BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'DNA-directed RNA polymerase subunit beta'' AND taxid = 83333   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
DNA-directed RNA polymerase subunit beta'


(Escherichia coli K-12)
BDBM43866
PNG
(2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,1...)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C1=O
Show InChI InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

DrugBank
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 160n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli DNA-dependent RNA polymerase


J Med Chem 22: 1051-5 (1979)

More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


(Escherichia coli K-12)
BDBM50000057
PNG
(CHEMBL3228737)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3oc4c(C)c(=O)c(NCCCNC5CC(C)(C)[N+]([O-])C(C)(C)C5)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C1=O
Show InChI InChI=1S/C74H109N14O17/c1-36(2)51-69(98)86-30-21-24-46(86)67(96)82(17)34-48(89)84(19)58(38(5)6)71(100)103-42(11)53(65(94)78-51)80-63(92)45-27-26-40(9)61-55(45)77-57-50(56(60(91)41(10)62(57)105-61)76-29-23-28-75-44-32-73(13,14)88(102)74(15,16)33-44)64(93)81-54-43(12)104-72(101)59(39(7)8)85(20)49(90)35-83(18)68(97)47-25-22-31-87(47)70(99)52(37(3)4)79-66(54)95/h26-27,36-39,42-44,46-47,51-54,58-59,75-76H,21-25,28-35H2,1-20H3,(H,78,94)(H,79,95)(H,80,92)(H,81,93)/t42-,43-,46+,47+,51-,52-,53+,54+,58+,59+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 2.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli DNA-dependent RNA polymerase


J Med Chem 22: 1051-5 (1979)

More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


(Escherichia coli K-12)
BDBM50000055
PNG
(CHEMBL3228736)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3oc4c(C)c(=O)c(NCCNC5CC(C)(C)[N+]([O-])C(C)(C)C5)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C1=O
Show InChI InChI=1S/C73H107N14O17/c1-35(2)50-68(97)85-29-21-23-45(85)66(95)81(17)33-47(88)83(19)57(37(5)6)70(99)102-41(11)52(64(93)77-50)79-62(91)44-26-25-39(9)60-54(44)76-56-49(55(59(90)40(10)61(56)104-60)75-28-27-74-43-31-72(13,14)87(101)73(15,16)32-43)63(92)80-53-42(12)103-71(100)58(38(7)8)84(20)48(89)34-82(18)67(96)46-24-22-30-86(46)69(98)51(36(3)4)78-65(53)94/h25-26,35-38,41-43,45-46,50-53,57-58,74-75H,21-24,27-34H2,1-20H3,(H,77,93)(H,78,94)(H,79,91)(H,80,92)/t41-,42-,45+,46+,50-,51-,52+,53+,57+,58+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli DNA-dependent RNA polymerase


J Med Chem 22: 1051-5 (1979)

More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


(Escherichia coli K-12)
BDBM50015214
PNG
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12
Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli DNA-primed RNA polymerase activity using [8-14C]ATP by scintillation counting


J Med Chem 19: 994-8 (1976)

More data for this
Ligand-Target Pair