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Compile Data Set for Download or QSAR

Found 32 hits Enz. Inhib. hit(s) with Target = 'DNA-directed RNA polymerase I subunit RPA1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019319
PNG
(CHEMBL3289424)
Show SMILES CC(CNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O)N(C)C
Show InChI InChI=1S/C22H22N4O2/c1-14(25(2)3)13-23-21(27)17-9-6-10-26-20(17)24-19-12-16-8-5-4-7-15(16)11-18(19)22(26)28/h4-12,14H,13H2,1-3H3,(H,23,27)
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n/an/a 40n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019324
PNG
(CHEMBL3289398)
Show SMILES CN(C)CCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C21H20N4O2/c1-24(2)11-9-22-20(26)16-8-5-10-25-19(16)23-18-13-15-7-4-3-6-14(15)12-17(18)21(25)27/h3-8,10,12-13H,9,11H2,1-2H3,(H,22,26)
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n/an/a 50n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019316
PNG
(CHEMBL3289421)
Show SMILES O=C(NCCN1CCCC1)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C23H22N4O2/c28-22(24-9-13-26-10-3-4-11-26)18-8-5-12-27-21(18)25-20-15-17-7-2-1-6-16(17)14-19(20)23(27)29/h1-2,5-8,12,14-15H,3-4,9-11,13H2,(H,24,28)
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n/an/a 90n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019318
PNG
(CHEMBL3289423)
Show SMILES CC(CN(C)C)NC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C22H22N4O2/c1-14(13-25(2)3)23-21(27)17-9-6-10-26-20(17)24-19-12-16-8-5-4-7-15(16)11-18(19)22(26)28/h4-12,14H,13H2,1-3H3,(H,23,27)
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n/an/a 110n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019317
PNG
(CHEMBL3289422)
Show SMILES CCN(CC)CCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C23H24N4O2/c1-3-26(4-2)13-11-24-22(28)18-10-7-12-27-21(18)25-20-15-17-9-6-5-8-16(17)14-19(20)23(27)29/h5-10,12,14-15H,3-4,11,13H2,1-2H3,(H,24,28)
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n/an/a 140n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019315
PNG
(CHEMBL3289420)
Show SMILES O=C(NCCN1CCCCC1)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C24H24N4O2/c29-23(25-10-14-27-11-4-1-5-12-27)19-9-6-13-28-22(19)26-21-16-18-8-3-2-7-17(18)15-20(21)24(28)30/h2-3,6-9,13,15-16H,1,4-5,10-12,14H2,(H,25,29)
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n/an/a 180n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019309
PNG
(CHEMBL3289414)
Show SMILES CN1CCC(CC1)NC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C23H22N4O2/c1-26-11-8-17(9-12-26)24-22(28)18-7-4-10-27-21(18)25-20-14-16-6-3-2-5-15(16)13-19(20)23(27)29/h2-7,10,13-14,17H,8-9,11-12H2,1H3,(H,24,28)
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n/an/a 180n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019308
PNG
(CHEMBL3289413)
Show SMILES O=C(NC1CNC1)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C20H16N4O2/c25-19(22-14-10-21-11-14)15-6-3-7-24-18(15)23-17-9-13-5-2-1-4-12(13)8-16(17)20(24)26/h1-9,14,21H,10-11H2,(H,22,25)
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n/an/a 210n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019305
PNG
(CHEMBL3289410)
Show SMILES CN(C)CCCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C22H22N4O2/c1-25(2)11-6-10-23-21(27)17-9-5-12-26-20(17)24-19-14-16-8-4-3-7-15(16)13-18(19)22(26)28/h3-5,7-9,12-14H,6,10-11H2,1-2H3,(H,23,27)
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n/an/a 430n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019304
PNG
(CHEMBL3289409)
Show SMILES CN(C)CCCCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C23H24N4O2/c1-26(2)12-6-5-11-24-22(28)18-10-7-13-27-21(18)25-20-15-17-9-4-3-8-16(17)14-19(20)23(27)29/h3-4,7-10,13-15H,5-6,11-12H2,1-2H3,(H,24,28)
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n/an/a 660n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019323
PNG
(CHEMBL3289428)
Show SMILES COCCN(C)CCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C23H24N4O3/c1-26(12-13-30-2)11-9-24-22(28)18-8-5-10-27-21(18)25-20-15-17-7-4-3-6-16(17)14-19(20)23(27)29/h3-8,10,14-15H,9,11-13H2,1-2H3,(H,24,28)
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n/an/a 730n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019298
PNG
(CHEMBL3289403)
Show SMILES O=C(NCCn1ccnc1)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C22H17N5O2/c28-21(24-8-11-26-10-7-23-14-26)17-6-3-9-27-20(17)25-19-13-16-5-2-1-4-15(16)12-18(19)22(27)29/h1-7,9-10,12-14H,8,11H2,(H,24,28)
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n/an/a 980n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019322
PNG
(CHEMBL3289427)
Show SMILES CN1CCN(CCNC(=O)c2cccn3c2nc2cc4ccccc4cc2c3=O)CC1
Show InChI InChI=1S/C24H25N5O2/c1-27-11-13-28(14-12-27)10-8-25-23(30)19-7-4-9-29-22(19)26-21-16-18-6-3-2-5-17(18)15-20(21)24(29)31/h2-7,9,15-16H,8,10-14H2,1H3,(H,25,30)
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n/an/a 1.09E+3n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019321
PNG
(CHEMBL3289426)
Show SMILES O=C(NCCN1CCOCC1)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C23H22N4O3/c28-22(24-7-9-26-10-12-30-13-11-26)18-6-3-8-27-21(18)25-20-15-17-5-2-1-4-16(17)14-19(20)23(27)29/h1-6,8,14-15H,7,9-13H2,(H,24,28)
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n/an/a 1.25E+3n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019326
PNG
(CHEMBL3289399)
Show SMILES CCN(CC)CCNC(=O)c1cccn2c1nc1ccccc1c2=O
Show InChI InChI=1S/C19H22N4O2/c1-3-22(4-2)13-11-20-18(24)15-9-7-12-23-17(15)21-16-10-6-5-8-14(16)19(23)25/h5-10,12H,3-4,11,13H2,1-2H3,(H,20,24)
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n/an/a 1.35E+3n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019306
PNG
(CHEMBL3289411)
Show SMILES CN1CCCC1CCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C24H24N4O2/c1-27-12-4-8-18(27)10-11-25-23(29)19-9-5-13-28-22(19)26-21-15-17-7-3-2-6-16(17)14-20(21)24(28)30/h2-3,5-7,9,13-15,18H,4,8,10-12H2,1H3,(H,25,29)
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n/an/a 2.01E+3n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019325
PNG
(CHEMBL160057)
Show SMILES CN(C)CCNC(=O)c1cccn2c1nc1ccccc1c2=O
Show InChI InChI=1S/C17H18N4O2/c1-20(2)11-9-18-16(22)13-7-5-10-21-15(13)19-14-8-4-3-6-12(14)17(21)23/h3-8,10H,9,11H2,1-2H3,(H,18,22)
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n/an/a 2.17E+3n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019320
PNG
(CHEMBL3289425)
Show SMILES CC(C)N(CCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O)C(C)C
Show InChI InChI=1S/C25H28N4O2/c1-16(2)28(17(3)4)13-11-26-24(30)20-10-7-12-29-23(20)27-22-15-19-9-6-5-8-18(19)14-21(22)25(29)31/h5-10,12,14-17H,11,13H2,1-4H3,(H,26,30)
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n/an/a 3.04E+3n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019303
PNG
(CHEMBL3289408)
Show SMILES CS(=O)(=O)CCNC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C20H17N3O4S/c1-28(26,27)10-8-21-19(24)15-7-4-9-23-18(15)22-17-12-14-6-3-2-5-13(14)11-16(17)20(23)25/h2-7,9,11-12H,8,10H2,1H3,(H,21,24)
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n/an/a 5.21E+3n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019299
PNG
(CHEMBL3289404)
Show SMILES O=C(NCCc1cccnc1)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C24H18N4O2/c29-23(26-11-9-16-5-3-10-25-15-16)19-8-4-12-28-22(19)27-21-14-18-7-2-1-6-17(18)13-20(21)24(28)30/h1-8,10,12-15H,9,11H2,(H,26,29)
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n/an/a 1.18E+4n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019301
PNG
(CHEMBL3289406)
Show SMILES O=C(NCCN1CCNC1=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C22H19N5O3/c28-20(23-7-10-26-11-8-24-22(26)30)16-6-3-9-27-19(16)25-18-13-15-5-2-1-4-14(15)12-17(18)21(27)29/h1-6,9,12-13H,7-8,10-11H2,(H,23,28)(H,24,30)
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n/an/a 1.31E+4n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019300
PNG
(CHEMBL3289405)
Show SMILES O=C(NCCc1ccccn1)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C24H18N4O2/c29-23(26-12-10-18-8-3-4-11-25-18)19-9-5-13-28-22(19)27-21-15-17-7-2-1-6-16(17)14-20(21)24(28)30/h1-9,11,13-15H,10,12H2,(H,26,29)
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n/an/a 1.58E+4n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019328
PNG
(CHEMBL3289401)
Show SMILES CN(C)CCN(C)C(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C22H22N4O2/c1-24(2)11-12-25(3)21(27)17-9-6-10-26-20(17)23-19-14-16-8-5-4-7-15(16)13-18(19)22(26)28/h4-10,13-14H,11-12H2,1-3H3
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n/an/a 2.21E+4n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019302
PNG
(CHEMBL3289407)
Show SMILES O=C(NCCc1c[nH]c2ccccc12)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C27H20N4O2/c32-26(28-12-11-19-16-29-23-10-4-3-8-20(19)23)21-9-5-13-31-25(21)30-24-15-18-7-2-1-6-17(18)14-22(24)27(31)33/h1-10,13-16,29H,11-12H2,(H,28,32)
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n/an/a 3.17E+4n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019314
PNG
(CHEMBL3289419)
Show SMILES CCN(CC)C1CCN(C1)C(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C25H26N4O2/c1-3-27(4-2)19-11-13-28(16-19)24(30)20-10-7-12-29-23(20)26-22-15-18-9-6-5-8-17(18)14-21(22)25(29)31/h5-10,12,14-15,19H,3-4,11,13,16H2,1-2H3
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n/an/a 3.18E+4n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019307
PNG
(CHEMBL3289412)
Show SMILES CN(C)CCCN(C)C(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C23H24N4O2/c1-25(2)11-7-12-26(3)22(28)18-10-6-13-27-21(18)24-20-15-17-9-5-4-8-16(17)14-19(20)23(27)29/h4-6,8-10,13-15H,7,11-12H2,1-3H3
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n/an/a 3.39E+4n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019310
PNG
(CHEMBL3289415)
Show SMILES CC(C)(C)OC(=O)N1CC(C1)NC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C25H24N4O4/c1-25(2,3)33-24(32)28-13-17(14-28)26-22(30)18-9-6-10-29-21(18)27-20-12-16-8-5-4-7-15(16)11-19(20)23(29)31/h4-12,17H,13-14H2,1-3H3,(H,26,30)
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n/an/a 3.54E+4n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019312
PNG
(CHEMBL3289417)
Show SMILES CN(C1CCN(C)C1)C(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C23H22N4O2/c1-25-11-9-17(14-25)26(2)22(28)18-8-5-10-27-21(18)24-20-13-16-7-4-3-6-15(16)12-19(20)23(27)29/h3-8,10,12-13,17H,9,11,14H2,1-2H3
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n/an/a 4.20E+4n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019327
PNG
(CHEMBL3289400)
Show SMILES CN(C)CCOC(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C21H19N3O3/c1-23(2)10-11-27-21(26)16-8-5-9-24-19(16)22-18-13-15-7-4-3-6-14(15)12-17(18)20(24)25/h3-9,12-13H,10-11H2,1-2H3
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n/an/a 5.09E+4n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019311
PNG
(CHEMBL3289416)
Show SMILES CC(C)N1CCN(CC1)C(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C24H24N4O2/c1-16(2)26-10-12-27(13-11-26)23(29)19-8-5-9-28-22(19)25-21-15-18-7-4-3-6-17(18)14-20(21)24(28)30/h3-9,14-16H,10-13H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019297
PNG
(CHEMBL3289402)
Show SMILES CCN(CCN(C)C)C(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C23H24N4O2/c1-4-26(13-12-25(2)3)22(28)18-10-7-11-27-21(18)24-20-15-17-9-6-5-8-16(17)14-19(20)23(27)29/h5-11,14-15H,4,12-13H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase I subunit RPA1


(Homo sapiens)
BDBM50019313
PNG
(CHEMBL3289418)
Show SMILES CN(C)[C@H]1CCN(C1)C(=O)c1cccn2c1nc1cc3ccccc3cc1c2=O
Show InChI InChI=1S/C23H22N4O2/c1-25(2)17-9-11-26(14-17)22(28)18-8-5-10-27-21(18)24-20-13-16-7-4-3-6-15(16)12-19(20)23(27)29/h3-8,10,12-13,17H,9,11,14H2,1-2H3/t17-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Induction of RNA polymerase-1 RPA194 subunit degradation in human U2OS cells after 3 hrs by epifluorescence microscopic analysis


Citation and Details
More data for this
Ligand-Target Pair