5-12(6-3-10)22-14-7-4-11(8-13(14)18)9-15-16(20)19-17(21)23-15/h2-9H,1H3,(H,19,20,21)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104068
PNG
((Z)-5-(4-(Cyclohexylthio)-3-nitrobenzylidene)-2-th...)
Show SMILES [O-][N+](=O)c1cc(C=C2SC(S)=NC2=O)ccc1SC1CCCCC1
Show InChI InChI=1S/C16H16N2O3S3/c19-15-14(24-16(22)17-15)9-10-6-7-13(12(8-10)18(20)21)23-11-4-2-1-3-5-11/h6-9,11H,1-5H2,(H,17,19,22)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50191511
PNG
(2-{4-[4'-chloro-4-(2-oxo-pyrrolidin-1-yl)-biphenyl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc(OCc2cc(ccc2-c2ccc(Cl)cc2)N2CCCC2=O)cc1F
Show InChI InChI=1S/C37H33ClFN3O4/c38-26-11-8-23(9-12-26)30-15-13-28(41-18-4-7-35(41)43)19-25(30)22-46-29-14-16-31(32(39)21-29)36-40-33-20-24(37(44)45)10-17-34(33)42(36)27-5-2-1-3-6-27/h8-17,19-21,27H,1-7,18,22H2,(H,44,45)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Central Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of DNA polymerase gamma


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104069
PNG
((Z)-5-(3-Nitro-4-(p-tolylthio)benzylidene)thiazoli...)
Show SMILES Cc1ccc(Sc2ccc(C=C3SC(O)=NC3=O)cc2[N+]([O-])=O)cc1
Show InChI InChI=1S/C17H12N2O4S2/c1-10-2-5-12(6-3-10)24-14-7-4-11(8-13(14)19(22)23)9-15-16(20)18-17(21)25-15/h2-9H,1H3,(H,18,20,21)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104074
PNG
((Z)-5-(1-(3-Nitro-4-(p-tolylthio)phenyl)ethylidene...)
Show SMILES Cc1ccc(Sc2ccc(cc2[N+]([O-])=O)C(=C)c2sc(S)nc2O)cc1
Show InChI InChI=1S/C18H14N2O3S3/c1-10-3-6-13(7-4-10)25-15-8-5-12(9-14(15)20(22)23)11(2)16-17(21)19-18(24)26-16/h3-9,21H,2H2,1H3,(H,19,24)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104098
PNG
((Z)-5-((4-Bromo-5-(p-tolylthio)thiophen-2-yl)methy...)
Show SMILES Cc1ccc(Sc2sc(C=C3SC(S)=NC3=O)cc2Br)cc1
Show InChI InChI=1S/C15H10BrNOS4/c1-8-2-4-9(5-3-8)20-14-11(16)6-10(21-14)7-12-13(18)17-15(19)22-12/h2-7H,1H3,(H,17,18,19)
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n/an/a<1.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM50356643
PNG
(CHEMBL1917198)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)Oc1cccc2C(=O)C=CC(=O)c12
Show InChI InChI=1S/C28H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-27(31)32-26-19-17-18-23-24(29)21-22-25(30)28(23)26/h9-10,17-19,21-22H,2-8,11-16,20H2,1H3/b10-9-
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n/an/a 1.02E+4n/an/an/an/an/an/a



Kyoto Prefectural University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human DNA polymerase lambda using poly(dA)/oligo(dT)18 (A/T = 2/1) and dTTP as the DNA template-primer and nucleotide substr...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50428818
PNG
(CHEMBL3142662)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)Nc1cccc2ccccc12
Show InChI InChI=1S/C30H37N3O5/c1-6-19(2)26(28(36)31-24-13-9-11-21-10-7-8-12-23(21)24)33-27(35)25(32-29(37)38-30(3,4)5)18-20-14-16-22(34)17-15-20/h7-17,19,25-26,34H,6,18H2,1-5H3,(H,31,36)(H,32,37)(H,33,35)
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n/an/a 1.15E+4n/an/an/an/an/an/a



Kobe Gakuin University

Curated by ChEMBL


Assay Description
Inhibition of rat DNA polymerase beta using poly(dA)/oligo(dT)18 (A/T, 2/1)/dTTP DNA template-primer substrate measured at 37 degC for 60 mins


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104076
PNG
((Z)-5-(3-Nitro-4-tosylbenzylidene)-2-thioxothiazol...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)c1ccc(C=C2SC(S)=NC2=O)cc1[N+]([O-])=O
Show InChI InChI=1S/C17H12N2O5S3/c1-10-2-5-12(6-3-10)27(23,24)15-7-4-11(8-13(15)19(21)22)9-14-16(20)18-17(25)26-14/h2-9H,1H3,(H,18,20,25)
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n/an/a<2.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104085
PNG
((Z)-5-(3-Nitro-4-((4-(trifluoromethoxy)phenyl)thio...)
Show SMILES [O-][N+](=O)c1cc(C=C2SC(S)=NC2=O)ccc1Sc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C17H9F3N2O4S3/c18-17(19,20)26-10-2-4-11(5-3-10)28-13-6-1-9(7-12(13)22(24)25)8-14-15(23)21-16(27)29-14/h1-8H,(H,21,23,27)
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n/an/a<2.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM104092
PNG
((Z)-5-(4-(Cyclopentylthio)-3-nitrobenzylidene)-2-t...)
Show SMILES [O-][N+](=O)c1cc(C=C2SC(S)=NC2=O)ccc1SC1CCCC1
Show InChI InChI=1S/C15H14N2O3S3/c18-14-13(23-15(21)16-14)8-9-5-6-12(11(7-9)17(19)20)22-10-3-1-2-4-10/h5-8,10H,1-4H2,(H,16,18,21)
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n/an/a<2.00E+4n/an/an/an/an/an/a



University of Konstanz



Assay Description
Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50251277
PNG
(CHEMBL458178 | Kasanosin A)
Show SMILES COc1cc(C)c(C(=O)O[C@H]2CC3=C(COC(\C=C\CO)=C3)C(=O)[C@@]2(C)O)c(O)c1
Show InChI InChI=1S/C22H24O8/c1-12-7-15(28-3)10-17(24)19(12)21(26)30-18-9-13-8-14(5-4-6-23)29-11-16(13)20(25)22(18,2)27/h4-5,7-8,10,18,23-24,27H,6,9,11H2,1-3H3/b5-4+/t18-,22-/m0/s1
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n/an/a 3.50E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM50208251
PNG
(3-5-dimethyl-8-methoxy-3,4-dihydroisocoumarin | CH...)
Show SMILES COc1ccc(C)c2CC(C)OC(=O)c12
Show InChI InChI=1S/C12H14O3/c1-7-4-5-10(14-3)11-9(7)6-8(2)15-12(11)13/h4-5,8H,6H2,1-3H3
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n/an/a 4.90E+4n/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase lambda


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408427
PNG
(CHEMBL483492)
Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)nc1N
Show InChI InChI=1S/C10H17FN3O12P3/c1-5-3-14(10(15)13-9(5)12)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H2,12,13,15)(H2,16,17,18)/t6-,7+,8+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50408425
PNG
(CHEMBL2092835)
Show SMILES Nc1ccn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)n1
Show InChI InChI=1S/C9H15FN3O12P3/c10-5-3-8(13-2-1-7(11)12-9(13)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8H,3-4H2,(H,18,19)(H,20,21)(H2,11,12,14)(H2,15,16,17)/t5-,6+,8+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50335554
PNG
(({[({[2-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)e...)
Show SMILES Nc1nc2n(CCOCP(O)(=O)OP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C8H14N5O11P3/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-22-4-25(15,16)23-27(20,21)24-26(17,18)19/h3H,1-2,4H2,(H,15,16)(H,20,21)(H2,17,18,19)(H3,9,11,12,14)
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n/an/a 5.94E+4n/an/an/an/an/an/a



USA.

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma by microplate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50251278
PNG
(CHEMBL457091 | Kasanosin B)
Show SMILES COc1cc(C)c(C(=O)O[C@@]2(C)[C@@H](O)CC3=C(COC(\C=C\CO)=C3)C2=O)c(O)c1
Show InChI InChI=1S/C22H24O8/c1-12-7-15(28-3)10-17(24)19(12)21(27)30-22(2)18(25)9-13-8-14(5-4-6-23)29-11-16(13)20(22)26/h4-5,7-8,10,18,23-25H,6,9,11H2,1-3H3/b5-4+/t18-,22-/m0/s1
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n/an/a 7.29E+4n/an/an/an/an/an/a



Tokyo University of Science

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50205415
PNG
(({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-...)
Show SMILES Cc1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O
Show InChI InChI=1S/C10H17N2O15P3/c1-4-2-12(10(16)11-8(4)15)9-7(14)6(13)5(25-9)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5-7,9,13-14H,3H2,1H3,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t5-,6-,7-,9-/m1/s1
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n/an/a 8.00E+4n/an/an/an/an/an/a



Max-Delbr�ck-Centrum f�r Molekulare Medizin

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase lambda


(Homo sapiens)
BDBM50208247
PNG
((3,4-dihydro-4-hydroxy-8-methoxynaphthalene-1(2H)-...)
Show SMILES COc1cccc2C(O)CCC(=O)c12
Show InChI InChI=1S/C11H12O3/c1-14-10-4-2-3-7-8(12)5-6-9(13)11(7)10/h2-4,8,12H,5-6H2,1H3
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n/an/a 8.20E+4n/an/an/an/an/an/a



Science University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase lambda


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50333127
PNG
((beta-D-2',3'-dideoxy-5'-F-cytidine-5'-triphosphat...)
Show SMILES Nc1ccn([C@H]2CC[C@H](O2)[C@@H](F)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)c(=O)n1
Show InChI InChI=1S/C9H15FN3O12P3/c10-8(23-27(18,19)25-28(20,21)24-26(15,16)17)5-1-2-7(22-5)13-4-3-6(11)12-9(13)14/h3-5,7-8H,1-2H2,(H,18,19)(H,20,21)(H2,11,12,14)(H2,15,16,17)/t5-,7+,8-/m0/s1
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n/an/a 8.50E+4n/an/an/an/an/an/a



303A College Road East

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50090910
PNG
(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)
Show SMILES C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1C[C@@H]3C[C@]21CC[C@]3(O)CO
Show InChI InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



303A College Road East

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50336502
PNG
(10-acetyl-11-(2,4-dichlorophenyl)-3,3-dimethyl-2,3...)
Show SMILES CC(=O)N1C(C2C(=O)CC(C)(C)CC2=Nc2ccccc12)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H22Cl2N2O2/c1-13(28)27-19-7-5-4-6-17(19)26-18-11-23(2,3)12-20(29)21(18)22(27)15-9-8-14(24)10-16(15)25/h4-10,21-22H,11-12H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tibotec BVBA

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma


Citation and Details
More data for this
Ligand-Target Pair
DNA polymerase gamma subunit 1


(Homo sapiens (human))
BDBM50336503
PNG
(10-acetyl-11-(3-(benzyloxy)-4-methoxyphenyl)-3,3-d...)
Show SMILES COc1ccc(cc1OCc1ccccc1)C1C2C(=O)CC(C)(C)CC2=Nc2ccccc2N1C(C)=O
Show InChI InChI=1S/C31H32N2O4/c1-20(34)33-25-13-9-8-12-23(25)32-24-17-31(2,3)18-26(35)29(24)30(33)22-14-15-27(36-4)28(16-22)37-19-21-10-6-5-7-11-21/h5-16,29-30H,17-19H2,1-4H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Tibotec BVBA

Curated by ChEMBL


Assay Description
Inhibition of human DNA polymerase gamma


Citation and Details
More data for this
Ligand-Target Pair
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